Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR

Journal of Medicinal Chemistry

Volumn 54, Issue 18, 2011, Pages 6375-6393

  Carvalho, João F S ^a   Silva, M Manuel Cruz ^a,b   Moreira, João N ^a,b   Simões, Sérgio ^a,b   Sá E Melo, M Luisa ^a,b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAMIDE; ACETIC ACID; OXIME; OXYSTEROL; PRODRUG; STEROL DERIVATIVE;

ARTICLE; CANCER CELL; CELL STRAIN HEPG2; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; STEROLS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80052798129     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200803d     Document Type: Article

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