Alzheimer's disease, amyloïd peptide and synaptic dysfunction;Maladie d'Alzheimer, peptide β-amyloïde et synapses

Medecine/Sciences

Volumn 27, Issue 8-9, 2011, Pages 733-736

  Hémar, Agnès ^a   Mulle, Christophe ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SECRETASE;

ALZHEIMER DISEASE; ANIMAL; ARTICLE; BIOLOGICAL MODEL; GENETICS; HUMAN; MAZE TEST; MEMORY DISORDER; METABOLISM; MOUSE; NERVE CELL PLASTICITY; PATHOLOGY; PHYSIOLOGY; PROTEIN PROCESSING; SYNAPSE; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; GLUTAMIC ACID; HUMANS; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; MODELS, NEUROLOGICAL; NEURONAL PLASTICITY; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPSES;

RODENTIA;

EID: 80052944913     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.1051/medsci/2011278015     Document Type: Article

References (31)

1. Hqqss C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 2007;8:101-12. (Pubitemid 46432529)
2. Palop JJ, Mucke L. Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nat Neurosci 2010;13:812-8.
3. Selkoe DJ. Alzheimer's disease is a synaptic failure. Science 2002;298:789-91. (Pubitemid 35231524)
4. Small DH, Mok SS, Bornstein JC. Alzheimer's disease and Abeta toxicity: from top to bottom. Nat Rev Neurosci 2001;2:595-8. (Pubitemid 33679833)
5. Knobloch M, Mansuy IM. Dendritic spine loss and synaptic alterations in Alzheimer's disease. Mot Neurobiol 2008;37:73-82.
6. De Strooper B, Annaert W. Proteolytic processing and cell biological functions of the amyloid precursor protein. J Cell Sci 2000;113:1857-70. (Pubitemid 30386490)
7. McGowan E, Pickford F, Kim J, et al. Abeta42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron 2005;47:191-9. (Pubitemid 41019251)
8. Marcello E, Epis R, Di Luca M. Amyloid flirting with synaptic failure: towards a comprehensive view of Alzheimer's disease pathogenesis. Eur J Pharmacol 2008;585:109-18.
9. Zheng H, Koo EH. The amyloid precursor protein: beyond amyloid. Mol Neurodegener 2006;1:5.
10. Thinakaran G, Koo EH. Amyloid precursor protein trafficking, processing, and function. J Biol Chem 2008;283:29615-9.
11. Ghosal K, Vogt DL, Liang M, et al. Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain. Proc Natl Acad Sci USA 2009;106:18367-72.
12. Walsh DM, Klyubin I, Fadeeva JV, et al. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002;416:535-9. (Pubitemid 34288854)
13. Ashe KH, Zahs KR. Probing the biology of Alzheimer's disease in mice. Neuron 2010;66:631-45.
14. Hsiao K, Chapman P, Nilsen S, et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 1996;274:99-102. (Pubitemid 26332733)
15. Lesné S, Koh MT, Kotilinek L, et al. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 2006;440:352-7.
16. Balducci C, Beeg M, Stravalaci M, et al. Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein. Proc Natl Acad Sci USA 2010;107:2295-300.
17. Shankar GM, Li S, Mehta TH, et al. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 2008;14:837-42.
18. Walsh DM, Selkoe DJ. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron 2004;44:181-93. (Pubitemid 39348839)
19. Lemere CA, Masliah E. Can Alzheimer disease be prevented by amyloid-beta immunotherapy? Wat Rev Neurol 2010;6:108-19.
20. Chapman PF, White GL, Jones MW, et al. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat Neurosci 1999;2:271-6. (Pubitemid 30491299)
21. Gureviciene I, Ikonen S, Gurevicius K, et al. Normal induction but accelerated decay of LTP in APP + PS1 transgenic mice. Neurobiol Dis 2004;15:188-95. (Pubitemid 38296749)
22. Hsia AY, Masliah E, McConlogue L, et al. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl Acad Sci USA 1999;96:3228-33. (Pubitemid 29148873)
23. Palop JJ, Mucke L. Epilepsy and cognitive impairments in Alzheimer disease. Arch Neurol 2009;66:435-40.
24. Chang EH, Savage MJ, Flood DG, et al. AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice. Proc Natl Acad Sci USA 2006;103:3410-5. (Pubitemid 43346482)
25. Hsieh H, Boehm J, Sato C, et al. AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine lass. Neuron 2006;52:831-43. (Pubitemid 44828454)
26. Snyder EM, Nong Y, Almeida CG, et al. Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci 2005;8:1051-8. (Pubitemid 41061516)
27. Li S, Hong S, Shepardson NE, et al. Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron 2009;62:788-801.
28. Lacor PN, Buniel MC, Furlow PW, et al. Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci 2007;27:796-807. (Pubitemid 46174498)
29. Wang Hy, Lee DH, D'Andrea MR, et al. Beta-Amyloid (1-42) binds to a!pha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology. J Biol Chem 2000;275:5626-32. (Pubitemid 30115201)
30. Gasparini L, Dityatev A. Beta-amyloid and glutamate receptors. Exp Neurol 2008;212:1-4.
31. Renner M, Lacor PN, Velasco PT, et al. Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5. Neuron 2010;66:739-54.