Effects of a glycogen synthase kinase-3β inhibitor (LiCl) on c-myc protein in intervertebral disc cells

Journal of Cellular Biochemistry

Volumn 112, Issue 10, 2011, Pages 2974-2986

  Hiyama, Akihiko ^a   Sakai, Daisuke ^a   Arai, Fumiyuki ^a   Nakajima, Daisuke ^a   Yokoyama, Katsuya ^a   Mochida, Joji ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

c myc; cell proliferation; intervertebral disc degeneration; nucleus pulposus; WNT signaling

Indexed keywords

AGGRECAN; BETA CATENIN; LITHIUM CHLORIDE; MESSENGER RNA; MYC PROTEIN; WNT PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; FEMALE; INTERVERTEBRAL DISK; MALE; NONHUMAN; NUCLEUS PULPOSUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL AVERAGED ELECTROCARDIOGRAPHY; SIGNAL TRANSDUCTION;

ANIMALS; BETA CATENIN; BLOTTING, WESTERN; CELL CYCLE; CELL SURVIVAL; CELLS, CULTURED; FEMALE; FLOW CYTOMETRY; GLYCOGEN SYNTHASE KINASE 3; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISC; LITHIUM CHLORIDE; MALE; PROTO-ONCOGENE PROTEINS C-MYC; RATS; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 80053177574     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.23217     Document Type: Article

References (34)

1. Alonso M, Martinez A,. 2004. GSK-3 inhibitors: Discoveries and developments. Curr Med Chem 11: 755-763. (Pubitemid 38380049)
2. Amati B, Land H,. 1994. Myc-Max-Mad: A transcription factor network controlling cell cycle progression, differentiation and death. Curr Opin Genet Dev 4: 102-108.
3. Behrens J, von Kries JP, Kühl M, Bruhn L, Wedlich D, Grosschedl R, Birchmeier W,. 1996. Functional interaction of β-catenin with the transcription factor LEF-1. Nature 382: 638-642. (Pubitemid 26268958)
4. Behrens J, Jerchow BA, Würtele M, Grimm J, Asbrand C, Wirtz R, Kühl M, Wedlich D, Birchmeier W,. 1998. Functional interaction of an axin homolog, conductin, with (-catenin, APC, and GSK3). Science 280: 596-599.
5. Berridge MJ, Downes CP, Hanley MR,. 1982. Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem J 206: 587-595. (Pubitemid 13199531)
6. Bouchard C, Staller P, Eilers M,. 1998. Control of cell proliferation by Myc. Trends Cell Biol 8 (5): 202-206. (Pubitemid 28188115)
7. Cadigan KM, Nusse R,. 1997. Wnt signaling: A common theme in animal development. Genes Dev 11: 3286-3305. (Pubitemid 28023954)
8. Clevers H, van de Wetering M,. 1997. TCF/LEF factor earn their wings. Trends Genet 13: 485-489. (Pubitemid 28004922)
9. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW,. 1998. Identification of c-MYC as a target of the APC pathway. Science 281: 1509-1512. (Pubitemid 28425575)
10. Hiyama A, Mochida J, Iwashina T, Omi H, Watanabe T, Serigano K, Iwabuchi S, Sakai D,. 2007. Synergistic effect of low-intensity pulsed ultrasound on growth factor stimulation of nucleus pulposus cells. J Orthop Res 25: 1574-1581. (Pubitemid 350293805)
11. Hiyama A, Mochida J, Iwashina T, Omi H, Watanabe T, Serigano K, Tamura F, Sakai D,. 2008. Transplantation of mesenchymal stem cells in a canine disc degeneration model. J Orthop Res 26: 589-600.
12. Hiyama A, Sakai D, Risbud MV, Tanaka M, Arai F, Abe K, Mochida J,. 2010. Enhancement of intervertebral disc cell senescence by WNT/β-catenin signaling-induced matrix metalloproteinase expression. Arthritis Rheum 62: 3036-3047.
13. Hiyama A, Sakai D, Tanaka M, Arai F, Nakajima D, Abe K, Mochida J,. 2011. The relationship between the Wnt/β-catenin and TGF-β/BMP signals in the intervertebral disc cell. J Cell Physiol 226: 1139-1148.
14. Huang MJ, Cheng YC, Liu CR, Lin S, Liu HE,. 2006. A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Exp Hematol 34: 1480-1489. (Pubitemid 44548118)
15. Hueber AO, Zörnig M, Lyon D, Suda T, Nagata S, Evan GI,. 1997. Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis. Science 278: 1305-1309. (Pubitemid 27495744)
16. Kikuchi A, Kishida S, Yamamoto H,. 2006. Regulation of Wnt signaling by protein-protein interactions and post-translational modifications. Exp Mol Med 38: 1-10. (Pubitemid 43352428)
17. -/- colon carcinoma. Science 275: 1784-1787. (Pubitemid 27136714)
18. Logan CY, Nusse R,. 2004. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 20: 781-810. (Pubitemid 39488658)
19. Madiehe AM, Mampuru LJ, Tyobeka EM,. 1995. Induction of apoptosis in HL-60 cells by lithium. Biochem Biophys Res Commun 209: 768-774.
20. Mateyak MK, Obaya AJ, Adachi S, Sedivy JM,. 1997. Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination. Cell Growth Differ 8: 1039-1048. (Pubitemid 27433292)
21. 2 regulates stem cells through Wnt/β-catenin signalling. Nat Cell Biol 12: 1007-1013.
22. Meijer L, Flajolet M, Greengard P,. 2004. Pharmacological inhibitors of glycogen synthase kinase 3. Trends Pharmacol Sci 25: 471-480. (Pubitemid 39149703)
23. Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, Kinzler KW,. 1997. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 275: 1787-1790. (Pubitemid 27136715)
24. Reinhold MI, Kapadia RM, Liao Z, Naski MC,. 2006. The Wnt-inducible transcription factor Twist1 inhibits chondrogenesis. J Biol Chem 281: 1381-1388.
25. Reya T, Clevers H,. 2005. Wnt signalling in stem cells and cancer. Nature 434: 843-850. (Pubitemid 40558990)
26. Schreiber-Agus N, DePinho RA,. 1998. Repression by the Mad (Mxi1)-Sin3 complex. BioEssays 20: 808-818.
27. Spencer GJ, Utting JC, Etheridge SL, Arnett TR, Genever PG,. 2006. Wnt signalling in osteoblasts regulates expression of the receptor activator of NFκB ligand and inhibits osteoclastogenesis in vitro. J Cell Sci 119: 1283-1296.
28. Stambolic V, Ruel L, Woodgett JR,. 1996. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol 6: 1664-1668. (Pubitemid 27050234)
29. Trout JJ, Buckwalter JA, Moore KC, Landas SK,. 1982. Ultrastructure of the human intervertebral disc. I. Changes in notochordal cells with age. Tissue Cell 14: 359-369. (Pubitemid 12021684)
30. Watanabe T, Sakai D, Yamamoto Y, Iwashina T, Serigano K, Tamura F, Mochida J,. 2010. Human nucleus pulposus cells significantly enhanced biological properties in a coculture system with direct cell-to-cell contact with autologous mesenchymal stem cells. J Orthop Res 28: 623-630.
31. Weng LH, Wang CJ, Ko JY, Sun YC, Wang FS,. 2010. Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees. Arthritis Rheum 62: 1393-1402.
32. Yin X, Giap C, Lazo JS, Prochownik EV,. 2003. Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene 22: 6151-6159. (Pubitemid 37281644)
33. Zhu M, Tang D, Wu Q, Hao S, Chen M, Xie C, Rosier RN, O'Keefe RJ, Zuscik M, Chen D,. 2009. Activation of β-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult β-catenin conditional activation mice. J Bone Miner Res 24: 12-21.
34. Zindy F, Eischen CM, Randle DH, Kamijo T, Cleveland JL, Sherr CJ, Roussel MF,. 1998. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev 12: 2424-2433. (Pubitemid 28371361)