메뉴 건너뛰기




Volumn 67, Issue 8, 2007, Pages 3912-3918

Degrasyn activates proteasomal-dependent degradation of c-Myc

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTINEOPLASTIC AGENT; DEGRASYN; MYC PROTEIN; PROTEASOME; UBIQUITIN; UNCLASSIFIED DRUG; WP 1130;

EID: 34248597738     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-4464     Document Type: Article
Times cited : (40)

References (50)
  • 1
    • 1842790378 scopus 로고    scopus 로고
    • c-Myc as a therapeutic target in cancer
    • Prochownik EV. c-Myc as a therapeutic target in cancer. Expert Rev Anticancer Ther 2004;4:289-302.
    • (2004) Expert Rev Anticancer Ther , vol.4 , pp. 289-302
    • Prochownik, E.V.1
  • 2
    • 0029779280 scopus 로고    scopus 로고
    • Cdc25 cell-cycle phosphatase as a target of c-myc
    • Galaktionov K, Chen X, Beach D. Cdc25 cell-cycle phosphatase as a target of c-myc. Nature 1996;382: 511-7.
    • (1996) Nature , vol.382 , pp. 511-517
    • Galaktionov, K.1    Chen, X.2    Beach, D.3
  • 3
    • 0036781812 scopus 로고    scopus 로고
    • c-MYC: More than just a matter of life and death
    • Pelengaris S, Khan M, Evan G. c-MYC: more than just a matter of life and death. Nat Rev Cancer 2002; 2:764-76.
    • (2002) Nat Rev Cancer , vol.2 , pp. 764-776
    • Pelengaris, S.1    Khan, M.2    Evan, G.3
  • 4
    • 0038641867 scopus 로고    scopus 로고
    • A strategy for identifying transcription factor binding sites reveals two classes of genomic c-Myc target sites
    • Haggerty TJ, Zeller KI, Osthus RC, Wonsey DR, Dang CV. A strategy for identifying transcription factor binding sites reveals two classes of genomic c-Myc target sites. Proc Natl Acad Sci U S A 2003;100:5313-8.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 5313-5318
    • Haggerty, T.J.1    Zeller, K.I.2    Osthus, R.C.3    Wonsey, D.R.4    Dang, C.V.5
  • 6
    • 0026096540 scopus 로고
    • Control of c-myc regulation in normal and neoplastic cells
    • Spencer CA, Groudine M. Control of c-myc regulation in normal and neoplastic cells. Adv Cancer Res 1991;56: 1-48.
    • (1991) Adv Cancer Res , vol.56 , pp. 1-48
    • Spencer, C.A.1    Groudine, M.2
  • 7
    • 0033551374 scopus 로고    scopus 로고
    • MYC oncogenes and human neoplastic disease
    • Nesbit CE, Tersak JM, Prochownik EV. MYC oncogenes and human neoplastic disease. Oncogene 1999; 18:3004-16.
    • (1999) Oncogene , vol.18 , pp. 3004-3016
    • Nesbit, C.E.1    Tersak, J.M.2    Prochownik, E.V.3
  • 8
    • 0035839844 scopus 로고    scopus 로고
    • Translocations involving c-myc and c-myc function
    • Boxer LM, Dang CV. Translocations involving c-myc and c-myc function. Oncogene 2001;20:5595-610.
    • (2001) Oncogene , vol.20 , pp. 5595-5610
    • Boxer, L.M.1    Dang, C.V.2
  • 10
    • 2342526543 scopus 로고    scopus 로고
    • A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
    • Yeh E, Cunningham M, Arnold H, et al. A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat Cell Biol 2004;6:308-18.
    • (2004) Nat Cell Biol , vol.6 , pp. 308-318
    • Yeh, E.1    Cunningham, M.2    Arnold, H.3
  • 11
    • 0034306997 scopus 로고    scopus 로고
    • Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability
    • Sears R, Nuckolls F, Haura E, Taya Y, Tamai K, Nevins JR. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev 2000;14:2501-14.
    • (2000) Genes Dev , vol.14 , pp. 2501-2514
    • Sears, R.1    Nuckolls, F.2    Haura, E.3    Taya, Y.4    Tamai, K.5    Nevins, J.R.6
  • 12
    • 0033081027 scopus 로고    scopus 로고
    • Destruction of Myc by ubiquitin-mediated proteolysis: Cancer-associated and transforming mutations stabilize Myc
    • Salghetti SE, Kim SY, Tansey WP. Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc. EMBO J 1999;18:717-26.
    • (1999) EMBO J , vol.18 , pp. 717-726
    • Salghetti, S.E.1    Kim, S.Y.2    Tansey, W.P.3
  • 13
    • 3543060464 scopus 로고    scopus 로고
    • myc boxes, which are conserved in myc family proteins, are signals for protein degradation via the proteasome
    • Flinn EM, Busch CM, Wright AP. myc boxes, which are conserved in myc family proteins, are signals for protein degradation via the proteasome. Mol Cell Biol 1998;18:5961-9.
    • (1998) Mol Cell Biol , vol.18 , pp. 5961-5969
    • Flinn, E.M.1    Busch, C.M.2    Wright, A.P.3
  • 14
    • 1042289729 scopus 로고    scopus 로고
    • 2 kinase (JNK) contributes to the regulation of c-Myc protein stability
    • 2 kinase (JNK) contributes to the regulation of c-Myc protein stability. J Biol Chem 2004;279:5008-16.
    • (2004) J Biol Chem , vol.279 , pp. 5008-5016
    • Alarcon-Vargas, D.1    Ronai, Z.2
  • 15
    • 2942614705 scopus 로고    scopus 로고
    • Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7
    • Yada M, Hatakeyama S, Kamura T, et al. Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J 2004;23:2116-25.
    • (2004) EMBO J , vol.23 , pp. 2116-2125
    • Yada, M.1    Hatakeyama, S.2    Kamura, T.3
  • 16
    • 0033539925 scopus 로고    scopus 로고
    • Protein stabilization: A common consequence of mutations in independently derived v-Myc alleles
    • Gavine PR, Neil JC, Crouch DH. Protein stabilization: a common consequence of mutations in independently derived v-Myc alleles. Oncogene 1999;18:7552-8.
    • (1999) Oncogene , vol.18 , pp. 7552-7558
    • Gavine, P.R.1    Neil, J.C.2    Crouch, D.H.3
  • 17
    • 0037028306 scopus 로고    scopus 로고
    • Stable and unstable pools of Myc protein exist in human cells
    • Tworkowski KA, Salghetti SE, Tansey WP. Stable and unstable pools of Myc protein exist in human cells. Oncogene 2002;21:8515-20.
    • (2002) Oncogene , vol.21 , pp. 8515-8520
    • Tworkowski, K.A.1    Salghetti, S.E.2    Tansey, W.P.3
  • 18
    • 0034652313 scopus 로고    scopus 로고
    • Ubiquitylation and destruction of endogenous c-mycS by the proteasome: Are myc boxes dispensable?
    • Chen L, Smith L, Accavitti-Loper MA, Omura S, Bingham Smith J. Ubiquitylation and destruction of endogenous c-mycS by the proteasome: are myc boxes dispensable? Arch Biochem Biophys 2000;374:306-12.
    • (2000) Arch Biochem Biophys , vol.374 , pp. 306-312
    • Chen, L.1    Smith, L.2    Accavitti-Loper, M.A.3    Omura, S.4    Bingham Smith, J.5
  • 19
    • 0034059667 scopus 로고    scopus 로고
    • c-Myc proteolysis by the ubiquitin-proteasome pathway: Stabilization of c-Myc in Burkitt's lymphoma cells
    • Gregory MA, Hann SR. c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells. Mol Cell Riol 2000;20:2423-35.
    • (2000) Mol Cell Riol , vol.20 , pp. 2423-2435
    • Gregory, M.A.1    Hann, S.R.2
  • 20
    • 2342507059 scopus 로고    scopus 로고
    • Multiple cell-type-specific elements regulate Myc protein stability
    • Herbst A, Salghetti SE, Kim SY, Tansey WP. Multiple cell-type-specific elements regulate Myc protein stability. Oncogene 2004;23:3863-71.
    • (2004) Oncogene , vol.23 , pp. 3863-3871
    • Herbst, A.1    Salghetti, S.E.2    Kim, S.Y.3    Tansey, W.P.4
  • 22
    • 12444264823 scopus 로고    scopus 로고
    • The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription
    • von der Lehr N, Johansson S, Wu S, et al. The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. Mol Cell 2003;11:1189-200.
    • (2003) Mol Cell , vol.11 , pp. 1189-1200
    • von der Lehr, N.1    Johansson, S.2    Wu, S.3
  • 23
    • 0842347423 scopus 로고    scopus 로고
    • Negative control of the Myc protein by the stress-responsive kinase Pak2
    • Huang Z, Traugh JA, Bishop JM. Negative control of the Myc protein by the stress-responsive kinase Pak2. Mol Cell Biol 2004;24:1582-94.
    • (2004) Mol Cell Biol , vol.24 , pp. 1582-1594
    • Huang, Z.1    Traugh, J.A.2    Bishop, J.M.3
  • 24
    • 4644324678 scopus 로고    scopus 로고
    • Stress signaling and Myc downregulation: Implications for cancer
    • Huang Z. Stress signaling and Myc downregulation: implications for cancer. Cell Cycle 2004;3:593-6.
    • (2004) Cell Cycle , vol.3 , pp. 593-596
    • Huang, Z.1
  • 25
    • 5444237088 scopus 로고    scopus 로고
    • STAT proteins as novel targets for cancer drug discovery
    • Turkson J. STAT proteins as novel targets for cancer drug discovery. Expert Opin Ther Targets 2004;8:409-22.
    • (2004) Expert Opin Ther Targets , vol.8 , pp. 409-422
    • Turkson, J.1
  • 26
    • 0034722896 scopus 로고    scopus 로고
    • STAT proteins: Novel molecular targets for cancer drug discovery
    • Turkson J, Jove R. STAT proteins: novel molecular targets for cancer drug discovery. Oncogene 2000;19: 6613-26.
    • (2000) Oncogene , vol.19 , pp. 6613-6626
    • Turkson, J.1    Jove, R.2
  • 27
    • 0021688655 scopus 로고
    • Proteins encoded by the human c-myc oncogene: Differential expression in neoplastic cells
    • Hann SR, Eisenman RN. Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells. Mol Cell Biol 1984;4:2486-97.
    • (1984) Mol Cell Biol , vol.4 , pp. 2486-2497
    • Hann, S.R.1    Eisenman, R.N.2
  • 28
    • 0034688946 scopus 로고    scopus 로고
    • htert expression correlates with MYC over-expression I n human prostate cancer
    • Latil A, Vidaud D, Valeri A, et al. htert expression correlates with MYC over-expression I n human prostate cancer. Int J Cancer 2000;89:172-6.
    • (2000) Int J Cancer , vol.89 , pp. 172-176
    • Latil, A.1    Vidaud, D.2    Valeri, A.3
  • 29
    • 0032485207 scopus 로고    scopus 로고
    • In vivo degradation of N-myc in neuroblastoma cells is mediated by the 26S proteasome
    • Bonvini P, Nguyen P, Trepel J, Neckers LM. In vivo degradation of N-myc in neuroblastoma cells is mediated by the 26S proteasome. Oncogene 1998;16: 1131-9.
    • (1998) Oncogene , vol.16 , pp. 1131-1139
    • Bonvini, P.1    Nguyen, P.2    Trepel, J.3    Neckers, L.M.4
  • 30
    • 0027980319 scopus 로고    scopus 로고
    • Rock KL, Gramm C, Rothstein L, et al. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 1994;78:761-71.
    • Rock KL, Gramm C, Rothstein L, et al. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 1994;78:761-71.
  • 31
  • 32
    • 0032493365 scopus 로고    scopus 로고
    • Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway
    • Gross-Mesilaty S, Reinstein E, Bercovich B, et al. Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway. Proc Natl Acad Sci U S A 1998;95:8058-63.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8058-8063
    • Gross-Mesilaty, S.1    Reinstein, E.2    Bercovich, B.3
  • 33
  • 34
    • 0038795112 scopus 로고    scopus 로고
    • Oncogenes in melanoma
    • Polsky D, Cordon-Cardo C. Oncogenes in melanoma. Oncogene 2003;22:3087-91.
    • (2003) Oncogene , vol.22 , pp. 3087-3091
    • Polsky, D.1    Cordon-Cardo, C.2
  • 35
    • 0041816008 scopus 로고    scopus 로고
    • Inhibition of c-Myc oncoprotein limits the growth of human melanoma cells by inducing cellular crisis
    • Biroccio A, Amodei S, Antonelli A, Benassi B, Zupi G. Inhibition of c-Myc oncoprotein limits the growth of human melanoma cells by inducing cellular crisis. J Biol Chem 2003;278:35693-701.
    • (2003) J Biol Chem , vol.278 , pp. 35693-35701
    • Biroccio, A.1    Amodei, S.2    Antonelli, A.3    Benassi, B.4    Zupi, G.5
  • 36
    • 10744233586 scopus 로고    scopus 로고
    • Targeted liposomal c-myc antisense oligodeoxynucleotides induce apoptosis and inhibit tumor growth and metastases in human melanoma models
    • Pastorino F, Brignole C, Marimpietri D, et al. Targeted liposomal c-myc antisense oligodeoxynucleotides induce apoptosis and inhibit tumor growth and metastases in human melanoma models. Clin Cancer Res 2003; 9:4595-605.
    • (2003) Clin Cancer Res , vol.9 , pp. 4595-4605
    • Pastorino, F.1    Brignole, C.2    Marimpietri, D.3
  • 37
    • 33748192942 scopus 로고    scopus 로고
    • The Myc oncoprotein as a therapeutic target for human cancer
    • Vita M, Henriksson M. The Myc oncoprotein as a therapeutic target for human cancer. Semin Cancer Biol 2006;16:318-30.
    • (2006) Semin Cancer Biol , vol.16 , pp. 318-330
    • Vita, M.1    Henriksson, M.2
  • 38
    • 33646907501 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase-dependent proliferation is mediated through the protein kinase A/B-Raf pathway in human uveal melanoma cells
    • Calipel A, Mouriaux F, Glotin AL, Malecaze F, Faussat AM, Mascarelli F. Extracellular signal-regulated kinase-dependent proliferation is mediated through the protein kinase A/B-Raf pathway in human uveal melanoma cells. J Biol Chem 2006;281:9238-50.
    • (2006) J Biol Chem , vol.281 , pp. 9238-9250
    • Calipel, A.1    Mouriaux, F.2    Glotin, A.L.3    Malecaze, F.4    Faussat, A.M.5    Mascarelli, F.6
  • 39
    • 0023136649 scopus 로고
    • Evolutionarily conserved regions of the human c-myc protein can be uncoupled from transforming activity
    • Sarid J, Halazonetis TD, Murphy W, Leder P. Evolutionarily conserved regions of the human c-myc protein can be uncoupled from transforming activity. Proc Natl Acad Sci U S A 1987;84:170-3.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 170-173
    • Sarid, J.1    Halazonetis, T.D.2    Murphy, W.3    Leder, P.4
  • 40
    • 0033551388 scopus 로고    scopus 로고
    • New Myc-interacting proteins: A second Myc network emerges
    • Sakamuro D, Prendergast GC. New Myc-interacting proteins: a second Myc network emerges. Oncogene 1999;18:2942-54.
    • (1999) Oncogene , vol.18 , pp. 2942-2954
    • Sakamuro, D.1    Prendergast, G.C.2
  • 41
    • 0027275755 scopus 로고
    • Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas
    • Bhatia K, Huppi K, Spangler G, Siwarski D, Iyer R, Magrath I. Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas. Nat Genet 1993;5:56-61.
    • (1993) Nat Genet , vol.5 , pp. 56-61
    • Bhatia, K.1    Huppi, K.2    Spangler, G.3    Siwarski, D.4    Iyer, R.5    Magrath, I.6
  • 42
    • 0034653998 scopus 로고    scopus 로고
    • c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover
    • Bahram F, von der Lehr N, Cetinkaya C, Larsson LG. c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover. Blood 2000;95:2104-10.
    • (2000) Blood , vol.95 , pp. 2104-2110
    • Bahram, F.1    von der Lehr, N.2    Cetinkaya, C.3    Larsson, L.G.4
  • 43
    • 0029001787 scopus 로고
    • A link between increased transforming activity of lymphomaderived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain
    • Hoang AT, Lutterbach B, Lewis BC, et al. A link between increased transforming activity of lymphomaderived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain. Mol Cell Biol 1995;15:4031-42.
    • (1995) Mol Cell Biol , vol.15 , pp. 4031-4042
    • Hoang, A.T.1    Lutterbach, B.2    Lewis, B.C.3
  • 45
    • 0023020262 scopus 로고
    • The myc oncogene: Its role in transformation and differentiation
    • Cole MD. The myc oncogene: its role in transformation and differentiation. Annu Rev Genet 1986;20:361-84.
    • (1986) Annu Rev Genet , vol.20 , pp. 361-384
    • Cole, M.D.1
  • 46
    • 0141569009 scopus 로고    scopus 로고
    • Myc-driven murine prostate cancer shares molecular features with human prostate tumors
    • Ellwood-Yen K, Graeber TG, Wongvipat J, et al. Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell 2003;4:223-38.
    • (2003) Cancer Cell , vol.4 , pp. 223-238
    • Ellwood-Yen, K.1    Graeber, T.G.2    Wongvipat, J.3
  • 47
    • 0035126052 scopus 로고    scopus 로고
    • c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations
    • D'Cruz CM, Gunther EJ, Boxer RB, et al. c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations. Nat Med 2001;7:235-9.
    • (2001) Nat Med , vol.7 , pp. 235-239
    • D'Cruz, C.M.1    Gunther, E.J.2    Boxer, R.B.3
  • 48
    • 7744220635 scopus 로고    scopus 로고
    • MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
    • Shachaf CM, Kopelman AM, Arvanitis C, et al. MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. Nature 2004;431:1112-7.
    • (2004) Nature , vol.431 , pp. 1112-1117
    • Shachaf, C.M.1    Kopelman, A.M.2    Arvanitis, C.3
  • 49
    • 8644219660 scopus 로고    scopus 로고
    • c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation
    • Wilson A, Murphy MJ, Oskarsson T, et al. c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev 2004;18: 2747-63.
    • (2004) Genes Dev , vol.18 , pp. 2747-2763
    • Wilson, A.1    Murphy, M.J.2    Oskarsson, T.3
  • 50
    • 0025730938 scopus 로고
    • Modulation of cis-platinum resistance in Friend erythroleukemia cells by c-myc
    • Sklar MD, Prochownik EV. Modulation of cis-platinum resistance in Friend erythroleukemia cells by c-myc. Cancer Res 1991;51:2118-23.
    • (1991) Cancer Res , vol.51 , pp. 2118-2123
    • Sklar, M.D.1    Prochownik, E.V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.