Dynamic signaling in the Hog1 MAPK pathway relies on high basal signal transduction

Science Signaling

Volumn 2, Issue 63, 2009, Pages

  Macia, Javier ^a   Regot, Sergi ^a   Peeters, Tom ^a   Conde, Núria ^a   Solé, Ricard ^a,b   Posas, Francesc ^a  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b SANTA FE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN HOG1; UNCLASSIFIED DRUG; FUS3 PROTEIN, S CEREVISIAE; HOG1 PROTEIN, S CEREVISIAE; MEMBRANE PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; SHO1 PROTEIN, S CEREVISIAE; SNL1 PROTEIN, S CEREVISIAE;

ARTICLE; CONTROLLED STUDY; FEEDBACK SYSTEM; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN RESTRICTION; PROTEIN VARIANT; RESPONSE TIME; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; YEAST; BIOLOGICAL MODEL; ELECTROLYTE BALANCE; FLOW CYTOMETRY; METABOLISM; PHYSIOLOGY; WESTERN BLOTTING;

BLOTTING, WESTERN; FLOW CYTOMETRY; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; WATER-ELECTROLYTE BALANCE; YEASTS;

EID: 66149137998     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000056     Document Type: Article

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39. We thank E. de Nadal for helpful discussions and support, M. Morillas and A. Vendrell for strains, and M. Grötli (Sweden) for inhibitor design and supply. This work was supported by an FPU fellowship to S.R.; grant CSD2007-0015 from Ministerio de Ciencia y Tecnología, Consolider Ingenio 2010 program; through the European Commission Directorate General Research, FP6 contract no. ERAS-CT-2003-980409 EURYI (European Young Investigator Awards) award (www.esf.org/euryi) and QUASI to F.P; and FP6-2005-NEST-PATH CELLCOMPUT project to F.P. and R.S. The FP laboratory also receives support from the Fundación Marcelino Botín and Institució Catalana de Recerca i Estudis Avançats (ICREA) Acadèmia (Generalitat de Catalunya).