X-ray powder diffractometry and liquid chromatography studies of sibutramine and its analogues content in herbal dietary supplements

Journal of Pharmaceutical and Biomedical Analysis

Volumn 56, Issue 5, 2011, Pages 969-975

  Stypulkowska K ^a   Blazewicz A ^a   Maurin, J ^a,b   Sarna, K ^a   Fijalek Z ^a,c  

^a National Medicines Institute   (Poland)

^b INSTITUTE OF ATOMIC ENERGY   (Poland)

^c MEDICAL UNIVERSITY OF WARSAW   (Poland)

Author keywords

Coulometric electrode array detection; N,N didesmethylsibutramine; N monodesmethylsibutramine; Sibutramine; X Ray powder diffractometry

Indexed keywords

SIBUTRAMINE;

ARTICLE; CIVILIZATION; DIET SUPPLEMENTATION; DRUG DETERMINATION; ELECTRODE; HEALTH CARE ORGANIZATION; HERBAL MEDICINE; LIQUID CHROMATOGRAPHY; MICROCAPSULE; MICROSCOPY; OBESITY; PRIORITY JOURNAL; TIME OF FLIGHT MASS SPECTROMETRY; ULTRAVIOLET RADIATION; X RAY POWDER DIFFRACTION;

CHROMATOGRAPHY, LIQUID; CYCLOBUTANES; DIETARY SUPPLEMENTS; HERBAL MEDICINE; POWDER DIFFRACTION;

EID: 80052799530     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.08.028     Document Type: Article

References (17)

1. Glick S.D., Haskew R.E., Maisonneuve I.M., Carlson J.N., Jerussi T.P. Enantioselective behavioral effects of sibutramine metabolites. Eur. J. Pharmacol. 2000, 397:93-102.
2. http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Sibutramine_107/WC500094238.pdf.
3. Chandorkar J.G., Kotwal V.B., Dhande N.S., Pachpor M.P., Pande V.V. Development and validation of high performance liquid chromatography method for analysis of sibutramine hydrochloride and its impurity. Pak. J. Pharm. Sci. 2008, 21:121-124.
4. Kim S.H., Lee J., Yoon T., Choi J., Choi D., Kima D., Kwona S.W. Simultaneous determination of anti-diabetes/anti-obesity drugs by LC/PDA, and targeted analysis of sibutramine analog in dietary supplements by LC/MS/MS. Biomed. Chromatogr. 2009, 23:1259-1265.
5. Jung J., Hermanns-Clausen M., Weinmann W. Anorectic sibutramine detected in a Chinese herbal drug for weight loss. Forensic Sci. Int. 2006, 161:221-222.
6. Strano-Rossi S., Colamonici C., Botre F. Detection of sibutramine administration: a gas chromatography/mass spectrometry study of the main urinary metabolites. Rapid Commun. Mass Spectrom. 2007, 21:79-88.
7. Ding L., Hao X., Huang X., Zhan S. A validated specific reverse phase liquid chromatographic method for the estimation of sibutramine hydrochloride monohydrate in bulk drug and capsule dosage forms. Anal. Chim. Acta 2003, 241-248.
8. Chen J., Lu W., Zhang Q., Jiang X. Determination of the active metabolite of sibutramine by liquid chromatography-electrospray ionization tandem mass spectrometry. J. Chromatogr. B 2003, 785:197-203.
9. Zou P., Oh S.S.Y., Kiang K.H., Low M.Y., Bloodworth B.C. Detection of sibutramine, its two metabolites and one analogue in a herbal product for weight loss by liquid chromatography triple quadrupole mass spectrometry and time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 2007, 21:614-618.
10. Chen Y., Zhao L., Lu F., Yu Y., Chai Y., Wu Y. Determination of synthetic drugs used to adulterate botanical dietary supplements using QTRAP LC-MS/MS. Food Addit. Contam. A 2009, 26:595-603.
11. Radhakrishna T., Narayana C.L., Rao D.S., Vyas K., Reddy G.O. LC method for the determination of assay and purity of sibutramine hydrochloride and its enantiomers by chiral chromatography. J. Pharm. Biomed. Anal. 2000, 22:627-639.
12. Bae K., Noh K., Jang K., Kim S., Yong C.S., Choi H.G., Chen J., Kang J.S., Ma E., Lee M., Shin B.S., Kwon K., Kang W. Analysis of enantiomers of sibutramine and its metabolites in rat plasma by liquid chromatography-mass spectrometry using a chiral stationary-phase column. J. Pharm. Biomed. Anal. 2009, 50:267-270.
13. Kang W., Bae K., Noh K. Enantioselective determination of sibutramine and its active metabolites in human plasma. J. Pharm. Biomed. Anal. 2010, 51:264-267.
14. Fang Q.K., Senanayake C.H., Han Z., Morency C., Grover P., Malone R.E., Bulter H., Wald S.A., Cameron T.S. First preparation of enantiomerically pure sibutramine and its major metabolite, and determination of their absolute configuration by single crystal X-ray analysis. Tetrahedron: Asymmetry 1999, 10:4477-4480.
15. Han Z., Krishnamurthy D., Pflum D., Fang Q.K., Butler H., Cameron T.S., Walda S.A., Senanayakea C.H. First practical synthesis of enantiomerically pure (R)- and (S)-desmethylsibutramine (DMS) and unambiguous determination of their absolute configuration by single-crystal X-ray analysis. Tetrahedron: Asymmetry 2002, 13:107-109.
16. Luque C.A., Rey J.A. The discovery and status of sibutramine as an anti-obesity drug. Eur. J. Pharmacol. 2002, 440:119-128.
17. International Conference on Harmonization (ICH), Topic Q2 (R1) (2009) Validation of analytical procedures: text and methodology, Geneva, http://www.emea.europa.eu/pdfs/human/ich/038195en.pdf.