Transmembrane helices 1 and 6 of the human breast cancer resistance protein (BCRP/ABCG2): Identification of polar residues important for drug transport

American Journal of Physiology - Cell Physiology

Volumn 299, Issue 5, 2010, Pages

  Ni, Zhanglin ^a   Bikadi, Zsolt ^a,b   Cai, Xiaokun ^a   Rosenberg, Mark F ^c   Mao, Qingcheng ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Virtua Drug Ltd   (Hungary)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Adenosine 5 triphosphate binding cassette efflux transporter; Multi drug resistance; Site directed mutagenesis; Structure function of adenosine 5 triphosphate binding cassette transporter

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; MUTANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CELL MEMBRANE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN STRUCTURE;

ADRENERGIC ALPHA-ANTAGONISTS; AMINO ACID SEQUENCE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; BREAST NEOPLASMS; CELL LINE; CELL MEMBRANE; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEOPLASM PROTEINS; PHARMACEUTICAL PREPARATIONS; POINT MUTATION; PRAZOSIN; PROTEIN STRUCTURE, SECONDARY; SEQUENCE ALIGNMENT;

EID: 78349300152     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00160.2010     Document Type: Article

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