Synthesis and biological evaluation of (S)-1,2,3,4-tetrahydroisoquinoline- 3-carboxylic acids: A novel series of PPARγ agonists

Chemical and Pharmaceutical Bulletin

Volumn 56, Issue 3, 2008, Pages 335-345

  Azukizawa, Satoru ^a   Kasai, Masayasu ^a   Takahashi, Kenji ^a   Miike, Tomohiro ^a   Kunishiro, Kazuyoshi ^a   Kanda, Mamoru ^a   Mukai, Chisato ^b   Shirahase, Hiroaki ^a  

^a Research Laboratories   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

Diabetes; Hypoglycemic effect; Hypolipidemic effect; KK Ay mouse; Peroxisome proliferators activated receptor (PPAR) agonist; Tetrahydroisoquinoline derivative

Indexed keywords

1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 2 [1 CARBOXY 2 [4 [2 (5 METHYL 2 PHENYL 4 OXAZOLYL)ETHOXY]PHENYL]ETHYLAMINO]BENZOIC ACID METHYL ESTER; 2 BENZYL 7 [2 (5 METHYL 2 PHENYLOXAZOL 4 YL)ETHOXY] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; FARGLITAZAR; GLUCOSE; ISOQUINOLINE DERIVATIVE; KY 021; MURAGLITAZAR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; REGLITAZAR; ROSIGLITAZONE; TESAGLITAZAR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; YM 440;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; MALE; MOUSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; RAT; STRUCTURE ACTIVITY RELATION; TRIACYLGLYCEROL BLOOD LEVEL;

3T3 CELLS; ADIPOCYTES; ANIMALS; ANTILIPEMIC AGENTS; BLOOD GLUCOSE; CELL DIFFERENTIATION; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, THIN LAYER; CYCLIZATION; HYPOGLYCEMIC AGENTS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE; MICE, INBRED ICR; OXAZOLES; PPAR GAMMA; RATS; RATS, SPRAGUE-DAWLEY; RATS, ZUCKER; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES; TRIGLYCERIDES; TYROSINE;

EID: 41549130259     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.56.335     Document Type: Article

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