Aging and HIV disease: Synergistic immunological effects?

Handbook on Immunosenescence: Basic Understanding and Clinical Applications

Volumn 9781402090639, Issue , 2009, Pages 949-964

  Effros, Rita B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80053051540     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4020-9063-9_47     Document Type: Chapter

References (88)

1. Almanzar G, Schwaiger S, Jenewein B, Keller M, Herndler-Brandstetter D, Wurzner R et al (2005) Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons. J Virol 79:3675-3683
2. Anton PA, Elliott J, Poles MA, McGowan IM, Matud J, Hultin LE et al (2000) Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissue. AIDS 14:1761-1765
3. Anton PA, Mitsuyasu RT, Deeks SG, Scadden DT, Wagner B, Huang C et al (2003) Multiple measures of HIV burden in blood and tissue are correlated with each other but not with clinical parameters in aviremic subjects. AIDS 17:53-63
4. Appay V, Rowland-Jones S (2002a) Premature ageing of the immune system: the cause of AIDS? Trends Immunol 23:580-585
5. Appay V, Dunbar PR, Callan M, Klenerman P, Gillespie GM, Papagno L et al (2002b) Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med 8:379-385
6. Arron JR, Choi Y (2000) Bone versus immune system. Int Immunol 408:535-536
7. Balslev U, Monforte AD, Stergiou G, Antunes F, Mulcahy F, Pehrson PO et al (1997) Influence of age on rates of new AIDS-defining diseases and survival in 6546 AIDS patients. Scand J Infect Dis 29:337-343
8. Berretta M, Tirelli U (2006) Colorectal cancer screening in HIV-infected patients 50 years of age and older: missed opportunities for prevention. Am J Gastroenterol 101:907-908
9. Blatt SP, McCarthy WF, Bucko-Krasnicka B, Melcher GP, Boswell RN, Dolan J et al (1995) Multivariate models for predicting progression to AIDS and survival in human immunodeficiency virus-infected persons. J Infect Dis 171:837-844
10. Borrow P, Lewicki H, Hahn BH, Shaw GM, Oldstone M B A (1994) Virus specific CD8+ cytotoxic T lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J Virol 68:6103-6110
11. Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ, Crotty LE et al (2003) Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood 101:2711-2720
12. Brinchmann JE, Dobloug JH, Heger BH, Haaheim LL, Sannes M, Egeland T (1994) Expression of costimulatory molecule CD28 on T cells in human immunodeficiency virus type 1 infection: Functional and clinical correlations. J Infect Dis 169:730-738
13. Cao W (2007). Immunological Factors Associated with HIV-1 Disease Progression to AIDS and Death. PhD
14. Carmichael A, Jin X, Sissons P, Borysiewicz L (1993) Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: Differential CTL responses to HIV-1 and Epstein-Barr virus in late disease. J Exp Med 177:249-256
15. Casau NC (2005) Perspective on HIV infection and aging: emerging research on the horizon. Clin Infect Dis 41:855-863
16. Comi G, Filippi M, Barkhof F, Durelli L, Edan G, Fernandez O et al (2001) Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study. (Comment In: Lancet. 2001 May 19;357 (9268) :1547 UI: 21272977). Lancet 357:1576-1582
17. Connor RI, Mohri H, Cao Y, Ho DD (1993) Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1-infected individuals. J Virol 67:1772-1777
18. Dagarag MD, Evazyan T, Rao N, Effros RB (2004) Genetic manipulation of telomerase in HIV-specific CD8+ T cells: enhanced anti-viral functions accompany the increased proliferative potential and telomere length stabilization. J Immunol 173:6303-6311
19. Dagarag MD, Ng H, Lubong R, Effros RB, Yang OO (2003) Differential impairment of lytic and cytokine functions in senescent HIV-1-specific cytotoxic T lymphocytes. J Virol 77:3077-3083
20. Daniels CK, Perez P, Schmucker DL (1993) Alterations in CD8+ cell distribution in gut-associated lymphoid tissues (GALT) of the aging Fischer 344 rat: a correlated immunohistochemical and flow cytometric analysis. Exp Gerontol 28:549-555
21. Darby SC, Ewart DW, Giangrande PL, Spooner RJ, Rizza CR (1996) Importance of age at infection with HIV-1 for survival and development of AIDS in UK haemophilia population. UK Haemophilia Centre Directors' Organisation. Lancet 347:1573-1579
22. Deng Y, Jing Y, Campbell AE, Gravenstein S (2004) Age-related impaired type 1 T cell responses to influenza: reduced activation ex vivo, decreased expansion in CTL culture in vitro, and blunted response to influenza vaccination in vivo in the elderly. J Immunol, 172:3437-3446
23. Doisne JM, Urrutia A, Lacabaratz-Porret C, Goujard C, Meyer L, Chaix ML et al (2004) CD8+ T cells specific for EBV, cytomegalovirus, and influenza virus are activated during primary HIV infection. J Immunol 173:2410-2418
24. Douek DD, McFarland RD, Keiser PH, Gage EA, Massey JM, Haynes BF et al (1998) Changes in thymic function with age and during the treatment of HIV infection. Int Immunol 396:690-695
25. Effros RB (2004) Replicative senescence of CD8 T cells: potential effects on cancer immune surveillance and immunotherapy. Cancer Immunol Immunother 53:925-933
26. Effros RB, Allsopp R, Chiu CP, Wang L, Hirji K, Harley CB et al (1996) Shortened telomeres in the expanded CD28-CD8+ subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS/Fast Track 10:F17-F22
27. Effros RB, Boucher N, Porter V, Zhu X, Spaulding C, Walford RL et al (1994) Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence. Exp Gerontol 29:601-609
28. Egger M, May M, Chene G, Phillips AN, Ledergerber B Dabis F et al (2002) Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies. Lancet 360:119-129
29. Engels EA, Pfeiffer RM, Goedert JJ, Virgo P, McNeel TS, Scoppa SM et al (2006) Trends in cancer risk among people with AIDS in the United States 1980-2002. AIDS 20:1645-1654
30. Fauce S, Jamieson BD, Chin A, Ng H, Yang OO, Harley CB et al (2005) Telomerase activators increase HIV-specific CD8+ T cell function: a novel approach to prevent or delay immune exhaustion and progression to AIDS. Cold Spring Harbor Symposium on telomeres and telomerase, p 197
31. Fayad R, Zhang H, Quinn D, Huang Y, Qiao L (2004) Oral administration with papillomavirus pseudovirus encoding IL-2 fully restores mucosal and systemic immune responses to vaccinations in aged mice. J Immunol 173:2692-2698
32. Ferro S, Salit IE (1992) HIV infection in patients over 55 years of age. J Acquir Immune Defic Syndr 5:348-355
33. Fordyce EJ, Singh TP, Nash D, Gallagher B, Forlenza S (2002) Survival rates in NYC in the era of combination ART. J Acquir Immune Defic Syndr 30:111-118
34. Fujihashi K, McGhee JR (2004) Mucosal immunity and tolerance in the elderly. Mech Ageing Dev 125:889-898
35. Grabar S, Weiss L, Costagliola D (2006) HIV infection in older patients in the HAART era. J Antimicrob Chemother 57:4-7
36. Grossman Z, Meier-Schellersheim M, Paul WE, Picker LJ (2006) Pathogenesis of HIV infection: what the virus spares is as important as what it destroys. Nat Med 12:289-295
37. Grulich AE, van Leeuwen MT, Falster MO, Vajdic CM (2007) Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet 370:59-67
38. Guy-Grand D, Cerf-Bensussan N, Malissen B, Malassis-Seris M, Briottet C, Vassalli P (1991) Two gut intraepithelial CD8 +lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation. J Exp Med 173:471-481
39. Haynes L, Eaton SM, Swain SL (2002) Effect of age on naive CD4 responses: impact on effector generation and memory development. Springer Semin Immunopathol 24:53-60
40. Haynes L, Swain SL (2006) Why aging T cells fail: implications for vaccination. Immunity, 24:663-666
41. Hinkin CH, Castellon SA, Atkinson JH, Goodkin K (2001) Neuropsychiatric aspects of HIV infection among older adults. J Clin Epidemiol 54 Suppl 1:S44-S52
42. Jin X, Bauer DE, Tuttleton SE, Lewin S, Gettie A, Blanchard J et al (1999) Dramatic rise in plasma viremia after CD8 (+) T cell depletion in simian immunodeficiency virus-infected macaques. J Exp Med 189:991-998
43. Kalayjian RC, Landay A, Pollard RB, Taub DD, Gross BH, Francis IR et al (2003) Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+ cells, and reduced thymic volumes. J Infect Dis 187:1924-1933
44. Koga T, McGhee JR, Kato H, Kato R, Kiyono H, Fujihashi K (2000) Evidence for early aging in the mucosal immune system. J Immunol 165:5352-5359
45. Koup RA (1994) Virus escape from CTL recognition. J Exp Med 180:779-782
46. Manfredi R (2004) HIV infection and advanced age emerging epidemiological, clinical, and management issues. Ageing Res Rev 3:31-54
47. Mehandru S, Poles MA, Tenner-Racz K, Jean-Pierre P, Manuelli V, Lopez P et al (2006) Lack of Mucosal Immune Reconstitution during Prolonged Treatment of Acute and Early HIV-1 Infection. PLoS Med 3:E484
48. Migueles SA, Laborico AC, Shupert WL, Sabbaghian MS, Rabin R, Hallahan CW et al (2002) HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nat Immunol 3:1061-1068
49. Monteiro J, Batliwalla F, Ostrer H, Gregersen PK (1996) Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts. J Immunol 156:3587-3590
50. Morse CG, Kovacs JA (2006) Metabolic and skeletal complications of HIV infection: the price of success. JAMA 296:844-854
51. Murphy EL, Collier AC, Kalish LA, Assmann SF, Para MF, Flanigan TP et al (2001) Highly active antiretroviral therapy decreases mortality and morbidity in patients with advanced HIV disease. Ann Intern Med 135:17-26
52. Neely MN, Benning L, Xu J, Strickler HD, Greenblatt RM, Minkoff H et al (2006) Cervical Shedding of HIV-1 RNA Among Women With Low Levels of Viremia While Receiving Highly Active Antiretroviral Therapy. J Acquir Immune Defic Syndr
53. Nobile M, Correa R, Borghans JA, D'Agostino C, Schneider P, De Boer RJ et al (2004) De novo T-cell generation in patients at different ages and stages of HIV-1 disease. Blood 104:470-477
54. Orlando G, Meraviglia P, Cordier L, Meroni L, Landonio S, Giorgi R et al (2006) Antiretroviral treatment and age-related comorbidities in a cohort of older HIV-infected patients. HIV Med 7:549-557
55. Ouyang Q, Wagner WM, Wikby A, Remarque E, Pawelec G (2002) Compromised interferon gamma (IFN-gamma) production in the elderly to both acute and latent viral antigen stimulation: contribution to the immune risk phenotype? Eur Cytokine Netw 13:392-394
56. Ouyang Q, Wagner WM, Wikby A, Walter S, Aubert G, Dodi AI et al (2003) Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old. J Clin Immunol 23:247-257
57. Palella FJ Jr, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA et al (1998) Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 338:853-860
58. Palella FJ Jr, Deloria-Knoll M, Chmiel JS, Moorman AC, Wood KC, Greenberg AE et al (2003) Survival benefit of initiating antiretroviral therapy in HIV-infected persons in different CD4+ cell strata. Ann Intern Med 138:620-626
59. Palmer LD, Weng N, Levine BL, June CH, Lane HC, Hodes RJ (1997) Telomere length, telomerase activity, and replicative potential in HIV infection: analysis of CD4+ and CD8+ T cells from HIV-discordant monozygotic twins. J Exp Med 185:1381-1386
60. Pawelec G, Akbar A, Caruso C, Effros RB, Grubeck-Loebenstein B, Wikby A (2004a) Is immunosenescence infectious? Trends Immunol 25:406-410
61. Pawelec G, Akbar A, Caruso C, Effros R, Grubeck-Loebenstein B, Wikby A (2004b) Is immunosenescence infectious? Trends Immunol 25:406-410
62. Pawelec G, Akbar A, Caruso C, Solana R, Grubeck-Loebenstein B, Wikby A (2005) Human immunosenescence: is it infectious? Immunol Rev 205:257-268
63. Phillips AN, Lee CA, Webster A, Janossy G, Timms A, Bodill M et al (1991) More rapid progression to AIDS in older HIV-infected people: the role of CD4+ T cell counts. J Acquir Immune Defic Syndr 4:970-975
64. Pietschmann P, Grisar J, Thien R, Willheim M, Kerschan-Schindl K, Preisinger E et al (2001) Immune phenotype and intracellular cytokine production of peripheral blood mononuclear cells from postmenopausal patients with osteoporotic fractures. Exp Gerontol 36:1749-1759
65. Po JL, Gardner EM, Anaraki F, Katsikis PD, Murasko DM (2002) Age-associated decrease in virus-specific CD8+ T lymphocytes during primary influenza infection. Mech Ageing Dev 123:1167-1181
66. Posnett DN, Edinger JW, Manavalan JS, Irwin C, Marodon G (1999) Differentiation of human CD8 T cells: implications for in vivo persistence of CD8+ CD28-cytotoxic effector clones. Int Immunol 11:229-241
67. Reynolds MR, Rakasz E, Skinner PJ, White C, Abel K, Ma ZM et al (2005) CD8+ T-lymphocyte response to major immunodominant epitopes after vaginal exposure to simian immunodeficiency virus: too late and too little. J Virol 79:9228-9235
68. Rickabaugh T, Kilpatrick R, Fauce S, Hultin L, Hultin P, Hausner MA et al (2007) Naïve CD4+ T-cell Homeostasis During HIV Infection. International AIDS Society Meeting Late Breaker Abstract Book
69. Rosenberg PS, Goedert JJ, Biggar RJ (1994) Effect of age at seroconversion on the natural AIDS incubation distribution. Multicenter Hemophilia Cohort Study and the International Registry of Seroconverters. AIDS 8:803-810
70. Sankaran S, Guadalupe M, Reay E, George MD, Flamm J, Prindiville T et al (2005) Gut mucosal T cell responses and gene expression correlate with protection against disease in long-term HIV-1-infected nonprogressors. Proc Natl Acad Sci U S A 102:9860-9865
71. Schirmer M, Goldberger C, Wurzner R, Duftner C, Pfeiffer KP, Clausen J et al (2002) Circulating cytotoxic CD8 (+) CD28 (-) T cells in ankylosing spondylitis. Arthritis Res 4:71-76
72. Schmitz JE, Kuroda MJ, Santra S, Sasseville VG, Simon MA, Lifton MA et al (1999) Control of viremia in simian immunodeficiency virus infection by CD8 +lymphocytes. Science 283:857-860
73. Schmucker DL, Heyworth MF, Owen RL, Daniels CK (1996). Impact of aging on gastrointestinal mucosal immunity (see comments). Dig Dis Sci 41:1183-1193
74. Shah S, Mildvan D (2006) HIV and Aging. Curr Infect Dis Rep 8:241-247
75. Spaulding CS, Guo W, Effros RB (1999) Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation. Exp Gerontol 34:633-644
76. Sun JC, Williams MA, Bevan MJ (2004) CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection. Nat Immunol 5:927-933
77. Swenson CD, Thorbecke GJ (1997) The effect of aging on IgD receptor expression by T cells and its functional implications. Immunol Rev 160:145-157
78. Taylor LD, Daniels CK, Schmucker DL (1992) Ageing compromises gastrointestinal mucosal immune response in the rhesus monkey. Immunology 75:614-618
79. Topp MS, Riddell SR, Akatsuka Y, Jensen MC, Blattman JN, Greenberg PD (2003) Restoration of CD28 expression in CD28-CD8+ memory effector T cells reconstitutes antigen-induced IL-2 production. J Exp Med 198:947-955
80. Tsukishiro T, Donnenberg AD, Whiteside TL (2003) Rapid turnover of the CD8 (+) CD28 (-) T-cell subset of effector cells in the circulation of patients with head and neck cancer. Cancer Immunol Immunother 52:599-607
81. Veazey RS, Lackner AA (2005) HIV swiftly guts the immune system. Nat Med 11:469-470
82. Wheeler CJ, Black KL, Liu G, Ying H, Yu JS, Zhang W et al (2003) Thymic CD8+ T cell production strongly influences tumor antigen recognition and age-dependent glioma mortality. J Immunol 171:4927-4933
83. Wikby A, Johansson B, Olsson J, Lofgren S, Nilsson BO, Ferguson F (2002) Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp Gerontol 37:445-453
84. Wohl DA, Zeng D, Stewart P, Glomb N, Alcorn T, Jones S et al (2005) Cytomegalovirus viremia, mortality, and end-organ disease among patients with AIDS receiving potent antiretroviral therapies. J Acquir Immune Defic Syndr 38:538-544
85. Wolthers KC, Bea G, Wisman P, Otto S, De Roda H, Schaft N et al (1996) T cell telomere length in HIV-1 infection. No evidence for increased CD4+ turnover. Science 274:1546-1547
86. Yang X, Stedra J, Cerny J (1996) Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice. J Exp Med 183:959-970
87. Zhang Y, Wang Y, Gilmore X, Xu K, Wyde PR, Mbawuike IN (2002) An aged mouse model for RSV infection and diminished CD8 (+) CTL responses. Exp Biol Med (Maywood.) 227:133-140
88. Zheng B, Han S, Takahashi Y, Kelsoe G (1997) Immunosenescence and germinal center reaction. Immunol Rev 160:63-77