Nrf2 activation diminishes during adipocyte differentiation of ST2 cells

International Journal of Molecular Medicine

Volumn 28, Issue 5, 2011, Pages 823-828

  Chartoumpekis, Dionysios V ^a   Ziros, Panos G ^a   Sykiotis, Gerasimos P ^a   Zaravinos, Apostolos ^b   Psyrogianis, Agathoklis I ^a   Kyriazopoulou, Venetsana E ^a   Spandidos, Demetrios A ^b   Habeos, Ioanis G ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b UNIVERSITY OF CRETE   (Greece)

Author keywords

Adipogenesis; Antioxidant; Glutathione obesity; Keap1; Oxidative stress; Reactive oxygen species

Indexed keywords

GLUTATHIONE; HYBRID PROTEIN; HYDROCORTISONE; INDOMETACIN; INSULIN; ISOBUTYLMETHYLXANTHINE; LUCIFERASE; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR NRF2;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; DNA BINDING; GEL MOBILITY SHIFT ASSAY; GENE ACTIVATION; MOUSE; NONHUMAN; OXIDATION REDUCTION POTENTIAL; OXIDATIVE STRESS; PRIORITY JOURNAL; STROMA CELL; WESTERN BLOTTING;

ADIPOCYTES; ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GLUTATHIONE; MICE; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; STROMAL CELLS;

EID: 80053115021     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2011.761     Document Type: Article

References (37)

1. Calkins MJ, Johnson DA, Townsend JA, et al: The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease. Antioxid Redox Signal 11: 497-508, 2009.
2. Kobayashi M and Yamamoto M: Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv Enzyme Regul 46: 113-140, 2006. (Pubitemid 44301353)
3. Sykiotis GP and Bohmann D: Stress-activated cap 'n' collar transcription factors in aging and human disease. Sci Signal 3: re3, 2010.
4. Kensler TW, Wakabayashi N and Biswal S: Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47: 89-116, 2007.
5. Osburn WO and Kensler TW: Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mutat Res 659: 31-39, 2008.
6. Mandrup S and Lane MD: Regulating adipogenesis. J Biol Chem 272: 5367-5370, 1997. (Pubitemid 27102351)
7. Rosen ED, Walkey CJ, Puigserver P and Spiegelman BM: Transcriptional regulation of adipogenesis. Genes Dev 14: 1293-1307, 2000. (Pubitemid 30397073)
8. Rosen ED and Spiegelman BM: Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol 16: 145-171, 2000. (Pubitemid 32037503)
9. Lee H, Lee YJ, Choi H, Ko EH and Kim JW: Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion. J Biol Chem 284: 10601-10609, 2009.
10. Jones DP: Redefining oxidative stress. Antioxid Redox Signal 8: 1865-1879, 2006.
11. Lee OH, Kwon YI, Hong HD, Park CS, Lee BY and Kim YC: Production of reactive oxygen species and changes in antioxidant enzyme activities during differentiation of 3T3-L1 adipocyte. J Korean Soc Appl Biol Chem 52: 70-75, 2009.
12. Ducluzeau PH, Priou M, Weitheimer M, et al: Dynamic regulation of mitochondrial network and oxidative functions during 3T3-L1 fat cell differentiation. J Physiol Biochem: doi: 10.1007/s13105-011-0074-6, (In press).
13. Imhoff BR and Hansen JM: Differential redox potential profiles during adipogenesis and osteogenesis. Cell Mol Biol Lett 16: 149-161, 2011.
14. Pi J, Leung L, Xue P, et al: Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity. J Biol Chem 285: 9292-9300, 2010.
15. Shin S, Wakabayashi N, Misra V, et al: NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Mol Cell Biol 27: 7188-7197, 2007. (Pubitemid 47549754)
16. Dixon JB: The effect of obesity on health outcomes. Mol Cell Endocrinol 316: 104-108, 2010.
17. Nishimura S, Manabe I, Nagasaki M, et al: Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels. Diabetes 56: 1517-1526, 2007. (Pubitemid 46842598)
18. Habeos IG, Ziros PG, Chartoumpekis D, Psyrogiannis A, Kyriazopoulou V and Papavassiliou AG: Simvastatin activates Keap1/Nrf2 signaling in rat liver. J Mol Med 86: 1279-1285, 2008.
19. Chartoumpekis D, Ziros PG, Psyrogiannis A, Kyriazopoulou V, Papavassiliou AG and Habeos IG: Simvastatin lowers reactive oxygen species level by Nrf2 activation via PI3K/Akt pathway. Biochem Biophys Res Commun 396: 463-466, 2010.
20. Ding J, Nagai K and Woo JT: Insulin-dependent adipogenesis in stromal ST2 cells derived from murine bone marrow. Biosci Biotechnol Biochem 67: 314-321, 2003. (Pubitemid 39251984)
21. Y ang J, Friedman MS, Bian H, Crofford LJ, Roessler B and McDonagh KT: Highly efficient genetic transduction of primary human synoviocytes with concentrated retroviral supernatant. Arthritis Res 4: 215-219, 2002.
22. Gutscher M, Pauleau AL, Marty L, et al: Real-time imaging of the intracellular glutathione redox potential. Nat Methods 5: 553-559, 2008. (Pubitemid 351761764)
23. Ziros PG, Gil AP, Georgakopoulos T, et al: The bone-specific transcriptional regulator Cbfa1 is a target of mechanical signals in osteoblastic cells. J Biol Chem 277: 23934-23941, 2002. (Pubitemid 34952238)
24. Black AR, Black JD and Azizkhan-Clifford J: Sp1 and kruppel-like factor family of transcription factors in cell growth regulation and cancer. J Cell Physiol 188: 143-160, 2001. (Pubitemid 32622905)
25. Habeos I, Ziros PG, Psyrogiannis A, Vagenakis AG and Papavassiliou AG: Statins and transcriptional regulation: the FXR connection. Biochem Biophys Res Commun 334: 601-605, 2005. (Pubitemid 40982409)
26. Finkel T and Holbrook NJ: Oxidants, oxidative stress and the biology of ageing. Nature 408: 239-247, 2000.
27. Droge W: Free radicals in the physiological control of cell function. Physiol Rev 82: 47-95, 2002.
28. D'Autreaux B and Toledano MB: ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat Rev Mol Cell Biol 8: 813-824, 2007. (Pubitemid 47462134)
29. Kawai Y, Garduno L, Theodore M, Yang J and Arinze IJ: Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization. J Biol Chem 286: 7629-7640, 2010.
30. Aleksunes LM and Manautou JE: Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease. Toxicol Pathol 35: 459-473, 2007. (Pubitemid 46911886)
31. Y ang H, Magilnick N, Lee C, et al: Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1. Mol Cell Biol 25: 5933-5946, 2005.
32. Chan JY and Kwong M: Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein. Biochim Biophys Acta 1517: 19-26, 2000.
33. Vigilanza P, Aquilano K, Baldelli S, Rotilio G and Ciriolo MR: Modulation of intracellular glutathione affects adipogenesis in 3T3-L1 cells. J Cell Physiol 226: 2016-2024, 2011.
34. Beyer TA, Xu W, Teupser D, et al: Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance. EMBO J 27: 212-223, 2008.
35. Takahashi T, Tabuchi T, Tamaki Y, Kosaka K, Takikawa Y and Satoh T: Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism. Biochem Biophys Res Commun 382: 549-554, 2009.
36. Spiegelman BM and Flier JS: Adipogenesis and obesity: rounding out the big picture. Cell 87: 377-389, 1996. (Pubitemid 26374313)
37. Furukawa S, Fujita T, Shimabukuro M, et al: Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114: 1752-1761, 2004. (Pubitemid 40385531)