Obesity, its associated disorders and the role of inflammatory adipokines in companion animals

Veterinary Journal

Volumn 185, Issue 1, 2010, Pages 4-9

  German, Alexander J ^a   Ryan, Vivien H ^a   German, Allison C ^a   Wood, I Stuart ^a   Trayhurn, Paul ^a,b  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF BUCKINGHAM   (United Kingdom)

Author keywords

Biomarkers; Cat; Dog; Insulin resistance; Metabolic syndrome; Obesity; Overweight

Indexed keywords

ACUTE PHASE PROTEIN; ADIPOCYTOKINE; BIOLOGICAL MARKER; C REACTIVE PROTEIN; INTERLEUKIN 6; LEPTIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL DISEASE; CLINICAL FEATURE; DISEASE ASSOCIATION; DISEASE COURSE; ENDOCRINE FUNCTION; HUMAN; HYPERTENSION; HYPOXEMIA; INFLAMMATION; INSULIN RESISTANCE; MACROPHAGE FUNCTION; METABOLIC SYNDROME X; NEOPLASM; NONHUMAN; OBESITY; OSTEOARTHRITIS; PATHOGENESIS; PROTEIN FUNCTION; RESPIRATORY TRACT DISEASE; REVIEW; RISK FACTOR; THROMBOSIS; WHITE ADIPOSE TISSUE; ADIPOSE TISSUE; ANIMAL; CAT; CAT DISEASE; DOG; DOG DISEASE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; VETERINARY;

ADIPOKINES; ADIPOSE TISSUE; ANIMALS; BIOLOGICAL MARKERS; CAT DISEASES; CATS; DOG DISEASES; DOGS; OBESITY;

ANIMALIA; CANIS FAMILIARIS;

EID: 77953679420     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2010.04.004     Document Type: Review

References (80)

1. Abbasi F., Chu J.W., Lamendola C., McLaughlin T., Hayden J., Reaven G.M., Reaven P.D. Discrimination between obesity and insulin resistance in the relationship with adiponectin. Diabetes 2004, 53:585-590.
2. Anderson R.S. Obesity in the dog and cat. Veterinary Annual 1973, 1441:82-186.
3. Appleton D.J., Rand J.S., Sunvold G.D. Plasma leptin concentrations in cats: reference range, effect of weight gain and relationship with adiposity as measured by dual energy X-ray absorptiometry. Journal of Feline Medicine and Surgery 2000, 2:191-199.
4. Appleton D.J., Rand J.S., Sunvold G.D. Plasma leptin concentrations are independently associated with insulin sensitivity in lean and overweight cats. Journal of Feline Medicine and Surgery 2002, 4:83-93.
5. Barb D., Williams C.J., Neuwirth A.K., Mantzoros C.S. Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence. American Journal of Clinical Nutrition 2007, 86:858-866.
6. Barzilai N., Wang J., Massilon D., Vuguin P., Hawkins M., Rossetti L. Leptin selectively decreases visceral adiposity and enhances insulin action. Journal of Clinical Investigation 1997, 100:3105-3110.
7. Bodey A.R., Mitchell A.R. Epidemiological study of blood pressure in domestic dogs. Journal of Small Animal Practice 1996, 37:116-125.
8. Bruun J.M., Pedersen S.B., Richelsen B. Regulation of interleukin 8 production and gene expression in human adipose tissue in vitro. Journal of Clinical Endocrinology and Metabolism 2001, 86:1267-1273.
9. 2. American Journal of Physiology Endocrinology and Metabolism 2005, 289:E62-E67.
10. Calle E.E., Kaaks S. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. National Reviews of Cancer 2004, 4:579-591.
11. Cheillini C., Santini F., Marsili A., Berti P., Bertacca A., Pelosini C., Scartabelli G., Pardini E., Lopez-Soriano J., Centoni R., Ciccarone A.M., Benzi L., Vitti P., Del Prato S., Pinchera A., Maffei M. Serum haptoglobin: a novel marker of adiposity in humans. Journal of Clinical Endocrinology and Metabolism 2004, 89:2678-2683.
12. Chen B., Lam K.S., Wang Y., Wu D., Lam M.C., Shen J., Wong L., Hoo R.L., Zhang J., Xu A. Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes. Biochemical and Biophysical Research Communications 2006, 341:549-556.
13. Christiansen T., Richelsen B., Bruun J.M. Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbidly obese subjects. International Journal of Obesity 2005, 29:146-150.
14. Chung K.F., Barnes P.J. Cytokines in asthma. Thorax 1999, 54:825-857.
15. Church T.S., Willis M.S., Priest E.L., Lamonte M.J., Earnest C.P., Wilkinson W.J., Wilson D.A., Giroir B.P. Obesity, macrophage migration inhibitory factor, and weight loss. International Journal of Obesity and Related Metabolic Disorders 2005, 29:675-681.
16. Cicuttini F.M., Baker J.R., Spector T.D. The association of obesity with osteoarthritis of the hand and knee in women: a twin study. Journal of Rheumatology 1996, 23:1221-1226.
17. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephen T.W., Nyce M.R., Ohannesian J.P., Marco C.C., McKee L.J., Bauer T.L., Caro J.F. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New England Journal of Medicine 1996, 334:292-295.
18. Dumond H., Presle N., Terlain B., Mainard D., Loeuille D., Netter P., Pottie P. Evidence for a key role of leptin in osteoarthritis. Arthritis and Rheumatism 2003, 48:3118-3129.
19. Ebihara K., Ogawa Y., Masuzaki H., Shintani M., Miyanaga F., Aizawa-Abe M., Hayashi T., Hosoda K., Inoue G., Yoshimasa Y., Gavrilova O., Reitman M.L., Nakao K. Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes. Diabetes 2001, 50:1440-1448.
20. Edney A.T., Smith P.M. Study of obesity in dogs visiting veterinary practices in the United Kingdom. Veterinary Record 1986, 118:391-396.
21. Eisele I., Wood I.S., German A.J., Hunter L., Trayhurn P. Adipokine gene expression in dog adipose tissues and dog white adipocytes differentiated in primary culture. Hormone and Metabolic Research 2005, 37:474-481.
22. Engeli S., Schling P., Gorzelniak K., Boschmann M., Janke J., Ailhaud G., Teboul M., Massiera F., Sharma A.M. The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome?. International Journal Biochemistry and Cell Biology 2003, 35:807-825.
23. Engeli S., Bohnke J., Gorzelniak K., Janke J., Schling P., Bader M., Luft F.C., Sharma A.M. Weight loss and the renin-angiotensin-aldosterone system. Hypertension 2005, 45:356-362.
24. Esposito K., Pontillo A., Ciotola M., Di Palo C., Grella E., Nicoletti G., Giugliano D. Weight loss reduces interleukin-18 levels in obese women. Journal of Clinical Endocrinology and Metabolism 2002, 87:3864-3866.
25. Esposito K., Pontillo A., Di Palo O., Giugalano G., Masella M., Marfella R., Giugliano D. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. Journal of the American Medical Association 2003, 87:3864-3866.
26. Folsom A.R., Qamhieh H.T., Wing R.R., Jeffery R.W., Stinson V.L., Kuller L.H., Wu K.K. Impact of weight loss on plasminogen activator inhibitor (PAI-1), factor VII, and other hemostatic factors in moderately overweight adults. Arteriosclerosis and Thrombosis 1993, 13:162-169.
27. Furukawa S., Fujita T., Shimabukuro M., Iwaki M., Yamada Y., Nakajima Y., Nakayama O., Makishima M., Matsuda M., Shimomura I. Increased oxidative stress in obesity and its impact on metabolic syndrome. Journal of Clinical Investigation 2004, 114:1752-1761.
28. German A.J. The growing problem of obesity in dogs and cats. Journal of Nutrition 2006, 136:1940-1946.
29. German, A.C., German, A.J., Wood, I.S., Hunter, L., Morris, P.J., Trayhurn, P., 2009a. Development and optimization of a primary cell culture system for feline adipocytes. In: Proceedings of the 2009 British Small Animal Veterinary Association Congress, Birmingham, UK, pp. 380-381.
30. German A.J., Hervera M., Hunter L., Holden S.L., Morris P.J., Biourge V., Trayhurn P. Improvement in insulin resistance and reduction in plasma inflammatory adipokines after weight loss in obese dogs. Domestic Animal Endocrinology 2009, 37:214-226.
31. Heijink I.H., Vellenga E., Borger P., Postma D.S., de Monchy J.G., Kauffman H.F. Interleukin-6 promotes the production of interleukin-4 and interleukin-5 by interleukin-2-dependent and -independent mechanisms in freshly isolated human T cells. Immunology 2002, 107:316-324.
32. Hoenig M., Thomaseth K., Waldron M., Ferguson D.C. Insulin sensitivity, fat distribution, and adipocytokine response to different diets in lean and obese cats before and after weight loss. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2007, 292:227-234.
33. 2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes 2005, 54:73-78.
34. Hotamisligil G.S., Murray D.L., Choy L.N., Spiegelman B.M. Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proceeding of the National Academy of Science USA 1994, 91:4854-4858.
35. Hotamisligil G.S., Arner P., Caro J.F., Atkinson R.L., Spiegelman B.M. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. Journal of Clinical Investigation 1995, 95:2409-2415.
36. Ishioka K., Omachi A., Sagawa M., Shubata H., Honjoh T., Kimura K., Saito M. Canine adiponectin: cDNA structure, mRNA expression in adipose tissues and reduced plasma levels in obesity. Research in Veterinary Science 2006, 80:127-132.
37. Jeusette I.C., Detilleux J., Shibata H., Saito M., Honjoh T., Delobei A., Istrasse L., Diez M. Effect of chronic obesity and weight loss on plasma ghrelin and leptin concentrations in dog. Research in Veterinary Science 2007, 79:169-175.
38. Juge-Aubry C.E., Somm E., Pernin A., Alizadeh N., Giusti V., Dayer J.M., Meier C.A. Adipose tissue is a regulated source of interleukin-10. Cytokine 2005, 29:270-274.
39. Juhan-Vague I., Alessi M.C., Vague P. Increased plasma plasminogen activator inhibitor 1 levels. A possible link between insulin resistance and atherothrombosis. Diabetologia 1991, 34:457-462.
40. Kealy R.D., Lawler D.F., Ballam J.M., Mantz S.L., Biery D.N., Greeley E.H., Lust G., Segre M., Smith G.K., Stowe H.D. Effects of diet restriction on life span and age-related changes in dogs. Journal of the American Veterinary Medical Association 2002, 220:1315-1320.
41. Kim S., Popkin B.M. Commentary: understanding the epidemiology of overweight and obesity - a real global public health concern. International Journal of Epidemiology 2006, 35:60-67.
42. Kopelman P.G. Obesity as a medical problem. Nature 2000, 404:635-643.
43. Lumeng C.N., Bodzin J.L., Saltiel A.R. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. Journal of Clinical Investigation 2007, 117:175-184.
44. Lund E.M., Armstrong P.J., Kirk C.A., Klausner J.S. Prevalence and risk factors for obesity in adult cats from private US veterinary practices. International Journal of Research in Veterinary Medicine 2005, 3:88-96.
45. Lund E.M., Armstrong P.J., Kirk C.A., Klausner J.S. Prevalence and risk factors for obesity in adult dogs from private US veterinary practices. International Journal of Research in Veterinary Medicine 2006, 4:177-186.
46. Manco M., Fernandez-Real J.M., Equitani F., Vendrell J., Valera Mora M.E., Nanni G., Tondolo V., Calvani M., Ricart W., Castagneto M., Mingrone G. Effect of massive weight loss on inflammatory adipocytokines and the innate immune system in morbidly obese women. Journal of Clinical Endocrinology and Metabolism 2007, 92:483-490.
47. Mohamed-Ali V., Flower L., Sethi J., Hotamsligil G., Gray R., Humphries S.E., York D.A., Pinkney J. Beta-adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro studies. Journal of Clinical Endocrinology and Metabolism 2001, 86:5864-5869.
48. O'Brien K.D., Brehm B.J., Seeley R.J., Bean J., Wener M.H., Daniels S., D'Alessio D.A. Diet-induced weight loss is associated with decreases in plasma serum amyloid A and C-reactive protein independent of dietary macronutrient composition in obese subjects. Journal of Clinical Endocrinology and Metabolism 2004, 90:2244-2249.
49. 2-terminal kinase activation. Endocrinology 2006, 147:4505-4516.
50. O'Hara A., Lim F.L., Mazzatti D.J., Trayhurn P. Molecular analysis identifies matrix metalloproteinases (MMPs) as key genes whose expression is upregulated in human adipocytes by macrophage-conditioned medium. Pflugers Archives - European Journal of Physiology 2009, 458:1103-1114.
51. Otero M., Gomez Reino J.J., Gualillo O. Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells. Arthritis and Rheumatism 2003, 48:404-409.
52. Ouchi N., Ohishi M., Kihara S., Funahashi T., Nakamura T., Nagaretani H., Kumada M., Ohashi K., Okamoto Y., Nishizawa H., Kishida K., Maeda N., Nagasawa A., Kobayashi H., Hiraoka H., Komai N., Kaibe M., Rakugi H., Ogihara T., Matsuzawa Y. Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension 2003, 42:231-234.
53. Presle N., Pottie P., Dumond H., Guillaume C., Lapicque F., Pallu S., Mainard D., Netter P., Terlain B. Differentials distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular production. Osteoarthritis and Cartilage 2006, 14:690-695.
54. Prospective Studies Collaboration Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet 2009, 373:1083-1096.
55. Radin M.J., Sharkey L.C., Holycross B.J. Adipokines: a review of biological and analytical principles and an update in dogs, cats, and horses. Veterinary Clinical Pathology 2009, 38:136-156.
56. Redinger R.N. The pathophysiology of obesity and its clinical manifestations. Gastroenterology and Hepatology 2007, 3:856-863.
57. Renehan A.G., Frystyk J., Flyvbjerg A. Obesity and cancer risk: the role of the insulin-IGF axis. Trends in Endocrinology and Metabolism 2006, 17:328-336.
58. Rennie K.L., Jebb S.A. Prevalence of obesity in Great Britain. Obesity Reviews 2005, 6:11-12.
59. Ryan V.H., German A.J., Wood I.S., Hunter L., Morris P., Trayhurn P. NGF gene expression and secretion by canine adipocytes in primary culture: upregulation by the inflammatory mediators LPS and TNFα. Hormone and Metabolic Research 2008, 40:861-868.
60. Ryan V.H., German A.J., Wood I.S., Hunter L., Morris P.J., Trayhurn P. Adipokine expression and secretion by canine adipocytes: stimulation of inflammatory adipokine production by LPS and TNFα. Journal of Veterinary Internal Medicine 2009, 23:714.
61. Sagawa M., Nakadomo F., Honjoh T., Ishioka K., Saito M. Correlation between plasma leptin concentration and body fat content in dogs. American Journal of Veterinary Research 2002, 63:7-10.
62. Schoen R.E., Tangen C.M., Kuller L.H., Burke G.L., Cushman M., Tracy R.P., Dobs A., Savage P.J. Increased blood glucose and insulin, body size, and incident colorectal cancer. Journal of the National Cancer Institute 1999, 91:1147-1154.
63. Senn J.J., Klover P.J., Nowak I.A., Mooney R.A. Interleukin-6 induces insulin resistance in hepatocytes. Diabetes 2002, 51:3391-3399.
64. Shore S.A. Obesity and asthma: lessons from animal models. Journal of Applied Physiology 2007, 102:516-528.
65. Spranger J., Kroke A., Mohlig M., Hoffmann K., Bergmann M.M., Ristow M., Boeing H., Pfeiffer A.F. Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes 2003, 52:812-817.
66. Straczkowski M., Kowalska I., Nikolajuk A., Otziomek E., Adamska A., Karolczuk-Zarachowicz M., Gorska M. Increased serum interleukin-18 concentration is associated with hypoadiponectinemia in obesity, independently of insulin resistance. International Journal of Obesity (London) 2007, 31:221-225.
67. Sukkar M.B., Hughes J.M., Armour C.L., Johnson P.R. Tumour necrosis factor-alpha potentiates contraction of human bronchus in vitro. Respirology 2001, 6:199-203.
68. Sutherland T.J.T., Cowan J.O., Young S., Goulding A., Grant A.M., Williamson A., Brassett K., Herbison G.P., Taylor D.R. The association between obesity and asthma: interactions between systemic and airway inflammation. American Journal of Respiratory and Critical Care Medicine 2008, 178:469-475.
69. Thomas P.S. Tumour necrosis factor-alpha: the role of this multifunctional cytokine in asthma. Immunology and Cell Biology 2001, 79:132-140.
70. Tilg H., Wolf A.M. Adiponectin: a key fat-derived molecule regulating inflammation. Expert Opinions in Therapeutic Targets 2005, 9:245-251.
71. Toda Y., Toda T., Takemura S., Wada T., Morimoto T., Ogawa R. Change in body fat, but not bodyweight or metabolic correlates of obesity, is related to symptomatic relief of obese patients with knee osteoarthritis after a weight control program. Journal of Rheumatology 1998, 25:2181-2186.
72. Trayhurn P. Adipose tissue in obesity - an inflammatory issue. Endocrinology 2005, 146:1003-1005.
73. Trayhurn P., Wood I.S. Adipokines: inflammation and the pleiotropic role of white adipose tissue. British Journal of Nutrition 2004, 92:347-355.
74. Um J.Y., Chung H.S., Song M.Y., Shin H.D., Kim H.M. Association of interleukin-1beta gene polymorphism with body mass index in women. Clinical Chemistry 2004, 50:647-650.
75. Wang B., Jenkins J.R., Trayhurn P. Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: integrated response to TNF-alpha. American Journal of Physiology: Endocrinology and Metabolism 2005, 288:731-740.
76. Wang S.N., Yeh Y.T., Yang S.F., Chai C.Y., Lee Y.T. Potential role of leptin expression in hepatocellular carcinoma. Journal of Clinical Pathology 2006, 59:930-934.
77. Weisberg S.P., McCann D., Desai M., Rosenbaum M., Leibel R.L., Ferrante A.W. Obesity is associated with macrophage accumulation in adipose tissue. Journal of Clinical Investigation 2003, 112:1796-1808.
78. Wood I.S., Wang B., Lorente-Cebrian S., Trayhurn P. Hypoxia increases expression of selective facilitative glucose transporters (GLUT) and 2-deoxy-d-glucose uptake in human adipocytes. Biochemical and Biophysical Research Communications 2007, 361:468-473.
79. Yamauchi T., Kamon J., Waki H., Terauchi Y., Kubota N., Hara K., Mori Y., Ide T., Murakami K., Tsuboyama-Kasaoka N., Ezaki O., Akanuma Y., Gavrilova O., Vinson C., Reitman M.L., Kagechika H., Shudo K., Yoda M., Nakano Y., Tobe K., Nagai R., Kimura S., Tomita M., Froguel P., Kadowaki T. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nature Medicine 2001, 7:941-946.
80. Ziccardi P., Nappo F., Giugliano G., Esposito K., Marfella R., Cioffi M., D'Andrea F., Molinari A.M., Giugliano D. Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over on year. Circulation 2002, 105:804-809.