PTEN restoration and PIK3CB knockdown synergistically suppress glioblastoma growth in vitro and in xenografts

Journal of Neuro-Oncology

Volumn 104, Issue 1, 2011, Pages 155-167

  Chen, Hongbo ^a   Mei, Lin ^a   Zhou, Lanzhen ^a   Shen, Xiaomeng ^a   Guo, Caiping ^a   Zheng, Yi ^a   Zhu, Huijun ^a   Zhu, Yongqiang ^a   Huang, Laiqiang ^a  

^a TSINGHUA UNIVERSITY   (China)

Author keywords

Gene therapy; Glioblastoma; PIK3CA; PIK3CB; PTEN

Indexed keywords

CASPASE; INHIBITOR OF APOPTOSIS PROTEIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN PIK3CA; PROTEIN PIK3CB; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GENE THERAPY; CANCER INHIBITION; CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME PHOSPHORYLATION; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PROTEIN DEPLETION; PROTEIN TARGETING; SUBCUTANEOUS TISSUE TUMOR; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; MALE; MICE; MICE, NUDE; MODELS, BIOLOGICAL; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; PTEN PHOSPHOHYDROLASE; RNA, SMALL INTERFERING; TIME FACTORS; TRANSPLANTATION, HETEROLOGOUS;

EID: 80052705340     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-010-0492-2     Document Type: Article

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