Signaling mechanisms underlying the insulinotropic effect of pituitary adenylate cyclase-activating polypeptide in HIT-T15 cells

Endocrinology

Volumn 137, Issue 7, 1996, Pages 2791-2798

  Af Klinteberg, K ^a   Karlsson, S ^a   Ahren B ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; POLYPEPTIDE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MECHANISM; EXTRACELLULAR CALCIUM; HORMONAL REGULATION; HORMONE ACTION; INSULIN LIKE ACTIVITY; INSULIN RELEASE; NONHUMAN; PRIORITY JOURNAL; TISSUE SPECIFICITY;

ANIMALS; BINDING, COMPETITIVE; CALCIUM; CELL LINE; CRICETINAE; CYCLIC AMP; CYTOPLASM; EGTAZIC ACID; FLUORESCENT DYES; FORSKOLIN; FURA-2; INOSITOL PHOSPHATES; INSULIN; ISLETS OF LANGERHANS; KINETICS; MESOCRICETUS; NEUROPEPTIDES; NEUROTRANSMITTER AGENTS; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; SIGNAL TRANSDUCTION;

EID: 0344908216     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.137.7.2791     Document Type: Article

References (37)

1. Miyata A, Arimura A, Dahl RR, Minamino N, Uehara A, Jiang L, Culler MD, Coy DH 1989 Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochem Biophys Res Commun 164:567-574
2. Miyata A, Jiang L, Dahl RR, Kitada C, Kubo K, Fujino M, Minamino N, Arimura A 1990 Isolation of a neuropeptide corresponding to the N-terminal 27 residues of the pituitary adenylate cyclase activating polypeptide with 38 residues (PACAP38). Biochem Biophys Res Commun 170:643-648
3. Kimura C, Ohkubo S, Ogi K, Hosoya M, Itoh Y, Onda H, Miyata A, Jiang L, Dahl RR, Stibbs HH, Arimura A, Fujino M 1990 A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs. Biochem Biophys Res Commun 166:81-89
4. Köves K, Arimura A, Somogyvári-Vigh A, Vigh S, Miller J 1990 Immunohistochemical demonstration of a novel hypothalamic peptide, pituitary adenylate cyclase activating-polypeptide. Endocrinology 127:264-271
5. Arimura A, Somogyvári-Vigh A, Miyata A, Mizuno K, Coy DH, Kitada C 1991 Tissue distribution of PACAP as determined by RIA: highly abundant in the rat brain and testes. Endocrinology 129: 2787-2789
6. Sundler F, Ekblad E, Absood A, Håkanson R, Köves K, Arimura A 1992 Pituitary adenylate cyclase activating peptide: a novel vasoactive intestinal peptide-like neuropeptide in the gut. Neuroscience 46:439-454
7. Uddman R, Luts A, Arimura A, Sundler F 1991 Pituitary adenylate cyclase-activating polypeptide (PACAP), a new vasoactive intestinal peptide (VIP)-like peptide in the respiratory tract. Cell Tissue Res 265:197-201
8. Arimura A 1992 Pituitary adenylate cyclase activating polypeptide (PACAP): discovery and current status of research. Regul Pept 37: 287-303
9. Shioda S, Legradi G, Leung WC, Nakajo S, Nakaya K, Arimura A 1994 Localization of pituitary adenylate cyclase-activating polypeptide and its messenger ribonucleic acid in the rat testis by light and electron microscopic immunocytochemistry and in situ hybridization. Endocrinology 135:818-825
10. Tsujii T, Ishizaka K, Winters SJ 1994 Effects of pituitary adenylate cyclase-activating polypeptide on gonadotropin secretion and subunit messenger ribonucleic acids in perifused rat pituitary cells. Endocrinology 135:826-833
11. 2+-dependent stimulatory effect of pituitary adenylate cyclase-activating polypeptide on catecholamine secretion from cultured porcine adrenal medullary chromaffin cells. Endocrinology 132:1757-1765
12. 2+ influx and cAMP. Jpn J Pharmacol 66:323-330
13. Kashimura J, Shimosegawa T, Iguchi K, Mochizuki T, Yanaihara N, Koizumi M, Toyota T 1993 The stimulatory effect and binding characteristics of PACAP27 in rat dispersed pancreatic acini. Tohoku J Exp Med 171:243-254
14. Tatsuno I, Yada T, Vigh S, Hidaka H, Arimura A 1992 Pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal pepride increase cytosolic free calcium concentration in cultured rat hippocampal neurons. Endocrinology 131:73-81
15. Hernandez A, Kimball B, Romanchuk G, Mulholland MW 1995 Pituitary adenylate cyclase-activating polypeptide stimulates neurite growth in PC12 cells. Peptides 16:927-932
16. Fridolf T, Sundler F, Ahrén B 1992 Pituitary adenylate cyclase activating polypeptide (PACAP): occurrence in rodent pancreas and effects on insulin and glucagon secretion in the mouse. Cell Tissue Res 269:275-279
17. Yada T, Sakurada M, Ihida K, Nakata M, Murata F, Arimura A, Kikuchi M 1994 Pituitary adenylate cyclase-activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet β-cells. J Biol Chem 269:1290-1293
18. De Stefanis P, Borboni P 1993 Pituitary adenylate cyclase activating polypeptide (PACAP-38) stimulates insulin release on isolated islets of Langerhans and its action is not antagonized by DBI33-50. In: Rosselin G (ed) Vasoactive Intestinal Peptide, Pituitary Adenylate Cyclase-Activating Polypeptide and Related Regulatory Peptides from Molecular Biology to Clinical Applications. World Scientific, Singapore, pp 418-423
19. Kawai K, Ohse C, Watanabe Y, Suzuki S, Yamashita K, Ohashi S 1992 Pituitary adenylate cyclase activating polypeptide stimulates insulin release from the isolated perfused rat pancreas. Life Sci 50:257-261
20. Yokota C, Kawai K, Ohashi S, Watanabe Y, Suzuki S, Yamashita K 1993 Stimulatory effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on insulin and glucagon release from the isolated perfused rat pancreas. Acta Endocrinol (Copenh) 129:473-479
21. Straub SG, Sharp GWG 1994 Evidence for a novel mechanism of action of VIP and PACAP to stimulate insulin release. Diabetologia [Suppl 1] 37:A22 (Abstract)
22. 2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion. Physiol Rev 67:1185-1248
23. Santerre RF, Cook RA, Crisel RMD, Sharp JD, Schmidt RJ, Williams DC, Wilson CP 1981 Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells. Proc Natl Acad Sci USA 78:4339-4343
24. 125I]VIF binding sites and effects of VIP on cAMP-formation in rat insulinoma (RINm5F and RIN14B) cells. Regul Pept 40:41-49
25. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ 1951 Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275
26. Kelley GG, Zawalich KC, Zawalich WS 1994 Calcium and a mitochondrial signal interact to stimulate phosphoinositide hydrolysis and insulin secretion in rat islets. Endocrinology 134:1648-1654
27. Berridge MJ, Dawson RMC, Downes CP, Heslop JP, Irvine RF 1983 Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. Biochem J 212:473-482
28. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440-3450
29. Zhang HJ, Walseth TF, Robertson RP 1989 Insulin secretion and cAMP metabolism in HIT cells. Reciprocal and serial passage-dependent relationships. Diabetes 38:44-48
30. Tanigawa K, Kashiwada J, Tamura K, Kawaguchi M, Seino Y, Kato Y 1994 Differential insulin secretory activity in rat pancreatic islets and HIT cells. Diabetes Res 26:1-11
31. Seamon K, Daly JW 1981 Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein. J Biol Chem 256:9799-9801
32. Wahl MA, Landsbeck EA, Ammon HP, Verspohl EJ 1992 Gastrin-releasing peptide: binding and functional studies in mouse pancreatic islets. Pancreas 7:345-351
33. 2+ and pancreatic B-cell function. Biochem Soc Trans 22:12-18
34. Leech CA, Holz GG, Habener JF 1995 Pituitary adenylate cyclase-activating polypeptide induces the voltage-independent activation of inward membrane currents and elevation of intracellular calcium in HIT-T15 insulinoma cells. Endocrinology 136:1530-1536
35. Ämmälä C, Ashcroft FM, Rorsman P 1993 Calcium-independent potentiation of insulin release by cyclic AMP in single β-cells. Nature 363:356-358
36. Kashiwada J, Tanigawa K, Kato Y, Tamura K 1994 Synergistic insulin release induced by glucose and carbachol is not associated with an increase in cytoplasmic free calcium levels. Endocr J 41: 677-683
37. Karlsson S, Simonsson E, Ahrén B 1995 Mechanisms of calcium mobilization induced by GRP in insulin producing HIT-T15 cells. Diabetologia [Suppl 1] 38:A119 (Abstract)