Time-dependent quantitative multicomponent control of the G 1-S network by the stress-activated protein kinase Hog1 upon osmostress

Science Signaling

Volumn 4, Issue 192, 2011, Pages

  Adrover, Miquel Àngel ^a   Zi, Zhike ^b,d   Duch, Alba ^a   Schaber, Jörg ^b,e   González Novo, Alberto ^a   Jimenez, Javier ^a   Nadal Ribelles, Mariona ^a   Clotet, Josep ^a,c   Klipp, Edda ^b   Posas, Francesc ^a  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b HUMBOLDT UNIVERSITY   (Germany)

^c UNIVERSITAT INTERNACIONAL DE CATALUNYA   (Spain)

^d UNIVERSITY OF FREIBURG   (Germany)

^e OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN B; CYCLIN B5; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR SIC1; CYCLIN G1; CYCLIN N1; CYCLIN N2; CYCLINE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE HOG1; UNCLASSIFIED DRUG; CLN1 PROTEIN, S CEREVISIAE; CLN2 PROTEIN, S CEREVISIAE; HOG1 PROTEIN, S CEREVISIAE; MITOGEN ACTIVATED PROTEIN KINASE; SACCHAROMYCES CEREVISIAE PROTEIN; SIC1 PROTEIN, S CEREVISIAE;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL DIVISION; DNA REPLICATION; GENETIC TRANSCRIPTION; HYPEROSMOTIC STRESS; IN VIVO STUDY; MORPHOGENESIS; NONHUMAN; OSMOTIC STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; YEAST CELL; BIOLOGICAL MODEL; CELL CYCLE; CHROMATIN IMMUNOPRECIPITATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; METABOLISM; OSMOTIC PRESSURE; PHYSIOLOGICAL STRESS; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; SACCHAROMYCES CEREVISIAE; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL CYCLE; CHROMATIN IMMUNOPRECIPITATION; CYCLIN-DEPENDENT KINASE INHIBITOR PROTEINS; CYCLINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, FUNGAL; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; OSMOTIC PRESSURE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STRESS, PHYSIOLOGICAL;

EID: 80053228416     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2002204     Document Type: Article

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38. Acknowledgments: We are grateful to G. Yaakov, S. Hohmann, E. Garí, and M. Aldea for helpful discussions and suggestions; M. L. Rodriguez and L. Subirana for excellent technical assistance; and E. de Nadal for constant support. Funding: M.A.A. is a recipient of an FPU fellowship (Ministerio de Educacion). Z.Z. was supported by the International Max Planck Research School for Computational Biology and Scientific Computing. This work was supported by grants QUASI, CELLCOMPUT, and UNICELLSYS from the European Community's sixth and seventh framework programs to F.P. and E.K. and grants from Ministerio de Ciencia y Innovación BIO2009-07762 and Consolider Ingenio 2010 program (grant CSD2007-0015) of the Spanish government and through contract no. ERAS-CT-2003-980409 of the European Commission, DG Research, FP6 as part of a European Young Investigator scheme award to F.P. F.P.'s research is supported by Institució Catalana de Recerca i Estudis Avançats Acadèmia for excellence in research (Generalitat de Catalunya) and Fundación Marcelino Botín. Author contributions: F.P. and E.K. designed the study; M.A.A., A.D., A.G.-N., J.J., M.N.-R., and J.C. performed the experiments; all authors analyzed the data; Z.Z., J.S., and E.K. built the model; and F.P., E.K., and Z.Z. wrote the manuscript. Competing interests: The authors declare that they have no competing interests.