메뉴 건너뛰기




Volumn 41, Issue 10, 2011, Pages 863-873

A comparison of hepatic in vitro metabolism of T-2 toxin in rats, pigs, chickens, and carp

Author keywords

carp; Comparative metabolism; CYP3A29; liver; T 2 toxin; toxicity

Indexed keywords

CARBOXYLESTERASE; CYTOCHROME P450 3A; CYTOCHROME P450 3A29; HT 2 TOXIN; NEOSOLANIOL; T 2 TOXIN; UNCLASSIFIED DRUG;

EID: 80052872724     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2011.593206     Document Type: Article
Times cited : (47)

References (57)
  • 3
    • 77951782674 scopus 로고    scopus 로고
    • Effect of long-term feeding of T-2 and HT-2 toxin contaminated diet on the glutathione redox status and lipid peroxidation processes in common carp Cyprinus carpio L
    • Balogh K, Heincinger M, Fodor J, Mes M. (2009).Effect of long-term feeding of T-2 and HT-2 toxin contaminated diet on the glutathione redox status and lipid peroxidation processes in common carp (Cyprinus carpio L.).Acta Biologica Szegediensis, 53:23-27.
    • (2009) Acta Biologica Szegediensis , vol.53 , pp. 23-27
    • Balogh, K.1    Heincinger, M.2    Fodor, J.3    Mes, M.4
  • 5
    • 0033066222 scopus 로고    scopus 로고
    • Utility of hepatocytes to model species differences in the metabolism of loxtidine and to predict pharmacokinetic parameters in rat, dog and man
    • Bayliss MK, Bell JA, Jenner WN, Park GR, Wilson K. (1999).Utility of hepatocytes to model species differences in the metabolism of loxtidine and to predict pharmacokinetic parameters in rat, dog and man. Xenobiotica 29:253-268. (Pubitemid 29140095)
    • (1999) Xenobiotica , vol.29 , Issue.3 , pp. 253-268
    • Bayliss, M.K.1    Bell, J.A.2    Jenner, W.N.3    Park, G.R.4    Wilson, K.5
  • 6
    • 34547830857 scopus 로고    scopus 로고
    • Worldwide occurrence of mycotoxins in commodities, feeds and feed ingredients
    • DOI 10.1016/j.anifeedsci.2007.06.005, PII S0377840107002192
    • Binder EM, Tan LM, Chin LJ, Handl J, Richard J. (2007).Worldwide occurrence of mycotoxins in commodities, feeds and feed ingredients. Anim Feed Sci Tech, 137:265-282. (Pubitemid 47248172)
    • (2007) Animal Feed Science and Technology , vol.137 , Issue.3-4 , pp. 265-282
    • Binder, E.M.1    Tan, L.M.2    Chin, L.J.3    Handl, J.4    Richard, J.5
  • 8
    • 0000220947 scopus 로고
    • Deepoxy T-2 tetraol: A metabolite of T-2 toxin found in cow urine
    • Chatterjee K, Visconti A, Microcha CJ. (1986).Deepoxy T-2 tetraol: a metabolite of T-2 toxin found in cow urine. J Agric Food Chem, 34:695-697.
    • (1986) J. Agric. Food. Chem. , vol.34 , pp. 695-697
    • Chatterjee, K.1    Visconti, A.2    Microcha, C.J.3
  • 9
    • 84886618949 scopus 로고
    • Excretion and tissue distribution of radioactivity from tritium-labeled T-2 toxin in chicks
    • DOI 10.1016/0041-008X(78)90103-5
    • Chi MS, Robison TS, Mirocha CJ, Swanson SP, Shimoda W. (1978).Excretion and tissue distribution of radioactivity from tritiumlabeled T-2 toxin in chicks. Toxicol Appl Pharmacol 45:391-402. (Pubitemid 9000999)
    • (1978) Toxicology and Applied Pharmacology , vol.45 , Issue.2 , pp. 391-402
    • Chi, M.S.1    Robison, T.S.2    Mirocha, C.J.3
  • 10
    • 2542635680 scopus 로고
    • Glucuronide conjugates of T-2 toxin and metabolites in swine bile and urine
    • Corley RA, Swanson SP, Buck WB. (1985).Glucuronide conjugates of T-2 toxin and metabolites in swine bile and urine. J Agric Food Chem, 33:1085-1089.
    • (1985) J. Agric. Food Chem. , vol.33 , pp. 1085-1089
    • Corley, R.A.1    Swanson, S.P.2    Buck, W.B.3
  • 11
    • 0023262594 scopus 로고
    • Lack of hepatic microsomal metabolism of deoxynivalenol and its metabolite DOM-1
    • DOI 10.1016/0278-6915(87)90125-6
    • C ôté LM, Buck W, Jeffery E. (1987).Lack of hepatic microsomal metabolism of deoxynivalenol and its metabolite, DOM-1. Food Chem Toxicol 25:291-295. (Pubitemid 17103339)
    • (1987) Food and Chemical Toxicology , vol.25 , Issue.4 , pp. 291-295
    • Cote, L.-M.1    Buck, W.2    Jeffery, E.3
  • 12
    • 67649401662 scopus 로고    scopus 로고
    • Interactions of deoxynivalenol and lipopolysaccharides on cytotoxicity protein synthesis and metabolism of DON in porcine hepatocytes and Kupffer cell enriched hepatocyte cultures
    • Döll S, Schrickx JA, Valenta H, Dicke S, Fink-Gremmels J. (2009).Interactions of deoxynivalenol and lipopolysaccharides on cytotoxicity protein synthesis and metabolism of DON in porcine hepatocytes and Kupffer cell enriched hepatocyte cultures. Toxicol Lett 189:121-129.
    • (2009) Toxicol. Lett. , vol.189 , pp. 121-129
    • Döll, S.1    Schrickx, J.A.2    Valenta, H.3    Dicke, S.4    Fink-Gremmels, J.5
  • 13
    • 0022255652 scopus 로고
    • Inhibition of mitogen-induced blastogenesis in human lymphocytes by T-2 toxin and its metabolites
    • Forsell JH, Kateley JR, Yoshizawa T, Pestka JJ. (1985).Inhibition of mitogen-induced blastogenesis in human lymphocytes by T-2 toxin and its metabolites. Appl Environ Microbiol 49:1523-1526. (Pubitemid 15021157)
    • (1985) Applied and Environmental Microbiology , vol.49 , Issue.6 , pp. 1523-1526
    • Forsell, J.H.1    Kateley, J.R.2    Yoshizawa, T.3    Pestka, J.J.4
  • 16
    • 0019453349 scopus 로고
    • Hydrolysis of permethrin, a pyrethroid insecticide, by rainbow trout and mouse tissues in vitro: A comparative study
    • DOI 10.1016/0041-008X(91)90222-Z
    • Glickman AH, Lech JJ. (1981).Hydrolysis of permethrin, a pyrethroid insecticide, by rainbow trout and mouse tissues in vitro: a comparative study. Toxicol Appl Pharmacol 60:186-192. (Pubitemid 11060811)
    • (1981) Toxicology and Applied Pharmacology , vol.60 , Issue.2 , pp. 186-192
    • Glickman, A.H.1    Lech, J.J.2
  • 17
    • 64249164752 scopus 로고    scopus 로고
    • Transformation of trichothecene mycotoxins by microorganisms from fish digesta
    • Guan S, He J, Young C, Zhu H, Li XZ, Ji C, Zhou T. (2009).Transformation of trichothecene mycotoxins by microorganisms from fish digesta. Aquaculture, 290:290-295.
    • (2009) Aquaculture , vol.290 , pp. 290-295
    • Guan, S.1    He, J.2    Young, C.3    Zhu, H.4    Li, X.Z.5    Ji, C.6    Zhou, T.7
  • 18
    • 0036295537 scopus 로고    scopus 로고
    • Cytotoxicity assays for mycotoxins produced by Fusarium strains: A review
    • DOI 10.1016/S1382-6689(02)00020-0, PII S1382668902000200
    • Gutleb AC, Morrison E, Albertina JM. (2002).Cytotoxicity assays for mycotoxins produced by Fusarium strains: A review. Environ Toxicol Pharmacol, 11:309-320. (Pubitemid 34694011)
    • (2002) Environmental Toxicology and Pharmacology , vol.11 , Issue.3-4 , pp. 309-320
    • Gutleb, A.C.1    Morrison, E.2    Murk, A.J.3
  • 19
    • 77958120640 scopus 로고    scopus 로고
    • The individual and combined effects of deoxynivalenol and aflatoxin b 1 on primary hepatocytes of cyprinus carpio
    • He CH, Fan YH, Wang Y, Huang CY, Wang XC, Zhang HB. (2010).The individual and combined effects of deoxynivalenol and aflatoxin b(1) on primary hepatocytes of cyprinus carpio. Int J Mol Sci 11:3760-3768.
    • (2010) Int. J. Mol. Sci. , vol.11 , pp. 3760-3768
    • He, C.H.1    Fan, Y.H.2    Wang, Y.3    Huang, C.Y.4    Wang, X.C.5    Zhang, H.B.6
  • 20
    • 0032134901 scopus 로고    scopus 로고
    • Structure-function relationship of T-2 toxin and its metabolites in inducing thymic apoptosis in vivo in mice
    • Islam Z, Nagase M, Ota A, Ueda S, Yoshizawa T, Sakato N. (1998).Structure-function relationship of T-2 toxin and its metabolites in inducing thymic apoptosis in vivo in mice. Biosci Biotechnol Biochem 62:1492-1497. (Pubitemid 128475072)
    • (1998) Bioscience, Biotechnology and Biochemistry , vol.62 , Issue.8 , pp. 1492-1497
    • Islam, Z.1    Nagase, M.2    Ota, A.3    Ueda, S.4    Yoshizawa, T.5    Sakato, N.6
  • 21
    • 0012799927 scopus 로고    scopus 로고
    • T-2 and HT-2 Joint FAO/WHO expert committee on food additives 56th report safety evaluation of certain mycotoxins in food
    • JECFA WHO. Geneva Available at Accessed on March 01, 2011
    • JECFA. (2001).T-2 and HT-2. Joint FAO/WHO Expert Committee on Food additives, 56th report. Safety evaluation of certain mycotoxins in food. WHO Food additives series 47. WHO. Geneva, 419-556. Available at: http://www.inchem.org/documents/jecfa/jecmono/v47je01.htm (Accessed on March 01, 2011).
    • (2001) WHO Food Additives Series , vol.47 , pp. 419-556
  • 23
    • 0022553141 scopus 로고
    • Metabolism of T-2 toxin by rat liver carboxylesterase
    • DOI 10.1016/0006-2952(86)90111-5
    • Johnsen H, Odden E, Lie O, Johnsen BA, Fonnum F. (1986).Metabolism of T-2 toxin by rat liver carboxylesterase. Biochem Pharmacol 35:1469-1473. (Pubitemid 16038000)
    • (1986) Biochemical Pharmacology , vol.35 , Issue.9 , pp. 1469-1473
    • Johnsen, H.1    Odden, E.2    Lie, O.3
  • 24
    • 0023547206 scopus 로고
    • Comparative in vitro metabolism of T-2 toxin by hepatic microsomes prepared from phenobarbital-induced or control rats, mice, rabbits and chickens
    • DOI 10.1016/0278-6915(87)90265-1
    • Knupp CA, Swanson SP, Buck WB. (1987).Comparative in vitro metabolism of T-2 toxin by hepatic microsomes prepared from phenobarbital-induced or control rats, mice, rabbits and chickens. Food Chem Toxicol 25:859-865. (Pubitemid 18017576)
    • (1987) Food and Chemical Toxicology , vol.25 , Issue.11 , pp. 859-865
    • Knupp, C.A.1    Swanson, S.P.2    Buck, W.B.3
  • 25
    • 0023237386 scopus 로고
    • The cytochrome P-450-dependent hydroxylation of T-2 toxin in various animal species
    • DOI 10.1016/0278-6915(87)90206-7
    • Kobayashi J, Horikoshi T, Ryu JC, Tashiro F, Ishii K, Ueno Y. (1987).The cytochrome P-450-dependent hydroxylation of T-2 toxin in various animal species. Food Chem Toxicol 25:539-544. (Pubitemid 17130558)
    • (1987) Food and Chemical Toxicology , vol.25 , Issue.7 , pp. 539-544
    • Kobayashi, J.1    Horikoshi, T.2    Ryu, J.-C.3
  • 26
    • 61349092282 scopus 로고    scopus 로고
    • Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture
    • K öigs M, Mulac D, Schwerdt G, Gekle M, Humpf HU. (2009).Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture. Toxicology 258:106-115.
    • (2009) Toxicology , vol.258 , pp. 106-115
    • Köigs, M.1    Mulac, D.2    Schwerdt, G.3    Gekle, M.4    Humpf, H.U.5
  • 28
    • 70350218699 scopus 로고    scopus 로고
    • Enzymatic hydrolysis of T-2 toxin for the quantitative determination of total T-2 and HT-2 toxins in cereals
    • Lattanzio VM, Solfrizzo M, Visconti A. (2009).Enzymatic hydrolysis of T-2 toxin for the quantitative determination of total T-2 and HT-2 toxins in cereals. Anal Bioanal Chem 395:1325-1334.
    • (2009) Anal. Bioanal. Chem. , vol.395 , pp. 1325-1334
    • Lattanzio, V.M.1    Solfrizzo, M.2    Visconti, A.3
  • 30
    • 33846990104 scopus 로고    scopus 로고
    • Competitive inhibition of carcinogen-activating CYP1A1 and CYP1B1 enzymes by a standardized complex mixture of PAH extracted from coal tar
    • Mahadevan B, Marston CP, Luch A, Dashwood WM, Brooks E, Pereira C, Doehmer J, Baird WM. (2007).Competitive inhibition of carcinogen-activating CYP1A1 and CYP1B1 enzymes by a standardized complex mixture of PAH extracted from coal tar. Int J Cancer 120:1161-1168.
    • (2007) Int. J. Cancer , vol.120 , pp. 1161-1168
    • Mahadevan, B.1    Marston, C.P.2    Luch, A.3    Dashwood, W.M.4    Brooks, E.5    Pereira, C.6    Doehmer, J.7    Baird, W.M.8
  • 31
    • 0032005776 scopus 로고    scopus 로고
    • Evaluation of chemicals as inhibitors of trout cytochrome P450s
    • DOI 10.1006/taap.1997.8341
    • Miranda CL, Henderson MC, Buhler DR. (1998).Evaluation of chemicals as inhibitors of trout cytochrome P450s. Toxicol Appl Pharmacol 148:237-244. (Pubitemid 28105606)
    • (1998) Toxicology and Applied Pharmacology , vol.148 , Issue.2 , pp. 237-244
    • Miranda, C.L.1    Henderson, M.C.2    Buhler, D.R.3
  • 32
    • 0025793496 scopus 로고
    • Comparison of rainbow trout and mammalian cytochrome P450 enzymes: Evidence for structural similarity between trout P450 LMC5 and human P450IIIA4
    • Miranda CL, Wang JL, Henderson MC, Zhao X, Guengerich FP, Buhler DR. (1991).Comparison of rainbow trout and mammalian cytochrome P450 enzymes: evidence for structural similarity between trout P450 LMC5 and human P450IIIA4. Biochem Biophys Res Commun 176:558-563.
    • (1991) Biochem. Biophys. Res. Commun. , vol.176 , pp. 558-563
    • Miranda, C.L.1    Wang, J.L.2    Henderson, M.C.3    Zhao, X.4    Guengerich, F.P.5    Buhler, D.R.6
  • 33
    • 0036879595 scopus 로고    scopus 로고
    • Mycotoxin review-2 Fusarium
    • Moss MO. (2002).Mycotoxin review-2 Fusarium. Mycologist, 16:158-161.
    • (2002) Mycologist , vol.16 , pp. 158-161
    • Moss, M.O.1
  • 34
    • 0017745629 scopus 로고
    • Metabolism of trichothecene mycotoxins. I. Microsomal deacetylation of T-2 toxin in animal tissues
    • Ohta M, Ishii K, Ueno Y. (1977).Metabolism of trichothecene mycotoxins. I. Microsomal deacetylation of T-2 toxin in animal tissues. J Biochem 82:1591-1598. (Pubitemid 8240318)
    • (1977) Journal of Biochemistry , vol.82 , Issue.6 , pp. 1591-1598
    • Ohta, M.1    Ishii, K.2    Ueno, Y.3
  • 36
    • 77952709058 scopus 로고    scopus 로고
    • SCF (Scientific Committee on Food Part 5. T-2 toxin and HT-2 toxin Accessed on March 01, 2011
    • SCF (Scientific Committee on Food).(2001).Opinion on Fusarium toxins. Part 5. T-2 toxin and HT-2 toxin), http://ec.europa.eu/food/fs/sc/scf/out123-en. pdf (Accessed on March 01, 2011).
    • (2001) Opinion on Fusarium Toxins
  • 37
    • 84860220879 scopus 로고    scopus 로고
    • SCF (Scientific Committee on Food Part 6. Group evaluation of T-2 toxin, HT-2 toxin, nivalenol and deoxynivalenol Accessed on March 01, 2011
    • SCF (Scientific Committee on Food).(2002).Opinion on Fusarium toxins. Part 6. Group evaluation of T-2 toxin, HT-2 toxin, nivalenol and deoxynivalenol, http://europa.eu.int/comm/food/fs/sc/scf/out123-en.pdf (Accessed on March 01, 2011).
    • (2002) Opinion on Fusarium Toxins
  • 38
    • 0017101039 scopus 로고
    • Preparation of isolated rat liver cells
    • Seglen PO. (1976).Preparation of isolated rat liver cells. Methods Cell Biol 13:29-83.
    • (1976) Methods Cell Biol. , vol.13 , pp. 29-83
    • Seglen, P.O.1
  • 39
    • 0025969021 scopus 로고
    • Cytotoxicity of trichothecene mycotoxins isolated from Fusarium sporotrichioides MC-72083 and Fusarium sambucinum in baby hamster kidney BHK-21 cells
    • Senter LH, Sanson DR, Corley DG, Tempesta MS, Rottinghaus AA, Rottinghaus GE. (1991).Cytotoxicity of trichothecene mycotoxins isolated from Fusarium sporotrichioides (MC-72083) and Fusarium sambucinum in baby hamster kidney (BHK-21) cells. Mycopathologia 113:127-131.
    • (1991) Mycopathologia , vol.113 , pp. 127-131
    • Senter, L.H.1    Sanson, D.R.2    Corley, D.G.3    Tempesta, M.S.4    Rottinghaus, A.A.5    Rottinghaus, G.E.6
  • 40
    • 0022186670 scopus 로고
    • Measurement of protein using bicinchoninic acid
    • DOI 10.1016/0003-2697(85)90442-7
    • Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC. (1985).Measurement of protein using bicinchoninic acid. Anal Biochem 150:76-85. (Pubitemid 16258399)
    • (1985) Analytical Biochemistry , vol.150 , Issue.1 , pp. 76-85
    • Smith, P.K.1    Krohn, R.I.2    Hermanson, G.T.3
  • 41
    • 0024418612 scopus 로고
    • Cytochrome P450 forms in fish: Catalytic, immunological and sequence similarities
    • Stegeman JJ. (1989).Cytochrome P450 forms in fish: catalytic, immunological and sequence similarities. Xenobiotica 19:1093-1110. (Pubitemid 19239875)
    • (1989) Xenobiotica , vol.19 , Issue.10 , pp. 1093-1110
    • Stegeman, J.J.1
  • 42
    • 0024238373 scopus 로고
    • The role of intestinal microflora in the metabolism of trichothecene mycotoxins
    • DOI 10.1016/0278-6915(88)90021-X
    • Swanson SP, Helaszek C, Buck WB, Rood HD Jr, Haschek WM. (1988).The role of intestinal microflora in the metabolism of trichothecene mycotoxins. Food Chem Toxicol 26:823-829. (Pubitemid 19026279)
    • (1988) Food and Chemical Toxicology , vol.26 , Issue.10 , pp. 823-829
    • Swanson, S.P.1    Helaszek, C.2    Buck, W.B.3    Rood Jr., H.D.4    Haschek, W.M.5
  • 43
    • 33747491155 scopus 로고    scopus 로고
    • The interference of pharmaceuticals with endogenous and xenobiotic metabolizing enzymes in carp liver: An in-vitro study
    • Thibaut R, Schnell S, Porte C. (2006).The interference of pharmaceuticals with endogenous and xenobiotic metabolizing enzymes in carp liver: an in-vitro study. Environ Sci Technol 40:5154-5160.
    • (2006) Environ. Sci. Technol. , vol.40 , pp. 5154-5160
    • Thibaut, R.1    Schnell, S.2    Porte, C.3
  • 44
    • 0022974505 scopus 로고
    • Structure-function relationships of 12,13-epoxytrichothecene mycotoxins in cell culture: Comparison to whole animal lethality
    • DOI 10.1016/0041-0101(86)90004-8
    • Thompson WL, Wannemacher RW Jr. (1986).Structure-function relationships of 12,13-epoxytrichothecene mycotoxins in cell culture: comparison to whole animal lethality. Toxicon 24:985-994. (Pubitemid 17213181)
    • (1986) Toxicon , vol.24 , Issue.10 , pp. 985-994
    • Thompson, W.L.1    Wannemacher Jr., R.W.2
  • 45
    • 58849124556 scopus 로고    scopus 로고
    • Liquid chromatographymass spectrometry in in vitro drug metabolite screening
    • Tolonen A, Turpeinen M, Pelkonen O. (2009).Liquid chromatographymass spectrometry in in vitro drug metabolite screening. Drug Discov Today 14:120-133.
    • (2009) Drug Discov. Today , vol.14 , pp. 120-133
    • Tolonen, A.1    Turpeinen, M.2    Pelkonen, O.3
  • 46
    • 0015852644 scopus 로고
    • Comparative toxicology of trichothec mycotoxins: Inhibition of protein synthesis in animal cells
    • Ueno Y, Nakajima M, Sakai K, Ishii K, Sato N. (1973).Comparative toxicology of trichothec mycotoxins: inhibition of protein synthesis in animal cells. J Biochem 74:285-296.
    • (1973) J. Biochem. , vol.74 , pp. 285-296
    • Ueno, Y.1    Nakajima, M.2    Sakai, K.3    Ishii, K.4    Sato, N.5
  • 47
    • 0021811498 scopus 로고
    • Identification of various T-2 toxin metabolites in chicken excreta and tissues
    • Visconti A, Mirocha CJ. (1985).Identification of various T-2 toxin metabolites in chicken excreta and tissues. Appl Environ Microbiol 49:1246-1250. (Pubitemid 15056842)
    • (1985) Applied and Environmental Microbiology , vol.49 , Issue.5 , pp. 1246-1250
    • Visconti, A.1    Mirocha, C.J.2
  • 52
    • 0020445632 scopus 로고
    • 3'-Hydroxy T-2 and 3'-hydroxy HT-2 toxins: New metabolites of T-2 toxin, a trichothecene mycotoxin, in animals
    • Yoshizawa T, Sakamoto T, Ayano Y, Mirocha CJ. (1982).3'-hydroxy T-2 and 3'-OH-HT-2 561 toxins: new metabolites of T-2 toxin, a trichothecene myctoxin, in animals. Agric Biol Chem 46:2613-2615. (Pubitemid 13202474)
    • (1982) Agricultural and Biological Chemistry , vol.46 , Issue.10 , pp. 2613-2615
    • Yoshizawa, T.1    Sakamoto, T.2    Ayano, Y.3    Mirocha, C.J.4
  • 53
    • 0022370771 scopus 로고
    • Structures of deepoxytrichothecene metabolites from 3'-hydroxy HT-2 toxin and T-2 tetraol in rats
    • Yoshizawa T, Sakamoto T, Kuwamura K. (1985).Structures of deepoxytrichothecene metabolites from 3′-hydroxy HT-2 toxin and T-2 tetraol in rats. Appl Environ Microbiol 50:676-679. (Pubitemid 16244146)
    • (1985) Applied and Environmental Microbiology , vol.50 , Issue.3 , pp. 676-679
    • Yoshizawa, T.1    Sakamoto, T.2    Kuwamura, K.3
  • 54
    • 0021349157 scopus 로고
    • In vitro formation of 3'-hydroxy T-2 and 3'-hydroxy HT-2 toxins from T-2 toxin by liver homogenates from mice and monkeys
    • Yoshizawa T, Sakamoto T, Okamoto K. (1984).In vitro formation of 3′-hydroxy T-2 and 3′-hydroxy HT-2 toxins from T-2 toxin by liver homogenates from mice and monkeys. Appl Environ Microbiol 47:130-134. (Pubitemid 14186972)
    • (1984) Applied and Environmental Microbiology , vol.47 , Issue.1 , pp. 130-134
    • Yoshizawa, T.1    Sakamoto, T.2    Okamoto, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.