Novel diarylpyridinones, diarylpyridazinones and diarylphthalazinones as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs)

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 20, 2011, Pages 5924-5934

  Venkatraj, Muthusamy ^a   Ariën, Kevin K ^b   Heeres, Jan ^a   Dirié, Bertrand ^a   Joossens, Jurgen ^a   Van Goethem, Sebastiaan ^a   Van Der Veken, Pieter ^a   Michiels, Johan ^b   Vande Velde, Christophe M L ^c   Vanham, Guido ^a,b,d   Lewi, Paul J ^a   Augustyns, Koen ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^c Karel de Grote University College   (Belgium)

^d VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Diarylphthalazinones; Diarylpyridazinones; Diarylpyridinones; HIV 1 reverse transcriptase; NNRTIs

Indexed keywords

1,5 BIS(PHENYLAMINO)PYRIDIN 2(1H) ONE; 2 (4 CHLOROPHENYLAMINO) 6 (MESITYLOXY)PYRIDAZIN 3(2H) ONE; 2 (4 FLUOROPHENYLAMINO) 6 (MESITYLOXY)PYRIDAZIN 3(2H) ONE; 3 [3 (MESITYLAMINO) 6 OXOPYRIDAZIN 1(6H) YLAMINO] BENZONITRILE; 3 [3 (MESITYLOXY) 6 OXOPYRIDAZIN 1(6H) YLAMINO]BENZONITRILE; 3 [5 (MESITYLAMINO) 2 OXOPYRIDIN 1(2H) YLAMINO] BENZONITRILE; 34 [[5 [(4 CYANOPHENYL)AMINO] 2 OXOPYRIDIN 1(2H) YL] AMINO]BENZONITRILE; 4 [2 OXO 5 (PHENYLAMINO)PYRIDIN 1(2H) YLAMINO]BENZONITRILE; 4 [3 (2,6 DIMETHYLPHENOXY) 6 OXOPYRIDAZIN 1(6H) YLAMINO]BENZONITRILE; 4 [3 (MESITYLAMINO) 6 OXOPYRIDAZIN 1(6H) YLAMINO] BENZONITRILE; 4 [3 (MESITYLOXY) 6 OXOPYRIDAZIN 1(6H) YLAMINO]BENZONITRILE; 4 [5 (MESITYLAMINO) 2 OXOPYRIDIN 1(2H) YLAMINO] BENZONITRILE; 5 (MESITYLAMINO) 1 (PHENYLAMINO)PYRIDIN 2(1H) ONE; 5 (MESITYLAMINO) 1 [4 (TRIFLUOROMETHYL)PHENYLAMINO] PYRIDIN 2(1H) ONE; 6 (MESITYLAMINO) 2 [4 (TRIFLUOROMETHYL)PHENYLAMINO] PYRADIZIN 3(2H) ONE; 6 (MESITYLOXY) 2 [4 (TRIFLUOROMETHYL)PHENYLAMINO]PYRIDAZIN 3(2H) ONE; DAPIVIRINE; DELAVIRDINE; DIARYLPHTHALAZINE DERIVATIVE; DIARYLPYRIDAZINONE DERIVATIVE; DIARYLPYRIDONE DERIVATIVE; EFAVIRENZ; ETRAVIRINE; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PHTHALAZINE DERIVATIVE; PYRIDAZINONE DERIVATIVE; PYRIDONE DERIVATIVE; RILPIVIRINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG INHIBITION; DRUG STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTI-HIV AGENTS; HIV REVERSE TRANSCRIPTASE; HUMANS; MODELS, MOLECULAR; PHTHALAZINES; PYRIDAZINES; PYRIDONES; REVERSE TRANSCRIPTASE INHIBITORS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 80053226864     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.08.060     Document Type: Article

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