Effect of LIGHT adjuvant on kinetics of T-Cell responses induced by HSV-1 DNA immunization

Iranian Journal of Immunology

Volumn 8, Issue 2, 2011, Pages 76-84

  Mohammady, Masumeh Gorgian ^a   Bamdad, Taravat ^a   Parsania, Masoud ^b   Soleimanjahi, Hoorieh ^a   Pouyanfard, Somayeh ^a   Hashemi, Hamidreza ^a   Jafarabadi, Mohammad Asghari ^a  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

Activity; Cytotoxic T Lymphocytes; HSV 1; Infection; LIGHT

Indexed keywords

DNA VACCINE; GLYCOPROTEIN B; GRANZYME B; HERPES SIMPLEX VACCINE; IMMUNOLOGICAL ADJUVANT; LIGHT ADJUVANT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG DELIVERY SYSTEM; DRUG RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; IMMUNIZATION; IMMUNOGENICITY; IMMUNOSTIMULATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; SPLEEN;

EID: 80052824570     PISSN: 17351383     EISSN: 1735367X     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. van Lint A, Ayers M, Brooks AG, Coles RM, Heath WR, Carbone FR: Herpes simplex virus-specific CD8+ T cells can clear established lytic infections from skin and nerves and can partially limit the early spread of virus after cutaneous inoculation. J Immunol. 2004; 172:392-7.
2. Orr MT, Mathis MA, Lagunoff M, Sacks JA, Wilson CB. CD8 T cell control of HSV reactivation from latency is abrogated by viral inhibition of MHC class I. Cell Host Microbe. 2007; 2:172-80.
3. Evans IA, Jones CA. HSV induces an early primary Th1 CD4 T cell response in neonatal mice, but reduced CTL activity at the time of the peak adult response. Eur J Immunol. 2005; 35:1454-62.
4. Johnson AJ, Chu CF, Milligan GN. Effector CD4+ T-cell involvement in clearance of infectious herpes simplex virus type 1 from sensory ganglia and spinal cords. J Virol. 2008; 82:9678-88.
5. Mills KH. Regulatory T cells: friend or foe in immunity to infection? Nat Rev Immunol. 2004; 4:841-55.
6. Chiarella P, Massi E, De Robertis M, Fazio VM, Signori E: Strategies for effective naked-DNA vaccination against infectious diseases. Recent Pat Antiinfect Drug Discov. 2008; 3:93-101.
7. Mester JC, Twomey TA, Tepe ET, Bernstein DI. Immunity induced by DNA immunization with herpes simplex virus type 2 glycoproteins B and C. Vaccine. 1999; 18:875-83.
8. Yu Z, Karem KL, Kanangat S, Manickan E, Rouse BT: Protection by minigenes. a novel approach of DNA vaccines. Vaccine. 1998; 16:1660-7.
9. Scheerlinck JP, Casey G, McWaters P, Kelly J, Woollard D, Lightowlers MW, et al. The immune response to a DNA vaccine can be modulated by co-delivery of cytokine genes using a DNA prime-protein boost strategy. Vaccine. 2001; 19:4053-60.
10. Pan CH, Chen HW, Tao MH. Modulation of immune responses to DNA vaccines by codelivery of cytokine genes. J Formos Med Assoc. 1999; 98:722-9.
11. Shi G, Wu Y, Zhang J, Wu J. Death decoy receptor TR6/DcR3 inhibits T cell chemotaxis in vitro and in vivo. J Immunol. 2003; 171:3407-14.
12. Tamada K, Shimozaki K, Chapoval AI, Zhu G, Sica G, Flies D, et al. Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nat Med. 2000; 6:283-9.
13. Tamada K, Shimozaki K, Chapoval AI, Zhai Y, Su J, Chen SF, et al. LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. J Immunol. 2000; 164:4105-10.
14. Zou GM, Martinson J, Hu WY, Tam Y, Klingemann HG: The effect of LIGHT in inducing maturation of monocyte-derived dendritic cells from MDS patients. Cancer Immunol Immunother. 2004; 53:681-9.
15. Aggarwal BB: Signalling pathways of the TNF superfamily. a double-edged sword. Nat Rev Immunol. 2003; 3:745-56.
16. Yu KY, Kwon B, Ni J, Zhai Y, Ebner R, Kwon BS. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. J Biol Chem. 1999; 274:13733-6.
17. Granger SW, Butrovich KD, Houshmand P, Edwards WR, Ware CF. Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis. J Immunol. 2001; 167:5122-8.
18. Kober J, Leitner J, Klauser C, Woitek R, Majdic O, Stockl J, et al. The capacity of the TNF family members 4-1BBL, OX40L, CD70, GITRL, CD30L and LIGHT to costimulate human T cells. Eur J Immunol. 2008; 38:2678-88.
19. DeBenedette MA, Wen T, Bachmann MF, Ohashi PS, Barber BH, Stocking KL, et al. Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus. J Immunol. 1999; 163:4833-41.
20. Tan JT, Whitmire JK, Murali-Krishna K, Ahmed R, Altman JD, Mittler RS, et al. 4-1BB costimulation is required for protective anti-viral immunity after peptide vaccination. J Immunol. 2000; 164:2320-5.
21. Tan JT, Whitmire JK, Ahmed R, Pearson TC, Larsen CP. 4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses. J Immunol. 1999; 163:4859-68.
22. Hendriks J, Xiao Y, Rossen JW, van der Sluijs KF, Sugamura K, Ishii N, et al. During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion. J Immunol. 2005; 175:1665-76.
23. Bertram EM, Lau P, Watts TH. Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection. J Immunol. 2002; 168:3777-85.
24. Bertram EM, Dawicki W, Sedgmen B, Bramson JL, Lynch DH, Watts TH. A switch in costimulation from CD28 to 4-1BB during primary versus secondary CD8 T cell response to influenza in vivo. J Immunol. 2004; 172:981-8.
25. Mauri DN, Ebner R, Montgomery RI, Kochel KD, Cheung TC, Yu GL, et al. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. Immunity. 1998; 8:21-30.
26. Raftery MJ, Behrens CK, Muller A, Krammer PH, Walczak H, Schonrich G. Herpes simplex virus type 1 infection of activated cytotoxic T cells: Induction of fratricide as a mechanism of viral immune evasion. J Exp Med. 1999; 190:1103-14.
27. Pouyanfard S, Bamdad T, Parsania M, Hashemi H, Mohammadi MG. Impact of timing strategy of LIGHT, a new TNF superfamily on immune platform induced by HSV-1 gB DNA vaccine. Cytokine. 2010; 50:99-103.
28. Misawa K, Nosaka T, Kojima T, Hirai M, Kitamura T. Molecular cloning and characterization of a mouse homolog of human TNFSF14, a member of the TNF superfamily. Cytogenet Cell Genet. 2000; 89:89-91.
29. Bamdad T, Roostaee MH, Sadeghizadeh M, Mahboudi F, Kazemnejad A, Soleimanjahi H. Immunogenicity and protective effect of a DNA construct encoding certain neutralizing epitopes of herpes simplex virus type-1 glycoprotein B. Folia Biol (Praha). 2005; 51:109-13.
30. Smith PM, Wolcott RM, Chervenak R, Jennings SR: Control of acute cutaneous herpes simplex virus infection T cell-mediated viral clearance is dependent upon interferon-gamma (IFN-gamma). Virology. 1994; 202:76-88.
31. Rininsland FH, Helms T, Asaad RJ, Boehm BO, Tary-Lehmann M. Granzyme B ELISPOT assay for ex vivo measurements of T cell immunity. J Immunol Methods. 2000; 240:143-55.
32. Hashemi H, Bamdad T, Jamali A, Pouyanfard S, Mohammadi MG. Evaluation of humoral and cellular immune responses against HSV-1 using genetic immunization by filamentous phage particles: a comparative approach to conventional DNA vaccine. J Virol Methods. 2010; 163:440-4.
33. Gorgian Mohammadi M, Bamdad T, Parsania M, Hashemi HR, Puyanfard S. Kinetics of primary and memory cytotoxic T lymphocyte responses to herpes simplex virus 1 infection: granzyme B mediated CTL activity. Iran J Immunol. 2009; 6:22-7.
34. Ewen C, Kane KP, Shostak I, Griebel PJ, Bertram EM, Watts TH, et al. A novel cytotoxicity assay to evaluate antigen-specific CTL responses using a colorimetric substrate for Granzyme B. J Immunol Methods. 2003; 276:89-101.
35. Hassett DE, Slifka MK, Zhang J, Whitton JL: Direct ex vivo kinetic and phenotypic analyses of CD8(+) T-cell responses induced by DNA immunization. J Virol. 2000; 74:8286-91.
36. Liu F, Whitton JL, Slifka MK. The rapidity with which virus-specific CD8+ T cells initiate IFN-gamma synthesis increases markedly over the course of infection and correlates with immunodominance. J Immunol. 2004; 173:456-62.
37. Zhang Y, Ohkuri T, Wakita D, Narita Y, Chamoto K, Kitamura H, et al. Sialyl lewisx antigen-expressing human CD4+ T and CD8+ T cells as initial immune responders in memory phenotype subsets. J Leukoc Biol. 2008; 84:730-5.
38. Zhang Y, Jiang W, Fan Y, Wen J, Hao W, Qian M. Engineering enhancement of the immune response to HBV DNA vaccine in mice by the use of LIGHT gene adjuvant. J Virol Methods. 2008; 153:142-8.