Age-Related Impaired Type 1 T Cell Responses to Influenza: Reduced Activation Ex Vivo, Decreased Expansion in CTL Culture in Vitro, and Blunted Response to Influenza Vaccination in Vivo in the Elderly

Journal of Immunology

Volumn 172, Issue 6, 2004, Pages 3437-3446

  Deng, Yuping ^a   Jing, Yu ^a   Campbell, Ann E ^a   Gravenstein, Stefan ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G1; INFLUENZA M1 PEPTIDE; INFLUENZA VACCINE; PEPTIDE; TRIPLE VACCINE; UNCLASSIFIED DRUG;

ADULT; AGED; AGING; ANTIBODY RESPONSE; ANTIGEN PRESENTING CELL; ARTICLE; CELL SPECIFICITY; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; DRUG EFFICACY; ENZYME LINKED IMMUNOSPOT ASSAY; EX VIVO STUDY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA; INFLUENZA VACCINATION; MEMORY CELL; MORBIDITY; MORTALITY; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; STAINING; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

EID: 1542514782     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.6.3437     Document Type: Article

References (39)

1. CDC. 2000. Prevention and control of influenza: recommendations of the Advisory Committee on Immunations Practice (ACIP). Morbid. Mortal. Wkly. Rep. 49:4.
2. Fedson, D. 1987. Influenza prevention and control: past practices and future prospects. Am. J. Med. 82:42.
3. Nichol, K. L., K. L. Margolis, J. Wuorenma, and T. Von Stemberg. 1994. The efficacy and cost effectiveness of vaccination against influenza among elderly persons living in the community. N. Engl. J. Med. 331:778.
4. Castle, S. C. 2000. Clinical relevance of age-related immune dysfunction. Clin. Infect. Dis. 31:578.
5. Powers, D. C. 1993. Influenza A virus-specific cytotoxic T lymphocyte activity declines with advancing age. J. Am. Geriatr. Soc. 41:1.
6. - T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. J. Immunol. 168:5893.
7. + T-cell mechanisms in the control of respiratory virus infections. Immunol. Rev. 159:105.
8. Gerhard, W., K. Mozdzanowska, M. Furchner, G. Washko, and K. Maiese. 1997. Role of the B-cell response in recovery of mice from primary influenza virus infection. Immunol. Rev. 159:95.
9. Spiegelberg, H. L. 1974. Biological activities of immunoglobulins of different classes and subclasses. Adv. Immunol. 19:259.
10. El-Madhun, A. S., R. J. Cox, and L. R. Haaheim. 1999. The effect of age and natural priming on the IgG and IgA subclass responses after parenteral influenza vaccination, J. Infect. Dis., 180:1356.
11. Garcon, N. M., J. Groothuis, S. Brown, B. Lauer, P. Pietrobon, and H. R. Six. 1990. Serum IgG subclass antibody responses in children vaccinated with influenza virus antigens by live attenuated or inactivated vaccines. Antiviral Res. 14:109.
12. Greve, B., C. G. Magnusson, A. Melms, and R. Weissert. 2001. Immunoglobulin isotypes reveal a predominant role of type 1 immunity in multiple sclerosis. J. Neuroimmunol. 121:120.
13. Walker, W., J. M. Brewer, and J. Alexander. 1996. Lipid vesicle-entrapped influenza A antigen modulates the influenza A-specific human antibody response in immune reconstituted SCID-human mice. Eur. J. Immunol. 26:1664.
14. Morbid. Mortal. Wkly. Rep. Recomm Rep. 1999. Prevention and control of influenza: recommendations of the Advisory Committee on Influenza Practices (ACIP). 48:1.
15. Bot, A., S. Bot, and C. A. Bona. 1998. Protective role of γ interferon during the recall response to influenza virus. J. Virol. 72:6637.
16. -/- mice. J. Virol. 74:9762.
17. Powers, D. C., and R. B. Belshe. 1993. Effect of age on cytotoxic T lymphocyte memory as well as serum and local antibody responses elicited by inactivated influenza virus vaccine. J. Infect. Dis. 167:584.
18. Remarque, E. J. 1999. Influenza vaccination in elderly people. Exp. Gerontol. 34:445.
19. Fagiolo, U. 1993. Humoral and cellular immune response to influenza virus vaccination in aged humans. Aging 5:451.
20. Lennette, E., and D. Lennette. 1995. Diagnostic Proceduresfor Viral, Rickettsial, and Chlamydial Infections. American Public Health Association, Washington, DC.
21. + T cell frequencies by flow cytometry: evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency. J. Clin. Invest. 99:1739.
22. + T cells. Blood 96:2828.
23. Gravenstein, S., P. Drinka, E. H. Duthie, B. A. Miller, C. S, Brown, M. Hensley, R. Circo, E. Langer, and W. B. Ershler. 1994. Efficacy of an influenza hemagglutinin-diphtheria toxoid conjugate vaccine in elderly nursing home subjects during an influenza outbreak. J. Am. Geriatr. Soc. 42:245.
24. Ershler, W. B., and E. T. Keller. 2000. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu. Rev. Med. 51:245.
25. Powers, D. C. 1994. Effect of age on serum immunoglobulin G subclass antibody responses to inactivated influenza virus vaccine. J. Med. Virol. 43:57.
26. Lung, T. L., M. Saurwein-Teissl, W. Parson, D. Schonitzer, and B. Grubeck-Loebenstein. 2000. Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells. Vaccine 18:1606.
27. Pawelec, G., Y. Barnett, R. Forsey, D. Frasca, A. Globerson, J. McLeod, C. Caruso, C. Franceschi, T. Fulop, S. Gupta, et al. 2002. T cells and aging, January 2002 update. Front. Biosci. 7:d1056.
28. Haynes, B. F., M. L. Markert, G. D. Sempowski, D. D. Patel, and L. P. Hale. 2000. The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu. Rev. Immunol. 18:529.
29. + T cell clones in elderly humans. J. Immunol. 158:4493.
30. Khan, N., N. Shariff, M. Cobbold, R. Bruton, J. A. Ainsworth, A. J. Sinclair, L. Nayak, and P. A. Moss. 2002. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J. Immunol. 169:1984.
31. + T cells. J. Interferon Cytokine Res. 20:235.
32. + CTL activity among elderly persons and the enhancing effect of IL-12. Mech. Ageing Dev. 94:25.
33. Bruunsgaard, H., M. Pedersen, and B. K. Pedersen. 2001. Aging and proinflammatory cytokines. Curr. Opin. Hematol. 8:131.
34. Weksler. M. E. 2000. Changes in the B-cell repertoire with age. Vaccine 18:1624.
35. Bernstein, E., D. Kaye, E. Abrutyn, P. Gross, M. Dorl'man, and D. M. Murasko. 1999. Immune response to influenza vaccination in a large healthy elderly population. Vaccine 17:82.
36. Uyemura, K., S. C. Castle, and T. Makinodan. 2002. The frail elderly: role of dendritic cells in the susceptibility of infection. Mech. Ageing Dev. 123:955.
37. Looney, R. J., A. R. Falsey, E. Walsh, and D. Campbell. 2002. Effect of aging on cytokine production to resporatory syncytial virus infection. J. Infect. Dis. 185:682.
38. Effros, R. B. 2000. Long-term immunological memory against viruses. Mech Ageing Dev. 12:161.
39. Linton, P. J., and S. L. Swain. 1997. From naive to effector: alterations with aging. Mech. Ageing. Dev. 93:95.