Immunohistologic markers for age-related changes of human lumbar intervertebral discs

Spine

Volumn 22, Issue 24, 1997, Pages 2781-2795

  Nerlich, Andreas G ^a   Schleicher, Erwin D ^b   Boos, Norbert ^c  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c ORTHOPEDIC UNIVERSITY HOSPITAL BALGRIST   (Switzerland)

Author keywords

Annulus fibrosus; Basement membrane; Collagen types; Endplate; Intervertebral disc; Nucleus pulposus; Oxidative stress

Indexed keywords

COLLAGEN FIBRIL; COLLAGEN TYPE 1; COLLAGEN TYPE 10; COLLAGEN TYPE 2; COLLAGEN TYPE 3; COLLAGEN TYPE 4; COLLAGEN TYPE 5; COLLAGEN TYPE 6; COLLAGEN TYPE 9; BIOLOGICAL MARKER; DRUG DERIVATIVE; LYSINE; N(6) CARBOXYMETHYLLYSINE; N(6)-CARBOXYMETHYLLYSINE;

ADOLESCENT; ADULT; AGED; AGING; ARTICLE; CHILD; CLINICAL ARTICLE; DISEASE MARKER; FETUS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOLOGY; INFANT; INTERVERTEBRAL DISK DEGENERATION; NEWBORN; PHENOTYPE; PRIORITY JOURNAL; SURGICAL ANATOMY; AGE; CHEMISTRY; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK; LUMBAR VERTEBRA; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PRESCHOOL CHILD;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; FETUS; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; INFANT, NEWBORN; INTERVERTEBRAL DISK; LUMBAR VERTEBRAE; LYSINE; MIDDLE AGED;

EID: 0031573622     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007632-199712150-00001     Document Type: Article

References (44)

1. Ahmed MU, Thorpe SR, Baynes JW. Identification of N-(carboxymethyl)lysine as a degradation product of fructose lysine in glycated protein. J Biol Chem 1986;261:4889-94.
2. Banga I. Investigation of fluorescent peptides and lipofuscins of human intervertebral disc relating to atherosclerosis. Atherosclerosis 1975;22:533-41.
3. Beard HK, Ryvar R, Brown R, Muir H. Immunochemical localization of collagen types and proteoglycan in pig intervertebral discs. Immunology 1980;41:491-501.
4. Beard HK, Roberts S, O'Brien JP. Immunofluorescent staining for collagen and proteoglycan in normal and scoliotic intervertebral discs. J Bone Joint Surg [Br] 1981;63 B:529-34.
5. Bernick S, Walker JM, Paule WJ. Age changes to the anulus fibrosus in human intervertebral discs. Spine 1991;16:520-4.
6. Betz P, Nerlich A, Wilske J, et al. Time dependent pericellular expression of collagen type IV, laminin and heparan sulfate proteoglycan in myofibroblasts. Int J Legal Med 1992;105: 169-72.
7. Boos N, Nerlich AG, Wiest I, von der Mark K, Aebi M. Immunolocalization of type 8 collagen in human lumbar intervertebral discs during aging and degeneration. Histochem Cell Biol 1997 (in press).
8. Buckwalter JA. Spine update: Ageing and degeneration of the human intervertebral disc. Spine 1995;20:1307-14.
9. Cordell JL, Falini B, Erber WN, et al. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase. J Histochem Cytochem 1984;32:219-25.
10. Coventry MB, Ghormley RK, Kernohan JW. The intervertebral disc: Its microscopic anatomy and pathology. Part II. Changes in the intervertebral disc concomittant with age. J Bone Joint Surg 1945;27 A:233-47.
11. Dyer DG, Dunn JA, Thorpe SR, et al. Accumulation of Maillard reaction products in skin collagen in diabetes and aging. J Clin Invest 1993;91:2463-9.
12. Eyre DR. Collagens of the disc. In: Ghosh P, ed. The Biology of the Intervertebral Disc. Boca Raton, Florida: CRC Press, 1988:171-88.
13. Fraser RD, Osti OL, Vernon-Roberts B. Intervertebral disc degeneration. Eur Spine J 1993;1:205-13.
14. Fu MX, Knecht KJ, Thorpe SR, Baynes JW. Role of oxygen in cross-linking and chemical modification of collagen by glucose. Diabetes 1992;41:42-8.
15. Ghosh P, Bushell GR, Taylor TFK, Akeson WH. Collagens, elastins and noncollagenous protein of the intervertebral disc. Clin Orthop 1977;129:124-32.
16. Girkontaite I, Frischholz S, Lammi P, et al. Immunolocalization of type X collagen in normal fetal and adult osteoarthritic cartilage with monoclonal antibodies. Matrix Biology 1996;15:231-8.
17. Hormel SE, Eyre DR. Collagen in the ageing human intervertebral disc: An increase in covalently bound fluorophores and chromophores. Biochim Biophys Acta 1991;1078:243-50.
18. Hsu SM, Raine L, Fanger H. A comparative study of the peroxidase-antiperoxidase method and an avidin-biotin complex method for studying polypeptide hormones with radio immunoassay antibodies. Am J Clin Pathol 1981;75:734-9.
19. Ishii T, Tsuji H, Sano A, Katoh Y, Matsui H, Terahata N. Histochemical and ultrastructural observations on brown degeneration of human intervertebral disc. J Orthop Res 1991;9: 78-90.
20. Kääpä E, Holm S, Han X, Takala T, Kovanen V, Vanharanta H. Collagens in the injured porcine intervertebral disc. J Orthop Res 1994;12:93-102.
21. Ledl F, Schleicher E. New aspects of the Maillard reaction in foods and in the human body. Augewaudte Chemie 1990;6: 565-94.
22. Melrose J, Ghosh P, Taylor TKF, et al. A longitudinal study of the matrix changes induced in the intervertebral disc by surgical damage to the annulus fibrosus. J Orthop Res 1992; 10:665-76.
23. Miller JAA, Schmatz C, Schultz AB. Lumbar disc degeneration: Correlation with age, sex and spine level in 600 autopsy specimens. Spine 1988;13:173-8.
24. Nerlich A, Schleicher E. Immunohisrochemical localization of extracellular matrix components in human diabetic glomerular lesions. Am J Pathol 1991;139:889-99.
25. Nerlich A, Kirsch T, Wiest I, Betz P, von der Mark K. Localization of collagen X in human fetal and juvenile articular cartilage and bone. Histochemistry 1992;98:275-81.
26. Nerlich AG, Wiest I, von der Mark K. Immunohistochemical analysis of interstitial collagens in cartilage of different stages of osteoarthrosis. Virchows Arch Cell Path 1993;63 B: 249-56.
27. Nerlich AG, Boos N, Wiest I, Aebi M. Immunolocalization of major interstitial collagen types in human lumbar intervertebral discs of various ages. Virchows Arch (1997) In press.
28. Oegema TR. Intervertebral disk - future directions. In: Buckwalter JA, Goldberg VM, Woo SLY, eds. Musculoskeletal Soft-Tissue Aging: Impact on Mobility. Rosemont: American Academy of Orthopaedic Surgeons, 1993:413-7.
29. Pearce RH, Grimmer BJ, Adams ME. Degeneration and chemical composition of the human lumbar intervertebral disc. J Orthop Res 1987;5:198-205.
30. Reddy S, Bichler J, Wells-Knecht KJ, Thorpe SR, Baynes JW. N-(carboxymethyl)lysine is a dominant advanced glycation end product (AGE) in tissue proteins. Biochemistry 1995; 34:10872-8.
31. Roberts S, Menage J, Duance V, Wotton S, Ayad S. Collagen types around the cells of the intervertebral disc and cartilage end plate: An immunolocalization study. Spine 1991;16: 1030-8.
32. Roberts S, Ayad S, Menage PJ. Immunolocalization of type VI collagen in the intervertebral disc. Ann Rheumatol Dis 1991;50:787-91.
33. Roberts S, Menage J, Duance V, Wotton SF. Type III collagen in the intervertebral disc. Histochem J 1991;23:503-8.
34. Schleicher ED, Wagner E, Nerlich AG. Increased accumulation of the glycoxidation product N-(carboxymethyl)lysine in human tissues in diabetes and aging. J Clin Invest 1997;99: 457-68.
35. Timpl R, Wick G, Gay S. Antibodies against distinct collagens and procollagens and their application in immunohistochemistry. J Immunol Methods 1977;18:165-75.
36. Thompson JP, Pearce RH, Schechter MT, Adams ME, Tsang IKY, Bishop PB. Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc. Spine 1990;15:411-5.
37. Urban JPG, Holm S, Maroudas A, Nachemson A. Nutrition of the intervertebral disk. Clin Orthop 1977;129:101-14.
38. Urban JPG. The effect of physical factors on disk cell metabolism. In: Buckwalter JA, Goldberg VM, Woo SLY, eds. Musculoskeletal Soft-Tissue Aging: Impact on Mobility. Rosemont: American Academy of Orthopaedic Surgeons, 1993: 391-412.
39. Vernon-Roberts B. Age-related and degenerative pathology of intervertebral discs and apophyseal joints, in: Jayson MIV, ed. The Lumbar Spine and Back Pain, 4th ed. Edinburgh: Churchill Livingstone, 1992:17-41.
40. von der Mark H, Aumailley M, Wick G, Fleishmajer R, Timpl R. Immunochemistry, genuine size and tissue localization of collagen VI. Eur J Biochem 1984;142:493-502.
41. Weidner N, Rice DT. Intervertebral disc material: Criteria for determining probable prolapse. Hum Pathol 1988;19:406-10.
42. Wells-Knecht MC, Thorpe SR, Baynes JW. Pathways of formation of glycoxidation products during glycation of collagen. Biochemistry 1995;34:15134-41.
43. Wu JJ, Eyre DR, Slayter HS. Type VI collagen of the intervertebral disc. Biochem J 1987;248:373-81.
44. Yasuma T, Koh S, Okamura T, Yamauchi Y. Histological changes in aging lumbar intervertebral discs. Their role in protrusions and prolapses. J Bone Joint Surg 1990;72A:220-9.