Identification of proline residues in or near the transmembrane helices of the human breast cancer resistance protein (BCRP/ABCG2) that are important for transport activity and substrate specificity

Biochemistry

Volumn 50, Issue 37, 2011, Pages 8057-8066

  Ni, Zhanglin ^a   Bikadi, Zsolt ^c   Shuster, Diana L ^a   Zhao, Chunsheng ^a,b   Rosenberg, Mark F ^a   Mao, Qingcheng ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Virtua Drug Ltd   (Hungary)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ATP-ASE ACTIVITY; CONCENTRATION-DEPENDENT; DRUG RESISTANCE; FLEXIBLE HINGES; FUNCTIONAL DOMAINS; HOECHST; HOMOLOGY MODELING; HUMAN BREAST CANCER; MEMBRANE SPANNING DOMAINS; MITOXANTRONE; MULTIDRUG RESISTANCE; NUCLEOTIDE-BINDING DOMAIN; PROLINE RESIDUES; SUBSTRATE SELECTIVITY; SUBSTRATE SPECIFICITY; TRANSMEMBRANE HELICES; TRANSPORT ACTIVITY; WILD TYPES;

AMINO ACIDS; BIOCHEMISTRY; CELL MEMBRANES; DISEASES;

SUBSTRATES;

ADENOSINE TRIPHOSPHATASE; ALANINE; BREAST CANCER RESISTANCE PROTEIN; MITOXANTRONE; PRAZOSIN; PROLINE;

AMINO ACID SUBSTITUTION; ARTICLE; CELL MEMBRANE; CONFORMATION; DRUG RESISTANCE; ENZYME ACTIVITY; ENZYME SPECIFICITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN TRANSPORT; WILD TYPE;

AMINO ACID SEQUENCE; ATP-BINDING CASSETTE TRANSPORTERS; CELL MEMBRANE; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HEK293 CELLS; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; PROLINE; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN TRANSPORT; SUBSTRATE SPECIFICITY;

EID: 80052784424     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200573t     Document Type: Article

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