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Volumn 79, Issue 3, 2008, Pages 184-191

Incretin-based therapies: A new potential treatment approach to overcome clinical inertia in type 2 diabetes

Author keywords

Clinical inertia; Incretins; Type 2 diabetes

Indexed keywords

ACARBOSE; DIPEPTIDYL PEPTIDASE IV; EXENDIN 4; GASTRIC INHIBITORY POLYPEPTIDE; GLICLAZIDE; GLIMEPIRIDE; GLIPIZIDE; GLITAZONE DERIVATIVE; GLUCAGON LIKE PEPTIDE 1; INSULIN; INSULIN DETEMIR; LIRAGLUTIDE; METFORMIN; MITIGLINIDE; PIOGLITAZONE; ROSIGLITAZONE; SITAGLIPTIN; SULFONYLUREA DERIVATIVE; TESAVEL; UNCLASSIFIED DRUG; VILDAGLIPTIN; XELEVIA; ADAMANTANE; ANTIDIABETIC AGENT; DIPEPTIDYL PEPTIDASE IV INHIBITOR; DRUG DERIVATIVE; GLYCOSYLATED HEMOGLOBIN; INCRETIN; NITRILE; PEPTIDE; PYRAZINE DERIVATIVE; PYRROLIDINE DERIVATIVE; TRIAZOLE DERIVATIVE; VENOM;

EID: 63049108672     PISSN: 03924203     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (49)

References (41)
  • 2
    • 34147109354 scopus 로고    scopus 로고
    • Relationship between patient medication adherence and subsequent clinical inertia in type 2 diabetes glycemic management
    • DOI 10.2337/dc06-2170
    • Grant R, Adams AS, Trinacty CM, Zhang F, Kleinman K, Soumerai SB, et al. Relationship between patient medication adherence and subsequent clinical inertia in type 2 diabetes glycemic management. Diabetes Care 2007; 30: 807-812 (Pubitemid 46556571)
    • (2007) Diabetes Care , vol.30 , Issue.4 , pp. 807-812
    • Grant, R.1    Adams, A.S.2    Trinacty, C.M.3    Zhang, F.4    Kleinman, K.5    Soumerai, S.B.6    Meigs, J.B.7    Ross-Degnan, D.8
  • 4
    • 14744274123 scopus 로고    scopus 로고
    • Clinical inertia in response to inadequate glycemic control: Do specialists differ from primary care physicians?
    • Shah BR, Hux JE, Laupacis A, Zinman B, van Walraven C. Clinical inertia in response to inadequate glycemic control: do specialists differ from primary care physicians? Diabetes Care 2005; 28: 600-606
    • (2005) Diabetes Care , vol.28 , pp. 600-606
    • Shah, B.R.1    Hux, J.E.2    Laupacis, A.3    Zinman, B.4    Van Walraven, C.5
  • 5
    • 3042714557 scopus 로고    scopus 로고
    • The burden of treatment failure in type 2 diabetes
    • DOI 10.2337/diacare.27.7.1535
    • Brown JB, Nichols GA, Perry A. The burden of treatment failure in type 2 diabetes. Diabetes Care 2004; 27: 1535-1540 (Pubitemid 38857422)
    • (2004) Diabetes Care , vol.27 , Issue.7 , pp. 1535-1540
    • Brown, J.B.1    Nichols, G.A.2    Perry, A.3
  • 9
    • 34249302408 scopus 로고    scopus 로고
    • Hypothesis: The "metabolic memory", the new challenge of diabetes
    • Ihnat MA, Thorpe JE, Ceriello A. Hypothesis: the "metabolic memory", the new challenge of diabetes. Diabet Med 2007; 24: 582-586
    • (2007) Diabet Med , vol.24 , pp. 582-586
    • Ihnat, M.A.1    Thorpe, J.E.2    Ceriello, A.3
  • 10
    • 41949084607 scopus 로고    scopus 로고
    • The changing landscape of type 2 diabetes: The role of incretin-based therapies in managed care outcomes
    • Triplitt C, McGill JB, Porte D Jr, Conner CS. The changing landscape of type 2 diabetes: the role of incretin-based therapies in managed care outcomes. J Manag Care Pharm 2007;13: S2-16.
    • (2007) J Manag Care Pharm , vol.13
    • Triplitt, C.1    McGill, J.B.2    Porte Jr., D.3    Conner, C.S.4
  • 12
    • 34247871323 scopus 로고    scopus 로고
    • Examining hypoglycaemic risk in diabetes: Effect of treatment and type of diabetes
    • UK Hypoglycaemia Study Group
    • UK Hypoglycaemia Study Group. Examining hypoglycaemic risk in diabetes: effect of treatment and type of diabetes. Diabetologia 2007; 50: 1140-1147
    • (2007) Diabetologia , vol.50 , pp. 1140-1147
  • 13
    • 0041666594 scopus 로고    scopus 로고
    • Frequency of severe hypoglycemia requiring emergency treatment in type 1 and type 2 diabetes: A population- Based study of health service resource use
    • DARTS/MEMO Collaboration
    • Leese GP,Wang J, Broomhall J, Kelly P, Marsden A, Morrison W, Frier BM, Morris AD; DARTS/MEMO Collaboration. Frequency of severe hypoglycemia requiring emergency treatment in type 1 and type 2 diabetes: a population- based study of health service resource use. Diabetes Care 2003; 26: 1176-1180
    • (2003) Diabetes Care , vol.26 , pp. 1176-1180
    • Leese, G.P.1    Wang, J.2    Broomhall, J.3    Kelly, P.4    Marsden, A.5    Morrison, W.6    Frier, B.M.7    Morris, A.D.8
  • 14
    • 45149131667 scopus 로고    scopus 로고
    • Effects of intensive glucose lowering in type 2 diabetes
    • Action to Control Cardiovascular Risk in Diabetes Study Group
    • Action to Control Cardiovascular Risk in Diabetes Study Group. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008; 358: 2545-2559
    • (2008) N Engl J Med , vol.358 , pp. 2545-2559
  • 15
    • 67049107345 scopus 로고    scopus 로고
    • Studio VADT (Veterans Affairs Diabetes Trial). Press release
    • Studio VADT (Veterans Affairs Diabetes Trial). Press release: http://www.diabetes.org/for-media/pr-intense-blood -glucose-control-yields-no- significant-effect-on-cvdreduction. jsp
  • 16
    • 34547161425 scopus 로고    scopus 로고
    • A review of the effects of antihyperglycaemic agents on body weight: The potential of incretin targeted therapies
    • DOI 10.1185/030079907X199691
    • Barnett A, Allsworth J, Jameson K, Mann R. A review of the effects of antihyperglycaemic agents on body weight: the potential of incretin targeted therapies. Curr Med Res Opin 2007; 23: 1493-1507 (Pubitemid 47122158)
    • (2007) Current Medical Research and Opinion , vol.23 , Issue.7 , pp. 1493-1507
    • Barnett, A.1    Allsworth, J.2    Jameson, K.3    Mann, R.4
  • 17
    • 33644798145 scopus 로고    scopus 로고
    • Resistance to insulin therapy among patients and providers: Results of the cross-national Diabetes Attitudes, Wishes, and Needs (DAWN) study
    • The International DAWN Advisory Panel
    • Peyrot M, Rubin RR, Lauritzen T, Skovlund SE, Snoek FJ, Matthews DR, et al; The International DAWN Advisory Panel. Resistance to insulin therapy among patients and providers: results of the cross-national Diabetes Attitudes, Wishes, and Needs (DAWN) study. Diabetes Care 2005; 28: 2673-2679
    • (2005) Diabetes Care , vol.28 , pp. 2673-2679
    • Peyrot, M.1    Rubin, R.R.2    Lauritzen, T.3    Skovlund, S.E.4    Snoek, F.J.5    Matthews, D.R.6
  • 18
    • 33746391488 scopus 로고    scopus 로고
    • A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-Naïve people with type 2 diabetes
    • DOI 10.2337/dc05-1365
    • Hermansen K, Davies M, Derezinski T, Martinez Ravn G, Clauson P, Home P. A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetes. Diabetes Care 2006; 29: 1269-1274 (Pubitemid 44125921)
    • (2006) Diabetes Care , vol.29 , Issue.6 , pp. 1269-1274
    • Hermansen, K.1    Davies, M.2    Derezinski, T.3    Ravn, G.M.4    Clauson, P.5    Home, P.6
  • 19
    • 6944244979 scopus 로고    scopus 로고
    • Insulin detemir and insulin aspart: A promising basal-bolus regimen for type 2 diabetes
    • DOI 10.1016/j.diabres.2004.03.003, PII S0168822704000695
    • Raslová K, Bogoev M, Raz I, Leth G, Gall MA, Hâncu N. Insulin detemir and insulin aspart: a promising basal-bolus regimen for type 2 diabetes. Diabetes Res Clin Pract 2004; 66: 193-201. (Pubitemid 39469347)
    • (2004) Diabetes Research and Clinical Practice , vol.66 , Issue.2 , pp. 193-201
    • Raslova, K.1    Bogoev, M.2    Raz, I.3    Leth, G.4    Gall, M.-A.5    Hancu, N.6
  • 20
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998; 352: 837-853
    • (1998) Lancet , vol.352 , pp. 837-853
  • 22
    • 33845405222 scopus 로고    scopus 로고
    • Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    • ADOPT Study Group
    • Kahn SE, Haffner SM, Heise MA, Herman WH, Holman RR, Jones NP, et al; ADOPT Study Group. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med 2006; 355: 2427-2443
    • (2006) N Engl J Med , vol.355 , pp. 2427-2443
    • Kahn, S.E.1    Haffner, S.M.2    Heise, M.A.3    Herman, W.H.4    Holman, R.R.5    Jones, N.P.6
  • 23
    • 33748748206 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: A randomised controlled trial
    • DREAM (Diabetes REduction Assessment with ramipril and rosiglitazone Medication) Trial Investigators
    • DREAM (Diabetes REduction Assessment with ramipril and rosiglitazone Medication) Trial Investigators, Gerstein HC, Yusuf S, Bosch J, Pogue J, Sheridan P, Dinccag N et al. Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. Lancet 2006; 368: 1096-1105
    • (2006) Lancet , vol.368 , pp. 1096-1105
    • Gerstein, H.C.1    Yusuf, S.2    Bosch, J.3    Pogue, J.4    Sheridan, P.5    Dinccag, N.6
  • 24
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • DOI 10.1016/S0140-6736(06)69705-5, PII S0140673606697055
    • Drucker DJ, Nauck MA. The incretin system: glucagonlike peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006; 368: 1696-1705 (Pubitemid 46048557)
    • (2006) Lancet , vol.368 , Issue.9548 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 25
    • 44949134945 scopus 로고    scopus 로고
    • Exploiting the antidiabetic properties of incretins to treat type 2 diabetes mellitus: Glucagon-like peptide 1 receptor agonists or insulin for patients with inadequate glycemic control?
    • Van Gaal LF, Gutkin SW, Nauck MA. Exploiting the antidiabetic properties of incretins to treat type 2 diabetes mellitus: glucagon-like peptide 1 receptor agonists or insulin for patients with inadequate glycemic control? Eur J Endocrinol 2008; 158: 773-784
    • (2008) Eur J Endocrinol , vol.158 , pp. 773-784
    • Van Gaal, L.F.1    Gutkin, S.W.2    Nauck, M.A.3
  • 26
    • 0036373430 scopus 로고    scopus 로고
    • Defective amplification of the late phase insulin response to glucose by gip in obese type ii diabetic patients
    • DOI 10.1007/s00125-002-0878-6
    • Vilsboll T, Krarup T, Madsbad S, Holst JJ. Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients. Diabetologia 2002; 45: 1111-1119 (Pubitemid 34985287)
    • (2002) Diabetologia , vol.45 , Issue.8 , pp. 1111-1119
    • Vilsboll, T.1    Krarup, T.2    Madsbad, S.3    Holst, J.4
  • 27
    • 34447267513 scopus 로고    scopus 로고
    • Efficacy and safety of incretin therapy in type 2 diabetes: Systematic review and meta-analysis
    • DOI 10.1001/jama.298.2.194
    • Amori RE, Lau J, Pittas AG. Efficacy and Safety of Incretin Therapy in Type 2 Diabetes Systematic Review and Meta-analysis. JAMA 2007; 298: 194-206. (Pubitemid 47057766)
    • (2007) Journal of the American Medical Association , vol.298 , Issue.2 , pp. 194-206
    • Amori, R.E.1    Lau, J.2    Pittas, A.G.3
  • 28
    • 38349163934 scopus 로고    scopus 로고
    • Exenatide (Byetta). Available at the website
    • U.S. Food and Drug Administration. Information for healthcare professionals. Exenatide (Byetta). Available at the website http://www.fda.gov/ cder/drug/InfoSheets/HCP/exenatide2008HCP.htm
    • Information for Healthcare Professionals
  • 29
    • 34249891874 scopus 로고    scopus 로고
    • Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes
    • DOI 10.2337/dc06-2375
    • Kim D, MacConell L, Zhuang D, Kothare PA, Trautmann M, Fineman M, et al. Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes. Diabetes Care 2007; 30: 1487-1493 (Pubitemid 46871159)
    • (2007) Diabetes Care , vol.30 , Issue.6 , pp. 1487-1493
    • Kim, D.1    MacConell, L.2    Zhuang, D.3    Kothare, P.A.4    Trautmann, M.5    Fineman, M.6    Taylor, K.7
  • 30
    • 56249125081 scopus 로고    scopus 로고
    • Exenatide once weekly results in significantly greater improvements in glycemic control compared to exenatide twice daily in patients with type 2 diabetes
    • Drucker DJ, Buse JB, Taylor K, Kendall B, Trautmann M, Zhuang D, et al. Exenatide once weekly results in significantly greater improvements in glycemic control compared to exenatide twice daily in patients with type 2 diabetes. Diabetes 2008; 57 (Suppl 1): A33.
    • (2008) Diabetes , vol.57 , Issue.SUPPL. 1
    • Drucker, D.J.1    Buse, J.B.2    Taylor, K.3    Kendall, B.4    Trautmann, M.5    Zhuang, D.6
  • 31
    • 67049168654 scopus 로고    scopus 로고
    • Liraglutide added to a sulphonylurea (SU) offers significantly better glycaemic control and favourable weight change compared with rosiglitazone and SU combination therapy in T2D
    • Marre M, Shaw J, Brandle M,Wan Bebakar WM, Kamaruddin NA, Strand J, et al. Liraglutide added to a sulphonylurea (SU) offers significantly better glycaemic control and favourable weight change compared with rosiglitazone and SU combination therapy in T2D. Diabetologia 2008; 51 (Suppl. 1): P897.
    • (2008) Diabetologia , vol.51 , Issue.SUPPL. 1
    • Marre, M.1    Shaw, J.2    Brandle, M.3    Wan Bebakar, W.M.4    Kamaruddin, N.A.5    Strand, J.6
  • 32
    • 67649318960 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, in type 2 diabetes provides similar glycemic control with reduced body weight compared with glimepiride when added to metformin
    • Hermansenn K, Nauck MA, Frid A, Shah NS, Tankova T, Mitha IH, et al. Liraglutide, a once-daily human GLP-1 analogue, in type 2 diabetes provides similar glycemic control with reduced body weight compared with glimepiride when added to metformin. Diabetologia 2008; 51 (Suppl. 1): P895.
    • (2008) Diabetologia , vol.51 , Issue.SUPPL. 1
    • Hermansenn, K.1    Nauck, M.A.2    Frid, A.3    Shah, N.S.4    Tankova, T.5    Mitha, I.H.6
  • 33
    • 67649356613 scopus 로고    scopus 로고
    • Significantly better glycaemic control and weight reduction with liraglutide, a once-daily human GLP-1 analogue, compared with glimepiride: All as monotherapy in type 2 diabetes
    • Garber A, Henry R, Ratner R, Garcia Hernandez P, Rodriguez Pattzi HM, Olvera-Alvarez I et al. Significantly better glycaemic control and weight reduction with liraglutide, a once-daily human GLP-1 analogue, compared with glimepiride: all as monotherapy in type 2 diabetes. Diabetologia 2008;51(Suppl. 1): P896.
    • (2008) Diabetologia , vol.51 , Issue.SUPPL. 1
    • Garber, A.1    Henry, R.2    Ratner, R.3    Garcia Hernandez, P.4    Rodriguez Pattzi, H.M.5    Olvera-Alvarez, I.6
  • 34
    • 67049153527 scopus 로고    scopus 로고
    • Effect of the GLP-1 analogue liraglutide on glycaemic control and weight reduction in patients on metformin and rosiglitazone: A randomized double-blind placebo-controlled trial
    • Zinman B, Gerich J, Buse J, Lewin A, Schwartz SL, Raskin P, et al. Effect of the GLP-1 analogue liraglutide on glycaemic control and weight reduction in patients on metformin and rosiglitazone: a randomized double-blind placebo-controlled trial. Diabetologia 2008; 51 (Suppl. 1): P898.
    • (2008) Diabetologia , vol.51 , Issue.SUPPL. 1
    • Zinman, B.1    Gerich, J.2    Buse, J.3    Lewin, A.4    Schwartz, S.L.5    Raskin, P.6
  • 35
    • 67049153526 scopus 로고    scopus 로고
    • Significantly better glycaemic control/ weight reduction with human GLP-1 analogue liraglutide, than with insulin glargine: All as add-on to metformin + sulphonylurea in type 2 diabetes
    • Russel-Jones D, Vaag A, Schmitz O, Sethi B, Lalic NM, Antic S, et al. Significantly better glycaemic control/ weight reduction with human GLP-1 analogue liraglutide, than with insulin glargine: all as add-on to metformin + sulphonylurea in type 2 diabetes. Diabetologia 2008; 51 (Suppl. 1): OP148.
    • (2008) Diabetologia , vol.51 , Issue.SUPPL. 1
    • Russel-Jones, D.1    Vaag, A.2    Schmitz, O.3    Sethi, B.4    Lalic, N.M.5    Antic, S.6
  • 36
    • 67049122423 scopus 로고    scopus 로고
    • Liraglutide, a human GLP-1 analogue, reduces bodyweight in subjects with type 2 diabetes, irrespective of body mass index at baseline
    • Schmitz O, Russel-Jones D, Shaw J, Brandle M, Matthews D, Frid A, et al. Liraglutide, a human GLP-1 analogue, reduces bodyweight in subjects with type 2 diabetes, irrespective of body mass index at baseline. Diabetologia 2008; 51 (Suppl. 1): P888
    • (2008) Diabetologia , vol.51 , Issue.SUPPL. 1
    • Schmitz, O.1    Russel-Jones, D.2    Shaw, J.3    Brandle, M.4    Matthews, D.5    Frid, A.6
  • 37
    • 70349142547 scopus 로고    scopus 로고
    • Liraglutide, a human GLP-1 analogue, reduces systolic blood pressure in subjects with type 2 diabetes
    • Colagiuri S, Frid A, Zdravkovic M, Le Thi TD, Vaag A, Garber A, et al. Liraglutide, a human GLP-1 analogue, reduces systolic blood pressure in subjects with type 2 diabetes. Diabetologia 2008; 51 Suppl 1: P899.
    • (2008) Diabetologia , vol.51 , Issue.SUPPL. 1
    • Colagiuri, S.1    Frid, A.2    Zdravkovic, M.3    Le Thi, T.D.4    Vaag, A.5    Garber, A.6
  • 38
    • 70349107886 scopus 로고    scopus 로고
    • Liraglutide, a human GLP-1 analogue, significantly improves beta-cell function in subjects with type 2 diabetes
    • Matthews DR, Marre M, Le Thi TD, Zdravkovic M, Simo R, Garber A, et al. Liraglutide, a human GLP-1 analogue, significantly improves beta-cell function in subjects with type 2 diabetes. Diabetologia 2008;51 (Suppl. 1): P892
    • (2008) Diabetologia , vol.51 , Issue.SUPPL. 1
    • Matthews, D.R.1    Marre, M.2    Le Thi, T.D.3    Zdravkovic, M.4    Simo, R.5    Garber, A.6
  • 39
    • 33845472504 scopus 로고    scopus 로고
    • Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes
    • Sitagliptin Study 021 Group
    • Aschner P, Kipnes MS, Lunceford JK, Sanchez M, Mickel C, Williams-Herman DE; Sitagliptin Study 021 Group. Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care 2006; 29: 2632-2637
    • (2006) Diabetes Care , vol.29 , pp. 2632-2637
    • Aschner, P.1    Kipnes, M.S.2    Lunceford, J.K.3    Sanchez, M.4    Mickel, C.5    Williams-Herman, D.E.6
  • 40
    • 33845489598 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus
    • Sitagliptin Study 023 Group
    • Raz I, Hanefeld M, Xu L, Caria C,Williams-Herman D, Khatami H; Sitagliptin Study 023 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia 2006; 49: 2564-2571
    • (2006) Diabetologia , vol.49 , pp. 2564-2571
    • Raz, I.1    Hanefeld, M.2    Xu, L.3    Caria, C.4    Williams-Herman, D.5    Khatami, H.6
  • 41
    • 53749085064 scopus 로고    scopus 로고
    • Special Features: Incretin-Based Therapies in Type 2 Diabetes Mellitus
    • in press
    • Chia CW, Egan JM. Special Features: Incretin-Based Therapies in Type 2 Diabetes Mellitus. J Clin Endocrinol Metab 2008 (in press)
    • (2008) J Clin Endocrinol Metab
    • Chia, C.W.1    Egan, J.M.2


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