Probing the druggability of protein - Protein interactions: Targeting the Notch1 receptor ankyrin domain using a fragment-based approach

Biochemical Society Transactions

Volumn 39, Issue 5, 2011, Pages 1327-1333

  Abdel Rahman, Noha ^a,b   Martinez Arias, Alfonso ^a   Blundell, Tom L ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MANSOURA UNIVERSITY   (Egypt)

Author keywords

Ankyrin domain; Druggability; Fragment based approach; Notch; Protein protein interaction

Indexed keywords

ANKYRIN; BENZENE DERIVATIVE; BIPHENYL; GUANIDINE; IMIDAZOLE; NOTCH1 RECEPTOR; PIPERIDINE;

ACUTE LYMPHOCYTIC LEUKEMIA; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CAENORHABDITIS ELEGANS; CELL COMMUNICATION; CHROMOSOME TRANSLOCATION; CONFERENCE PAPER; CRYSTAL STRUCTURE; DIMERIZATION; DROSOPHILA; GASTROINTESTINAL TOXICITY; GENE MUTATION; GENE TARGETING; HYDROGEN BOND; HYDROPHOBICITY; LIPOPHILICITY; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STATIC ELECTRICITY; T CELL LEUKEMIA; TEMPERATURE;

AMINO ACID SEQUENCE; ANKYRINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DRUG DESIGN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION;

EID: 80053367108     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0391327     Document Type: Conference Paper

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