Asymmetric synthesis of anticancer β-lactams via Staudinger reaction: Utilization of chiral ketene from carbohydrate

European Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2010, Pages 846-848

  Banik, Bimal K ^a   Banik, Indrani ^b   Becker, Frederick F ^b  

^a UNIVERSITY OF TEXAS PAN AMERICAN   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Lactams; Anticancer agents; Asymmetric synthesis; Carbohydrate; In vitro tests; Staudinger reaction

Indexed keywords

ANTINEOPLASTIC AGENT; BETA LACTAM DERIVATIVE; CARBOHYDRATE; KETENE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ASYMMETRIC SYNTHESIS; CANCER INHIBITION; CHEMICAL REACTION; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; METHODOLOGY; STAUDINGER REACTION;

ANTINEOPLASTIC AGENTS; BETA-LACTAMS; CARBOHYDRATES; CELL LINE, TUMOR; CELL PROLIFERATION; ETHYLENES; HUMANS; KETONES; STEREOISOMERISM;

EID: 73549100633     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.11.024     Document Type: Article

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32. 3) δ (ppm): 20.72, 21.10, 22.64, 23.68, 62.61, 63.23, 65.09, 66.74, 85.93, 97.61, 115.11, 120. 90, 122.87, 123.60, 124.52, 126.68, 126.73, 126.76, 126.88, 127.03, 127.39, 127.56, 128.93, 129.16, 130.05, 131.17, 132.22, 136.16, 165.54, 169.94, 170.78.