Activated Ki-ras enhances sensitivity of ceramide-induced apoptosis without c-Jun NH2-terminal kinase/stress-activated protein kinase or extracellular signal-regulated kinase activation in human colon cancer cells

Cancer Research

Volumn 57, Issue 21, 1997, Pages 4714-4717

  Ohmori, Mariko ^a   Shirasawa, Senji ^a   Furuse, Masanori ^a   Okumura, Koji ^a   Sasazuki, Takehiko ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; MITOGEN ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; COLORECTAL CANCER; ENZYME ACTIVATION; GENE MUTATION; GENE TARGETING; HUMAN; HUMAN CELL; ONCOGENE C JUN; ONCOGENE K RAS; PRIORITY JOURNAL;

APOPTOSIS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CERAMIDES; COLONIC NEOPLASMS; DNA FRAGMENTATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, RAS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-RAF; TUMOR CELLS, CULTURED;

EID: 0030830687     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Hannun, Y. A., and Obeid, L. M. Ceramide: an intracellular signal for apoptosis. Trends Biochem. Sci., 20: 73-77, 1995.
2. Kolesnick, R. Signal transduction through the sphingomyelin pathway. Mol. Chem. Neuropathol., 21: 287-297, 1994.
3. Verheij, M., Bose, R., Lin, X. H., Yao, B., Jarvis, W. D., Grant, S., Birrer, M. J., Szabo, E., Zon, L. I., Kyriakis, J. M., Haimovitz, F. A., Fuks, Z., and Kolesnick, R. N. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature (Lond), 380: 75-79, 1996.
4. Derijard, B., Hibi, M., Wu, I. H., Barrett, T., Su, B., Deng, T., Karin, M., and Davis, R. J. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell, 76: 1025-1037, 1994.
5. Hibi, M., Lin, A., Smeal, T., Minden, A., and Karin, M. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev., 7: 2135-2148, 1993.
6. Gulbins, E., Bissonnette, R., Mahboubi, A., Martin, S., Nishioka, W., Brunner, T., Baier, G., Baier-Bitterlich, G., Byrd, C., Lang, F., Kolesnick, R., Altman, A., and Green, D. FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway. Immunity, 2: 341-351, 1995.
7. Shirasawa, S., Furuse, M., Yokoyama, N., and Sasazuki, T. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science (Washington DC), 260: 85-88, 1993.
8. Furuse, M., Shirasawa, S., Okumura, K., Ohmori, M., and Sasazuki, T. Suppression of serum-induced c-Jun expression by activated Ki-ras in human colon cancer cells. Jpn. J. Hum. Genet., in press, 1997.
9. Ishida, Y., Agata, Y., Shibahara, K., and Honjo, T. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J., 11: 3887-3895, 1992.
10. Bielawska, A., Crane, H. M., Liotta, D., Obeid, L. M., and Hannun, Y. A. Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide. J. Biol. Chem., 268: 26226-26232, 1993.
11. Stokoe, D., Macdonald, S. G., Cadwallader, K., Symons, M., and Hancock, J. F. Activation of Raf as a result of recruitment to the plasma membrane (Published erratum in Science (Washington DC), 266: 1792-1793, 1994). Science (Washington DC), 264: 1463-1467, 1994.
12. Leevers, S. J., Paterson, H. F., and Marshall, C. J. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature (Lond.), 369: 411-414, 1994.
13. Huwiler, A., Brunner, J., Hummel, R., Vervoordeldonk, M., Stabel, S., van den Bosch, H., and Pfeilschifter, J. Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase. Proc. Natl. Acad. Sci. USA, 93: 6959-6963, 1996.
14. Yao, B., Zhang, Y., Delikat, S., Mathias, S., Basu, S. and Kolesnick, R. Phosphorylation of Raf by ceramide-activated protein kinase. Nature (Lond.), 378: 307-310, 1995.
15. Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M., Waters, C. M., Penn, L. Z., and Hancock, D. C. Induction of apoptosis in fibroblasts by c-myc protein. Cell, 69: 119-128, 1992.