Absence of mutations in the ATM gene in breast cancer patients with severe responses to radiotherapy

British Journal of Cancer

Volumn 76, Issue 12, 1997, Pages 1546-1549

  Appleby, J M ^a   Barber, J B P ^a   Levine, E ^a   Varley, J M ^a   Taylor, A M R ^b   Stankovic, T ^b   Heighway, J ^a   Warren, C ^a   Scott, D ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Ataxia telangiectasia; ATM mutations; Breast cancer; Severe reaction

Indexed keywords

RESTRICTION ENDONUCLEASE;

ARTICLE; ATAXIA TELANGIECTASIA; BREAST CANCER; CANCER RADIOTHERAPY; CANCER RISK; CLINICAL ARTICLE; FEMALE; HETEROZYGOTE; HUMAN; NECROSIS; PRIORITY JOURNAL; RADIOSENSITIVITY;

EID: 0030702833     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.593     Document Type: Article

References (23)

1. Athma P, Rappaport R and Swift M (1996) Molecular genotyping shows that ataxia-telangiectasia heterozygotes are predisposed to breast cancer. Cancer Genet Cytogenet 92: 130-134
2. Bishop DT and Hopper J (1997) AT-tributable risks? Nature Genet 15: 226
3. Burnet NG, Nyman J, Turesson I, Wurn R, Yarnold JR and Peacock JH (1995) Relationship between cellular radiation sensitivity and tissue response may provide the basis of individualising radiotherapy schedule. Radiother Oncol 33: 228-238
4. Byrd PJ, McConville CM, Cooper P, Parkhill J, Stankovic T, McGuire GM, Thick JA and Taylor AMR (1996) Mutations revealed by sequencing the 5′ half of the gene for ataxia telangiectasia. Hum Mol Genet 5: 145-149
5. Cunliffe PN, Mann JR, Cameron AH and Roberts KD (1975) Radiosensitivity in ataxia-telangiectasia. Br J Radiol 48: 374-376
6. Dahlberg WK and Little BJ (1995) Response of dermal fibroblast cultures from patients with unusually severe responses to radiotherapy and from ataxia-telangiectasia heterozygotes to fractionated radiation. Clin Cancer Rev 1: 785-790
7. Easton DF (1994) Cancer risks in A-T heterozygotes. Int J Radiat Biol 66 (suppl): 177-182
8. Fitzgerald MG, Bean JM, Hedge SR, Unsal H, MacDonald DJ, Harkin DP, Finkelstein DM, Isselbacher KJ and Haber DA (1997) Heterozygous ATM mutations do not contribute to early onset of breast cancer. Nature Genet 15: 307-310
9. Gotoff SP, Amirnokri E and Liebnor EJ (1967) Ataxia-telangiectasia, neoplasia, untoward response to X-irradiation and tuberous sclerosis. Am J Dis Child 114: 617-627
10. Johansen J, Bentzen SM, Overgaard J and Overgaard M (1996) Relationship between in vitro radiosensitivity of skin fibroblasts and the expression of subcutaneous fibrosis, telangiectasia, and skin erythema after radiotherapy. Radiother Oncol 40: 101-109
11. Jones LA, Scott D, Cowan R and Roberts SA (1995) Abnormal radiosensitivity of lymphocytes from breast cancer patients with excessive normal tissue damage after radiotherapy chromosome aberrations after low dose-rate irradiation. Int J Radiat Biol 67: 519-528
12. Lakin ND, Weber P, Stankovic T, Rottinghaus ST, Taylor AMR and Jackson SP (1996) Analysis of the ATM protein in wild type and ataxia telangiectasia cells. Oncogene 13: 2707-2716
13. Liu Q and Sommer SS (1995) Restriction endonuclease fingerprinting (REF): a sensitive method for screening mutations in long contiguous segments of DNA. Biotechniques 18: 470-477
14. McConville CM, Stankovic T, Byrd PJ, McGuire GM, Yao Q-Y, Lennox GG and Taylor AMR (1996) Mutations associated with variant phenotypes in ataxic-telangcectasia. Am J Hum Genet 59: 320-330
15. Norman A, Kagan AR and Chan SL (1988) The importance of genetics for the optimisation of radiation therapy. Am J Clin Oncol 11: 84-88
16. Norman A, Iwamoto KS, Kagan AR and Wollin M (1992) Radiation sensitive breast cancer patients. Radiother Oncol 23: 196-197
17. Ramsay J, Birrell G and Lavin M (1996) Breast cancer and radiotherapy in ataxia-telangiectasia heterozygote. Lancet 347: 1627
18. Ribeiro GG, Magee B, Swindell R, Harris M and Banerjee SS (1993) The Christie Hospital breast conservation trial: an update at 8 years from inception. Clin Oncol 5: 278-283
19. Swift M, Morrell D, Cromartie E, Chamberlin AR, Skolnick MH and Bishop DT (1986) The incidence and gene frequency of ataxia-telangiectasia in the United States. Am J Hum Genet 39: 573-583
20. Taylor AMR, Harnden DG, Arlett CF, Harcourt SA, Lehmann AR, Stevens S and Bridges BA (1975) Ataxia-telangiectasia: a human mutation with abnormal radiation sensitivity. Nature 258: 427
21. Vořechovsky, Luo L, Lindblom A, Negrini M, Webster DB, Croce CM and Hammarström L (1996) ATM mutations in cancer families. Cancer Res 56: 4130-4133
22. West CML (1995) Intrinsic radiosensitivity as a predictor of patient response to radiotherapy. Br J Radiol 68: 827-837
23. West CML and Hendry JH (1992) Intrinsic radiosensitivity as predictor of patient response to radiotherapy. Br J Cancer 24 (suppl.): 146-152