Impaired immune response to Candida albicans in aged mice

Journal of Medical Microbiology

Volumn 55, Issue 12, 2006, Pages 1649-1656

  Murciano, Celia ^a   Villamón, Eva ^a   Yáñez, Alberto ^a   O'Connor, José Enrique ^b   Gozalbo, Daniel ^a   Gil, M Luisa ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; TUMOR NECROSIS FACTOR ALPHA;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANDIDA ALBICANS; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FUNGUS HYPHAE; FUNGUS IMMUNITY; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; SPLEEN CELL; STATISTICAL ANALYSIS; SURVIVAL TIME; TH1 CELL; VACCINATION; WESTERN BLOTTING; YEAST CELL;

AGING; ANIMALS; ANTIBODIES, FUNGAL; BLOTTING, WESTERN; CANDIDA ALBICANS; CANDIDIASIS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DISEASE SUSCEPTIBILITY; FEMALE; FUNGAL VACCINES; HYPHAE; IMMUNOGLOBULIN G; INJECTIONS, INTRAVENOUS; INTERFERON TYPE II; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; SPLEEN; TUMOR NECROSIS FACTOR-ALPHA; VACCINATION;

EID: 33845394426     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.46740-0     Document Type: Article

References (27)

1. Boehmer, E. D., Goral, J., Faunce, D. E. & Kovacs, E. J. (2004). Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. J Leukoc Biol 75, 342-349.
2. Boehmer, E. D., Meehan, M. J., Cutro, B. T. & Kovacs, E. J. (2005). Aging negatively skews macrophage TLR2- and TLR4-mediated proinflammatory responses without affecting the IL-2-stimulated pathway. Mech Ageing Dev 126, 1305-1313.
3. Bromuro, C., Torosantucci, A., Chiani, P., Conti, S., Polonelli, L. & Cassone, A. (2002). Interplay between protective and inhibitory antibodies dictates the outcome of experimentally disseminated candidiasis in recipients of Candida albicans vaccine. Infect Immun 70, 5462-5470.
4. Calderone, R. A. (2001). Candida and Candidiasis. New York: American Society for Microbiology.
5. Effros, R. B. (2001). Ageing and the immune system. Novartis Found Symp 235, 130-139.
6. Garber, G. (2001). An overview of fungal infections. Drugs 61, 1-12.
7. Gil, M. L. & Gozalbo, D. (2006). TLR2, but not TLR4, triggers cytokine production by murine cells in response to Candida albicans yeasts and hyphae. Microbes Infect 8, 2299-2304.
8. Gil-Navarro, I., Gil, M. L., Casanova, M., O'Connor, J. E., Martinez, J. P. & Gozalbo, D. (1997). The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase of Candida albicans is a surface antigen. J Bacteriol 179, 4992-4999.
9. Ginaldi, L., Loreto, M. F., Corsi, M. P., Modesti, M. & De Martinis, M. (2001). Immunosenescence and infectious diseases. Microbes Infect 3, 851-857.
10. Gozalbo, D., Gil-Navarro, I., Azorín, I., Renau-Piqueras, J., Martínez, J. P. & Gil, M. L. (1998). The cell wall-associated glyceraldehyde-3-phosphate dehydrogenase of Candida albicans is also a fibronectin and laminin binding protein. Infect Immun 66, 2052-2059.
11. Kauffman, C. A. (2001). Fungal infections in older adults. Clin Infect Dis 33, 550-555.
12. Matthews, R. C., Rigg, G., Hodgetts, S., Carter, T., Chapman, C., Gregory, C., Illidge, C. & Burnie, J. (2003). Preclinical assessment of the efficacy of Mycograb, a human recombinant antibody against fungal HSP90. Antimicrobial Agents Chemother 47, 2208-2216.
13. McGlauchlen, K. S. & Vogel, L. A. (2003). Ineffective humoral immunity in the elderly. Microbes Infect 5, 1279-1284.
14. Montagnoli, C., Sandini, S., Bacci, A., Romani, L. & La Valle, R. (2004). Immunogenicity and protective effect of recombinant enolase of Candida albicans in a murine model of systemic candidiasis. Med Mycol 42, 319-324.
15. Netea, M. G., van Tits, L. J. H., Curfs, J. H. A. J., Amiot, F., Meis, J. F. G. M., van der Meer, J. W. M. & Kullberg, B. J. (1999). Increased susceptibility of TNF-α lymphotoxin-α double knockout mice to systemic candidiasis through impaired recruitment of neutrophils and phagocytosis of Candida albicans. J Immunol 163, 1498-1505.
16. Nucci, M., Colombo, A. L., Silveira, F., Richtmann, R., Salomāo, R., Branchini, M. L. & Spector, N. (1998). Risk factors for death in patients with candidemia. Infect Control Hosp Epidemiol 11, 846-850.
17. Plackett, T. P., Boehmer, E. D., Faunce, D. E. & Kovacs, E. J. (2004). Aging and innate immune cells. J Leukoc Biol 76, 291-299.
18. Renshaw, M., Rockwell, J., Engleman, C., Gewirtz, A., Katz, J. & Sambhara, S. (2002). Cutting edge: impaired Toll-like receptor expression and function in aging. J Immunol 169, 4697-4701.
19. Romani, L. (2004). Immunity to fungal infections. Nat Rev Immunol 4, 1-23.
20. Romani, L., Mocci, S., Bietta, C., Lanfaloni, L., Puccetti, P. & Bistoni, F. (1991). Th1 and Th2 cytokine secretion patterns in murine candidiasis: association of Th1 responses with acquired resistance. Infect Immun 59, 4647-4654.
21. Steinshamn, S., Bemelmans, M. H. A., Van Tits, L. H. J., Bergh, K., Buurman, W. A. & Waage, A. (1996). TNF receptors in murine Candida albicans infection: evidence for an important role of TNF receptor p55 in antifungal defense. J Immunol 157, 2155-2159.
22. Torosantucci, A., Bromuro, C., Chiani, P. & 9 other authors (2005). A novel glyco-conjugate vaccine against fungi pathogens. J Exp Med 202, 597-606.
23. Vilanova, M., Teixeira, L., Caramalho, I. & 7 other authors (2004). Protection against systemic candidiasis in mice immunized with secreted aspartic proteinase 2. Immunology 111, 334-342.
24. Villamȯn, E., Gozalbo, D., Roig, P., Murciano, C., O'Connor, J. E., Fradelizi, D. & Gil, M. L. (2004a). Myeloid differentiation factor 88 (MyD88) is required for murine resistance to Candida albicans and is critically involved in Candida-induced production of cytokines. Eur Cytokine Netw 15, 263-271.
25. Villamon, E., Gozalbo, D., Roig, P., O'Connor, J. E., Fradelizi, D. & Gil, M. L. (2004b). Toll-like receptor-2 is essential in murine defenses against Candida albicans infections. Microbes Infect 6, 1-7.
26. Villamón, E., Gozalbo, D., Roig, P., O'Connor, J. E., Ferrandiz, M. L., Fradelizi, D. & Gil, M. L. (2004c). Toll-like receptor 2 is dispensable for acquired host immune resistance to Candida albicans in a murine model of disseminated candidiasis. Microbes Infect 6, 542-548.
27. Zhang, M. X., Bohlman, M. C., Itatani, C., Burton, D. R., Parren, P. W. H. I., St Jeor, S. C. & Kozel, T. R. (2006). Human recombinant antimannan immunoglobulin G1 antibody confers resistance to hematogenously disseminated candidiasis in mice. Infect Immun 74, 362-369.