Role of hepatitis B virus base core and precore/core promoter mutations on hepatocellular carcinoma in untreated older genotype C Chinese patients

Journal of Viral Hepatitis

Volumn 18, Issue 10, 2011, Pages

  Zheng, J X ^a   Zeng, Z ^a   Zheng, Y Y ^a   Yin, S J ^a   Zhang, D Y ^a   Yu, Y Y ^a   Wang, F ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

basal core promoter mutants; HBV genotypes; hepatocellular carcinoma; precore mutants

Indexed keywords

HEPATITIS B(E) ANTIGEN; VIRUS DNA;

ADULT; AGED; AGING; ARTICLE; BASAL CORE PROMOTER MUTANT; CHINESE; CHRONIC HEPATITIS; FEMALE; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; VIRUS MUTANT; VIRUS MUTATION;

ADULT; CARCINOMA, HEPATOCELLULAR; CHINA; FEMALE; GENOTYPE; HEPATITIS B CORE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; MALE; MIDDLE AGED; MUTATION; PROMOTER REGIONS, GENETIC; SEQUENCE ANALYSIS, DNA;

EID: 80052824569     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2011.01458.x     Document Type: Article

References (34)

1. Kao JH, Chen DS,. Global control of hepatitis B virus infection. Lancet Infect Dis 2002; 2: 395-403.
2. Sun Z, Ming L, Zhu X, Lu J,. Prevention and control of hepatitis B in China. J Med Virol 2002; 67: 447-450.
3. Chinese Society of Hepatology, Chinese Medical Association, Chinese Society of Infectious Diseases, Chinese Medical Association. Guideline on prevention and treatment of chronic hepatitis B in China (2005). Chin Med J (Engl) 2007; 120, 2159-2173.
4. Lavanchy D,. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 2004; 11: 97-107. (Pubitemid 38365759)
5. Yuen MF, Hou JL, Chutaputti A, Asia Pacific Working Party on Prevention of Hepatocellular Carcinoma. Hepatocellular carcinoma in the Asia pacific region. J Gastroenterol Hepatol 2009; 24, 346-353.
6. Sezaki H, Kobayashi M, Hosaka T, et al. Hepatocellular carcinoma in noncirrhotic young adult patients with chronic hepatitis B viral infection. J Gastroenterol 2004; 39: 550-556. (Pubitemid 38996897)
7. Brunetto MR, Oliveri F, Coco B, Leandro G, Colombatto P, Gorin JM,. Outcome of anti-HBe positive chronic hepatitis B in alpha-interferon treated and untreated patients: a long term cohort study. J Hepatol 2002; 36: 263-270. (Pubitemid 34146434)
8. Fattovich G, Stroffolini T, Zagni I, Donato F,. Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology 2004; 127: S35-S50. (Pubitemid 39423368)
9. Iloeje UH, Yang HI, Jen CL, You SL, Chen CJ,. Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 2006; 130: 678-686. (Pubitemid 43374518)
10. Fattovich G, Bortolotti F, Donato F,. Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors. J Hepatol 2008; 48: 335-352.
11. Kramvis A, Kew MC,. Relationship of genotypes of hepatitis B virus to mutations, disease progression and response to antiviral therapy. J Viral Hepat 2005; 12: 456-464. (Pubitemid 41224248)
12. Chu CM, Liaw YF,. Genotype C hepatitis B virus infection is associated with a higher risk of reactivation of hepatitis B and progression to cirrhosis than genotype B: a longitudinal study of hepatitis B e antigen-positive patients with normal aminotransferase levels at baseline. J Hepatol 2005; 43: 411-417.
13. Kao JH, Chen PJ, Lai MY, Chen DS,. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology 2000; 118: 554-559.
14. Fang ZL, Ling R, Wang SS, Nong J, Huang CS, Harrison TJ,. HBV core promoter mutations prevail in patients with hepatocellular carcinoma from Guangxi, China. J Med Virol 1998; 56: 18-24. (Pubitemid 28380425)
15. Baptista M, Kramvis A, Kew MC,. High prevalence of 1762T 1764A mutations in the basic core promoter of hepatitis B virus isolated from black Africans with hepatocellular carcinoma compared with asymptomatic carriers. Hepatology 1999; 29: 946-953. (Pubitemid 29109614)
16. Kao JH, Chen PJ, Lai MY, Chen DS,. Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers. Gastroenterology 2003; 124: 327-334.
17. Liu CJ, Chen BF, Chen PJ, et al. Role of hepatitis B viral load and basal core promoter mutation in hepatocellular carcinoma in hepatitis B carriers. J Infect Dis 2006; 193: 1258-1265.
18. Liu CJ, Chen BF, Chen PJ, et al. Role of hepatitis B Virus precore/core promoter mutations and serum viral load on noncirrhotic hepatocellular carcinoma: a case-control study. J Infect Dis 2006; 194: 594-599.
19. Tong MJ, Blatt LM, Kao JH, Cheng JT, Corey WG,. Basal core promoter T1762/A1764 and precore A1896 gene mutations in hepatitis B surface antigen-positive hepatocellular carcinoma: a comparison with chronic carriers. Liver Int 2007; 10: 1356-1363. (Pubitemid 350142249)
20. Buckwold VE, Xu ZC, Chen M, Benedict TS, Hsiung J,. Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J Virol 1996; 70: 5845-5851. (Pubitemid 26266795)
21. Buckwold VE, Xu ZC, Benedict TS, Hsiung J,. Effects of a frequent double-nucleotide basal core promoter mutation and its putative single-nucleotide precursor mutations on hepatitis B virus gene expression and replication. J Gen Virol 1997; 78: 2055-2065. (Pubitemid 27367694)
22. Tacke F, Gehrke C, Luedde T, Heim A, Manns MP, Trautwein C,. Basal core promoter and precore mutations in the hepatitis B virus genome enhance replication efficacy of lamivudine-resistant mutants. J Virol 2004; 78: 8524-8535. (Pubitemid 39025118)
23. Chun YK, Kim JY, Woo HJ, et al. No significant correlation exists between core promoter mutations, viral Replication, and liver damage in chronic hepatitis B infection. Hepatology 2000; 32: 1154-1162.
24. Yoo BC, Park JW, Kim HJ, Lee DH, Cha YJ, Park SM,. Precore and core promoter mutations of hepatitis B virus and hepatitis B e antigen-negative chronic hepatitis B in Korea. J Hepatol 2003; 38: 98-103. (Pubitemid 36078530)
25. Brunetto MR, Stemler M, Schodel F,. Identification of HBV variants which cannot produce precore derived HBeAg and may be responsible for severe hepatitis. Ital J Gastroenterol 1989; 21: 151-154. (Pubitemid 19206678)
26. Raimondo G, Schneider R, Stemler C, Will A,. A new hepatitis B virus variant in a chronic carrier with multiple episodes of viral reactivation and acute hepatitis. Virology 1990; 179: 64-68. (Pubitemid 20354316)
27. Yotsuyanagi H, Hino K, Tomita E, Toyoda J, Yasuda K, Iino S,. Precore and core promoter mutations, hepatitis B virus DNA levels and progressive liver injury in chronic hepatitis B. J Hepatol 2002; 37: 355-363. (Pubitemid 34969952)
28. Zeng Z, Guan L, An P, Sun S, O'Brien SJ, Winkler CA, HBV study consortium. A population-based study to investigate host genetic factors associated with hepatitis B infection and pathogenesis in the Chinese population. BMC Infect Dis 2008; 8, 1.
29. Moriyama K, Okamoto H, Tsuda F, Mayumi M,. Reduced precore transcription and enhanced core-pregenomic transcription of hepatitis B virus DNA after replacement of the precore-core promoter with sequences associated with e-antigen-seronegative persistent infections. Virology 1996; 226: 269-280. (Pubitemid 27025807)
30. Parekh S, Zoulim F, Ahn SH, et al. Genome replication, virion secretion, and e antigen expression of naturally occurring hepatitis B virus core promoter mutants. J Virol 2003; 77: 6601-6612. (Pubitemid 36666854)
31. Fang ZL, Sabin CA, Dong BQ, et al. The association of HBV core promoter double mutations (A1762T and G1764A) with viral load differs between HBeAg positive and anti-HBe positive individuals: a longitudinal analysis. J Hepatol 2009; 50: 273-280.
32. Chen CH, Changchien CS, Lee CM, et al. Combined mutations in Pre-S/Surface and core promoter/precore regions of hepatitis B virus increase the risk of hepatocellular carcinoma: a case-control study. J Infect Dis 2008; 198: 1634-1642.
33. Naugler WE, Sakurai T, Kim S, et al. Gender disparity in liver cancer due to sex differences in MyD88-Dependent IL-6 production. Science 2007; 317: 121-124. (Pubitemid 47056470)
34. Rebouissou S, Amessou M, Couchy G, et al. Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. Nature 2009; 457: 200-204.