2-Acyl-tetrahydroisoquinoline-3-carboxylic Acids: Lead compounds with triple actions, peroxisome proliferator-activated receptor α/γ agonist and protein-tyrosine phosphatase 1B inhibitory activities

Chemical and Pharmaceutical Bulletin

Volumn 59, Issue 7, 2011, Pages 876-879

  Otake, Kazuya ^a   Azukizawa, Satoru ^a   Takahashi, Kenji ^a   Fukui, Masaki ^a   Shibabayashi, Michiko ^a   Kamemoto, Hikaru ^a   Kasai, Masayasu ^a   Shirahase, Hiroaki ^a  

^a Research Laboratories   (Japan)

Author keywords

Diabetes; Hypoglycemic effect; Peroxisome proliferator activated receptor; Protein tyrosine phosphatase 1B; Tetrahydroisoquinoline derivative

Indexed keywords

2 (2 HEXYNOYL) 7 [2 (5 METHYL 2 PHENYLOXAZOL 4 YL)ETHOXY] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 2 (5 HEXENOYL) 7 [2 (5 METHYL 2 PHENYLOXAZOL 4 YL)ETHOXY] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 2 (HEXADIENOYL) 7 [2 (5 METHYL 2 PHENYLOXAZOL 4 YL)ETHOXY] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID TERT BUTYL AMINE SALT; 2 HEXANOYL 7 [2 (5 METHYL 2 PHENYLOXAZOL 4 YL)ETHOXY] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID; ERTIPROTAFIB; ETHYL 2 HEXANOYL 7 [2 (5 METHYL 2 PHENYLOXAZOL 4 YL)ETHOXY] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLATE; KY 021; METHYL 2 (2 HEXENOYL) 7 [2 (5 METHYL 2 PHENYLOXAZOL 4 YL)ETHOXY] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLATE; METHYL 2 (5 HEXENOYL) 7 [2 (5 METHYL 2 PHENYLOXAZOL 4 YL)ETHOXY] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLATE; METHYL 2 (HEXADIENOYL) 7 [2 (5 METHYL 2 PHENYLOXAZOL 4 YL)ETHOXY] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLATE; METHYL 2 (HEXENOYL) 7 [2 (5 METHYL 2 PHENYLOXAZOL 4 YL)ETHOXY] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLATE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; ROSIGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; MALE; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ANIMALS; ENZYME INHIBITORS; HYPOGLYCEMIC AGENTS; MICE; PPAR ALPHA; PPAR GAMMA; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RATS; TETRAHYDROISOQUINOLINES;

EID: 79959772980     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.59.876     Document Type: Article

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