The PAS-domain kinase PASKIN: A new sensor in energy homeostasis

Cellular and Molecular Life Sciences

Volumn 66, Issue 5, 2009, Pages 876-883

  Schlafli P ^a   Borter, E ^a,b   Spielmann, P ^a   Wenger, R H ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b CYTOS BIOTECHNOLOGY AG   (Switzerland)

Author keywords

Diabetes mellitus; Glucose tolerance; Glycogen synthesis; Insulin; Metabolic syndrome; Nitrogen fixation; Protein translation; Respiration

Indexed keywords

GLUCOSE; GLYCOGEN; HEME; INSULIN; LIGAND; NITROGEN; OXYGEN; PASKIN; PHOSPHOTRANSFERASE; PROTEIN; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; ARCHAEAL PROTEIN; BACTERIAL PROTEIN; FUNGAL PROTEIN; ISOPROTEIN; PAS DOMAIN KINASES;

ANIMAL HUSBANDRY; ARCHAEBACTERIUM; AUTOPHOSPHORYLATION; BACTERIUM; BINDING SITE; CELL TYPE; CLINICAL RESEARCH; ENERGY; ENVIRONMENT; FEEDING; GLYCOGEN SYNTHESIS; HOMEOSTASIS; HUMAN; KNOCKOUT MOUSE; LIGAND BINDING; LIPID DIET; MAMMAL; METABOLIC SYNDROME X; MODEL; NONHUMAN; PANCREAS; PROTEIN DOMAIN; PROTEIN SYNTHESIS; REGULATORY MECHANISM; REVIEW; SENSOR; STRESS; SYMPTOM; TURNOVER TIME; YEAST; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; ENERGY METABOLISM; FAT INTAKE; GENETICS; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION;

ANIMALIA; MAMMALIA; MUS;

ANIMALS; ARCHAEAL PROTEINS; BACTERIAL PROTEINS; DIETARY FATS; ENERGY METABOLISM; FUNGAL PROTEINS; HOMEOSTASIS; HUMANS; INSULIN; METABOLIC SYNDROME X; MICE; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EID: 63049102010     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-009-8699-0     Document Type: Review

References (36)

1. Lowrey, P. L. and Takahashi, J. S. (2000) Genetics of the mammalian circadian system: photic entrainment, circadian pacemaker mechanisms, and posttranslational regulation. Annu. Rev. Genet. 34, 533-562.
2. Mimura, J. and Fujii-Kuriyama, Y. (2003) Functional role of AhR in the expression of toxic effects by TCDD. Biochim. Biophys. Acta 1619, 263 - 268.
3. 2-regulated gene expression. FASEB J. 16,1151-1162.
4. Chen, H., Chrast, R., Rossier, C., Gos, A., Antonarakis, S. E., Kudoh, J., Yamaki, A., Shindoh, N., Maeda, H., Minoshima, S. et al. (1995) Single-minded and Down syndrome? Nat. Genet. 10, 9-10.
5. Chrast, R., Scott, H. S., Chen, H., Kudoh, J., Rossier, C., Minoshima, S., Wang, Y., Shimizu, N. and Antonarakis, S. E. (1997) Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region. Genome Res. 7, 615-624.
6. Crews, S. T. (1998) Control of cell lineage-specific development and transcription by bHLH-PAS proteins. Genes Dev. 12, 607-620.
7. Dioum, E. M., Rutter, J., Tuckerman, J. R., Gonzalez, G., Gilles-Gonzalez, M. A. and McKnight, S. L. (2002) NPAS2: a gas-responsive transcription factor. Science 298, 2385 - 2387.
8. Ponting, C. P. and Aravind, L. (1997) PAS: a multifunctional domain family comes to light. Curr. Biol. 7, R 674-R 677.
9. Zhulin, I. B. and Taylor, B. L. (1997) PAS domain S-boxes in archaea, bacteria and sensors for oxygen and redox. Trends Biochem. Sci. 22, 331 -333.
10. Taylor, B. L. and Zhulin, I. B. (1999) PAS domains: internal sensors of oxygen, redox potential and light. Microbiol. Mol. Biol. Rev. 63, 479-506.
11. Gu, Y. Z., Hogenesch, J. B. and Bradfield, C. A. (2000) The PAS superfamily: sensors of environmental and developmental signals. Annu. Rev. Pharmacol. Toxicol. 40, 519-561.
12. Morais Cabral, J. H., Lee, A., Cohen, S. L., Chait, B. T., Li, M. and Mackinnon, R. (1998) Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. Cell 95, 649-655.
13. Sousa, E. H., Tuckerman, J. R., Gonzalez, G. and Gilles-Gonzalez, M. A. (2007) A memory of oxygen binding explains the dose response of the heme-based sensor FixL. Biochemistry 46, 6249-6257.
14. Marvin, K. A., Kerby, R. L., Youn, H., Roberts, G. P. and Burstyn, J. N. (2008) The transcription regulator RcoM-2 from Burkholderia xenovorans is a cysteine-ligated hemoprotein that undergoes a redox-mediated ligand switch. Biochemistry 47, 9016-9028.
15. Schofield, C. J. and Ratcliffe, P. J. (2004) Oxygen sensing by HIF hydroxylases. Nat. Rev. Mol. Cell. Biol. 5, 343-354.
16. Hofer, T., Spielmann, P., Stengel, P., Stier, B., Katschinski, D. M., Desbaillets, I., Gassmann, M. and Wenger, R. H. (2001) Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors. Biochem. Biophys. Res. Commun. 288, 757-764.
17. Rutter, J., Michnoff, C. H., Harper, S. M., Gardner, K. H. and McKnight, S. L. (2001) PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase. Proc. Natl. Acad. Sci. USA 98, 8991-8996.
18. Ushiro, H., Tsutsumi, T., Suzuki, K., Kayahara, T. and Nakano, K. (1998) Molecular cloning and characterization of a novel Ste20-related protein kinase enriched in neurons and transporting epithelia. Arch. Biochem. Biophys. 355, 233 -240.
19. Miao, N., Fung, B., Sanchez, R., Lydon, J., Barker, D. and Pang, K. (2000) Isolation and expression of PASK, a serine/threonine kinase, during rat embryonic development, with special emphasis on the pancreas. J. Histochem. Cytochem. 48, 1391-1400.
20. Amezcua, C. A., Harper, S. M., Rutter, J. and Gardner, K. H. (2002) Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation. Structure 10, 1349-1361.
21. Beausoleil, S. A., Jedrychowski, M., Schwartz, D., Elias, J. E., Villen, J., Li, J., Cohn, M. A., Cantley, L. C. and Gygi, S. P. (2004) Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc. Natl. Acad. Sci. USA 101, 12130-12135.
22. Rutter, J., Probst, B. L. and McKnight, S. L. (2002) Coordinate regulation of sugar flux and translation by PAS kinase. Cell 111, 17-28.
23. Smith, T. L. and Rutter, J. (2007) Regulation of glucose partitioning by PAS kinase and Ugp1 phosphorylation. Mol. Cell 26, 491 -499.
24. Grose, J. H., Smith, T. L., Sabic, H. and Rutter, J. (2007) Yeast PAS kinase coordinates glucose partitioning in response to metabolic and cell integrity signaling. EMBO J. 26,4824 - 4830.
25. Hao, H. X. and Rutter, J. (2008) The role of PAS kinase in regulating energy metabolism. IUBMB Life 60, 204-209.
26. Wilson, W. A., Skurat, A. V., Probst, B., de Paoli-Roach, A., Roach, P. J. and Rutter, J. (2005) Control of mammalian glycogen synthase by PAS kinase. Proc. Natl. Acad. Sci. USA 102, 16596-16601.
27. Eckhardt, K., Tröger, J., Reissmann, J., Katschinski, D. M., Wagner, K. F., Stengel, P., Paasch, U., Hunziker, P., Borter, E., Barth, S. et al. (2007) Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1. Cell. Physiol. Biochem. 20, 227-240.
28. Katschinski, D. M., Marti, H. H., Wagner, K. F., Shibata, J., Eckhardt, K., Martin, F., Depping, R., Paasch, U., Gassmann, M., Ledermann, B. et al. (2003) Targeted disruption of the mouse PAS domain serine/threonine kinase PASKIN. Mol. Cell. Biol. 23, 6780-6789.
29. Wenger, R. H. and Katschinski, D. M. (2005) The hypoxic testis and post-meiotic expression of PAS domain proteins. Semin. Cell. Dev. Biol. 16, 547-553.
30. Soliz, J., Soulage, C., Borter, E., van Patot, M. T. and Gassmann, M. (2008) Ventilatory responses to acute and chronic hypoxia are altered in female but not male Paskin-deficient mice. Am. J. Physiol. 295, R649-658.
31. da Silva Xavier, G., Rutter, J. and Rutter, G. A. (2004) Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose. Proc. Natl. Acad. Sci. USA 101, 8319-8324.
32. An, R., da Silva Xavier, G., Hao, H. X., Semplici, F., Rutter, J. and Rutter, G. A. (2006) Regulation by Per-Arnt-Sim (PAS) kinase of pancreatic duodenal homeobox-1 nuclear import in pancreatic beta-cells. Biochem. Soc. Trans. 34, 791 -793.
33. Borter, E., Niessen, M., Zuellig, R., Spinas, G. A., Spielmann, P., Camenisch, G. and Wenger, R. H. (2007) Glucose-stimulated insulin production in mice deficient for the PAS kinase PASKIN. Diabetes 56,113-117.
34. Hao, H. X., Cardon, C. M., Swiatek, W., Cooksey, R. C., Smith, T. L., Wilde, J., Boudina, S., Abel, E. D., McClain, D. A. and Rutter, J. (2007) PAS kinase is required for normal cellular energy balance. Proc. Natl. Acad. Sci. USA 104, 15466-15471.
35. Card, P. B., Erbel, P. J. and Gardner, K. H. (2005) Structural basis of ARNT PAS-B dimerization: use of a common β-sheet interface for hetero- and homodimerization. J. Mol. Biol. 353, 664-677.
36. Miyatake, H., Mukai, M., Park, S. Y., Adachi, S., Tamura, K., Nakamura, H., Nakamura, K., Tsuchiya, T., Iizuka, T. and Shiro, Y. (2000) Sensory mechanism of oxygen sensor FixL from Rhizobium meliloti: crystallographic, mutagenesis and resonance Raman spectroscopic studies. J. Mol. Biol. 301, 415-431.