A continuous observation of the degenerative process in the intervertebral disc of Smad3 gene knock-out mice

Spine

Volumn 34, Issue 13, 2009, Pages 1363-1369

  Li, Chen Guang ^a   Liang, Qian Qian ^a   Zhou, Quan ^a,b   Menga, Emmanuel ^b   Cui, Xue Jun ^a   Shu, Bing ^a   Zhou, Chong Jian ^a   Shi, Qi ^a   Wang, Yong Jun ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Degeneration; Extracellular matrix; Intervertebral disc; Knock out mice; Smad3

Indexed keywords

AGGRECAN; COLLAGEN TYPE 10; COLLAGEN TYPE 2; MESSENGER RNA; PROTEOGLYCAN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE; CONTROLLED STUDY; GENE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK DEGENERATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RADIOGRAPHY; REAL TIME POLYMERASE CHAIN REACTION; SMAD3 GENE; STAINING;

AGGRECANS; ANIMALS; COLLAGEN TYPE II; COLLAGEN TYPE X; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DISPLACEMENT; MALE; MICE; MICE, KNOCKOUT; OSTEOARTHRITIS; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SMAD3 PROTEIN; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 67749118232     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e3181a3c7c7     Document Type: Article

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