Dexamethasone augments ischemia-induced extracellular accumulation of glutamate in gerbil hippocampus

European Journal of Pharmacology

Volumn 347, Issue 1, 1998, Pages 67-70

  Chen, Junfeng ^a   Adachi, Naoto ^a   Tsubota, Shinzo ^a   Nagaro, Takumi ^a   Arai, Tatsuru ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

(Gerbil); Cerebral ischemia; Dexamethasone; Glutamate; Hippocampus; Microdialysis

Indexed keywords

ASPARTIC ACID; DEXAMETHASONE; GLUTAMIC ACID; GLYCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CELL DEATH; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG EFFECT; EXTRACELLULAR SPACE; GERBIL; HIPPOCAMPUS; HYPOGLYCEMIA; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; DEXAMETHASONE; DISEASE MODELS, ANIMAL; EXTRACELLULAR SPACE; GERBILLINAE; GLUCOCORTICOIDS; GLUTAMIC ACID; HIPPOCAMPUS; HUMANS; ISCHEMIC ATTACK, TRANSIENT; MALE; PROSENCEPHALON;

EID: 0032540194     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00198-8     Document Type: Article

References (15)

1. Adachi N., Oishi R., Saeki K. Changes in the metabolism of histamine and monoamines after occlusion of the middle cerebral artery in rats. J. Neurochem. 57:1991;61-66.
2. 2+ concentration in gerbil hippocampus. J. Cereb. Blood Flow Metab. 18:1998;274-280.
3. Amakawa K., Adachi N., Liu K., Ikemune K., Fujitani T., Arai T. Effects of pre- and postischemic administration of thiopental on transmitter amino acid release and histologic outcome in gerbils. Anesthesiology. 55:1996;1422-1430.
4. Armanini M.P., Hutchins C., Stein B.A., Sapolsky R.M. Glucocorticoid endangerment of hippocampal neurons is NMDA-receptor dependent. Brain Res. 532:1990;7-12.
5. Benveniste H., Drejer J., Schousboe A., Diemer N.H. Elevation of the extracellular concentration of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 43:1984;1369-1374.
6. + gradients, and neurotransmitter amino acid levels in isolated rat brain synaptosomes. J. Neurochem. 49:1987;1229-1240.
7. Drejer J., Benveniste H., Deimer N.H., Schousboe A. Cellular origin of ischemia-induced glutamate release from brain tissue in vivo and in vitro. J. Neurochem. 45:1985;145-151.
8. Kadekaro M., Ito M., Gross P.M. Local cerebral glucose utilization is increased in acutely adrenalectomized rats. Neuroendocrinology. 47:1988;329-334.
9. Kauppinen R., Enkvist K., Holopainen I., Akerman K. Glucose deprivation depolarizes plasma membrane of cultured astrocytes and collapses transmembrane potassium and glutamate gradients. Neuroscience. 26:1988;283-290.
10. 2+ and energy levels during in vitro ischemia in the gerbil hippocampal slice. J. Neurochem. 62:1994;626-634.
11. Moghaddam B., Bolinao M.L., Stein-Behrens B., Sapolsky R. Glucocorticoids mediate the stress-induced extracellular accumulation of glutamate. Brain Res. 655:1994;251-254.
12. Sapolsky R.M. Glucocorticoids, hippocampal damage and the glutamatergic synapse. Prog. Brain Res. 86:1990;13-23.
13. Stein-Behrens B.A., Elliott E.M., Miller C.A., Schilling J.W., Newcombe R., Sapolsky R.M. Glucocorticoids exacerbate kainic acid-induced extracellular accumulation of excitatory amino acids in the rat hippocampus. J. Neurochem. 58:1992;1730-1735.
14. Stein-Behrens B.A., Lin W.J., Sapolsky R.M. Physiological elevations of glucocorticoids potentiate glutamate accumulation in the hippocampus. J. Neurochem. 63:1994;596-602.
15. Virgin C.E., Ha T., Packan D.R., Tombaugh G.C., Yang S.H., Horner C.H., Sapolsky R.M. Glucocorticoids inhibit glucose transport and glutamate uptake in hippocampal astrocytes: implications for glucocorticoid neurotoxicity. J. Neurochem. 57:1991;1422-1428.