메뉴 건너뛰기




Volumn 179, Issue 4, 2011, Pages 1792-1806

Defective myofibroblast formation from mesenchymal stem cells in the aging murine heart: Rescue by activation of the AMPK pathway

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENOSINE PHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; SMAD3 PROTEIN; TRANSCRIPTION FACTOR NANOG; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

EID: 80053250417     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.06.022     Document Type: Article
Times cited : (47)

References (70)
  • 1
    • 11144346203 scopus 로고    scopus 로고
    • Structural and functional characterisation of cardiac fibroblasts
    • DOI 10.1016/j.cardiores.2004.08.020, PII S0008636304003955
    • P. Camelliti, T.K. Borg, and P. Kohl Structural and functional characterization of cardiac fibroblasts Cardiovasc Res 65 2005 40 51 (Pubitemid 40038477)
    • (2005) Cardiovascular Research , vol.65 , Issue.1 , pp. 40-51
    • Camelliti, P.1    Borg, T.K.2    Kohl, P.3
  • 2
    • 79958851882 scopus 로고    scopus 로고
    • Cardiac mesenchymal stem cells contribute to scar formation after myocardial infarction
    • S. Carlson, J. Trial, C. Soeller, and M.L. Entman Cardiac mesenchymal stem cells contribute to scar formation after myocardial infarction Cardiovasc Res 91 2011 99 107
    • (2011) Cardiovasc Res , vol.91 , pp. 99-107
    • Carlson, S.1    Trial, J.2    Soeller, C.3    Entman, M.L.4
  • 3
    • 0141653901 scopus 로고    scopus 로고
    • Ventricular remodeling after infarction and the extracellular collagen matrix: When is enough enough?
    • DOI 10.1161/01.CIR.0000085658.98621.49
    • B.I. Jugdutt Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough? Circulation 108 2003 1395 1403 (Pubitemid 37174420)
    • (2003) Circulation , vol.108 , Issue.11 , pp. 1395-1403
    • Jugdutt, B.I.1
  • 7
    • 41149107026 scopus 로고    scopus 로고
    • Aging-Related Defects Are Associated With Adverse Cardiac Remodeling in a Mouse Model of Reperfused Myocardial Infarction
    • DOI 10.1016/j.jacc.2008.01.011, PII S0735109708003331
    • M. Bujak, H.J. Kweon, K. Chatila, N. Li, G. Taffet, and N.G. Frangogiannis Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction J Am Coll Cardiol 51 2008 1384 1392 (Pubitemid 351443080)
    • (2008) Journal of the American College of Cardiology , vol.51 , Issue.14 , pp. 1384-1392
    • Bujak, M.1    Kweon, H.J.2    Chatila, K.3    Li, N.4    Taffet, G.5    Frangogiannis, N.G.6
  • 10
    • 33745503987 scopus 로고    scopus 로고
    • Mesenchymal stem cells reside in virtually all post-natal organs and tissues
    • DOI 10.1242/jcs.02932
    • L. da Silva Meirelles, P.C. Chagastelles, and N.B. Nardi Mesenchymal stem cells reside in virtually all post-natal organs and tissues J Cell Sci 119 2006 2204 2213 (Pubitemid 43960310)
    • (2006) Journal of Cell Science , vol.119 , Issue.11 , pp. 2204-2213
    • Da Silva Meirelles, L.1    Chagastelles, P.C.2    Nardi, N.B.3
  • 11
    • 68349128436 scopus 로고    scopus 로고
    • Human mesenchymal stem cells self-renew and differentiate according to a deterministic hierarchy
    • R. Sarugaser, L. Hanoun, A. Keating, W.L. Stanford, and J.E. Davies Human mesenchymal stem cells self-renew and differentiate according to a deterministic hierarchy PLoS One 4 2009 e6498
    • (2009) PLoS One , vol.4 , pp. 6498
    • Sarugaser, R.1    Hanoun, L.2    Keating, A.3    Stanford, W.L.4    Davies, J.E.5
  • 12
    • 0033007353 scopus 로고    scopus 로고
    • Age-related osteogenic potential of mesenchymal stromal stem cells from human vertebral bone marrow
    • DOI 10.1359/jbmr.1999.14.7.1115
    • G. D'Ippolito, P.C. Schiller, C. Ricordi, B.A. Roos, and G.A. Howard Age-related osteogenic potential of mesenchymal stromal stem cells from human vertebral bone marrow J Bone Miner Res 14 1999 1115 1122 (Pubitemid 29314054)
    • (1999) Journal of Bone and Mineral Research , vol.14 , Issue.7 , pp. 1115-1122
    • D'Ippolito, G.1    Schiller, P.C.2    Ricordi, C.3    Roos, B.A.4    Howard, G.A.5
  • 14
    • 33747195353 scopus 로고    scopus 로고
    • Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
    • DOI 10.1016/j.cell.2006.07.024, PII S0092867406009767
    • K. Takahashi, and S. Yamanaka Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 2006 663 676 (Pubitemid 44233629)
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 16
    • 0038322020 scopus 로고    scopus 로고
    • Transforming growth factor-β inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function
    • DOI 10.1074/jbc.M212259200
    • L. Choy, and R. Derynck Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function J Biol Chem 278 2003 9609 9619 (Pubitemid 36800456)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.11 , pp. 9609-9619
    • Choy, L.1    Derynck, R.2
  • 17
    • 0021824214 scopus 로고
    • 5-Amino-4-imidazolecarboxamide riboside (Z-riboside) metabolism in eukaryotic cells
    • R.L. Sabina, D. Patterson, and E.W. Holmes 5-Amino-4-imidazolecarboxamide riboside (Z-riboside) metabolism in eukaryotic cells J Biol Chem 260 1985 6107 6114 (Pubitemid 15071307)
    • (1985) Journal of Biological Chemistry , vol.260 , Issue.10 , pp. 6107-6114
    • Sabina, R.L.1    Patterson, D.2    Holmes, E.W.3
  • 18
    • 62349090391 scopus 로고    scopus 로고
    • AICAR activates the pluripotency transcriptional network in embryonic stem cells and induces KLF4 and KLF2 expression in fibroblasts
    • L. Adamo, Y. Zhang, and G. Garcia-Cardena AICAR activates the pluripotency transcriptional network in embryonic stem cells and induces KLF4 and KLF2 expression in fibroblasts BMC Pharmacol 9 2009 2
    • (2009) BMC Pharmacol , vol.9 , pp. 2
    • Adamo, L.1    Zhang, Y.2    Garcia-Cardena, G.3
  • 20
    • 23844434595 scopus 로고    scopus 로고
    • Isolation and characterization of neurogenic mesenchymal stem cells in human scalp tissue
    • DOI 10.1634/stemcells.2004-0125
    • D.T. Shih, D.C. Lee, S.C. Chen, R.Y. Tsai, C.T. Huang, C.C. Tsai, E.Y. Shen, and W.T. Chiu Isolation and characterization of neurogenic mesenchymal stem cells in human scalp tissue Stem Cells 23 2005 1012 1020 (Pubitemid 41170957)
    • (2005) Stem Cells , vol.23 , Issue.7 , pp. 1012-1020
    • Shih, D.T.-B.1    Lee, D.-C.2    Chen, S.-C.3    Tsai, R.-Y.4    Huang, C.-T.5    Tsai, C.-C.6    Shen, E.-Y.7    Chiu, W.-T.8
  • 21
    • 33749060495 scopus 로고    scopus 로고
    • Identification and functional analysis of candidate genes regulating mesenchymal stem cell self-renewal and multipotency
    • DOI 10.1634/stemcells.2005-0604
    • L. Song, N.E. Webb, Y. Song, and R.S. Tuan Identification and functional analysis of candidate genes regulating mesenchymal stem cell self-renewal and multipotency Stem Cells 24 2006 1707 1718 (Pubitemid 44474184)
    • (2006) Stem Cells , vol.24 , Issue.7 , pp. 1707-1718
    • Song, L.1    Webb, N.E.2    Song, Y.3    Tuan, R.S.4
  • 22
    • 0031893013 scopus 로고    scopus 로고
    • Increased c-fos mRNA expression by human fibroblasts contracting stressed collagen matrices
    • H. Rosenfeldt, D.J. Lee, and F. Grinnell Increased c-fos mRNA expression by human fibroblasts contracting stressed collagen matrices Mol Cell Biol 18 1998 2659 2667 (Pubitemid 28183435)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.5 , pp. 2659-2667
    • Rosenfeldt, H.1    Lee, D.J.2    Grinnell, F.3
  • 23
    • 0343841187 scopus 로고
    • The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes
    • S. Boyden The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes J Exp Med 115 1962 453 466
    • (1962) J Exp Med , vol.115 , pp. 453-466
    • Boyden, S.1
  • 24
    • 17544376741 scopus 로고    scopus 로고
    • Ligand-independent activation of transforming growth factor (TGF) β signaling pathways by heteromeric cytoplasmic domains of TGF-β receptors
    • DOI 10.1074/jbc.271.22.13123
    • X.H. Feng, and R. Derynck Ligand-independent activation of transforming growth factor (TGF) beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors J Biol Chem 271 1996 13123 13129 (Pubitemid 26175889)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.22 , pp. 13123-13129
    • Feng, X.-H.1    Derynck, R.2
  • 25
    • 69149091047 scopus 로고    scopus 로고
    • BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage
    • H. Huang, T.J. Song, X. Li, L. Hu, Q. He, M. Liu, M.D. Lane, and Q.Q. Tang BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage Proc Natl Acad Sci USA 106 2009 12670 12675
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 12670-12675
    • Huang, H.1    Song, T.J.2    Li, X.3    Hu, L.4    He, Q.5    Liu, M.6    Lane, M.D.7    Tang, Q.Q.8
  • 26
    • 0344845415 scopus 로고    scopus 로고
    • BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3
    • DOI 10.1016/S0092-8674(03)00847-X
    • Q.L. Ying, J. Nichols, I. Chambers, and A. Smith BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3 Cell 115 2003 281 292 (Pubitemid 37487702)
    • (2003) Cell , vol.115 , Issue.3 , pp. 281-292
    • Ying, Q.-L.1    Nichols, J.2    Chambers, I.3    Smith, A.4
  • 29
    • 0025767891 scopus 로고
    • Differential effects of transforming growth factor-beta 1 and phorbol myristate acetate on cardiac fibroblasts: Regulation of fibrillar collagen mRNAs and expression of early transcription factors
    • M. Eghbali, R. Tomek, V.P. Sukhatme, C. Woods, and B. Bhambi Differential effects of transforming growth factor-beta 1 and phorbol myristate acetate on cardiac fibroblasts: regulation of fibrillar collagen mRNAs and expression of early transcription factors Circ Res 69 1991 483 490
    • (1991) Circ Res , vol.69 , pp. 483-490
    • Eghbali, M.1    Tomek, R.2    Sukhatme, V.P.3    Woods, C.4    Bhambi, B.5
  • 30
    • 0033745462 scopus 로고    scopus 로고
    • CTGF expression is induced by TGF-beta in cardiac fibroblasts and cardiac myocytes: A potential role in heart fibrosis
    • M.M. Chen, A. Lam, J.A. Abraham, G.F. Schreiner, and A.H. Joly CTGF expression is induced by TGF-beta in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis J Mol Cell Cardiol 32 2000 1805 1819
    • (2000) J Mol Cell Cardiol , vol.32 , pp. 1805-1819
    • Chen, M.M.1    Lam, A.2    Abraham, J.A.3    Schreiner, G.F.4    Joly, A.H.5
  • 31
    • 0025992778 scopus 로고
    • Measurement of mechanical forces generated by skin fibroblasts embedded in a three-dimensional collagen gel
    • P. Delvoye, P. Wiliquet, J.L. Leveque, B.V. Nusgens, and C.M. Lapiere Measurement of mechanical forces generated by skin fibroblasts embedded in a three-dimensional collagen gel J Invest Dermatol 97 1991 898 902
    • (1991) J Invest Dermatol , vol.97 , pp. 898-902
    • Delvoye, P.1    Wiliquet, P.2    Leveque, J.L.3    Nusgens, B.V.4    Lapiere, C.M.5
  • 32
    • 0042831330 scopus 로고    scopus 로고
    • Smad3 mediates transforming growth factor-β-induced α-smooth muscle actin expression
    • DOI 10.1165/rcmb.2003-0063OC
    • B. Hu, Z. Wu, and S.H. Phan Smad3 mediates transforming growth factor-betainduced alphasmooth muscle actin expression Am J Respir Cell Mol Biol 29 2003 397 404 (Pubitemid 37093999)
    • (2003) American Journal of Respiratory Cell and Molecular Biology , vol.29 , Issue.3 , pp. 397-404
    • Hu, B.1    Wu, Z.2    Phan, S.H.3
  • 33
    • 0037099745 scopus 로고    scopus 로고
    • TGF-β receptor-activated p38 MAP kinase mediates smad-independent TGF-β responses
    • DOI 10.1093/emboj/cdf366
    • L. Yu, M.C. Hebert, and Y.E. Zhang TGF-beta receptoractivated p38 MAP kinase mediates Smad-independent TGF-beta responses EMBO J 21 2002 3749 3759 (Pubitemid 34787048)
    • (2002) EMBO Journal , vol.21 , Issue.14 , pp. 3749-3759
    • Yu, L.1    Hebert, M.C.2    Zhang, Y.E.3
  • 34
  • 35
    • 58249109358 scopus 로고    scopus 로고
    • Requirement of transforming growth factor betaactivated kinase 1 for transforming growth factor betainduced alphasmooth muscle actin expression and extracellular matrix contraction in fibroblasts
    • X. Shi-wen, S.K. Parapuram, D. Pala, Y. Chen, D.E. Carter, M. Eastwood, C.P. Denton, D.J. Abraham, and A. Leask Requirement of transforming growth factor betaactivated kinase 1 for transforming growth factor betainduced alphasmooth muscle actin expression and extracellular matrix contraction in fibroblasts Arthritis Rheum 60 2009 234 241
    • (2009) Arthritis Rheum , vol.60 , pp. 234-241
    • Shi-Wen, X.1    Parapuram, S.K.2    Pala, D.3    Chen, Y.4    Carter, D.E.5    Eastwood, M.6    Denton, C.P.7    Abraham, D.J.8    Leask, A.9
  • 36
    • 16344363621 scopus 로고    scopus 로고
    • Gene expression profiling studies of aging in cardiac and skeletal muscles
    • DOI 10.1016/j.cardiores.2005.01.005
    • S.K. Park, and T.A. Prolla Gene expression profiling studies of aging in cardiac and skeletal muscles Cardiovasc Res 66 2005 205 212 (Pubitemid 40471035)
    • (2005) Cardiovascular Research , vol.66 , Issue.2 , pp. 205-212
    • Park, S.-K.1    Prolla, T.A.2
  • 37
    • 33748612432 scopus 로고    scopus 로고
    • AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model
    • S. Giri, R. Rattan, E. Haq, M. Khan, R. Yasmin, J.S. Won, L. Key, A.K. Singh, and I. Singh AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model Nutr Metab (Lond) 3 2006 31
    • (2006) Nutr Metab (Lond) , vol.3 , pp. 31
    • Giri, S.1    Rattan, R.2    Haq, E.3    Khan, M.4    Yasmin, R.5    Won, J.S.6    Key, L.7    Singh, A.K.8    Singh, I.9
  • 38
    • 33746560203 scopus 로고    scopus 로고
    • Collagen synthesis by mesenchymal stem cells and aortic valve interstitial cells in response to mechanical stretch
    • DOI 10.1016/j.cardiores.2006.03.022, PII S0008636306001507
    • C.H. Ku, P.H. Johnson, P. Batten, P. Sarathchandra, R.C. Chambers, P.M. Taylor, M.H. Yacoub, and A.H. Chester Collagen synthesis by mesenchymal stem cells and aortic valve interstitial cells in response to mechanical stretch Cardiovasc Res 71 2006 548 556 (Pubitemid 44131527)
    • (2006) Cardiovascular Research , vol.71 , Issue.3 , pp. 548-556
    • Ku, C.-H.1    Johnson, P.H.2    Batten, P.3    Sarathchandra, P.4    Chambers, R.C.5    Taylor, P.M.6    Yacoub, M.H.7    Chester, A.H.8
  • 39
    • 0037067666 scopus 로고    scopus 로고
    • The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
    • DOI 10.1074/jbc.M202489200
    • L.G. Fryer, A. Parbu-Patel, and D. Carling The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways J Biol Chem 277 2002 25226 25232 (Pubitemid 34951829)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.28 , pp. 25226-25232
    • Fryer, L.G.D.1    Parbu-Patel, A.2    Carling, D.3
  • 40
    • 0036324142 scopus 로고    scopus 로고
    • The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism
    • S.A. Hawley, A.E. Gadalla, G.S. Olsen, and D.G. Hardie The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism Diabetes 51 2002 2420 2425 (Pubitemid 34827390)
    • (2002) Diabetes , vol.51 , Issue.8 , pp. 2420-2425
    • Hawley, S.A.1    Gadalla, A.E.2    Olsen, G.S.3    Grahame Hardie, D.4
  • 41
    • 27144511497 scopus 로고    scopus 로고
    • AICAR stimulates IL-6 production via p38 MAPK in cardiac fibroblasts in adult mice: A possible role for AMPK
    • DOI 10.1016/j.bbrc.2005.09.174, PII S0006291X05021844
    • J.H. Du, N. Xu, Y. Song, M. Xu, Z.Z. Lu, C. Han, and Y.Y. Zhang AICAR stimulates IL-6 production via p38 MAPK in cardiac fibroblasts in adult mice: a possible role for AMPK Biochem Biophys Res Commun 337 2005 1139 1144 (Pubitemid 41509193)
    • (2005) Biochemical and Biophysical Research Communications , vol.337 , Issue.4 , pp. 1139-1144
    • Du, J.-H.1    Xu, N.2    Song, Y.3    Xu, M.4    Lu, Z.-Z.5    Han, C.6    Zhang, Y.-Y.7
  • 42
    • 34250795558 scopus 로고    scopus 로고
    • Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway
    • R. Vepachedu, M.M. Gorska, N. Singhania, G.P. Cosgrove, K.K. Brown, and R. Alam Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway J Immunol 179 2007 682 690 (Pubitemid 46986587)
    • (2007) Journal of Immunology , vol.179 , Issue.1 , pp. 682-690
    • Vepachedu, R.1    Gorska, M.M.2    Singhania, N.3    Cosgrove, G.P.4    Brown, K.K.5    Alam, R.6
  • 46
    • 33748747706 scopus 로고    scopus 로고
    • Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro
    • DOI 10.1074/jbc.M604399200
    • M. Momcilovic, S.P. Hong, and M. Carlson Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro J Biol Chem 281 2006 25336 25343 (Pubitemid 44401921)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.35 , pp. 25336-25343
    • Momcilovic, M.1    Hong, S.-P.2    Carlson, M.3
  • 48
    • 69249131695 scopus 로고    scopus 로고
    • Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells
    • S.I. Kim, J.H. Kwak, H.J. Na, J.K. Kim, Y. Ding, and M.E. Choi Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells J Biol Chem 284 2009 22285 22296
    • (2009) J Biol Chem , vol.284 , pp. 22285-22296
    • Kim, S.I.1    Kwak, J.H.2    Na, H.J.3    Kim, J.K.4    Ding, Y.5    Choi, M.E.6
  • 49
    • 29144470455 scopus 로고    scopus 로고
    • Contribution of mesenchymal progenitor cells to tissue repair in rat cardiac allografts undergoing chronic rejection
    • DOI 10.1016/j.healun.2005.05.017, PII S1053249805003414
    • G.D. Wu, M.E. Bowdish, Y.S. Jin, H. Zhu, N. Mitsuhashi, L.W. Barsky, and M.L. Barr Contribution of mesenchymal progenitor cells to tissue repair in rat cardiac allografts undergoing chronic rejection J Heart Lung Transplant 24 2005 2160 2169 (Pubitemid 41814741)
    • (2005) Journal of Heart and Lung Transplantation , vol.24 , Issue.12 , pp. 2160-2169
    • Wu, G.D.1    Bowdish, M.E.2    Jin, Y.-S.3    Zhu, H.4    Mitsuhashi, N.5    Barsky, L.W.6    Barr, M.L.7
  • 52
    • 0027245963 scopus 로고
    • Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation
    • DOI 10.1016/0092-8674(93)90252-L
    • C.M. Smas, and H.S. Sul Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation Cell 73 1993 725 734 (Pubitemid 23159011)
    • (1993) Cell , vol.73 , Issue.4 , pp. 725-734
    • Smas, C.M.1    Hei Sook Sul2
  • 53
    • 33947164677 scopus 로고    scopus 로고
    • The EGF-like Protein dlk1 Inhibits Notch Signaling and Potentiates Adipogenesis of Mesenchymal Cells
    • DOI 10.1016/j.jmb.2006.10.043, PII S002228360601415X
    • M.L. Nueda, V. Baladron, B. Sanchez-Solana, M.A. Ballesteros, and J. Laborda The EGF-like protein dlk1 inhibits notch signaling and potentiates adipogenesis of mesenchymal cells J Mol Biol 367 2007 1281 1293 (Pubitemid 46413261)
    • (2007) Journal of Molecular Biology , vol.367 , Issue.5 , pp. 1281-1293
    • Nueda, M.-L.1    Baladron, V.2    Sanchez-Solana, B.3    Ballesteros, M.-A.4    Laborda, J.5
  • 54
    • 0026718865 scopus 로고
    • Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures
    • J.N. Beresford, J.H. Bennett, C. Devlin, P.S. Leboy, and M.E. Owen Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures J Cell Sci 102 Pt 2 1992 341 351
    • (1992) J Cell Sci , vol.102 , Issue.PART 2 , pp. 341-351
    • Beresford, J.N.1    Bennett, J.H.2    Devlin, C.3    Leboy, P.S.4    Owen, M.E.5
  • 58
    • 44449150712 scopus 로고    scopus 로고
    • AICAR induces astroglial differentiation of neural stem cells via activating the JAK/STAT3 pathway independently of AMP-activated protein kinase
    • Y. Zang, L.F. Yu, T. Pang, L.P. Fang, X. Feng, T.Q. Wen, F.J. Nan, L.Y. Feng, and J. Li AICAR induces astroglial differentiation of neural stem cells via activating the JAK/STAT3 pathway independently of AMP-activated protein kinase J Biol Chem 283 2008 6201 6208
    • (2008) J Biol Chem , vol.283 , pp. 6201-6208
    • Zang, Y.1    Yu, L.F.2    Pang, T.3    Fang, L.P.4    Feng, X.5    Wen, T.Q.6    Nan, F.J.7    Feng, L.Y.8    Li, J.9
  • 59
    • 53449093439 scopus 로고    scopus 로고
    • AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells
    • X. Li, Y. Han, W. Pang, C. Li, X. Xie, J.Y. Shyy, and Y. Zhu AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells Arterioscler Thromb Vasc Biol 28 2008 1789 1795
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1789-1795
    • Li, X.1    Han, Y.2    Pang, W.3    Li, C.4    Xie, X.5    Shyy, J.Y.6    Zhu, Y.7
  • 60
    • 0033168915 scopus 로고    scopus 로고
    • Regulation of Smad signalling by protein associations and signalling crosstalk
    • DOI 10.1016/S0962-8924(99)01579-2
    • Y. Zhang, and R. Derynck Regulation of Smad signalling by protein associations and signalling crosstalk Trends Cell Biol 9 1999 274 279 (Pubitemid 29305517)
    • (1999) Trends in Cell Biology , vol.9 , Issue.7 , pp. 274-279
    • Zhang, Y.1    Derynck, R.2
  • 61
    • 0034678908 scopus 로고    scopus 로고
    • Transcriptional control by the TGF-β/Smad signaling system
    • J. Massague, and D. Wotton Transcriptional control by the TGF-beta/Smad signaling system EMBO J 19 2000 1745 1754 (Pubitemid 30204386)
    • (2000) EMBO Journal , vol.19 , Issue.8 , pp. 1745-1754
    • Massague, J.1    Wotton, D.2
  • 62
    • 0034613385 scopus 로고    scopus 로고
    • Requirement of Ras/MAPK pathway activation by transforming growth factor beta for transforming growth factor beta 1 production in a Smad-dependent pathway
    • J. Yue, and K.M. Mulder Requirement of Ras/MAPK pathway activation by transforming growth factor beta for transforming growth factor beta 1 production in a Smad-dependent pathway J Biol Chem 275 2000 30765 30773
    • (2000) J Biol Chem , vol.275 , pp. 30765-30773
    • Yue, J.1    Mulder, K.M.2
  • 63
    • 0036883881 scopus 로고    scopus 로고
    • Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway
    • R. Stratton, V. Rajkumar, M. Ponticos, B. Nichols, X. Shiwen, C.M. Black, D.J. Abraham, and A. Leask Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway FASEB J 16 2002 1949 1951
    • (2002) FASEB J , vol.16 , pp. 1949-1951
    • Stratton, R.1    Rajkumar, V.2    Ponticos, M.3    Nichols, B.4    Shiwen, X.5    Black, C.M.6    Abraham, D.J.7    Leask, A.8
  • 64
    • 0032461852 scopus 로고    scopus 로고
    • Transfection of the type II TGF-β receptor into colon cancer cells increases receptor expression, inhibits cell growth, and reduces the malignant phenotype
    • DOI 10.1097/00000658-199806000-00001
    • S.L. MacKay, T. Auffenberg, C.L. Tannahill, R. Ksontini, M.D. Josephs, M. Nowak, L.L. Moldawer, and E.M. Copeland III Transfection of the type II TGF-beta receptor into colon cancer cells increases receptor expression, inhibits cell growth, and reduces the malignant phenotype Ann Surg 227 1998 781 789 (Pubitemid 29119525)
    • (1998) Annals of Surgery , vol.227 , Issue.6 , pp. 781-789
    • Mackay, S.L.D.1    Auffenberg, T.2    Tannahill, C.L.3    Ksontini, R.4    Josephs, M.D.5    Nowak, M.6    Moldawer, L.L.7    Copeland III, E.M.8
  • 65
    • 0031694080 scopus 로고    scopus 로고
    • Transfection of the type I TGF-β receptor restores TGF-β responsiveness in pancreatic cancer
    • DOI 10.1002/(SICI)1097-0215(19981005)78:2<255::AID-IJC21>3.0.CO;2-8
    • M. Wagner, J. Kleeff, M.E. Lopez, I. Bockman, J. Massaque, and M. Korc Transfection of the type I TGF-beta receptor restores TGF-beta responsiveness in pancreatic cancer Int J Cancer 78 1998 255 260 (Pubitemid 28443185)
    • (1998) International Journal of Cancer , vol.78 , Issue.2 , pp. 255-260
    • Wagner, M.1    Kleeff, J.2    Lopez, M.E.3    Bockman, I.4    Massaque, J.5    Korc, M.6
  • 67
    • 0030011880 scopus 로고    scopus 로고
    • A function for filamentous α-smooth muscle actin: Retardation of motility in fibroblasts
    • DOI 10.1083/jcb.134.1.67
    • L. Ronnov-Jessen, and O.W. Petersen A function for filamentous alphasmooth muscle actin: retardation of motility in fibroblasts J Cell Biol 134 1996 67 80 (Pubitemid 26231521)
    • (1996) Journal of Cell Biology , vol.134 , Issue.1 , pp. 67-80
    • Ronnov-Jessen, L.1    Petersen, O.W.2
  • 68
    • 0033594123 scopus 로고    scopus 로고
    • Rho GTPases control polarity, protrusion, and adhesion during cell movement
    • DOI 10.1083/jcb.144.6.1235
    • C.D. Nobes, and A. Hall Rho GTPases control polarity, protrusion, and adhesion during cell movement J Cell Biol 144 1999 1235 1244 (Pubitemid 29157301)
    • (1999) Journal of Cell Biology , vol.144 , Issue.6 , pp. 1235-1244
    • Nobes, C.D.1    Hall, A.2
  • 69
    • 77649126524 scopus 로고    scopus 로고
    • Heart disease and stroke statistics2010 update: A report from the American Heart Association
    • American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • D. Lloyd-Jones, R.J. Adams, T.M. Brown, M. Carnethon, S. Dai, G. De Simone American Heart Association Statistics Committee and Stroke Statistics Subcommittee Heart disease and stroke statistics2010 update: a report from the American Heart Association Circulation 121 2010 e46 e215
    • (2010) Circulation , vol.121
    • Lloyd-Jones, D.1    Adams, R.J.2    Brown, T.M.3    Carnethon, M.4    Dai, S.5    De Simone, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.