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Volumn 118, Issue 12, 2011, Pages 3280-3289

Lack of the T cell-specific alternative p38 activation pathway reduces autoimmunity and inflammation

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; GAMMA INTERFERON; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45 ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 11; MITOGEN ACTIVATED PROTEIN KINASE 14; PHENYLALANINE; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR T BET; TUMOR NECROSIS FACTOR ALPHA; TYROSINE; UNCLASSIFIED DRUG;

EID: 80053196380     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-01-333039     Document Type: Article
Times cited : (51)

References (45)
  • 1
    • 33745530860 scopus 로고    scopus 로고
    • The many paths to p38 mitogen-activated protein kinase activation in the immune system
    • DOI 10.1038/nri1865, PII N1865
    • Ashwell JD. The many paths to p38 mitogen-activated protein kinase activation in the immune system. Nat Rev Immunol. 2006;6(7):532-540. (Pubitemid 43980525)
    • (2006) Nature Reviews Immunology , vol.6 , Issue.7 , pp. 532-540
    • Ashwell, J.D.1
  • 3
    • 0029982565 scopus 로고    scopus 로고
    • Characterization of the structure and function of a new mitogen- activated protein kinase (p38beta)
    • DOI 10.1074/jbc.271.30.17920
    • Jiang Y, Chen C, Li Z, et al. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J Biol Chem. 1996;271(30):17920-17926. (Pubitemid 26250772)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.30 , pp. 17920-17926
    • Jiang, Y.1    Chen, C.2    Li, Z.3    Guo, W.4    Gegner, J.A.5    Lin, S.6    Han, J.7
  • 4
    • 8744256717 scopus 로고    scopus 로고
    • Active mutants of the human p38alpha mitogen-activated protein kinase
    • DOI 10.1074/jbc.M404595200
    • Diskin R, Askari N, Capone R, Engelberg D, Livnah O. Active mutants of the human p38alpha mitogen-activated protein kinase. J Biol Chem. 2004;279(45):47040-47049. (Pubitemid 39518359)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.45 , pp. 47040-47049
    • Diskin, M.1    Askari, N.2    Capone, R.3    Engelberg, D.4    Livnah, O.5
  • 5
    • 0031916832 scopus 로고    scopus 로고
    • Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6
    • DOI 10.1074/jbc.273.3.1741
    • Enslen H, Raingeaud J, Davis RJ. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J Biol Chem. 1998;273(3):1741-1748. (Pubitemid 28133705)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.3 , pp. 1741-1748
    • Enslen, H.1    Raingeaud, J.2    Davis, R.J.3
  • 6
    • 67650138623 scopus 로고    scopus 로고
    • T cell receptor-mediated activation of p38alpha by mono-phosphorylation of the activation loop results in altered substrate specificity
    • Mittelstadt PR, Yamaguchi H, Appella E, Ashwell JD. T cell receptor-mediated activation of p38alpha by mono-phosphorylation of the activation loop results in altered substrate specificity. J Biol Chem. 2009;284(23):15469-15474.
    • (2009) J Biol Chem , vol.284 , Issue.23 , pp. 15469-15474
    • Mittelstadt, P.R.1    Yamaguchi, H.2    Appella, E.3    Ashwell, J.D.4
  • 8
    • 64049117360 scopus 로고    scopus 로고
    • Genetic disruption of p38alpha Tyr323 phosphorylation prevents T-cell receptor-mediated p38alpha activation and impairs interferon-gamma production
    • Jirmanova L, Sarma DN, Jankovic D, Mittelstadt PR, Ashwell JD. Genetic disruption of p38alpha Tyr323 phosphorylation prevents T-cell receptor-mediated p38alpha activation and impairs interferon-gamma production. Blood. 2009;113(10):2229-2237.
    • (2009) Blood , vol.113 , Issue.10 , pp. 2229-2237
    • Jirmanova, L.1    Sarma, D.N.2    Jankovic, D.3    Mittelstadt, P.R.4    Ashwell, J.D.5
  • 10
    • 16844366591 scopus 로고    scopus 로고
    • The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway
    • DOI 10.1038/ni1176
    • Salvador JM, Mittelstadt PR, Belova GI, Fornace AJJ, Ashwell JD. The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway. Nat Immunol. 2005;6(4):396-402. (Pubitemid 41716780)
    • (2005) Nature Immunology , vol.6 , Issue.4 , pp. 396-402
    • Salvador, J.M.1    Mittelstadt, P.R.2    Belova, G.I.3    Fornace Jr., A.J.4    Ashwell, J.D.5
  • 11
    • 0032514967 scopus 로고    scopus 로고
    • A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK
    • Takekawa M, Saito H. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell. 1998;95(4):521-530. (Pubitemid 28533308)
    • (1998) Cell , vol.95 , Issue.4 , pp. 521-530
    • Takekawa, M.1    Saito, H.2
  • 12
    • 33947658043 scopus 로고    scopus 로고
    • Gadd45alpha regulates p38-dependent dendritic cell cytokine production and Th1 differentiation
    • Jirmanova L, Jankovic D, Fornace AJJ, Ashwell JD. Gadd45alpha regulates p38-dependent dendritic cell cytokine production and Th1 differentiation. J Immunol. 2007;178(7):4153-4158. (Pubitemid 46492365)
    • (2007) Journal of Immunology , vol.178 , Issue.7 , pp. 4153-4158
    • Jirmanova, L.1    Jankovic, D.2    Fornace Jr., A.J.3    Ashwell, J.D.4
  • 15
    • 70350607858 scopus 로고    scopus 로고
    • Inhibition of anti-tuberculosis T-lymphocyte function with tumour necrosis factor antagonists
    • Hamdi H, Mariette X, Godot V, et al. Inhibition of anti-tuberculosis T-lymphocyte function with tumour necrosis factor antagonists. Arthritis Res Ther. 2006;8(4):R114.
    • (2006) Arthritis Res Ther , vol.8 , Issue.4
    • Hamdi, H.1    Mariette, X.2    Godot, V.3
  • 16
  • 17
    • 77949394122 scopus 로고    scopus 로고
    • Peripheral neuropathy in chronic obstructive pulmonary disease
    • Oncel C, Baser S, Cam M, Akdag B, Taspinar B, Evyapan F. Peripheral neuropathy in chronic obstructive pulmonary disease. COPD. 2010;7(1):11-16.
    • (2010) COPD , vol.7 , Issue.1 , pp. 11-16
    • Oncel, C.1    Baser, S.2    Cam, M.3    Akdag, B.4    Taspinar, B.5    Evyapan, F.6
  • 18
    • 0036730319 scopus 로고    scopus 로고
    • The pathogenesis of rheumatoid arthritis: Pivotal cytokines involved in bone degradation and inflammation
    • Bingham CO III. The pathogenesis of rheumatoid arthritis: pivotal cytokines involved in bone degradation and inflammation. J Rheumatol Suppl. 2002;65:3-9.
    • (2002) J Rheumatol Suppl , vol.65 , pp. 3-9
    • Bingham III, C.O.1
  • 19
    • 77951879282 scopus 로고    scopus 로고
    • Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis
    • Murphy AC, Lalor SJ, Lynch MA, Mills KH. Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis. Brain Behav Immun. 2010;24(4):641-651.
    • (2010) Brain Behav Immun , vol.24 , Issue.4 , pp. 641-651
    • Murphy, A.C.1    Lalor, S.J.2    Lynch, M.A.3    Mills, K.H.4
  • 20
    • 77953124358 scopus 로고    scopus 로고
    • Kinetics of IL- 17-and interferon-gamma-producing PLPp-specific CD4 T cells in EAE induced by coinjection of PLPp/IFA with pertussis toxin in SJL mice
    • Hofstetter HH, Forsthuber TG. Kinetics of IL- 17-and interferon-gamma- producing PLPp-specific CD4 T cells in EAE induced by coinjection of PLPp/IFA with pertussis toxin in SJL mice. Neurosci Lett. 2010;476(3):150-155.
    • (2010) Neurosci Lett , vol.476 , Issue.3 , pp. 150-155
    • Hofstetter, H.H.1    Forsthuber, T.G.2
  • 21
    • 0037626583 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinases in experimental autoimmune encephalomyelitis
    • DOI 10.1016/S0165-5728(03)00174-7
    • Shin T, Ahn M, Jung K, et al. Activation of mitogen-activated protein kinases in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2003;140(1):118-125. (Pubitemid 36840905)
    • (2003) Journal of Neuroimmunology , vol.140 , Issue.1-2 , pp. 118-125
    • Shin, T.1    Ahn, M.2    Jung, K.3    Heo, S.4    Kim, D.5    Jee, Y.6    Lim, Y.-K.7    Yeo, E.-J.8
  • 22
    • 0030426902 scopus 로고    scopus 로고
    • Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function
    • Badger AM, Bradbeer JN, Votta B, Lee JC, Adams JL, Griswold DE. Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J Pharmacol Exp Ther. 1996;279(3):1453-1461. (Pubitemid 27166795)
    • (1996) Journal of Pharmacology and Experimental Therapeutics , vol.279 , Issue.3 , pp. 1453-1461
    • Badger, A.M.1    Bradbeer, J.N.2    Votta, B.3    Lee, J.C.4    Adams, J.L.5    Griswold, D.E.6
  • 23
    • 77349118681 scopus 로고    scopus 로고
    • KR-003048, a potent, orally active inhibitor of p38 mitogen-activated protein kinase
    • Montalban AG, Boman E, Chang CD, et al. KR-003048, a potent, orally active inhibitor of p38 mitogen-activated protein kinase. Eur J Pharmacol. 2010;632(1):93-102.
    • (2010) Eur J Pharmacol , vol.632 , Issue.1 , pp. 93-102
    • Montalban, A.G.1    Boman, E.2    Chang, C.D.3
  • 25
    • 0032429160 scopus 로고    scopus 로고
    • A statistically defined endpoint titer determination method for immunoassays
    • DOI 10.1016/S0022-1759(98)00170-7, PII S0022175998001707
    • Frey A, Di Canzio J, Zurakowski D. A statistically defined endpoint titer determination method for immunoassays. J Immunol Methods. 1998;221(1):35-41. (Pubitemid 29017921)
    • (1998) Journal of Immunological Methods , vol.221 , Issue.1-2 , pp. 35-41
    • Frey, A.1    Di, C.J.2    Zurakowski, D.3
  • 26
    • 0033120590 scopus 로고    scopus 로고
    • Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages
    • Hale KK, Trollinger D, Rihanek M, Manthey CL. Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages. J Immunol. 1999;162(7):4246-4252. (Pubitemid 29314814)
    • (1999) Journal of Immunology , vol.162 , Issue.7 , pp. 4246-4252
    • Hale, K.K.1    Trollinger, D.2    Rihanek, M.3    Manthey, C.L.4
  • 27
    • 12344269852 scopus 로고    scopus 로고
    • T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
    • DOI 10.1126/science.1103336
    • Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science. 2005;307(5708):430-433. (Pubitemid 40139989)
    • (2005) Science , vol.307 , Issue.5708 , pp. 430-433
    • Hwang, E.S.1    Szabo, S.J.2    Schwartzberg, P.L.3    Glimcher, L.H.4
  • 28
    • 40649093769 scopus 로고    scopus 로고
    • The identification of a small molecule inhibitor that specifically reduces T cell-mediated adaptive but not LPS-mediated innate immunity by T cell membrane-monocyte contact bioassay
    • Li YY, Bao M, Meurer J, et al. The identification of a small molecule inhibitor that specifically reduces T cell-mediated adaptive but not LPS-mediated innate immunity by T cell membrane-monocyte contact bioassay. Immunol Lett. 2008;117(1):114-118.
    • (2008) Immunol Lett , vol.117 , Issue.1 , pp. 114-118
    • Li, Y.Y.1    Bao, M.2    Meurer, J.3
  • 29
    • 70350052626 scopus 로고    scopus 로고
    • Preferential recruitment of interferon-gamma-expressing T H 17 cells in multiple sclerosis
    • Kebir H, Ifergan I, Alvarez JI, et al. Preferential recruitment of interferon-gamma-expressing T H 17 cells in multiple sclerosis. Ann Neurol. 2009;66(3):390-402.
    • (2009) Ann Neurol , vol.66 , Issue.3 , pp. 390-402
    • Kebir, H.1    Ifergan, I.2    Alvarez, J.I.3
  • 30
    • 19344369383 scopus 로고    scopus 로고
    • Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice
    • Bygrave AE, Rose KL, Cortes-Hernandez J, et al. Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice. PLoS Biol. 2004;2(8):E243.
    • (2004) PLoS Biol , vol.2 , Issue.8
    • Bygrave, A.E.1    Rose, K.L.2    Cortes-Hernandez, J.3
  • 31
    • 33645841633 scopus 로고    scopus 로고
    • IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9
    • Hoshino K, Sugiyama T, Matsumoto M, et al. IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9. Nature. 2006;440(7086):949-953.
    • (2006) Nature , vol.440 , Issue.7086 , pp. 949-953
    • Hoshino, K.1    Sugiyama, T.2    Matsumoto, M.3
  • 32
    • 79956015064 scopus 로고    scopus 로고
    • Differential pharmacological behaviour of p38 inhibitors in regulating the LPS-induced TNF-alpha production in human and rat whole blood in vitro
    • Pont-Giralt M, Godessart N, Balague C. Differential pharmacological behaviour of p38 inhibitors in regulating the LPS-induced TNF-alpha production in human and rat whole blood in vitro. Inflammation. 2010;34(2):119-132.
    • (2010) Inflammation , vol.34 , Issue.2 , pp. 119-132
    • Pont-Giralt, M.1    Godessart, N.2    Balague, C.3
  • 33
    • 53149099696 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate suppresses TNF-alpha-induced production of MMP-1 and -3 in rheumatoid arthritis synovial fibroblasts
    • Yun HJ, Yoo WH, Han MK, Lee YR, Kim JS, Lee SI. Epigallocatechin-3- gallate suppresses TNF-alpha-induced production of MMP-1 and -3 in rheumatoid arthritis synovial fibroblasts. Rheumatol Int. 2008;29(1):23-29.
    • (2008) Rheumatol Int , vol.29 , Issue.1 , pp. 23-29
    • Yun, H.J.1    Yoo, W.H.2    Han, M.K.3    Lee, Y.R.4    Kim, J.S.5    Lee, S.I.6
  • 34
    • 0028958263 scopus 로고
    • Collagen-induced arthritis in B10.RIII mice (H-2r): Identification of an arthritogenic T-cell determinant
    • Myers LK, Miyahara H, Terato K, Seyer JM, Stuart JM, Kang AH. Collagen-induced arthritis in B10.RIII mice (H-2r): identification of an arthritogenic T-cell determinant. Immunology. 1995;84(4):509-513.
    • (1995) Immunology , vol.84 , Issue.4 , pp. 509-513
    • Myers, L.K.1    Miyahara, H.2    Terato, K.3    Seyer, J.M.4    Stuart, J.M.5    Kang, A.H.6
  • 35
    • 0033622470 scopus 로고    scopus 로고
    • Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development
    • Adams RH, Porras A, Alonso G, et al. Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol Cell. 2000;6(1):109-116.
    • (2000) Mol Cell , vol.6 , Issue.1 , pp. 109-116
    • Adams, R.H.1    Porras, A.2    Alonso, G.3
  • 36
    • 33645773184 scopus 로고    scopus 로고
    • Selective requirement of p38alpha MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1 responses
    • Berenson LS, Yang J, Sleckman BP, Murphy TL, Murphy KM. Selective requirement of p38alpha MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1 responses. J Immunol. 2006;176(8):4616-4621.
    • (2006) J Immunol , vol.176 , Issue.8 , pp. 4616-4621
    • Berenson, L.S.1    Yang, J.2    Sleckman, B.P.3    Murphy, T.L.4    Murphy, K.M.5
  • 38
    • 55249087446 scopus 로고    scopus 로고
    • Therapeutic benefits of regulating inflammation in autoimmunity
    • Nikoopour E, Schwartz JA, Singh B. Therapeutic benefits of regulating inflammation in autoimmunity. Inflamm Allergy Drug Targets. 2008;7(3):203-210.
    • (2008) Inflamm Allergy Drug Targets , vol.7 , Issue.3 , pp. 203-210
    • Nikoopour, E.1    Schwartz, J.A.2    Singh, B.3
  • 39
    • 70449413372 scopus 로고    scopus 로고
    • Anti-cytokine antibodies for rheumatic diseases
    • Atzeni F, Sarzi-Puttini P. Anti-cytokine antibodies for rheumatic diseases. Curr Opin Investig Drugs. 2009;10(11):1204-1211.
    • (2009) Curr Opin Investig Drugs , vol.10 , Issue.11 , pp. 1204-1211
    • Atzeni, F.1    Sarzi-Puttini, P.2
  • 40
    • 72749121087 scopus 로고    scopus 로고
    • A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients
    • Singh D, Smyth L, Borrill Z, Sweeney L, Tal-Singer R. A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients. J Clin Pharmacol. 2010;50(1):94-100.
    • (2010) J Clin Pharmacol , vol.50 , Issue.1 , pp. 94-100
    • Singh, D.1    Smyth, L.2    Borrill, Z.3    Sweeney, L.4    Tal-Singer, R.5
  • 41
    • 75749115980 scopus 로고    scopus 로고
    • Efficacy and safety of pamapimod in patients with active rheumatoid arthritis receiving stable methotrexate therapy
    • Alten RE, Zerbini C, Jeka S, et al. Efficacy and safety of pamapimod in patients with active rheumatoid arthritis receiving stable methotrexate therapy. Ann Rheum Dis. 2010;69(2):364-367.
    • (2010) Ann Rheum Dis , vol.69 , Issue.2 , pp. 364-367
    • Alten, R.E.1    Zerbini, C.2    Jeka, S.3
  • 42
    • 66049086274 scopus 로고    scopus 로고
    • Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: Results of two randomized, double-blind, placebo-controlled clinical studies
    • Damjanov N, Kauffman RS, Spencer-Green GT. Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum. 2009;60(5):1232-1241.
    • (2009) Arthritis Rheum , vol.60 , Issue.5 , pp. 1232-1241
    • Damjanov, N.1    Kauffman, R.S.2    Spencer-Green, G.T.3
  • 43
    • 77950290250 scopus 로고    scopus 로고
    • Kinase inhibitors: A new approach to rheumatoid arthritis treatment
    • Cohen S, Fleischmann R. Kinase inhibitors: a new approach to rheumatoid arthritis treatment. Curr Opin Rheumatol. 2010;22(3):330-335.
    • (2010) Curr Opin Rheumatol , vol.22 , Issue.3 , pp. 330-335
    • Cohen, S.1    Fleischmann, R.2
  • 44
    • 58149262009 scopus 로고    scopus 로고
    • Systematic review to establish the safety profiles for direct and indirect inhibitors of p38 mitogen-activated protein kinases for treatment of cancer: A systematic review of the literature
    • Noel JK, Crean S, Claflin JE, Ranganathan G, Linz H, Lahn M. Systematic review to establish the safety profiles for direct and indirect inhibitors of p38 mitogen-activated protein kinases for treatment of cancer: a systematic review of the literature. Med Oncol. 2008;25(3):323-330.
    • (2008) Med Oncol , vol.25 , Issue.3 , pp. 323-330
    • Noel, J.K.1    Crean, S.2    Claflin, J.E.3    Ranganathan, G.4    Linz, H.5    Lahn, M.6
  • 45
    • 34249331264 scopus 로고    scopus 로고
    • Novel strategies for inhibition of the p38 MAPK pathway
    • DOI 10.1016/j.tips.2007.04.008, PII S0165614707000879
    • Zhang J, Shen B, Lin A. Novel strategies for inhibition of the p38 MAPK pathway. Trends Pharmacol Sci. 2007;28(6):286-295. (Pubitemid 46818466)
    • (2007) Trends in Pharmacological Sciences , vol.28 , Issue.6 , pp. 286-295
    • Zhang, J.1    Shen, B.2    Lin, A.3


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