HIV-mediated phosphatidylinositol 3-kinase/serine-threonine kinase activation in APCs leads to programmed death-1 ligand upregulation and suppression of HIV-specific CD8 T cells

Journal of Immunology

Volumn 187, Issue 6, 2011, Pages 2932-2943

  Muthumani, Karuppiah ^a   Shedlock, Devon J ^a   Choo, Daniel K ^a   Fagone, Paolo ^a   Kawalekar, Omkar U ^a   Goodman, Jonathan ^a   Bian, Chaoran B ^a   Ramanathan, Aarti A ^a   Atman, Parikh ^a   Tebas, Pablo ^a   Chattergoon, Michael A ^b   Choo, Andrew Y ^c   Weiner, David B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROGRAMMED DEATH 1 LIGAND; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; DENDRITIC CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME RELEASE; ENZYME REPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; MACROPHAGE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; CD8-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HIV INFECTIONS; HIV-1; HUMANS; LIGANDS; LYMPHOCYTE ACTIVATION; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 80053089977     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1100594     Document Type: Article

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