Ventilator-associated pneumonia in burn patients: A cause or consequence of critical illness?

Expert Review of Respiratory Medicine

Volumn 5, Issue 5, 2011, Pages 663-673

  Huzar, Todd F ^a   Cross, James M ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

hospital acquired pneumonia; inhalation injury; multidrug resistant organisms; nosocomial infection; respiratory tract; VAP bundles; ventilator associated pneumonia

Indexed keywords

ANTIBIOTIC AGENT;

ARTIFICIAL VENTILATION; BACTERIAL COLONIZATION; BACTERIAL PNEUMONIA; BACTERIUM; BURN; CAUSE OF DEATH; CELLULAR IMMUNODEFICIENCY; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; DIAGNOSTIC ACCURACY; ENDOTRACHEAL INTUBATION; HIGH FREQUENCY VENTILATION; HOSPITALIZATION; HUMAN; HUMORAL IMMUNE DEFICIENCY; INTENSIVE CARE UNIT; LUNG BIOPSY; LUNG BURN; LUNG LAVAGE; REVIEW; THERMAL INJURY; TISSUE INJURY; VENTILATOR ASSOCIATED PNEUMONIA; VIRUS PNEUMONIA; WOUND HEALING;

EID: 80053352379     PISSN: 17476348     EISSN: 17476356     Source Type: Journal    
DOI: 10.1586/ers.11.61     Document Type: Review

References (138)

1. Howard PA, Cancio LC, McManus AT, Goodwin CW, Kim SH, Pruitt BA Jr.. Whats new in burn-associated infection. Curr. Surg. 56, 497-405 (1999).
2. Eckert MJ, Wade TE, Davis KA et al. Ventilator-associated pneumonia after combined burn and trauma is caused by associated injuries and not the burn wound. J. Burn Care Res. 27, 457-462 (2006). (Pubitemid 44510434)
3. Klebs E. Beiträge zur kenntniss der pathogenen schistomyceten. vii die monadinen. Arch. Exptl. Pathol. Parmakol. 4(5-6), 409-488 (1875).
4. Osler W, McCrae T. The Principles And Practice Of Medicine: Designed For The Use Of Practitioners And Students Of Medicine D. Appleton and Company, New York, NY, USA, 78 (1912).
5. Finland M, Davidson CS, Levenson SM. Clinical and therapeutic aspects of the conflagration injuries to the respiratory tract sustained by victims of the Cocoanut Grove disaster. Medicine 2, 215-283 (1946).
6. Saffle JR. The 1942 fire at Bostons Cocoanut Grove nightclub. Am. J. Surg. 166, 581-591 (1993 (Pubitemid 24309327)
7. Phillips AW, Cope O. Burn therapy II. The revelation of respiratory tract damage as a principal killer of the burned patient. Ann. Surg. 155, 1-19 (1962).
8. Moncrief JA, Lindberg RR, Switzer WE et al. Use of topical antibacterial therapy in the treatment of the burn wound. Arch. Surg. 92, 558-565 (1966).
9. Pruitt BA Jr., DiVincenti FC, Mason AD Jr. et al. The occurrence and significance of pneumonia and other pulmonary complications in burned patients: comparison of conventional and topical treatments. J. Trauma 10(7), 519-531 (1970).
10. Pruitt BA Jr., Flemma RJ, DiVincenti FC et al. Pulmonary complications in burn patients. J. Thorac. Cardiovasc. Surg. 59(1), 7-20 (1970).
11. Tablan OC, Anderson LJ, Besser R et al. Guidelines for preventing health-care-associated pneumonia, 2003: recommendations of the CDC and the Healthcare Infection Control Practices Advisory Committee. MMWR Recomm. Rep. 53(RR-3), 1-36 (2004).
12. Klevens RM, Edwards JR, Richards CL Jr. et al. Estimating health care-associated infections and deaths in U.S. hospitals, 2002. Public Health Rep. 122, 160-166 (2007).
13. Mosier MJ, Pham TN. American burn association practice guidelines for prevention, diagnosis, and treatment of ventilator-associated pneumonia (VAP) in burn patients. J. Burn Care Res. 30, 910-928 (2009).
14. American Thoracic Society Infectious Diseases Society of America. Guidelines for the management of adults with hospital-, ventilator- associated and healthcare-associated pneumonia. Am. J. Respir. Crit. Care Med. 171(4), 388-416 (2005).
15. Worrall CL, Anger BP, Simpson KN et al. Impact of a hospital-acquired/ ventilator-associated/healthcare-associated pneumonia practice guideline on outcomes in surgical trauma patients. J. Trauma 68(2), 382-6 (2010).
16. Chastre J, Fagon JY. Ventilator-associated pneumonia. Am. J. Respir. Crit. Care Med. 165, 867-903 (2002). (Pubitemid 34774654)
17. Wip C, Napolitano L. Bundles to prevent ventilator-associated pneumonia: how valuable are they? Curr. Opin. Infect. Dis. 22, 159-166 (2009).
18. Safdar N, Dezfulian C, Collard HR et al. Clinical and economic consequences of ventilator associated pneumonia: a systematic review. Crit. Care. Med. 33, 2184-2193 (2005).
19. Wibbenmeyer L, Danks R, Faucher L et al. prospective analysis of nosocomial infection rates, antibiotic use, and patterns of resistance in a burn population. J. Burn Care Res. 27, 152-160 (2006). (Pubitemid 43970315)
20. Branski LK, Al-Mousawi A, Rivero H et al. Emerging infections in burns. Surg. Infect. 10(5), 389-397 (2009).
21. Wurtz R, Karajovic M, Dacumos E et al. Nosocomial infections in the burn intensive care unit. Burns 21(3), 181-184 (1995).
22. Darling GE, Keresteci MA, Ibanez D et al. Pulmonary complications in inhalation injuries with associate cutaneous Burns. J. Trauma 40, 83-89 (1996). (Pubitemid 26045024)
23. Hall JJ, Hunt JL, Arnoldo BD, Purdue GF. Use of high-frequency percussive ventilation in inhalation injuries. J. Burn Care Res. 28, 396-400 (2007). (Pubitemid 46733245)
24. Thompson PB, Herndon DN, Traber DL et al. Effect on mortality of inhalation injury. J. Trauma 26, 163-165 (1986 (Pubitemid 16113109)
25. Pruitt BA Jr., Cioffi WG, Shimazu T, Ikeuchi H, Mason AD Jr. et al. Evaluation and management of patients with inhalation injury. J. Trauma 30, S63-S69 (1990).
26. Harvey JS, Watkins GM, Sherman RT. Emergent burn care. South. Med. J. 77(2), 204-214 (1984). (Pubitemid 14154510)
27. Zawacki BE, Jung RC, Joyce J, Rincon E. Smoke, burns, and the natural history of inhalation injury in fire victims: a correlation of experimental and clinical data. Ann. Surg. 185(1), 100-110 (1977). (Pubitemid 8015199)
28. Finnerty CC, Herndon DN, Jeschke MG. Inhalation injury in severely burned children does not augment the systemic inflammatory response. Crit. Care 11(1), R22 (2007).
29. Fraser JF, Mullany D, Traber, D. Inhalational lung injury in patients with severe thermal Burns. Cont. Crit. Care 4(9), 1-12 (2007).
30. Shirani KZ, Pruitt BA Jr., Mason AD Jr.. The influence of inhalation injury and pneumonia on burn mortality. Ann. Surg. 205, 82-87 (1987). (Pubitemid 17225029)
31. Mlcak RP, Suman OE, Herndon DN. Respiratory management of inhalation injury (review). Burns 33, 2-13 (2007). (Pubitemid 46073457)
32. Edelman DA, Khan N, Kempf K, White MT. Pneumonia after inhalation injury. J. Burn Care Res. 28, 241-246 (2007). (Pubitemid 46411559)
33. Kollef MH. What is Ventilator-associated pneumonia and why is it important? Respir. Care 50(6), 714-721 (2005). (Pubitemid 46187577)
34. Cook DJ, Walter SD, Cook RJ et al. Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients. Ann. Intern. Med. 129(6), 433-440 (1998). (Pubitemid 28428078)
35. Torres A, Gatell JM, Aznar E et al. Re-intubation increases the risk of nosocomial pneumonia in patients needing mechanical ventilation. Am. J. Respir. Crit. Care. Med. 152(1), 137-141 (1995).
36. Eckert MJ, Davis KA, Reed RL II et al. Urgent airways after trauma: who get pneumonia? J. Trauma 57, 750-755 (2004). (Pubitemid 39431195)
37. Eckert MJ, Davis KA, Reed RL II et al. Ventilator-associated pneumonia, like real estate: location really matters. J. Trauma 60, 104-110 (2006).
38. Mosier MJ, Gamelli RL, Halerz MM et al. Microbial contamination in burn patients undergoing urgent intubation as part of their early airway management. J. Burn Care Res. 29, 304-310 (2008). (Pubitemid 351498824)
39. Langeron O, Birenbaum A, Amour J. Airway management in trauma. Minerva Anestesiol. 75(5), 307-311 (2008).
40. Efrati S, Deutsch I, Antonelli M et al. Ventilator-associated pneumonia: current status and future recommendations. J. Clin. Monit. Comput. 24, 161-168 (2010).
41. Safdar N, Crnich CJ, Maki DG. The pathogenesis of ventilator-associated pneumonia: its relevance to developing effective strategies for prevention. Respir. Care 50(6), 725-741 (2005).
42. Lillehoj ER, Kim KC. Airway mucus: its components and function. Arch. Pharm. Res. 25(6), 770-780 (2002). (Pubitemid 43066562)
43. Antunes MD, Cohen NA. Mucociliary clearance-a critical upper airway host defense mechanism and methods of assessment. Curr. Opin. Allergy Clin. Immunol. 7(1), 5-10 (2007). (Pubitemid 46095880)
44. Reynolds HY. Defense mechanisms against infections. Curr. Opin. Pulm. Med. 5(3), 136-142 (1999).
45. Strieter RM, Belperio JA, Keane MP. Host innate defense in the lung: the role of cytokines. Curr. Opin. Infect. Dis. 16(3), 193-198 (2003). (Pubitemid 36677311)
46. McCool FD. Global Physiology and pathophysiology of cough: ACCP evidence-based clinical practice guidelines. Chest 129, 48S-53S (2006). (Pubitemid 43265203)
47. Klainer As, Turndorf H, Wu WH et al. Surface alterations due to endotracheal intubation. Am. J. Med. 58, 674-683 (1975).
48. Rue III LW, Cioffi WG, Mason AD Jr. et al. The risk of pneumonia in thermally injured patients requiring ventilatory support. J. Burn Care Rehabil. 16, 262-268 (1995).
49. Church D, Elsayed S, Reid O et al. Burn wound infections. Clin. Microbiol. Rev. 19(2), 403-434 (2006).
50. Collart MA, Belin D, Vassalli JD et al. g interferon enhances macrophage transcription of the tumor necrosis factor/ cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors. J. Exp. Med. 164, 2113-2118 (1986). (Pubitemid 17217991)
51. Alexander JW. Mechanism of immunologic suppression in burn injury. J. Trauma 30(12S), S70-S75 (1990).
52. OSullivan ST, OConnor TP. Immunosuppression following thermal injury: the pathogenesis of immunodysfunction. Br. J. Plast. Surg. 50(8), 615-623 (1997).
53. Stephan RN, Ayala A, Harkema JM et al. Mechanism of immunosuppression following hemorrhage: defective antigen presentation by macrophages. J. Surg. Res. 46, 553-556 (1989). (Pubitemid 19170320)
54. Griswold JA. White blood cell response to burn injury. Semin. Nephrol. 12, 409-415 (1993). (Pubitemid 23199590)
55. Grogan JB. Altered neutrophil phagocytic function in burn patients. J. Trauma 16, 734-738 (1976).
56. Heideman M, Bengtsson A. The immunologic response to thermal injury. World J. Surg. 16, 53-56 (1992).
57. Schlüter B, Konig W, Koller M et al. Studies on B-lymphocyte dysfunctions in severely burned patients. J. Trauma 31, 239-246 (1990).
58. Cancio LC, Howard PA, McManus AT, Goodwin CW, Pruitt BA Jr.. Thermal injury. In:Basic Science for Surgeons: A review. Argenta LC (Ed.). WB Saunders, Philadelphia, PA, USA, 405-432 (2003).
59. Crnich CH, Safdar N, Maki DG. The role of the intensive care unit environment in the pathogenesis and prevention of ventilator-associated pneumonia. Respir. Care 50(6), 813-836 (2005). (Pubitemid 46187579)
60. America ATSIDSo. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am. J. Respir. Crit. Care Med. 171, 388-416 (2005).
61. Rello J, Ollendorf DA, Oster G et al. Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest 122, 2115-2121 (2002). (Pubitemid 36051151)
62. Torres A, Weig S, Lode H et al. Defining, treating, and preventing hospital acquired pneumonia: European prospective. Intensive Care Med. 35, 9-29 (2009).
63. Bonten MJ, Gaillard CA, de Leeuw PW et al. Role of colonization of the upper intestinal tract in the pathogenesis of ventilator-associated pneumonia. Clin. Infect. Dis. 24(3), 309-319 (1997). (Pubitemid 27096781)
64. De la Cal MA, Cerd E, Garci-Hierro P et al. Pneumonia in patients with severe burns. Chest 119, 1160-1165 (2001).
65. Scannapieco FA, Stewart EM, Mylotte JM. Colonization of dental plaque by respiratory pathogens in medical intensive care patients. Crit. Care. Med. 20(6), 740-745 (1992
66. Silvestri L, Monti Bragadin C, Milanese M et al. Are most ICU infections really nosocomial? A prospective observational cohort study in mechanically ventilated patients. J. Hosp. Infect. 42, 125-133 (1999). (Pubitemid 29273819)
67. Adair CG, Gorman SP, Feron BM et al. Implications of endotracheal tube biofilm on ventilator-associated pneumonia. Intensive Care Med. 25(10), 1072-1076 (1999). (Pubitemid 29525061)
68. Reper P, Dankaert R, van Hille F et al. The usefulness of combined high frequency percussive ventilation during acute respiratory failure after smoke inhalation. Burns 24, 34-38 (1998). (Pubitemid 28195782)
69. Reper P, Wibaux O, Van Laeke P et al. High frequency percussive ventilation and conventional ventilation after smoke inhalation: a randomized study. Burns 28, 503-508 (2002). (Pubitemid 34876885)
70. Cancio LC. Current concepts in the pathophysiology and treatment of inhalation injury. Trauma 7, 19-35 (2005). (Pubitemid 40467745)
71. Herndon DN, Traber LD, Linares H et al. Etiology of the pulmonary pathophysiology associated with inhalation injury. Resuscitation 14, 43-59 (1986). (Pubitemid 16031077)
72. Herndon DN, Traber DL, Traber LD. The effect of Resuscitation on inhalation injury. Surgery 100, 248-251 (1986). (Pubitemid 16070857)
73. Hubbard GB, Shimazu T, Yukioka T et al. Smoke inhalation injury in sheep. Am. J. Pathol. 133(3), 660-663 (1988).
74. Hubbard GB, Langlinais PC, Shimazu T et al. The morphology of smoke inhalation injury in sheep. J. Trauma 31(11), 1477-1486 (1991).
75. Soejima K, McGuire R, Snyder NT et al. The effect of inducible nitric oxide synthase (iNOS) inhibition on smoke inhalation injury in sheep. Shock 13, 261-266 (2000).
76. Linares HA, Herndon DN, Traber DL. Sequence of morphologic events in experimental smoke inhalation. J. Burn Care Rehabil. 10, 27-37 (1989). (Pubitemid 19074998)
77. Traber DL, Herndon DN, Stein MD et al. The pulmonary lesion of smoke inhalation in the ovine model. Circ. Shock 18, 311-323 (1986). (Pubitemid 16143322)
78. Herndon DN, Traber DL, Niehaus GD et al. The pathophysiology of smoke inhalation in a sheep model. J. Trauma 24, 1044-1051 (1984). (Pubitemid 15194164)
79. Traber DL, Herndon DN, Enkhbaatar P, Maybauer MO, Maybauer DM. The pathophysiology of inhalation injury. In:Total Burn Care. Herndon DN (Ed.). WB Saunders, Philadelphia, PA, USA, 248-261 (2007).
80. Youn YK, Lalonde C, Demling R. Oxidants and the pathophysiology of burn and smoke inhalation injury. Free Radic. Biol. Med. 12, 409-415 (1992).
81. Seeger W, Stohr G, Wolf HR, Neuhof H. Alteration of surfactant function due to protein leakage: special interaction with fibrin monomer. J. Appl. Physiol. 58, 326-338 (1985). (Pubitemid 15057739)
82. Heimbach DM, Waeckerle JF. Inhalation injuries. Ann. Emerg. Med. 17, 1316-1320 (1988). (Pubitemid 19009838)
83. Merrel P, Mayo D. Inhalation injury in the burn patient. Crit. Care Nurs. Clin. North Am. 16, 27-38 (2004). (Pubitemid 38609484)
84. Byers RJ, Hasleton PS, Quigley A et al. Pulmonary herpes simplex in burn patients. Eur. Respir. J. 9, 2313-2317 (1996). (Pubitemid 26366659)
85. Park DR. The microbiology of ventilator-associated pneumonia. Respir. Care 50(6), 742-765 (2005).
86. File TM Jr., Marrie TJ. Burden of community-acquired pneumonia in North American adults. Postgrad. Med. 122(2), 130-141 (2010).
87. Lynch JP 3rd, Zhanel GG. Streptococcus pneumonia: epidemiology and risk factors, evolution of antimicrobial resistance, and impact of vaccines. Curr. Opin. Pulm. Med. 16(3), 217-225 (2010).
88. Trouillet JL, Chastre J, Vuagnat A et al. Ventilator-associated pneumonia caused by potentially drug-resistant bacteria. Am. J. Respir. Crit. Care Med. 157, 531-539 (1998). (Pubitemid 28090546)
89. Armour AD, Shankowsky HA, Swanson T et al. The impact of nosocomially-acquired resistant Pseudomonas aeruginosa infection in a burn unit. J. Trauma 63, 164-171 (2007). (Pubitemid 47057580)
90. Richards MJ, Edwards JR, Culver DH et al. Nosocomial infections in medical ICUs in the United States: national nosocomial infection surveillance system. Crit. Care. Med. 27, 887-892 (1999). (Pubitemid 29266004)
91. Fridkin SK. Increasing prevalence of antimicrobial resistance in intensive care units. Crit. Care. Med. 29, N64-N68 (2001). (Pubitemid 32319753)
92. Chang S, Sievert DM, Hageman JC et al. Infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance gene. Lancet 358, 207-208 (2001).
93. Howden BP, Davies JK, Johnson PD et al. Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogenous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications. Clin. Microbiol. Rev. 23(1), 99-139 (2010).
94. Still J, Newton T, Friedman B et al. Experience with pneumonia in acutely burned patients requiring ventilator support. Ann. Surg.66(2), 206-209 (2000). (Pubitemid 30106308)
95. Giamarellou H, Poulakou G. Multidrug-resistant Gram-negative infections: what are the treatment options? Drugs 69(14), 1879-1901 (2009).
96. Niederman MS. The clinical diagnosis of ventilator-associated pneumonia. Repsir. Care. 50(6), 788-796 (2005). (Pubitemid 46179547)
97. Mabie M, Wunderink RG. Use and limitations of clinical and radiological diagnosis of pneumonia. Semin. Respir. Infect.18(2), 72-79 (2003). (Pubitemid 36718478)
98. Lauzier F, Ruest A, Cook D et al. The value of pretest probability and modified clinical pulmonary infection score to diagnose ventilator-associated pneumonia. J. Crit. Care 23(1), 50-57 (2008). (Pubitemid 351400359)
99. Pugin J, Auckenthaler R, Mili N et al. Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and non-bronchoscopic blind bronchoalveolar lavage fluid. Am. Rev. Respir. Dis. 143(5 Pt 1), 1121-1129 (1991).
100. Singh N, Falestiny MN, Rogers P et al. Pulmonary infiltrates in the Surgical ICU. Prospective assessment of predictors of etiology and mortality. Chest 114, 1129-1136 (1998). (Pubitemid 28495913)
101. Schurink CA, Van Nieuwenhoven CA, Jacobs JA et al. Clinical pulmonary infection score for ventilator-associated pneumonia accuracy and inter-observer variability. Intensive Care Med. 30(2), 217-224 (2004). (Pubitemid 38253411)
102. Croce MA, Swanson JM, Magnotti LJ et al. The futility of the clinical pulmonary infection score in trauma patients. J. Trauma 60(3), 523-527 (2006).
103. Pham TN, Neff MJ, Simmons JM et al. The clinical pulmonary infection score poorly predicts pneumonia in patients with burns. J. Burn Care Res. 28(1), 76-79 (2007). (Pubitemid 46087860)
104. Fagon JY, Chastre J. Diagnosis and treatment of nosocomial pneumonia in ALI/ARDS. Eur. Respir. J. 42, S77-S83 (2003).
105. Chastre J, Combes A, Luyt CE. The invasive (quantitative) diagnosis of ventilator-associated pneumonia. Respir. Care 50(6), 797-812 (2005
106. Wahl W, Ahrns KS, Brandt MM et al. Bronchoalveolar lavage in diagnosis of ventilator-associated pneumonia in patients with burns. J. Burn Care Rehabil. 26, 57-61 (2005). (Pubitemid 40105196)
107. Aarts MA, Hancock JN, Heyland D. Empiric antibiotic therapy for suspected ventilator-associated pneumonia: a systematic review and meta-analysis of randomized trials. Crit. Care. Med. 36(1), 108-117 (2008).
108. Valencia M, Torres A. Ventilator-associated pneumonia. Curr. Opin. Crit. Care 15, 30-35 (2009).
109. Bake AM, Meredith JW, Chang M et al. Bronchoscopically guided management of ventilator-associated pneumonia in trauma patients. J. Bronchology 10(1), 7-16 (2003). (Pubitemid 36254371)
110. Iregui M, Ward S, Sherman G et al. Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest 122(1), 262-268 (2002). (Pubitemid 34754172)
111. Mueller EW, Hanes SD, Croce MA et al. Effect from multiple episodes of inadequate empiric antibiotic therapy for ventilator-associated pneumonia on morbidity and mortality among critically ill trauma patients. J. Trauma 58(1), 94-101 (2005).
112. Torres A, El-Ebiary M. Bronchoscopic BAL in the diagnosis of ventilator associated pneumonia. Chest 117(4 Suppl. 2), 198S-202S (2000). (Pubitemid 30230859)
113. Muscedere J, Dodek P, Keenan S et al. Comprehensive evidence-based clinical practice guidelines for ventilator-associated pneumonia: diagnosis and treatment. J. Crit. Care 23, 138-147 (2008). (Pubitemid 351400356)
114. Chastre J, Wolff M, Fagon JY et al. Comparison of 8 vs. 15 days of antibiotic therapy for ventilator-associated pneumonia in adults. JAMA 290, 2588-2598 (2003). (Pubitemid 37443289)
115. Wahl WL, Taddonio MA, Arbabi S et al. duration of antibiotic therapy for ventilator-associated pneumonia in burn patients. J. Burn Care Res. 30, 801-806 (2009).
116. Mueller EW, Croce MA, Boucher BA et al. Repeat bronchoalveolar lavage to guide antibiotic duration for ventilator-associated pneumonia. J. Trauma 63, 1329-1337 (2007).
117. Eachempati SR, Hydo LJ, Shou J et al. Does de-escalation of antibiotic therapy for ventilator-associated pneumonia affect the likelihood of recurrent pneumonia or mortality in critically ill surgical patients? J. Trauma 66, 1343-1348 (2009).
118. Joffe AR, Muscedere J, Marshall JC et al. The safety of targeted antibiotic therapy for ventilator-associated pneumonia: a multicenter observational study. J. Crit. Care 23, 82-90 (2008). (Pubitemid 351400353)
119. Cioffi WG, Graves TA, McManus WF et al. High-frequency percussive ventilation in patients with inhalation injury. J. Trauma 29, 350-354 (1989 (Pubitemid 19106804)
120. ARDS Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N. Engl. J. Med. 342, 1301-1308 (2000
121. Cioffi WG, Rue LW, Graves TA et al. Prophylactic use of high-frequency percussive ventilation in patients with inhalation injury. Ann. Surg. 213, 575-582 (1991).
122. Rue LW, Cioffi WG, Mason A. Improved survival of burned patients with inhalation injury. Arch. Surg. 128, 328-337 (1993).
123. OKeefe-McCarthy S, Santiago C, Lau G. Ventilator-associated pneumonia bundled strategies: an evidence-based practice. Worldviews on evidence-based Nurs. 5(4), 193-204 (2008).
124. Drakulovic MB, Torres A, Bauer TT et al. Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomized trial. Lancet 354, 1861-1859 (1999).
125. Torres A, Serra-Batlles J, Ros E et al. Pulmonary aspiration of gastric contents in patients receiving mechanical ventilation: the effect of body position. Ann. Intern. Med. 116, 540-543 (1992).
126. Cason CL, Tyner T, Saunders S et al. Nurses implementation of guidelines for ventilator-associated pneumonia from the centers of disease control and prevention. Am. J. Crit. Care 16(1), 28-38 (2007).
127. Muscedere J, Dodek P, Keenan S et al. Comprehensive evidence-based clinical practice guidelines for ventilator-associated pneumonia: prevention. J. Crit. Care 23, 126-137 (2008). (Pubitemid 351400352)
128. Lorente L, Lecuona M, Jimenez A et al. Influence of an endotracheal tube with polyurethane cuff and subglottic secretion drainage on pneumonia. Am. J. Respir. Crit. Care Med. 176(11), 1079-1083 (2007). (Pubitemid 350223753)
129. Saffle JR, Morris SE, Edelman L. Early tracheostomy does not improve outcome in burn patients. J. Burn Care Rehabil. 23, 431-438 (2002). (Pubitemid 35453590)
130. Palmieri TL, Jackson W, Greenhalgh DG. Benefits of early tracheostomy in severely burned children. Crit. Care. Med. 30(4), 922-924 (2002). (Pubitemid 34297820)
131. Barret JP, Desai MH, Herndon DN. Effects of tracheostomies on infection and airway complications in pediatric burn patients. Burns 26, 190-193 (2000). (Pubitemid 30050614)
132. Griffiths J, Barber VS, Morgan L et al. Systematic review and meta-analysis of studies of the timing of tracheostomy in adult patients undergoing artificial ventilation. BMJ 330, 1243-1246 (2005). (Pubitemid 40780475)
133. Dellit TH, Chan DJ, Skerrett SJ. Development of a guideline for the management of ventilator associated pneumonia based on local microbiologic findings and impact of the guideline on antimicrobial use practices. Infect. Control Hosp. Epidemiol. 29, 525-533 (2008 (Pubitemid 351918031)
134. Hippocrates, on acute disease. History of pneumonia www. experiencefestival.com/a/ Pneumonia-History/id/5254351
135. Maimonides, Fusul Musa. History of pneumonia www.experiencefestival.com/ a/Pneumonia-History/id/5254351
136. Centers for Disease Control and Prevention. The national healthcare safety network (NHSN) manual: patient safety component protocol 2007 www.cdc.gov.ncidod/dhqp/pdf/nhsn/ NHSN-Manual-PatientSafetyProtocol-CURRENT.pdf
137. Dudeck MA, Horan TC, Peterson KD et al. national healthcare safety network (NHSN) report, data summary for 2009, device-associated module www.cdc.gov/nhsn/PDFs/ dataStat/2010NHSNReport.pdf
138. Institute of Healthcare improvement www.ihi.org