Cell cycle-dependent cytotoxicity, G2/M phase arrest, and disruption of p34cdc2/cyclin B1 activity induced by doxorubicin in synchronized P388 cells

Molecular Pharmacology

Volumn 49, Issue 5, 1996, Pages 832-841

  Ling, Yi He ^a   El Naggar, Adel K ^a   Priebe, Waldemar ^a   Perez Soler, Roman ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN B; CYCLIN B1; DOXORUBICIN; PROTEIN KINASE; PROTEIN KINASE P 34; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL FREE SYSTEM; CELL NUCLEUS; CENTROSOME; CONTROLLED STUDY; CYTOPLASM; DEPHOSPHORYLATION; DNA DAMAGE; DRUG CYTOTOXICITY; ENZYME INHIBITION; ENZYME LOCALIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CDC2 PROTEIN KINASE; CELL COMPARTMENTATION; CELL CYCLE; CELL SURVIVAL; CYCLIN B; CYCLINS; DOXORUBICIN; LEUKEMIA P388; MICE; PHOSPHORYLATION;

EID: 0029892120     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Arcamone, F. Properties of antitumor athracyclines and new developments in their application: Cain Memorial Award Lecture. Cancer Res. 45:5995-5999 (1985).
2. Cater, S. K Adriamycin: a review. J. Natl. Cancer Inst. 55:1265-1274 (1975).
3. Davis, H. J. L., and T. E. Davis. Doxorubicin and adriamycin in cancer treatment: an analysis of the roles and limitation. Cancer Treat. Rep. 63:809-815 (1979).
4. Cummings, J., L. Anderson, N. Willmott, and J. F. Smyth. The molecular pharmacology of doxorubicin in vivo. Eur. J. Cancer 27:532-535 (1991).
5. Tewey, K. M., T. C. Rowe, L. Yang, B. D. Halligan, and L. F. Liu. Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science (Washington D. C.) 226:466-468, (1984).
6. Nigg, E. A. Targets of cyclin-dependent protein kinase. Curr. Opin. Cell Biol. 5:187-193 (1993).
7. Pines, J. Cell proliferation and control. Curr. Opin. Cell Biol. 4:144-148 (1992).
8. Pang, F., and J. W. Newport. Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes. Cell 66:731-742 (1991).
9. cdc2, cAMP-dependent protein kinase and protein kinase C at multiple sites clustered within regulatory regions. Oncogene 6:2179-2185 (1991).
10. cdc2 in mammalian cells: implications for cell cycle control and oncogenesis. Oncogene 5:795-801 (1990).
11. Lin, B. T.-Y., S. D. Gruenwald, A. Maria, W.-H. Lee, and J. Y. Wang. Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc kinase. EMBO J. 10:857-864 (1991).
12. Draetta, G., and D. Beach. Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell 54:17-26 (1988).
13. cdc2. Cell 68:787-797 (1992).
14. cdc2 kinase activity by etoposide or irradiations as a mechanism of G2 arrest in Chinese ovary cells. Cancer Res. 50:3767-3771 (1990).
15. cdc2/cyclin B. Cancer Res. 52:1823-1829 (1992).
16. O'Connor, P. M., D. K. Ferris, M. Pagano, G. Draetta, J. Pines, T. Hunter, D. L. Longo, and K. W. Kohn. G2 delay induced by nitrogen mustard in cancer cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J. Biol. Chem. 268:8298-8308:1993.
17. Muschel, R. J., H. B. Zhang, G. Iliakis, and W. G. McKenna. Cyclin B expression in HeLa cells during the G2 block induced by ionizing radiation. Cancer Res. 51:5113-5117 (1991).
18. Stein G. S., and J. L. Stein. Cell synchronization, in Cell Growth and Division: A Practical Approach (R. Buserga, ed.). IRL Press/Oxford University Press, Oxford, UK, 133-137 (1989).
19. Ling, Y. H., W. Priebe, L.-Y. Yang, T. G. Burke, Y. Pommier, and R. Perez-Soler. In vitro cytotoxicity, cellular pharmacology, and DNA lesions induced by annamycin, an anthracycline derivative with high affinity for lipid membranes. Cancer Res. 53:1583-1589,1993.
20. cdc2 protein kinase. J. Cell Biochem. 45:391-400 (1991).
21. Keyse, S. M., and E. A. Ernslie. Oxidative stress and heat shock induce a human gene encoding a pratein-tyrosine phosphatase. Nature (Lond.) 359: 644-647 (1992).
22. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254 (1976).
23. Kohn, K. W., R. A. G. Ewing, L. C. Erickson, and L. A. Zwelling. Measurement of strand breaks and crosslinks by alkaline elution, in DNA Repair: A Laboratory Manual of Research Procedures (E. C. Friedberg and P. C. Hanawalt, eds.). Marcel Dekker, New York, 379-401 (1981).
24. Traganos, F., M. Israel, R. Silber, R. Seshadri, S. Kirschenbaum, and M. Potmesil. Effects of new N-alkyl analogues of adriamycin on in vitro survival and cell cycle progression of L1210 cells. Cancer Res. 45:6273-6279 (1985).
25. cdc2 is located in both nucleus and cytoplasm: part is centrosomally associated at G2/M and enters vesicles at anaphase. EMBO J. 8:3985-3995 (1989).
26. Lee, M. G., C. J. Norbury, N. K. Spurr, and P. Nurse. Regulated expression and phosphorylation of a possible mammalian cell-cycle control protein. Nature (Lond.) 33:676-679 (1988).
27. Murray, A. W., and M. W. Kirshner. Dominoes and clocks: the union of two views of the cell cycle. Science (Washington D. C.) 246:614-621 (1989).
28. Millar, J. B. A., and P. Russell. The cdc25 M-phase inducer: an unconventional protein phosphatase. Cell 68:407-410 (1992).
29. cdc25 is a nuclear protein required for the initiation of mitosis in human cells. Proc. Natl. Acad. Sci. USA 88:10500-10504 (1991).
30. Van Den Heuvel, S., and E. Harlow. Distinct role for cyclin dependent kinases in cell cycle control. Science (Washington D. C.) 262:2050-2054 (1993).
31. Sherwood, S. W., D. F. Rush, A. L. Kung, and R. T. Schimke. Cyclin B1 expression in HeLa S3 cells studied by flow cytometry. Exp. Cell Res. 211:275-281 (1994).
32. Hartwell, L. H., and T. A. Weinert. Checkpoints: controls that ensure the order of cell cycle events. Science (Washington D. C.) 246:629-634 (1989).
33. Kohn, K. W., J. Jackman, and P. M. O'Connor. Cell cycle control and cancer chemotherapy. J. Cell Biochem. 54:440-452 (1994).
34. Jeggo, P. A., K. Caldecott, S. Pidsley, and G. R. Banks. Sensitivity of Chinese hamster ovary mutants defective in DNA double strand break repair to topoisomerase II inhibitors. Cancer Res. 49:7057-7063 (1989).
35. Weinert, T. A., and L. H. Hartwell. The RAD9 gene control cell cycle response to DNA damage in Saccharomyces cerevisiae. Science (Washington D. C.) 241:317-322 (1988).
36. cdc2 protein kinase in vertebrates. EMBO J. 10:3321-3329 (1991).
37. Hunter, T. Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 80:225-236 (1995).
38. Izumi, T., and J. L. Maller. Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase. Mol. Biol. Cell 4:1337-1350 (1994).
39. cdc2-activating kinase. Trends Biochem. Sci. 19:496-500 (1994).
40. King, R. W., P. K. Jackson, and M. W. Kirschner. Mitosis in transition. Cell 79:563-571 (1994).
41. Lundgren, K., N. Walworth, R. Booher, M. Dembski, M. Kirschner, and D. Beach. Mik and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell 64:1111-1122 (1991).
42. Dasso, M., and J. W. Newport. Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: studies in Xenopus. Cell 61:811-823 (1990).
43. Ling, Y. H., W. Priebe, and R. Perez-Soler. Apoptosis induced by anthracycline antibiotics in P388 parent and multidrug resistant cells. Cancer Res. 53:1845-1852 (1993).