MiR-18a impairs DNA damage response through downregulation of Ataxia telangiectasia mutated (ATM) kinase

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Song, Libing ^a   Lin, Chuyong ^b   Wu, Zhiqiang ^b   Gong, Hui ^b   Zeng, Yong ^a   Wu, Jueheng ^b   Li, Mengfeng ^b   Li, Jun ^b  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; MICRORNA; MICRORNA 18A; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; MIRN18A MICRORNA, HUMAN; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN;

3' UNTRANSLATED REGION; ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CELL CYCLE ARREST; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOWN REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; UPREGULATION; ADULT; BREAST TUMOR; CELL CYCLE CHECKPOINT; FEMALE; GENETICS; METABOLISM; PATHOLOGY; RADIATION DOSE; RECOMBINATION REPAIR; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ATAXIA TELANGIECTASIA;

3' UNTRANSLATED REGIONS; ADULT; BREAST NEOPLASMS; CELL CYCLE CHECKPOINTS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; DNA DAMAGE; DNA-BINDING PROTEINS; DOWN-REGULATION; FEMALE; HUMANS; MICRORNAS; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; RECOMBINATIONAL DNA REPAIR; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 80053194900     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025454     Document Type: Article

References (49)

1. Harper JW, Elledge SJ, (2007) The DNA damage response: ten years after. Mol Cell 28: 739-45.
2. Myung K, Datta A, Kolodner RD, (2001) Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae. Cell 104: 397-408.
3. Zhou BB, Elledge SJ, (2000) The DNA damage response: putting checkpoints in perspective. Nature 408: 433-439.
4. Jiri Bartek, Jiri Lukas, (2003) Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 3: 421-429.
5. Weinert T, Lydall D, (1993) Cell cycle checkpoints, genetic instability and cancer. Semin Cancer Biol 4: 129-140.
6. Christopher JBakkenist, Michael BKastan, (2002) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421: 499-506.
7. Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, et al. (2000) Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci U S A 97: 10389-94.
8. Matsuoka S, Huang M, Elledge SJ, (1998) Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282: 1893-7.
9. Stiff T, O'Driscoll M, Rief N, Iwabuchi K, Löbrich M, et al. (2004) ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res 64: 2390-6.
10. Adams MM, Carpenter PB, (2006) Tying the loose ends together in DNA double strand break repair with 53BP1. Cell Div 1: 19.
11. Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, et al. (2006) spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J Cell Biol 173: 195-206.
12. Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen HT, et al. (2002) Genomic instability in mice lacking histone H2AX. Science 296: 922-7.
13. Ward IM, Minn K, Jorda KG, Chen J, (2003) Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J Biol Chem 278: 19579-82.
14. Shiloh Y, (2003) ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 3: 155-68.
15. Savitsky K, Sfez S, Tagle DA, Ziv Y, Sartiel A, et al. (1995) the complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Hum Mol Genet 4: 2025-32.
16. Mavrou A, Tsangaris GT, Roma E, Kolialexi A, (2008) The ATM gene and ataxia telangiectasia. Anticancer Res 28: 401-5.
17. Barlow C, Hirotsune S, Paylor R, Liyanage M, Eckhaus M, et al. (1996) Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 86: 159-71.
18. Kurz EU, Lees-Miller SP, (2004) DNA damage-induced activation of ATM and ATM-dependent signaling pathways. DNA Repair (Amst) 3: 889-900.
19. Appleby JM, Barber JB, Levine E, Varley JM, Taylor AM, et al. (1997) Absence of mutations in the ATM gene in breast cancer patients with severe responses to radiotherapy. Br J Cancer 76: 1546-9.
20. Yu G, Zhu MH, Zhu Z, Ni CR, Zheng JM, et al. (2004) Expression of ATM protein and its relationship with p53 in pancreatic carcinoma with tissue array. Pancreas 28: 421-6.
21. González MB, Hernández JM, García JL, Lumbreras E, Castellanos M, et al. (2004) The value of fluorescence in situ hybridization for the detection of 11q in multiple myeloma. Haematologica 89: 1213-8.
22. Vorechovský I, Luo L, Dyer MJ, Catovsky D, Amlot PL, et al. (1997) Clustering of missense mutations in the ataxia-telangiectasia gene in a sporadic T-cell leukaemia. Nat Genet 17: 96-9.
23. Bullrich F, Rasio D, Kitada S, Starostik P, Kipps T, et al. (1999) ATM mutations in B-cell chronic lymphocytic leukemia. Cancer Res 59: 24-7.
24. Boultwood J, (2001) Ataxia telangiectasia gene mutations in leukaemia and lymphoma. J Clin Pathol 54: 512-6.
25. Berkovich E, Ginsberg D, (2003) ATM is a target for positive regulation by E2F-1. Oncogene 22: 161-7.
26. Valerie K, Povirk LF, (2003) Regulation and mechanisms of mammalian double-strand break repair. Oncogene 22: 5792-812.
27. Lees-Miller SP, Meek K, (2003) Repair of DNA double strand breaks by non-homologous end joining. Biochimie 85: 1161-73.
28. Khanna KK, Jackson SP, (2001) DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet 27: 247-54.
29. Orii KE, Lee Y, Kondo N, McKinnon PJ, (2006) Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Proc Natl Acad Sci U S A 103: 10017-22.
30. Mills KD, Ferguson DO, Essers J, Eckersdorff M, Kanaar R, et al. (2004) Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability. Genes Dev 18: 1283-92.
31. Beucher A, Birraux J, Tchouandong L, Barton O, Shibata A, et al. (2009) ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. EMBO J 28: 3413-27.
32. Chen BP, Uematsu N, Kobayashi J, Lerenthal Y, Krempler A, et al. (2007) Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break. J Biol Chem 282: 6582-7.
33. Kim WJ, VO QN, Shrivastav M, Lataxes TA, Brown KD, (2002) aberrant methylation of the ATM promoter correlates with increased radiosensitivity in a human colorectal tumor cell line. Oncogene 21: 3864-71.
34. Roy K, Wang L, Makrigiorgos GM, Price BD, (2006) Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity. Biochem Biophys Res Commun 344: 821-6.
35. Lawrie CH, (2007) MicroRNA expression in lymphoma. Expert Opin Biol Ther 7: 1363-74.
36. Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, et al. (2006) A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A 103: 2257-61.
37. Ota A, Tagawa H, Karnan S, Tsuzuki S, Karpas A, et al. (2004) Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma.
38. Schulte JH, Horn S, Otto T, Samans B, Heukamp LC, et al. (2008) MYCN regulates oncogenic MicroRNAs in neuroblastoma. Int J Cancer 122: 699-704.
39. Sylvestre Y, De Guire V, Querido E, Mukhopadhyay UK, Bourdeau V, et al. (2007) An E2F/miR-20a autoregulatory feedback loop. J Biol Chem 282: 2135-43.
40. Woods K, Thomson JM, Hammond SM, (2007) Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors. J Biol Chem 282: 2130-4.
41. Ji M, Rao E, Ramachandrareddy H, Shen Y, Jiang C, et al. (2011) The miR-17-92 MicroRNA Cluster Is Regulated by Multiple Mechanisms in B-Cell Malignancies. Am J Pathol. [Epub ahead of print].
42. Guil S, Cáceres JF, (2007) The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a. Nat Struct Mol Biol 14: 91-6.
43. Patry C, Bouchard L, Labrecque P, Gendron D, Lemieux B, et al. (2003) Small interfering RNA-mediated reduction in heterogeneous nuclear ribonucleoparticule A1/A2 proteins induces apoptosis in human cancer cells but not in normal mortal cell lines. Cancer Res 63: 7679-88.
44. Li H, Bian C, Liao L, Li J, Zhao RC, (2011) miR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1. Breast Cancer Res Treat 1263: 565-75.
45. Kim K, Chadalapaka G, Lee SO, Yamada D, Sastre-Garau X, et al. (2011) Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer. Oncogene. [Epub ahead of print].
46. Al-Nakhle H, Burns PA, Cummings M, Hanby AM, Hughes TA, et al. (2010) Estrogen receptor {beta}1 expression is regulated by miR-92 in breast cancer. Cancer Res 70: 4778-84.
47. Li J, Zhang N, Song LB, Liao WT, Jiang LL, et al. (2008) Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival. Clin Cancer Res 14: 3319-26.
48. Franken NP, Rodermond HM, Stap J, Haveman J, van Bree C, (2006) Clonogenic assay of cells in vitro. Nature Protocols 1: 2315-2319.
49. Taghian, G D, A. Nickoloff J, (1997) Chromosomal double-strand breaks induce gene conversion at high frequency in mammalian cells. Mol. Cell. Biol 17: 6386-6393.