Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture

Toxicology

Volumn 258, Issue 2-3, 2009, Pages 106-115

  Königs, Maika ^a   Mulac, Dennis ^a   Schwerdt, Gerald ^b   Gekle, Michael ^b   Humpf, Hans Ulrich ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Apoptosis; Cytotoxicity; HT 2 toxin; Human renal proximal tubule epithelial cells (RPTEC); LC ESI MS MS; Metabolism; Mycotoxin; Normal human lung fibroblasts (NHLF); Primary cells; T 2 toxin

Indexed keywords

CASPASE 3; DRUG METABOLITE; HT 2 TOXIN; LACTATE DEHYDROGENASE; NEOSOLANIOL; T 2 TOXIN; T 2 TOXIN TETRAOL; T 2 TOXIN TRIOL; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME RELEASE; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; KIDNEY TUBULE EPITHELIUM; LUNG FIBROBLAST; METABOLITE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; XENOBIOTIC METABOLISM;

CELL LINE, TRANSFORMED; CELL SURVIVAL; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; FIBROBLASTS; HUMANS; INDICATORS AND REAGENTS; KIDNEY; KIDNEY TUBULES, PROXIMAL; LUNG; MOLECULAR STRUCTURE; T-2 TOXIN; TETRAZOLIUM SALTS; TRICHOTHECENES;

ANIMALIA; FUSARIUM;

EID: 61349092282     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.01.012     Document Type: Article

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