Optically active 1,3,4,4-tetrasubstituted β-lactams: Synthesis and evaluation as tumor cell growth inhibitors

European Journal of Medicinal Chemistry

Volumn 46, Issue 10, 2011, Pages 5108-5119

  Pérez Faginas, Paula ^a   Aranda, M Teresa ^a   García López, M Teresa ^a   Francesch, Andrés ^b   Cuevas, Carmen ^b   González Muñiz, Rosario ^a  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b PHARMAMAR S A   (Spain)

Author keywords

Amino acids; Beta lactams; Cytotoxicity; SAR studies; Solid phase synthesis

Indexed keywords

4 BENZYL 1 PARA METHOXYBENZYL 3 METHYL 4 (4 MORPHOLINE)CARBONYL 2 AZETIDINONE; 4 BENZYL 1 PARA METHOXYBENZYL 3 METHYL 4 [(2' PIPERIDIN 1'' IL)ETHYL]CARBAMOYL 2 AZETIDINONE; 4 BENZYL 1 PARA METHOXYBENZYL 3 METHYL 4 METHOXYCARBONYL DERIVATIVE; 4 BENZYL 4 BENZYLCARBAMOYL 1 PARA METHOXYBENZYL 3 METHYL 2 AZETIDINONE; 4 BENZYL 4 CARBOXY 1 PARA FLUOROBENZYL 3 METHYL 2 AZETIDINONE; 4 BENZYL 4 CARBOXY 3 METHYL 1 (2 NAPHTYLMETHYL) 2 AZETIDINONE; 4 BENZYL 4 CARBOXY 3 METHYL 1 PARA METHYLBENZYL 2 AZETIDINONE; 4 BENZYL 4 CARBOXY 3 METHYL 1 PARA NITROBENZYL 2 AZETIDINONE; 4 BENZYL 4 CARBOXY 3 METHYL 1 PARA PHENYLMETHYL 2 AZETIDINONE; 4 BENZYL 4 CARBOXY 3 METHYL 1 PARA PROPOXYBENZYL 2 AZETIDINONE; 4 BENZYL 4 CARBOXY 3 METHYL 1 PARA TRIFLUOROMETHYL BENZYL 2 AZETIDINONE; 4 BENZYL 4 CARBOXY 3 METHYL 1 PARA[2' (MORPHOLIN 4'' IL)ETHOXY]BENZYL 2 AZETIDINONE TRIFLUOROACETATE; 4 BENZYL 4 CARBOXY 3 METHYL 1 PHENETHYL 2 AZETIDINONE; 4 BENZYL 4 CICLOHEXYLCARBAMOYL 1 PARA METHOXYBENZYL 3 METHYL 2 AZETIDINONE; 4 BENZYL 4 METHOXYCARBONYL 3 METHYL 1 PARA PROPOXYBENZYL 2 AZETIDINONE; 4 BENZYL 4 METHOXYCARBONYL 3 METHYL 1 PHENETHYL 2 AZETIDINONE; 4 CARBOXY 1,4 DIBENZYL 3 METHYL 2 AZETIDINONE; 4 CARBOXY 4 PARA(2,6 DICHLOROBENZYLOXY)BENZYL 1 PARA METHOXYBENZYL 3 METHYL 2 AZETIDINONE; 4 CYCLOHEXYLCARBAMOYL 4 PARA(2,6 DICHLOROBENZYLOXY)BENZYL 1 P METHOXYBENZYL 3 METHYL 2 AZETIDINONE; 4 PARA BENZYLOXYBENZYL 1 PARA METHOXYBENZYL 4 METHOXYCARBONYL 3 METHYL 2 AZETIDINONE; 4 PARA HYDROXYBENZYL 1 PARA METHOXYBENZYL 4 METHOXYCARBONYL 3 METHYL 2 AZETIDINONE; 4 PARA(2,6 DICHLOROBENZYLOXI)BENZYL 1 PARA METHOXYBENZYL 4 METHOXYCARBONYL 3 METHYL 2 AZETIDINONE; 4 PARA(2,6 DICHLOROBENZYLOXY)BENZYL 1 PARA METHOXYBENZYL 3 METHYL 4 [(2' PIPERIDIN 1'' IL)ETHYL]CARBAMOYL 2 AZETIDINONE; AMINO ACID DERIVATIVE; ANTINEOPLASTIC AGENT; BETA LACTAM; DOXORUBICIN; N (2 NITROPHENYL)SULFONYL LEVO PHENYLALANINE OME; N (4 PROPOXY)BENZYL LEVO PHENYLALANINE OME; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; ENANTIOMER; HUMAN; HUMAN CELL; IN VITRO STUDY;

ANTINEOPLASTIC AGENTS; BETA-LACTAMS; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMISTRY TECHNIQUES, SYNTHETIC; COLONIC NEOPLASMS; HUMANS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80053207975     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.08.025     Document Type: Article

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