Porcine intramuscular fat content and composition are regulated by quantitative trait loci with muscle-specific effects

Journal of Animal Science

Volumn 89, Issue 10, 2011, Pages 2963-2971

  Quintanilla, R ^a   Pena, R N ^a,c   Gallardo, D ^b   Canovas A ^a   Ramirez O ^b,d   Diaz I ^a   Noguera, J L ^a   Amills, M ^b  

^a IRTA   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c UNIVERSITY OF LLEIDA   (Spain)

^d INSTITUTE OF EVOLUTIONARY BIOLOGY CSIC UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

Fatty acid profile; Genetics of muscle lipids; Intramuscular fat; Pig; Quantitative trait locus

Indexed keywords

MICROSATELLITE DNA;

ADIPOSE TISSUE; ANIMAL; ARTICLE; BODY COMPOSITION; GENETIC SELECTION; GENETICS; LIPID METABOLISM; MALE; PHYSIOLOGY; QUANTITATIVE TRAIT LOCUS; SKELETAL MUSCLE; SWINE;

ADIPOSE TISSUE; ANIMALS; BODY COMPOSITION; LIPID METABOLISM; MALE; MICROSATELLITE REPEATS; MUSCLE, SKELETAL; QUANTITATIVE TRAIT LOCI; SELECTION, GENETIC; SWINE;

SUIDAE; SUS;

EID: 80053024611     PISSN: 00218812     EISSN: 15253163     Source Type: Journal    
DOI: 10.2527/jas.2011-3974     Document Type: Article

References (40)

1. Carrapiso, A. I., F. Bonilla, and C. Garcia. 2003. Effect of cross-breeding and rearing system on sensory characteristics of Iberian ham. Meat Sci. 65:623-629.
2. Casellas, J., J. L. Noguera, J. Reixach, I. Díaz, M. Amills, and R. Quintanilla. 2010. Bayes factor analyses of heritability for serum and muscle lipid traits in Duroc pigs. J. Anim. Sci. 88:2246-2254.
3. Cayuela, J. M., M. D. Garrido, S. J. Bañón, and J. M. Ros. 2003. Simultaneous HPLC analysis of α-tocopherol and cholesterol in fresh pig meat. J. Agric. Food Chem. 51:1120-1124.
4. Chizzolini, R., E. Novelli, and E. Zanardi. 1998. Oxidation in traditional Mediterranean meat products. Meat Sci. 49:S87-S99.
5. Churchill, G. A., and R. W. Doerge. 1994. Empirical threshold values for quantitative trait mapping. Genetics 138:963-971.
6. Clop, A., C. Óvilo, M. Pérez-Enciso, A. Cercós, A. Tomàs, A. Fernández, A. Coll, J. M. Folch, C. Barragán, I. Díaz, M. A. Oliver, L. Varona, L. Silió, A. Sànchez, and J. L. Noguera. 2003. Detection of QTL affecting fatty acid composition in the pig. Mamm. Genome 14:650-656.
7. de Koning, D. J., A. P. Rattink, B. Harlizius, J. A. van Arendonk, E. W. Brascamp, and M. A. Groenen. 2000. Genome-wide scan for body composition in pigs reveals important role of imprinting. Proc. Natl. Acad. Sci. USA 97:7947-7950.
8. Donsmark, M., J. Langfort, T. Ploug, and H. Galbo. 2002. Protein kinase C is involved in the contraction-mediated activation of hormone-sensitive lipase (HSL) in rat skeletal muscle. J. Physiol. 539(Suppl. S):98P.
9. Dumont, B. L. 1980. Carcass composition and muscle hypertrophied animals. Page 111 in Muscle Hypertrophy of Genetic Origin and Its Use To Improve Beef Production. J. W. B. King and F. Ménissier, ed. Martinus Nijhoff Publishers, The Hague, the Netherlands.
10. Gallardo, D., R. N. Pena, M. Amills, L. Varona, O. Ramírez, J. Reixach, I. Díaz, J. Tibau, J. Soler, J. M. Prat-Cuffi, J. L. Noguera, and R. Quintanilla. 2008. Mapping of quantitative trait loci for cholesterol, LDL, HDL and triglyceride serum con- centrations in pigs. Physiol. Genomics 35:199-209.
11. Gallardo, D., R. Quintanilla, L. Varona, I. Díaz, O. Ramírez, R. N. Pena, and M. Amills. 2009. Polymorphism of the pig ace- tyl-coenzyme A carboxylase α gene is associated with fatty acid composition in a Duroc commercial line. Anim. Genet. 40:410-417.
12. 2 population. Anim. Genet. 40:185-191.
13. Hamelin, M., T. Sayd, C. Chambon, J. Bouix, B. Bibé, D. Milen-Kovic, H. Leveziel, M. Georges, A. Clop, P. Marinova, and E. Laville. 2006. Proteomic analysis of ovine muscle hypertrophy. J. Anim. Sci. 84:3266-3276.
14. Harris, W. S., W. C. Poston, and C. K. Haddock. 2007. Tissue n-3 and n-6 fatty acids and risk for coronary heart disease events. Atherosclerosis 193:1-10.
15. Janovská, A., G. Hatzinikolas, M. Mano, and G. A. Wittert. 2010. The effect of dietary fat content on phospholipid fatty acid profile is muscle fiber type dependent. Am. J. Physiol. Endocrinol. Metab. 298:E779-E786.
16. Kiens, B. 2006. Skeletal muscle lipid metabolism in exercise and insulin resistance. Physiol. Rev. 86:205-243.
17. Kim, J. H., P. N. Seong, S. H. Cho, B. Y. Park, K. H. Hah, L. H. Yu, D. G. Lim, I. H. Hwang, D. H. Kim, J. L. Lee, and C. N. Ahn. 2008. Characterization of nutritional value for twenty-one pork muscles. Asian-australas. J. Anim. Sci. 21:138-144.
18. Knott, S. A. 2005. Regression-based quantitative trait loci mapping: Robust, efficient and effective. Philos. Trans. R. Soc. Lond. B Biol. Sci. 360:1435-1442.
19. Knott, S. A., J. M. Elsen, and C. S. Haley. 1996. Methods for multiple marker mapping of quantitative trait loci in half-sib populations. Theor. Appl. Genet. 93:71-80.
20. Kobayashi, M., T. Ohno, N. Hada, M. Fujiyoshi, M. Kuga, M. Nishimura, A. Murai, and F. Horio. 2010. Genetic analysis of abdominal fat distribution in SM/J and A/J mice. J. Lipid Res. 51:3463-3469.
21. Li, Y., Z. Xu, H. Li, Y. Xiong, and B. Zuo. 2010. Differential transcriptional analysis between red and white skeletal muscle of Chinese Meishan pigs. Int. J. Biol. Sci. 6:350-360.
22. Lionikas, A., R. Cheng, J. E. Lim, A. A. Palmer, and D. A. Blizard. 2010. Fine-mapping of muscle weight QTL in LG/J and SM/J intercrosses. Physiol. Genomics 42A:33-38.
23. López-Bote, C. 1998. Sustained utilization of the Iberian pig breed. Meat Sci. 49(Suppl. 1):S17-S27.
24. Mach, N., M. Devant, A. Bach, I. Díaz, M. Font, M. A. Oliver, and J. A. García. 2006. Increasing the amount of n-3 fatty acid in meat from young Holstein bulls through nutrition. J. Anim. Sci. 84:3039-3048.
25. Malek, M., J. C. Dekkers, H. K. Lee, T. J. Baas, K. Prusa, E. Huff-Lonergan, and M. F. Rothschild. 2001. A molecular genome scan analysis to identify chromosomal regions influencing economic traits in the pig. II. Meat and muscle composition. Mamm. Genome 12:637-645.
26. McDonald, B. E. 1991. Monounsaturated fatty acids and heart health. Can. Med. Assoc. J. 145:473.
27. Muñoz, G., E. Alves, A. Fernández, C. Óvilo, C. Barragán, J. Estellé, R. Quintanilla, J. M. Folch, L. Silió, M. C. Rodríguez, and A. I. Fernández. 2007. QTL detection on porcine chromosome 12 for fatty-acid composition and association analyses of the fatty acid synthase, gastric inhibitory polypeptide and acetyl- coenzyme A carboxylase α genes. Anim. Genet. 38:639-646.
28. Musunuru, K., A. Strong, M. Frank-Kamenetsky, N. E. Lee, T. Ahfeldt, K. V. Sachs, X. Li, H. Li, N. Kuperwasser, V. M. Ruda, J. P. Pirruccello, B. Muchmore, L. Prokunina-Olsson, J. L. Hall, E. E. Schadt, C. R. Morales, S. Lund-Katz, M. C. Phillips, J. Wong, W. Cantley, T. Racie, K. G. Ejebe, M. Orho-Melander, O. Melander, V. Koteliansky, K. Fitzgerald, R. M. Krauss, C. A. Cowan, S. Kathiresan, and D. J. Rader. 2010. From noncod- Muscle-specific intramuscular fat quantitative trait loci in ing variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature 466:714-719.
29. Nii, M., T. Hayashi, F. Tani, A. Niki, N. Mori, N. Fujishima-Kanaya, M. Komatsu, K. Aikawa, T. Awata, and S. Mikawa. 2006. Quantitative trait loci mapping for fatty acid composition traits in perirenal and back fat using a Japanese wild boar × Large White intercross. Anim. Genet. 37:342-347.
30. Reed, D. R., A. H. McDaniel, X. Li, M. G. Tordoff, and A. A. Bachmanov. 2006. Quantitative trait loci for individual adipose depot weights in C57BL/6ByJ × 129P3/J F2 mice. Mamm. Genome 17:1065-1077.
31. Sanchez, M. P., N. Iannuccelli, B. Basso, J. P. Bidanel, Y. Billon, G. Gandemer, H. Gilbert, C. Larzul, C. Legault, J. Riquet, D. Milan, and P. Le Roy. 2007. Identification of QTL with effects on intramuscular fat content and fatty acid composition in a Duroc × Large White cross. BMC Genet. 8:55.
32. 2 resource population. J. Anim. Sci. 81:2938-2949.
33. Seaton, G., C. S. Haley, S. A. Knott, M. Kearsey, and P. M. Visscher. 2002. QTL Express: Mapping quantitative trait loci in simple and complex pedigrees. Bioinformatics 18:339-340.
34. Stachowiak, M., K. Flisikowski, M. Szydlowski, R. Fries, and M. Switonski. 2010. Postnatal transcription profile and polymor- phism of the ADIPOR1 gene in five pig breeds. Anim. Genet. 41:97-100.
35. Switonski, M., M. Stachowiak, J. Cieslak, M. Bartz, and M. Grzes. 2010. Genetics of fat tissue accumulation in pigs: A comparative approach. J. Appl. Genet. 51:153-168.
36. Szyda, J., Z. Liu, E. Grindflek, and S. Lien. 2002. Application of a mixed inheritance model to the detection of quantitative trait loci in swine. J. Appl. Genet. 43:69-83.
37. Tyra, M., K. Ropka-Molik, R. Eckert, K. Piórkowska, and M. Oczkowicz. 2011. H-FABP and LEPR gene expression profile in skeletal muscles and liver during ontogenesis in various breeds of pigs. Domest. Anim. Endocrinol. 40:147-154.
38. Van Laere, A. S., M. Nguyen, M. Braunschweig, C. Nezer, C. Collette, L. Moreau, A. L. Archibald, C. S. Haley, N. Buys, M. Tally, G. Andersson, M. Georges, and L. Andersson. 2003. A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature 425:832-836.
39. Vidal, O., J. L. Noguera, M. Amills, L. Varona, M. Gil, N. Jiménez, G. Dávalos, J. M. Folch, and A. Sánchez. 2005. Identification of carcass and meat quality quantitative trait loci in a Landrace pig population selected for growth and leanness. J. Anim. Sci. 83:293-300.
40. Wood, J. D., M. Enser, A. V. Fisher, G. R. Nute, P. R. Sheard, R. I. Richardson, S. I. Hughes, and F. M. Whittington. 2008. Fat deposition, fatty acid composition and meat quality: A review. Meat Sci. 78:343-358.