A novel series of (S)-2,7-substituted-1,2,3,4-tetrahydroisoquinoline-3- carboxylic acids: Peroxisome proliferator-activated receptor α/γ dual agonists with protein-tyrosine phosphatase 1B inhibitory activity

Chemical and Pharmaceutical Bulletin

Volumn 59, Issue 10, 2011, Pages 1233-1242

  Otake, Kazuya ^a   Azukizawa, Satoru ^a   Fukui, Masaki ^a   Shibabayashi, Michiko ^a   Kamemoto, Hikaru ^a   Miike, Tomohiro ^a   Kunishiro, Kazuyoshi ^a   Kasai, Masayasu ^a   Shirahase, Hiroaki ^a  

^a Research Laboratories   (Japan)

Author keywords

Diabetes; Hypoglycemic effect; KK A y mouse; Peroxisome proliferator activated receptor; Protein tyrosine phosphatase 1B; Tetrahydroisoquinoline derivative

Indexed keywords

1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID DERIVATIVE; 2 [HEXADIENOYL] 7 [2 [5 METHYL 2 (2 (1 METHYLCYCLOHEXYL)VINYL)OXAZOL 4 YL]ETHOXY] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 2 [HEXADIENOYL] 7 [2 [5 METHYL 2 (2 (1 METHYLCYCLOPENTYL)VINYL)OXAZOL 4 YL]ETHOXY] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 7 [2 [2 (2 CYCLOBUTYLVINYL) 5 METHYLOXAZOL 4 YL]ETHOXY] 2 [HEXADIENOYL] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID TERT BUTYLAMSINE SALT; 7 [2 [2 (2 CYCLOHEXYLIDENEMETHYL 5 METHYLOXAZOL 4 YL)ETHOXY] 2 [HEXADIENOYL] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID TERT BUTYLAMSINE SALT; 7 [2 [2 (2 CYCLOHEXYLVINYL) 5 METHYLOXAZOL 4 YL]ETHOXY] 2 [HEXADIENOYL] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID TERT BUTYLAMSINE SALT; 7 [2 [2 (2 CYCLOPENTYL 1 METHYLVINYL) 5 METHYLOXAZOL 4 YL]ETHOXY] 2 [HEXADIENOYL] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID TERT BUTYLAMSINE SALT; 7 [2 [2 (2 CYCLOPENTYLETHYL) 5 METHYLOXAZOL 4 YL]ETHOXY] 2 HEXADIENOYL] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID TERT BUTYLAMINE SALT; 7 [2 [2 (2 CYCLOPENTYLVINYL) 5 METHYLOXAZOL 4 YL]ETHOXY] 2 [HEXADIENOYL] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID TERT BUTYLAMSINE SALT; 7 [2 [2 (2 CYCLOPROPYLVINYL) 5 METHYLOXAZOL 4 YL]ETHOXY] 2 [HEXADIENOYL] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID TERT BUTYLAMSINE SALT; ACYL COENZYME A OXIDASE; CARBOXYLIC ACID DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; ROSIGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG SYNTHESIS; ENZYME ACTIVITY; MOUSE; NONHUMAN; PLASMA VOLUME; SYRIAN HAMSTER;

ANIMALS; BLOOD GLUCOSE; CARBOXYLIC ACIDS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MICE; MICE, INBRED ICR; MOLECULAR TARGETED THERAPY; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PROTEIN TYROSINE PHOSPHATASES; QUINAZOLINONES; TETRAHYDROISOQUINOLINES; THIAZOLIDINEDIONES;

EID: 80053433824     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.59.1233     Document Type: Article

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