Precore and core promoter mutations, hepatitis B virus DNA levels and progressive liver injury in chronic hepatitis B

Journal of Hepatology

Volumn 37, Issue 3, 2002, Pages 355-363

  Yotsuyanagi, Hiroshi ^a   Hino, Kunihiko ^b   Tomita, Eiichi ^b   Toyoda, Joji ^c   Yasuda, Kiyomi ^a   Iino, Shiro ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Gifu Municipal Hospital   (Japan)

^c Sapporo Kosei General Hospital   (Japan)

Author keywords

Basic core promoter; Fibrosis; Hepatitis B virus DNA; Mutant; Precore

Indexed keywords

HEPATITIS B ANTIGEN; VIRUS DNA; HEPATITIS B CORE ANTIGEN;

ADULT; ARTICLE; DISEASE COURSE; FEMALE; GENE MUTATION; GENE SEQUENCE; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LIVER FIBROSIS; LIVER INJURY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; BLOOD; GENETICS; LIVER CIRRHOSIS; MIDDLE AGED; PATHOLOGY; POINT MUTATION; VIROLOGY;

ADULT; DNA, VIRAL; FEMALE; GENOTYPE; HEPATITIS B CORE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMAN; LIVER CIRRHOSIS; MALE; MIDDLE AGE; POINT MUTATION; PROMOTER REGIONS (GENETICS); SUPPORT, NON-U.S. GOV'T; HUMANS; MIDDLE AGED;

EID: 0036708285     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(02)00180-0     Document Type: Article

References (46)

1. Seroconversion from hepatitis B e antigen to anti HBe in chronic hepatitis B virus infection
2. Seroconversion from hepatitis B e antigen to antibody in chronic type B hepatitis
3. Hepatitis B in adults
4. Long-term follow up study of asymptomatic HBsAg-positive voluntary blood donors in Austria: A clinical and histological evaluation of 242 cases
5. A long-term follow-up study of asymptomatic hepatitis B surface antigen-positive carriers in Montreal
6. The development of cirrhosis in patients with chronic type B hepatitis: A prospective study
7. Hepatitis B virus DNA levels, precore mutations, genotypes and histological activity in chronic hepatitis B
8. Core promoter mutations and genotypes in relation to viral replication and liver damage in east Asian hepatitis B virus carriers
9. The precore/core promoter mutant (T1762A1764) of hepatitis B virus: Clinical significance and an easy method for detection
10. High prevalence of 1762T 1764A mutations in the basic core promoter of hepatitis B virus isolated from black Africans with hepatocellular carcinoma compared with asymptomatic carriers
11. Mutation of nucleotide 1762 in the core promoter region during hepatitis B e seroconversion and its relation to liver damage in HBeAg + carriers
12. Hepatitis B virus core promoter sequence analysis in fulminant and chronic hepatitis B
13. Differences in the entire nucleotide sequence between hepatitis B virus genomes from carriers positive for antibody to hepatitis B e antigen with and without active disease
14. Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen
15. A new hepatitis B virus variant in a chronic carrier with multiple episodes of viral reactivation and acute hepatitis
16. Identification of HBV variants which cannot produce precore derived HBeAg and may be responsible for severe hepatitis
17. Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen
18. Detection of precore hepatitis B virus mutants in asymptomatic HBs-positive family members
19. Hepatitis B virus infection: Precore mutants and its relation to viral genotypes and core mutations
20. Hepatitis B virus genotype A rarely circulates as an HBe-minus mutant: Possible contribution of a single nucleotide in the precore region
21. Serological detection of hepatitis B virus genotypes by ELISA with monoclonal antibodies to type-specific epitopes in the preS2-region product
22. Classification of chronic viral hepatitis: A need for reassessment
23. Quantitive detection of hepatitis B virus by transcription-mediated amplification and hybridization-protection assay
24. Correlation between serum transaminase activity and virus load among patients with chronic liver disease type B
25. Association of mutations in the core promoter and precore region of hepatitis virus with fulminant and severe acute hepatitis in Japan
26. Complete genomes, phylogenetic relatedness, and structural proteins of six strains of the hepatitis B virus, four of which represent two new genotypes
27. Typing hepatitis B virus by homology in nucleotide sequence: Comparison of surface antigen subtypes
28. A new genotype of hepatitis B virus: Complete genome and phylogenetic relatedness
29. Different hepatitis B virus genotypes are associated with different mutations in the core promoter and precore regions during hepatitis B e antigen seroconversion
30. HBsAg subtypes among HBsAg carriers in Okinawa, Japan. Evidence of an important relationship in seroconversion from HBeAg to anti-HBe
31. Relationship of HBsAg subtypes with HBeAg/anti-HBe status and chronic liver disease. Part I. Analysis of 1744 HBsAg carriers
32. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B
33. A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C
34. Detection of mutations in the enhancer 2/core promoter region of hepatitis B virus in patients with chronic hepatitis B infection: Comparison with mutations in precore and core regions in relation to clinical status
35. Effects of a naturally occurring mutation in hepatitis B virus basal core promoter on precore gene expression and viral replication
36. Two core promoter mutations identified in hepatitis viral strain associated with fulminant hepatitis result in enhanced viral replication
37. Reduced precore transcription and enhanced core-pregenomic transcription of hepatitis B virus DNA after replacement of the precore-core promoter with sequences associated with e-antigen-seronegative persistent infections
38. Effects of a frequent double-nucleotide basal core promoter mutation and its putative single-nucleotide precursor mutations on hepatitis B virus gene expression and replication
39. Enhanced replication of a hepatitis B virus mutant associated with an epidemic of fulminant hepatitis
40. Hepatitis B virus strains with mutations in the core promoter in patients with fulminant hepatitis
41. Probable implication of mutations in the X open reading frame in the onset of fulminant hepatitis B
42. Hepatitis B virus unable to secrete e antigen and response to interferon in chronic hepatitis B
43. Natural course and response to interferon of chronic hepatitis B accompanied by antibody to hepatitis B e antigen
44. Wild-type and HBeAg-minus HBV fluctuations: Cause or effect of chronic hepatitis B pathogenic mechanisms?
45. Mutations of the core promoter and response to interferon treatment in chronic replicative hepatitis B
46. Core promoter mutations of hepatitis B virus for the response to interferon in e antigen-positive chronic hepatitis B