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Volumn 4, Issue 6, 2011, Pages 1107-1113

Anti-obesity effects of Geranium thunbergii extract via improvement of lipid metabolism in high-fat diet-induced obese mice

Author keywords

Body weight; Cholesterol; Geranium thunbergii; Leptin; Obesity

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ALANINE AMINOTRANSFERASE; ANTIOBESITY AGENT; ASPARTATE AMINOTRANSFERASE; CREATININE; FATTY ACID BINDING PROTEIN 4; FATTY ACID SYNTHASE; GERANIUM THUNBERGII EXTRACT; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; NITROGEN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLANT EXTRACT; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UREA;

EID: 80053121187     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2011.568     Document Type: Article
Times cited : (30)

References (34)
  • 1
    • 72149105311 scopus 로고    scopus 로고
    • The Korean traditional medicine gyeongshingangjeehwan inhibits adipocyte hypertrophy and visceral adipose tissue accumulation by activating PPARalpha actions in rat white adipose tissues
    • Shin SS, Jung YS, Yoon KH, Choi S, Hong Y, Park D, Lee H, Seo BI, Lee HY and Yoon M: The Korean traditional medicine gyeongshingangjeehwan inhibits adipocyte hypertrophy and visceral adipose tissue accumulation by activating PPARalpha actions in rat white adipose tissues. J Ethnopharmacol 127: 47-54, 2010.
    • (2010) J Ethnopharmacol , vol.127 , pp. 47-54
    • Shin, S.S.1    Jung, Y.S.2    Yoon, K.H.3    Choi, S.4    Hong, Y.5    Park, D.6    Lee, H.7    Seo, B.I.8    Lee, H.Y.9    Yoon, M.10
  • 2
    • 34249673987 scopus 로고    scopus 로고
    • Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice
    • DOI 10.1038/sj.ijo.0803502, PII 0803502
    • Lei F, Zhang XN, Wang W, Xing DM, Xie WD, Su H and Du LJ: Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice. Int J Obes 31: 1023-1029, 2007. (Pubitemid 46842679)
    • (2007) International Journal of Obesity , vol.31 , Issue.6 , pp. 1023-1029
    • Lei, F.1    Zhang, X.N.2    Wang, W.3    Xing, D.M.4    Xie, W.D.5    Su, H.6    Du, L.J.7
  • 5
    • 0035490242 scopus 로고    scopus 로고
    • Drug treatment of obesity
    • Bray GA: Drug treatment of obesity. Rev Endocr Metab Disord2: 403-418, 2001.
    • (2001) Rev Endocr Metab Disord , vol.2 , pp. 403-418
    • Bray, G.A.1
  • 6
    • 34547401085 scopus 로고    scopus 로고
    • Platycodon grandiflorum extract represses up-regulated adipocyte fatty acid binding protein triggered by a high fat feeding in obese rats
    • Park YS, Yoon Y and Ahn HS: Platycodon grandiflorum extract represses up-regulated adipocyte fatty acid binding protein triggered by a high fat feeding in obese rats. World J Gastroenterol13: 3493-3499, 2007. (Pubitemid 47162023)
    • (2007) World Journal of Gastroenterology , vol.13 , Issue.25 , pp. 3493-3499
    • Park, Y.S.1    Yoon, Y.2    Ahn, H.S.3
  • 7
    • 34547674943 scopus 로고    scopus 로고
    • Administration of Cyperus rotundus tubers extract prevents weight gain in obese Zucker rats
    • DOI 10.1002/ptr.2147
    • Lemaure B, Touché A, Zbinden I, Moulin J, Courtois D, MacéK and Darimont C: Administration of Cyperus rotundus tubers extract prevents weight gain in obese Zucker rats. Phytother Res 21: 724-730, 2007. (Pubitemid 47217770)
    • (2007) Phytotherapy Research , vol.21 , Issue.8 , pp. 724-730
    • Lemaure, B.1    Touche, A.2    Zbinden, I.3    Moulin, J.4    Courtois, D.5    Mace, K.6    Darimont, C.7
  • 8
    • 33646773975 scopus 로고    scopus 로고
    • Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats
    • DOI 10.1016/j.jep.2005.12.036, PII S0378874106000067
    • Ono Y, Hattori E, Fukaya Y, Imai S and Ohizumi Y: Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats. J Ethnopharmacol 106: 238-244, 2006. (Pubitemid 43766196)
    • (2006) Journal of Ethnopharmacology , vol.106 , Issue.2 , pp. 238-244
    • Ono, Y.1    Hattori, E.2    Fukaya, Y.3    Imai, S.4    Ohizumi, Y.5
  • 9
    • 34250007451 scopus 로고    scopus 로고
    • 4-Hydroxykobusin inhibits the induction of nitric oxide synthase by inhibiting NF-kappaB and AP-1 activation
    • DOI 10.1248/bpb.30.1097
    • Pokharel YR, Liu QH, Oh JW, Woo ER and Kang KW: 4-Hydroxykobusin inhibits the induction of nitric oxide synthase by inhibiting NF-kappaB and AP-1 activation. Biol Pharm Bull30: 1097-1101, 2007. (Pubitemid 46883875)
    • (2007) Biological and Pharmaceutical Bulletin , vol.30 , Issue.6 , pp. 1097-1101
    • Pokharel, Y.R.1    Liu, Q.-H.2    Oh, J.W.3    Woo, E.-R.4    Kang, K.W.5
  • 10
    • 21544468576 scopus 로고    scopus 로고
    • Antimutagenicity of Japanese traditional herbs, gennoshoko, yomogi, senburi and iwa-tobacco
    • Hiramatsu N, Xiufen W, Takechi R, Itoh Y, Mamo J and Pal S: Antimutagenicity of Japanese traditional herbs, gennoshoko, yomogi, senburi and iwa-tobacco. Biofactors 22: 123-125, 2004. (Pubitemid 40921773)
    • (2005) BioFactors , vol.22 , Issue.1-4 , pp. 123-125
    • Hiramatsu, N.1    Xiufen, W.2    Takechi, R.3    Itoh, Y.4    Mamo, J.5    Pal, S.6
  • 11
    • 0026346224 scopus 로고
    • Effects of geraniin on morphology and function of macrophages
    • Ushio Y, Okuda T and Abe H: Effects of geraniin on morphology and function of macrophages. Int Arch Allergy Appl Immunol 96: 224-230, 1991.
    • (1991) Int Arch Allergy Appl Immunol , vol.96 , pp. 224-230
    • Ushio, Y.1    Okuda, T.2    Abe, H.3
  • 12
    • 16444373787 scopus 로고    scopus 로고
    • The antioxidative activity of traditional Japanese herbs
    • Xiufen W, Hiramatsu N and Matsubara M: The antioxidative activity of traditional Japanese herbs. Biofactors 21: 281-284, 2004. (Pubitemid 40921869)
    • (2004) BioFactors , vol.21 , Issue.1-4 , pp. 281-284
    • Xiufen, W.1    Hiramatsu, N.2    Matsubara, M.3
  • 13
    • 0028012685 scopus 로고
    • Antihypertensive action of geraniin in rats
    • Cheng JT, Chang SS and Hsu FL: Antihypertensive action of geraniin in rats. J Pharm Pharmacol 46: 46-49, 1994.
    • (1994) J Pharm Pharmacol , vol.46 , pp. 46-49
    • Cheng, J.T.1    Chang, S.S.2    Hsu, F.L.3
  • 15
    • 34250217074 scopus 로고    scopus 로고
    • A water-soluble extract from Cucurbita moschata shows anti-obesity effects by controlling lipid metabolism in a high fat diet-induced obesity mouse model
    • DOI 10.1016/j.bbrc.2007.05.107, PII S0006291X0701056X
    • Choi H, Eo H, Park K, Jin M, Park EJ, Kim SH, Park JE and Kim S: A water-soluble extract from Cucurbita moschata shows anti-obesity effects by controlling lipid metabolism in a high fat diet-induced obesity mouse model. Biochem Biophys Res Commun 359: 419-425, 2007. (Pubitemid 46898967)
    • (2007) Biochemical and Biophysical Research Communications , vol.359 , Issue.3 , pp. 419-425
    • Choi, H.1    Eo, H.2    Park, K.3    Jin, M.4    Park, E.-J.5    Kim, S.-H.6    Park, J.E.7    Kim, S.8
  • 16
    • 67649526476 scopus 로고    scopus 로고
    • Antiobesity activity of aqueous extracts of Rhizoma Dioscoreae Tokoronis on high-fat diet-induced obesity in mice
    • Song MY, Lv N, Kim EK, et al: Antiobesity activity of aqueous extracts of Rhizoma Dioscoreae Tokoronis on high-fat diet-induced obesity in mice. J Med Food 12: 304-309, 2009.
    • (2009) J Med Food , vol.12 , pp. 304-309
    • Song, M.Y.1    Lv, N.2    Kim, E.K.3
  • 17
    • 80053118732 scopus 로고
    • Studies on the basic data of Ktc: C57BL/6 mice with age: Body weight, organ weight, hematology, serum chemistry and urinalysis
    • Han SS, Han HS, Cho KH, Kim YB, Seo JW and Song CW: Studies on the basic data of Ktc: C57BL/6 mice with age: body weight, organ weight, hematology, serum chemistry and urinalysis. Korea J Lab Anim Sci 10: 197-209, 1994.
    • (1994) Korea J Lab Anim Sci , vol.10 , pp. 197-209
    • Han, S.S.1    Han, H.S.2    Cho, K.H.3    Kim, Y.B.4    Seo, J.W.5    Song, C.W.6
  • 18
    • 0036149134 scopus 로고    scopus 로고
    • Effect of blood collection technique in mice on clinical pathology parameters
    • DOI 10.1089/10430340152712700
    • Schnell MA, Hardy C, Hawley M, Propert KJ and Wilson JM: Effect of blood collection technique in mice on clinical pathology parameters. Hum Gene Ther 13: 155-161, 2002. (Pubitemid 34075179)
    • (2002) Human Gene Therapy , vol.13 , Issue.1 , pp. 155-161
    • Schnell, M.A.1    Hardy, C.2    Hawley, M.3    Propert, K.J.4    Wilson, J.M.5
  • 19
    • 77950138348 scopus 로고    scopus 로고
    • Suppression of murine preadipocyte differentiation and reduction of visceral fat accumulation by a Petasites japonicus ethanol extract in mice fed a high-fat diet
    • Watanabe T, Hata K, Hiwatashi K, Hori K, Suzuki N and ItohH: Suppression of murine preadipocyte differentiation and reduction of visceral fat accumulation by a Petasites japonicus ethanol extract in mice fed a high-fat diet. Biosci Biotechnol Biochem 74: 499-503, 2010.
    • (2010) Biosci Biotechnol Biochem , vol.74 , pp. 499-503
    • Watanabe, T.1    Hata, K.2    Hiwatashi, K.3    Hori, K.4    Suzuki, N.5    Itoh, H.6
  • 20
    • 0030602866 scopus 로고    scopus 로고
    • The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation
    • DOI 10.1016/0005-2760(96)00066-5
    • Schoonjans K, Staels B and Auwerx J: The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta 1302: 93-109, 1996. (Pubitemid 26247079)
    • (1996) Biochimica et Biophysica Acta - Lipids and Lipid Metabolism , vol.1302 , Issue.2 , pp. 93-109
    • Schoonjans, K.1    Staels, B.2    Auwerx, J.3
  • 21
    • 0033695790 scopus 로고    scopus 로고
    • Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: Troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice
    • Memon RA, Tecott LH, Nonogaki K, Beigneux A, Moser AH, Grunfeld C and Feingold KR: Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice. Endocrinology 141: 4021-4031, 2000.
    • (2000) Endocrinology , vol.141 , pp. 4021-4031
    • Memon, R.A.1    Tecott, L.H.2    Nonogaki, K.3    Beigneux, A.4    Moser, A.H.5    Grunfeld, C.6    Feingold, K.R.7
  • 23
    • 0031898610 scopus 로고    scopus 로고
    • PPAR-gamma: Adipogenic regulator and thiazolidinedione receptor
    • Spiegelman BM: PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. Diabetes 47: 507-514, 1998.
    • (1998) Diabetes , vol.47 , pp. 507-514
    • Spiegelman, B.M.1
  • 24
    • 0032557156 scopus 로고    scopus 로고
    • Physiological properties and functions of intracellular fatty acid-binding proteins
    • Coe NR and Bernlohr DA: Physiological properties and functions of intracellular fatty acid-binding proteins. Biochim Biophys Acta 1391: 287-306, 1998.
    • (1998) Biochim Biophys Acta , vol.1391 , pp. 287-306
    • Coe, N.R.1    Bernlohr, D.A.2
  • 25
    • 0032582685 scopus 로고    scopus 로고
    • Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors
    • DOI 10.1074/jbc.273.44.29164
    • Boizard M, Le Liepvre X, Lemarchand P, Foufelle F, Ferré P and Dugail I: Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors. J Biol Chem 273: 29164-29171, 1998. (Pubitemid 28507616)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.44 , pp. 29164-29171
    • Boizard, M.1    Le, L.X.2    Lemarchand, P.3    Foufelle, F.4    Ferre, P.5    Dugail, I.6
  • 26
    • 12644314084 scopus 로고    scopus 로고
    • Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoter
    • DOI 10.1074/jbc.271.51.32689
    • Magaña MM and Osborne TF: Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoter. J Biol Chem 271: 32689-32694, 1996. (Pubitemid 27008692)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.51 , pp. 32689-32694
    • Magana, M.M.1    Osborne, T.F.2
  • 28
    • 0348107406 scopus 로고    scopus 로고
    • Regulation of adipocytokines and insulin resistance
    • DOI 10.1007/s00125-003-1228-z
    • Fasshauer M and Paschke R: Regulation of adipocytokines and insulin resistance. Diabetologia 46: 1594-1603, 2003. (Pubitemid 38005321)
    • (2003) Diabetologia , vol.46 , Issue.12 , pp. 1594-1603
    • Fasshauer, M.1    Paschke, R.2
  • 30
    • 33845864967 scopus 로고    scopus 로고
    • Adipocytes as regulators of energy balance and glucose homeostasis
    • DOI 10.1038/nature05483, PII NATURE05483
    • Rosen ED and Spiegelman BM: Adipocytes as regulators of energy balance and glucose homeostasis. Nature 444: 847-853, 2006. (Pubitemid 46024991)
    • (2006) Nature , vol.444 , Issue.7121 , pp. 847-853
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 32
    • 33845982919 scopus 로고    scopus 로고
    • A new furofuran lignan from Geranium thunbergii Sieb. et Zucc
    • Liu QH, Jeong JE, Choi EJ, Moon YH and Woo ER: A new furofuran lignan from Geranium thunbergii Sieb. et Zucc. Arch Pharm Res 29: 1109-1113, 2006.
    • (2006) Arch Pharm Res , vol.29 , pp. 1109-1113
    • Liu, Q.H.1    Jeong, J.E.2    Choi, E.J.3    Moon, Y.H.4    Woo, E.R.5
  • 33
    • 50649107938 scopus 로고    scopus 로고
    • Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats
    • Silver Spring
    • Rivera L, Morón R, Sánchez M, Zarzuelo A and Galisteo M: Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Obesity (Silver Spring) 16: 2081-2087, 2008.
    • (2008) Obesity , vol.16 , pp. 2081-2087
    • Rivera, L.1    Morón, R.2    Sánchez, M.3    Zarzuelo, A.4    Galisteo, M.5
  • 34
    • 79953317030 scopus 로고    scopus 로고
    • Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice
    • Kobori M, Masumoto S, Akimoto Y and Oike H: Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice. Mol Nutr Food Res 55: 530-540, 2011.
    • (2011) Mol Nutr Food Res , vol.55 , pp. 530-540
    • Kobori, M.1    Masumoto, S.2    Akimoto, Y.3    Oike, H.4


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