The pathophysiology of inhalation injury

Total Burn Care

Volumn , Issue , 2007, Pages 248-261

  Traber, Daniel L ^a   Herndon, David N ^b,c   Enkhbaatar, Perenlei ^a   Maybauer, Marc O ^c   Maybauer, Dirk M ^c  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^c SHRINERS HOSPITALS FOR CHILDREN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 36448985798     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-1-4160-3274-8.50021-0     Document Type: Chapter

References (155)

1. DN Herndon, DL Traber, GD Niehaus, et al. (1984) The pathophysiology of smoke inhalation injury in a sheep model. J Trauma 24 1044-1051.
2. DN Herndon, PB Thompson and DL Traber (1985) Pulmonary injury in burned patients. Crit Care Clin 1 79-96.
3. R Alcorta (2004) Smoke inhalation and acute cyanide poisoning. Hydrogen cyanide poisoning proves increasingly common in smoke-inhalation victims. JEMS 29((8):suppl 6–15), quiz suppl 6–7.
4. BA Pruitt Jr, CW Goodwin and AD Mason Jr (2002) Epidemiological, demographic and outcome characteristics of burn injury. DN Herndon (Eds) Total burn care London: WB Saunders 16-32.
5. K Kobayashi, H Ikeda, R Higuchi, et al. (2005) Epidemiological and outcome characteristics of major burns in Tokyo. Burns 31(Suppl 1), S3-S11.
6. SP Pegg (2005) Burn epidemiology in the Brisbane and Queensland area. Burns 31(Suppl 1), S27-S31.
7. C Song and A Chua (2005) Epidemiology of burn injuries in Singapore from 1997 to 2003. Burns 31(Suppl 1), S18-S26.
8. KY Tung, ML Chen, HJ Wang, et al. (2005) A seven-year epidemiology study of 12 381 admitted burn patients in Taiwan — using the Internet registration system of the Childhood Burn Foundation. Burns 31(Suppl 1), S12-S17.
9. LB Ware and MA Matthay (2000) The acute respiratory distress syndrome. N Engl J Med 342(18), 1334-1349.
10. L Fodor, A Fodor, Y Ramon, et al. (2006) Controversies in fluid resuscitation for burn management: literature review and our experience. Injury 37(5), 374-379.
11. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 342(18), 1301-1308.
12. KZ Shirani, BA Pruitt Jr and AD Mason Jr (1987) The influence of inhalation injury and pneumonia on burn mortality. Ann Surg 205 82-87.
13. HA Linares (1982) A report of 115 consecutive autopsies in burned children: 1966–80. Burns 8 263-270.
14. JR Saffle, JJ Sullivan, GM Tuohig, et al. (1993) Multiple organ failure in patients with thermal injury. Crit Care Med 21(11), 1673-1683.
15. DH Schwela, JG Goldammer, LH Morawska, et al. (1999) Health guidelines for vegitation fire events Geneva: World Health Organization
16. D Schwela (1997) Cooking smoke: a silent killer. People Planet 6(3), 24-25.
17. JR Saffle (1993) The 1942 fire at Boston's Cocoanut Grove nightclub. Am J Surg 166(6), 581-591.
18. HS Pittman and R Schatzki (1949) Pulmonary effects of the Cocoanut Grove fire; a 5 year follow up study. N Engl J Med 241(25), 1008.
19. V Blocker and TG Blocker Jr (1949) The Texas City disaster: a survey of 3000 casualties. Am J Surg 78 756-771.
20. MH Jordan, KA Hollowed, DG Turner, et al. (2005) The Pentagon attack of September 11, 2001: a burn center's experience. J Burn Care Rehabil 26(2), 109-116.
21. RW Yurt, PQ Bessey, GJ Bauer, et al. (2005) A regional burn center's response to a disaster: September 11, 2001, and the days beyond. J Burn Care Rehabil 26(2), 117-124.
22. Rapid assessment of injuries among survivors of the terrorist attack on the World Trade Center, New York City, September 2001. MMWR — Morbidity & Mortality Weekly Report 51(01), 1-5.
23. From the Centers for Disease Control and Prevention (2002) Rapid assessment of injuries among survivors of the terrorist attack on the World Trade Center, New York City, September 2001. JAMA 287(7), 835-838.
24. T Prien and DL Traber (1988) Toxic smoke compounds and inhalation injury — a review. Burns 14 451-460.
25. SJ Moore, IK Ho and AS Hume (1991) Severe hypoxia produced by concomitant intoxication with sublethal doses of carbon monoxide and cyanide. Toxicol Appl Pharmacol 109 412-420.
26. BR Pitt, EP Radford, GH Gurtner, et al. (1979) Interaction of carbon monoxide and cyanide on cerebral circulation and metabolism. Arch Environ Health 34 345-349.
27. EF Haponik (1993) Clinical smoke inhalation injury: pulmonary effects. Occup Med 8 430-468.
28. JB Terrill, RR Montgomery and CF Reinhardt (1978) Toxic gases from fires. Science 200(4348), 1343-1347.
29. RP Smith (1986) Toxic responses of the blood. CD Klaassen, MO Amdur, J Doull (Eds) Casarett and Doull's toxicology, the basic science of poisons New York: MacMillan 223-244.
30. JB West (2003) Pulmonary pathophysiology: the essentials 6th edn. Baltimore: Lippincott Williams & Wilkins
31. LR Goldbaum, T Orellano and E Dergal (1976) Mechanism of the toxic action of carbon monoxide. Ann Clin Lab Sci 6 372-376.
32. T Shimazu, H Ikeuchi, H Sugimoto, et al. (2000) Half-life of blood carboxyhemoglobin after short-term and long-term exposure to carbon monoxide. J Trauma 49(1), 126-131.
33. JR Alonso, F Cardellach, J Casademont, et al. (2004) Reversible inhibition of mitochondrial complex IV activity in PBMC following acute smoking. Eur Respir J 23(2), 214-218.
34. O Miro, JR Alonso, J Casademont, et al. (1999) Oxidative damage on lymphocyte membranes is increased in patients suffering from acute carbon monoxide poisoning. Toxicol Lett 110(3), 219-223.
35. IN Einhorn (1975) Physiological and toxicological aspects of smoke produced during the combustion of polymeric materials. Environ Health Perspect 11 163-189.
36. JH Schulte (1963) Effects of mild carbon monoxide intoxication. Arch Environ Health 7 524-530.
37. M Westphal, N Morita, P Enkhbaatar, et al. (2003) Carboxyhemoglobin formation following smoke inhalation injury in sheep is interrelated with pulmonary shunt fraction. Biochem Biophys Res Commun 311(3), 754-758.
38. EL Charnock and JJ Meehan (1980) Postburn respiratory injuries in children. Pediatr Clin North Am 27 661-676.
39. CJ Clark, D Campbell and WH Reid (1981) Blood carboxyhaemoglobin and cyanide levels in fire survivors. Lancet 1 1332-1335.
40. RO Crapo (1981) Smoke-inhalation injuries. JAMA 246 1694-1696.
41. N Pace, E Strajman and EL Walker (1950) Acceleration of carbon monoxide elimination in man by high pressure oxygen. Science 111(2894), 652-654.
42. SR Thom (1990) Antagonism of carbon monoxide-mediated brain lipid peroxidation by hyperbaric oxygen. Toxicol Appl Pharmacol 105 340-344.
43. SD Brown and CA Piantadosi (1989) Reversal of carbon monoxide-cytochrome c oxidase binding by hyperbaric oxygen in vivo. Adv Exp Med Biol 248 747-754.
44. RA Myers, SK Snyder, S Linberg, et al. (1981) Value of hyperbaric oxygen in suspected carbon monoxide poisoning. JAMA 246 2478-2480.
45. JM McCord (1987) Oxygen-derived radicals: a link between reperfusion injury and inflammation. Fed Proc 46 2402-2406.
46. SR Thom (1993) Functional inhibition of leukocyte B 2 integrins by hyperbaric oxygen in carbon monoxide-mediated brain injury in rats. Toxicol Appl Pharmacol 123 248-256.
47. KJ Chou, JL Fisher and EJ Silver (2000) Characteristics and outcome of children with carbon monoxide poisoning with and without smoke exposure referred for hyperbaric oxygen therapy. Pediatr Emerg Care 16(3), 151-155.
48. E Villanueva, MH Bennett, J Wasiak, et al. (2004) Hyperbaric oxygen therapy for thermal burns. Cochrane Database Syst Rev (3), CD004727.
49. DA Purser, P Grimshaw and KR Berrill (1984) Intoxication by cyanide in fires: a study in monkeys using polyacrylonitrile. Arch Environ Health 39 394-400.
50. FJ Baud, P Barriot, V Toffis, et al. (1991) Elevated blood cyanide concentrations in victims of smoke inhalation. N Engl J Med 325 1761-1766.
51. SH Silverman, GF Purdue, JL Hunt, et al. (1988) Cyanide toxicity in burned patients. J Trauma 28 171-176.
52. Biological and chemical terrorism: strategic plan for preparedness and response. Recommendations of the CDC Strategic Planning Workgroup. MMWR Recomm Rep 49(RR-4), 1-14.
53. M Eckstein (2004) Cyanide as a chemical terrorism weapon. JEMS 29((8):suppl 22–31),
54. PW Smith, R Crane, DC Sanders, et al. (1976) Effects of exposure to carbon monoxide and hydrogen cyanide. Physiological and toxological aspects of combustion products Washington, DC: National Academy of Science 75-78.
55. AP Morocco (2005) Cyanides. Crit Care Clin 21(4), 691-705.
56. CE Becker (1985) The role of cyanide in fires. Vet Human Toxicol 27 487-490.
57. G Kimmerle (1973) Aspects and methodology for the evaluation of toxicological parameters during fire exposure. Polymer conference series: flammability characteristics of materials Salt Lake City: University of Utah
58. MA Kirk, R Gerace and KW Kulig (1993) Cyanide and methemoglobin kinetics in smoke inhalation victims treated with the cyanide antidote kit. Ann Emerg Med 22 1413-1418.
59. DM Beasley and WI Glass (1998) Cyanide poisoning: pathophysiology and treatment recommendations. Occup Med (Lond) 48(7), 427-431.
60. SJ Moore, JC Norris, DA Walsh, et al. (1987) Antidotal use of methemoglobin forming cyanide antagonists in concurrent carbon monoxide/cyanide intoxication. J Pharmacol Exp Ther 242 70-73.
61. AH Hall and BH Rumack (1986) Clinical toxicology of cyanide. Ann Emerg Med 15(9), 1067-1074.
62. JL Fortin, M Ruttiman, L Domanski, et al. (2004) Hydroxocobalamin: treatment for smoke inhalation-associated cyanide poisoning. Meeting the needs of fire victims. JEMS 29((8):suppl 18–21),
63. Hughart JL, Bashor MM. Industrial chemicals and terrorism: human health threat analysis, mitigation prevention. Atlanta, GA: Agency for Toxic Substances and Disease Registry, US Public Health Service.
64. Anonymous (1999) Combating terrorism: observations on the threat of chemical and biological terrorism. Office UGA (Eds) Statement of Henry L. Hinton Jr, Assistant Comptroller General Washington, DC: National Security and International Affairs Division
65. N Author (2000) Pulmonary agent. US Army Medical Research Institute of Chemical Defence Medical Management of chemical casualties handbook Aberdeen, MA: USAMRICD 18-34.
66. Medical management for phosgene. Managing hazardous material incidents, Vol. III: agency for toxic substances and disease registry Atlanta, GA: US Department of Health and Human Services
67. J Borak and WF Diller (2001) Phosgene exposure: mechanisms of injury and treatment strategies. J Occup Environ Med 43(2), 110-119.
68. TR Burns, ML Mace, SD Greenberg, et al. (1985) Ultrastructure of acute ammonia toxicity in the human lung. Am J Forensic Med Pathol 6(3), 204-210.
69. EH Starling (1896) On the absorption of fluids from the connective tissue spaces. J Physiol 19 312-326.
70. EM Landis and JR Pappenheimer (1963) Exchange of substances through the capillary walls. WF Hamilton, P Dow (Eds) Handbook of physiology Baltimore, MD: Williams & Wilkins 2. (2):961–1034.
71. HP Friedl, GO Till, O Trentz, et al. (1989) Roles of histamine, complement and xanthine oxidase in thermal injury of skin. Am J Pathol 135 203-217.
72. KT Oldham, KS Guice, GO Till, et al. (1988) Evidence of local complement activation in cutaneous thermal injury in rats. Prog Clin Biol Res 264 421-424.
73. HJ Schlayer, H Laaff, T Peters, et al. (1988) Involvement of tumor necrosis factor in endotoxin-triggered neutrophil adherence to sinusoidal endothelial cells of mouse liver and its modulation in acute phase. J Hepatol 7 239-249.
74. DN Granger, JM McCord, DA Parks, et al. (1986) Xanthine oxidase inhibitors attenuate ischemia-induced vascular permeability changes in the cat intestine. Gastroenterology 90 80-84.
75. DN Granger (1988) Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury. Am J Physiol 255 H1269-H1275.
76. AG McBride and GC Brown (1997) Activated human neutrophils rapidly break down nitric oxide. FEBS Lett 417 231-234.
77. RH DemLing and C LaLonde (1987) Topical ibuprofen decreases early postburn edema. Surgery 102 857-861.
78. DN Herndon, S Abston and MD Stein (1984) Increased thromboxane B2 levels in the plasma of burned and septic burned patients. Surg Gynecol Obstet 159 210-213.
79. H Vindenes, E Ulvestad and R Bjerknes (1995) Increased levels of circulating interleukin-8 in patients with large burns: relation to burn size and sepsis. J Trauma 39 635-640.
80. RM Pitt, JC Parker, GJ Jurkovich, et al. (1987) Analysis of altered capillary pressure and permeability after thermal injury. J Surg Res 42 693-702.
81. T Lund (1999) The 1999 Everett Idris Evans memorial lecture. Edema generation following thermal injury: an update. J Burn Care Rehabil 20(6), 445-452.
82. J Pitkanen, T Lund, L Aanderud, et al. (1987) Transcapillary colloid osmotic pressures in injured and non-injured skin of seriously burned patients. Burns 13 198-203.
83. H Zetterstrom and G Arturson (1980) Plasma oncotic pressure and plasma protein concentration in patients following thermal injury. Acta Anaesthesiol Scandi 24 288-294.
84. H Onarheim and RK Reed (1991) Thermal skin injury: effect of fluid therapy on the transcapillary colloid osmotic gradient. J Surg Res 50 272-278.
85. ZY Sheng and YL Tung (1987) Neutrophil chemiluminescence in burned patients. J Trauma 27 587-595.
86. RL Conhaim and BA Harms (1992) A simplified two-pore filtration model explains the effects of hypoproteinemia on lung and soft tissue lymph flux in awake sheep. Microvasc Res 44 14-26.
87. KH Calhoun, RW Deskin, C Garza, et al. (1988) Long-term airway sequelae in a pediatric burn population. Laryngoscope 98 721-725.
88. BA Brazeal, D Honeycutt, LD Traber, et al. (1995) Pentafraction for superior resuscitation of the ovine thermal burn. Crit Care Med 23 332-339.
89. RH DemLing, GC Kramer, R Gunther, et al. (1984) Effect of nonprotein colloid on postburn edema formation in soft tissues and lung. Surgery 95 593-602.
90. EM Baile, RW Dahlby, BR Wiggs, et al. (1985) Role of tracheal and bronchial circulation in respiratory heat exchange. J Appl Physiol 58 217-222.
91. AR Moritz, FC Henriques and R McLean (1945) The effect of inhaled heat on the air passages and lungs: an experimental investigation. Am J Pathol 21 311-326.
92. R Kimura, LD Traber, DN Herndon, et al. (1988) Increasing duration of smoke exposure induces more severe lung injury in sheep. J Appl Physiol 64 1107-1113.
93. MG Magno and AP Fishman (1982) Origin, distribution, and blood flow of bronchial circulation in anesthetized sheep. J Appl Physiol 53 272-279.
94. NC Staub, RD Bland, KL Brigham, et al. (1975) Preparation of chronic lung lymph fistulas in sheep. J Surg Res 19 315-320.
95. S Abdi, D Herndon, J McGuire, et al. (1990) Time course of alterations in lung lymph and bronchial blood flows after inhalation injury. J Burn Care Rehabil 11 510-515.
96. DN Herndon, RE Barrow, DL Traber, et al. (1987) Extravascular lung water changes following smoke inhalation and massive burn injury. Surgery 102 341-349.
97. PI Ramzy, JP Barret and DN Herndon (1999) Thermal injury. Crit Care Clin 15(2), 333-352. ix.
98. Inhalation injury: diagnosis. J Am Coll Surg 196(2), 307-312.
99. JC Stothert Jr, KD Ashley, GC Kramer, et al. (1990) Intrapulmonary distribution of bronchial blood flow after moderate smoke inhalation. J Appl Physiol 69 1734-1739.
100. CA Hales, P Barkin, W Jung, et al. (1989) Bronchial artery ligation modifies pulmonary edema after exposure to smoke with acrolein. J Appl Physiol 67 1001-1006.
101. F Hinder, N Matsumoto, M Booke, et al. (1997) Inhalation injury increases the anastomotic bronchial blood flow in the pouch model of the left ovine lung. Shock 8 131-135.
102. HA Linares, DN Herndon and DL Traber (1989) Sequence of morphologic events in experimental smoke inhalation. J Burn Care Rehabil 10 27-37.
103. S Abdi, MJ Evans, RA Cox, et al. (1990) Inhalation injury to tracheal epithelium in an ovine model of cotton smoke exposure. Early phase (30 minutes). Am Rev Respir Dis 142 1436-1439.
104. RE Barrow, SE Morris, JO Basadre, et al. (1990) Selective permeability changes in the lungs and airways of sheep after toxic smoke inhalation. J Appl Physiol 68 2165-2170.
105. RA Cox, AS Burke, K Soejima, et al. (2003) Airway obstruction in sheep with burn and smoke inhalation injuries. Am J Respir Cell Mol Biol 29(3 Pt 1), 295-302.
106. M Mathru, B Venus, T Rao, et al. (1983) Noncardiac pulmonary edema precipitated by tracheal intubation in patients with injury. Crit Care Med 11 804-806.
107. DN Herndon, LD Traber, H Linares, et al. (1986) Etiology of the pulmonary pathophysiology associated with inhalation injury. Resuscitation 14 43-59.
108. JJ Perez Fontan (2002) On lung nerves and neurogenic injury. Ann Med 34(4), 226-240.
109. JJ Fontan, DN Cortright, JE Krause, et al. (2000) Substance P and neurokinin-1 receptor expression by intrinsic airway neurons in the rat. Am J Physiol Lung Cell Mol Physiol 278(2), L344-L355.
110. AD Kraneveld and FP Nijkamp (2001) Tachykinins and neuro-immune interactions in asthma. Int Immunopharmacol 1(9–10), 1629-1650.
111. L Virag (2005) Poly(ADP-ribosyl)ation in asthma and other lung diseases. Pharmacol Res 52(1), 83-92.
112. K Soejima, LD Traber, FC Schmalstieg, et al. (2001) Role of nitric oxide in vascular permeability after combined burns and smoke inhalation injury. Am J Respir Crit Care Med 163 745-752.
113. K Shimoda, K Murakami, P Enkhbaatar, et al. (2003) Effect of poly(ADP ribose) synthetase inhibition on burn and smoke inhalation injury in sheep. Am J Physiol Lung Cell Mol Physiol 285(1), L240-L249.
114. AH Boulares, AJ Zoltoski, ZA Sherif, et al. (2003) Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma. Am J Respir Cell Mol Biol 28(3), 322-329.
115. DL Traber, G Schlag, H Redl, et al. (1985) Pulmonary edema and compliance changes following smoke inhalation. J Burn Care Rehabil 6 490-494.
116. K Sugi, JL Theissen, LD Traber, et al. (1990) Impact of carbon monoxide on cardiopulmonary dysfunction after smoke inhalation injury. Circ Res 66 69-75.
117. T Isago, K Fujioka, LD Traber, et al. (1991) Derived pulmonary capillary pressure changes after smoke inhalation in sheep. Crit Care Med 19 1407-1413.
118. T Isago, S Noshima, LD Traber, et al. (1991) Analysis of pulmonary microvascular permeability after smoke inhalation. J Appl Physiol 71 1403-1408.
119. M Westphal, RA Cox, LD Traber, et al. (2006) Combined burn and smoke inhalation injury impairs ovine hypoxic pulmonary vasconstriction. Crit Care Med 34(5), 1428-1436.
120. P Enkhbaatar, K Murakami, K Shimoda, et al. (2003) The inducible nitric oxide synthase inhibitor BBS-2 prevents acute lung injury in sheep after burn and smoke inhalation injury. Am J Respir Crit Care Med 167(7), 1021-1026.
121. K Murakami, P Enkhbaatar, K Shimoda, et al. (2004) Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis. Shock 21(2), 126-133.
122. NB Charan, GM Turk and R Dhand (1984) Gross and subgross anatomy of bronchial circulation in sheep. J Appl Physiol 57 658-664.
123. O Efimova, AB Volokhov, S Iliaifar, et al. (2001) Ligation of the bronchial artery in sheep attenuates early pulmonary changes following exposure to smoke. J Appl Physiol 88 888-893.
124. K Soejima, FC Schmalstieg, H Sakurai, et al. (2001) Pathophysiological analysis of combined burn and smoke inhalation injuries in sheep. Am J Physiol Lung Cell Mol Physiol 280 L1233-L1241.
125. CM Doerschuk, N Beyers, HO Coxson, et al. (1993) Comparison of neutrophil and capillary diameters and their relation to neutrophil sequestration in the lung. J Appl Physiol 74 3040-3045.
126. YK Youn, C LaLonde and R Demling (1992) Oxidants and the pathophysiology of burn and smoke inhalation injury. Free Radic Biol Med 12 409-415.
127. GD Niehaus, R Kimura, LD Traber, et al. (1990) Administration of a synthetic antiprotease reduces smoke-induced lung injury. J Appl Physiol 69 694-699.
128. DL Traber, DN Herndon, MD Stein, et al. (1986) The pulmonary lesion of smoke inhalation in an ovine model. Circ Shock 18 311-323.
129. TT Nguyen, CS Cox Jr, DN Herndon, et al. (1995) Effects of manganese superoxide dismutase on lung fluid balance after smoke inhalation. J Appl Physiol 78 2161-2168.
130. TT Nguyen, CS Cox, DL Traber, et al. (1993) Free radical activity and loss of plasma antioxidants, vitamin E, and sulfhydryl groups in patients with burns: the 1993 Moyer Award. J Burn Care Rehabil 14 602-609.
131. TT Nguyen, DN Herndon, CS Cox, et al. (1993) Effect of manganous superoxide dismutase on lung fluid balance after smoke inhalation injury. Proceedings of the American Burn Association 25 31.
132. PJ Schenarts, FC Schmalstieg, H Hawkins, et al. (2000) Effects of an L-selectin antibody on the pulmonary and systemic manifestations of severe smoke inhalation injuries in sheep. J Burn Care Rehabil 21 229-240.
133. H Sakurai, FC Schmalstieg, LD Traber, et al. (1999) Role of L-selectin in physiological manifestations after burn and smoke inhalation injury in sheep. J Appl Physiol 86(4), 1151-1159.
134. JO Basadre, K Sugi, DL Traber, et al. (1988) The effect of leukocyte depletion on smoke inhalation injury in sheep. Surgery 104 208-215.
135. YM Yu, CM Ryan, L Castillo, et al. (2001) Arginine and ornithine kinetics in severely burned patients: increased rate of arginine disposal. Am J Physiol Endocrinol Metab 280 E509-E517.
136. Y Xia, LJ Roman, BS Masters, et al. (1998) Inducible nitric-oxide synthase generates superoxide from the reductase domain. J Biol Chem 273 22635-226339.
137. RS Bruno and MG Traber (2005) Cigarette smoke alters human vitamin E requirements. J Nutr 135(4), 671-674.
138. N Morita, MG Traber, M Westphal, et al. (2006) Oral supplementation of alpha-tocopherol attenuates acute lung injury following combined burn and smoke inhalation injury in sheep. Shock (In press).
139. DF Fitzpatrick and WG Gioffi (2002) Diagnosis and treatment of inhalation injury. D Herndon (Eds) Total burn care New York: WB Saunders 232-242.
140. R Mlcak and D Herndon (2002) Respiratory care. D Herndon (Eds) Total burn care New York: WB Saunders 242-267.
141. M Brown, M Desai, LD Traber, et al. (1988) Dimethylsulfoxide with heparin in the treatment of smoke inhalation injury. J Burn Care Rehabil 9 22-25.
142. A Kowal-Vern, V McGill, JM Walenga, et al. (2000) Antithrombin(H) concentrate infusions are safe and effective in patients with thermal injuries. J Burn Care Rehabil 21 115-127.
143. K Murakami, R McGuire, RA Cox, et al. (2003) Recombinant antithrombin attenuates pulmonary inflammation following smoke inhalation and pneumonia in sheep. Crit Care Med 31(2), 577-583.
144. JL Vincent (2003) Infection/inflammation and hemostasis. Curr Hematol Rep 2(5), 407-410.
145. P Enkhbaatar, K Murakami, R Cox, et al. (2004) Aerosolized tissue plasminogen activator improves pulmonary function in sheep with burn and smoke inhalation. Shock 22(1), 70-75.
146. JM Costello, D Steinhorn, S McColley, et al. (2002) Treatment of plastic bronchitis in a Fontan patient with tissue plasminogen activator: a case report and review of the literature. Pediatrics 109(4), e67.
147. MK Wakeham, AH Van Bergen, LE Torero, et al. (2005) Long-term treatment of plastic bronchitis with aerosolized tissue plasminogen activator in a Fontan patient. Pediatr Crit Care Med 6(1), 76-78.
148. MH Desai, R Mlcak, J Richardson, et al. (1998) Reduction in mortality in pediatric patients with inhalation injury with aerosolized heparin/N-acetylcystine [correction of acetylcystine] therapy. J Burn Care Rehabil 19(3), 210-212.
149. P Enkhbaatar, K Murakami, K Shimoda, et al. (2003) Inducible nitric oxide synthase dimerization inhibitor prevents cardiovascular and renal morbidity in sheep with combined burn and smoke inhalation injury. Am J Physiol Heart Circ Physiol 285(6), H2430-H2436.
150. EJ Pierre, JB Zwischenberger, C Angel, et al. (1998) Extracorporeal membrane oxygenation in the treatment of respiratory failure in pediatric patients with burns. J Burn Care Rehabil 19 131-134.
151. SK Alpard, JB Zwischenberger, W Tao, et al. (1999) Reduced ventilator pressure and improved P/F ratio during percutaneous arteriovenous carbon dioxide removal for severe respiratory failure. Ann Surg 230 215-224.
152. FC Schmalstieg, J Chow, C Savage, et al. (2001) Interleukin-8, aquaporin-1, and inducible nitric oxide synthase in smoke and burn injured sheep treated with percutaneous carbon dioxide removal. ASAIO J 47 365-371.
153. JB Zwischenberger, D Wang, SD Lick, et al. (2002) The paracorporeal artificial lung improves 5-day outcomes from lethal smoke/burn-induced acute respiratory distress syndrome in sheep. Ann Thorac Surg 74(4), 1011-1016. discussion 7–8.
154. JB Zwischenberger, C Savage, SA Witt, et al. (2002) Arterio-venous CO 2 removal (AVCO 2R) perioperative management: rapid recovery and enhanced survival. J Invest Surg 15(1), 15-21.
155. H Nakae, H Tanaka and H Inaba (2001) Failure to clear casts and secretions following inhalation injury can be dangerous: report of a case. Burns 27(2), 189-191.