Vitamin B6 in pLants: More than meets the eye

Advances in Botanical Research

Volumn 59, Issue , 2011, Pages 1-38

  Fitzpatrick, Teresa B ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Antioxidant; Cofactor; Enzyme; Glutamine amidotransferase; Stress response; Vitamin B6

Indexed keywords

EID: 80052696807     PISSN: 00652296     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-385853-5.00006-4     Document Type: Chapter

References (115)

1. Asensi-Fabado M.A., Munné-Bosch S. Vitamins in plants: Occurrence, biosynthesis and antioxidant function. Trends in Plant Sciences 2010, 15:582-592.
2. Banks J., Cane D.E. Biosynthesis of vitamin B6: Direct identification of the product of the PdxA-catalyzed oxidation of 4-hydroxy-L-threonine-4-phosphate using electrospray ionization mass spectrometry. Bioorganic & Medicinal Chemistry Letters 2004, 14:1633-1636.
3. Belitsky B.R. Physical and enzymological interaction of Bacillus subtilis proteins required for de novo pyridoxal 5'-phosphate biosynthesis. Journal of Bacteriology 2004, 186:1191-1196.
4. Bilski P., Li M.Y., Ehrenshaft M., Daub M.E., Chignell C.F. Vitamin B6 (Pyridoxine) and its derivatives are efficient singlet oxygen quenchers and potential fungal antioxidants. Photochemistry and Photobiology 2000, 71:129-134.
5. Brosnan J.T., Brosnan M.E. The sulfur-containing amino acids: An overview. The Journal of Nutrition 2006, 136:1636S-1640S.
6. Burns J.J., Conney A.H. Water-soluble vitamins. Annual Review of Biochemistry 1960, 29:413-436.
7. Burns K.E., Xiang Y., Kinsland C.L., McLafferty F.W., Begley T.P. Reconstitution and biochemical characterization of a new pyridoxal-5'-phosphate biosynthetic pathway. Journal of the American Chemical Society 2005, 127:3682-3683.
8. Cane D.E., Hsiung Y., Cornish J.A., Robinson J.K., Spenser I.D. Biosynthesis of vitamin B6: The oxidation of 4-(phosphohydroxy)-L-threonine by PdxA. Journal of the American Chemical Society 1998, 120:1936-1937.
9. Cane D.E., Du S., Robinson J.K., Hsiung Y., Spenser I.D. Biosynthesis of vitamin B6: Enzymatic conversion of 1-deoxy-D-xylulose-5-phosphate to pyridoxol phosphate. Journal of the American Chemical Society 1999, 121:7722-7723.
10. Chen H., Xiong L. Pyridoxine is required for post-embryonic root development and tolerance to osmotic and oxidative stresses. The Plant Journal 2005, 44:396-408.
11. Chen H., Xiong L. Enhancement of vitamin B6 levels in seeds through metabolic engineering. Plant Biotechnology Journal 2009, 7:673-681.
12. Chen H., Xiong L.M. The short-rooted vitamin B6-deficient mutant pdx1 has impaired local auxin biosynthesis. Planta 2009, 229:1303-1310.
13. Christen P., Mehta P.K. From cofactor to enzymes. The molecular evolution of pyridoxal 5'-phosphate dependent enzymes. The Chemical Record 2001, 1:436-447.
14. Chumnantana R., Yokochi N., Yagi T. Vitamin B6 compounds prevent the death of yeast cells due to menadione, a reactive oxygen generator. Biochimica et Biophysica Acta 2005, 1722:84-91.
15. Conklin P.L., Saracco S.A., Norris S.R., Last R.L. Identification of ascorbic acid-deficient Arabidopsis thaliana mutants. Genetics 2000, 154:847-856.
16. Danon A., Miersch O., Felix G., op den Camp R.G.L., Apel K. Concurrent activation of cell death-regulating signaling pathways by singlet oxygen in Arabidopsis thaliana. The Plant Journal 2005, 41:68-80.
17. Denslow S.A., Walls A.A., Daub M.E. Regulation of biosynthetic genes and antioxidant properties of vitamin B6 vitamers during plant defense responses. Physiological and Molecular Plant Pathology 2005, 66:244-255.
18. Denslow S.A., Reuschhoff E.E., Daub M.E. Regulation of the Arabidopsis thaliana vitamin B6 biosynthesis genes by abiotic stress. Plant Physiology and Biochemistry 2007, 45:152-161.
19. Di Salvo M., Yang E., Zhao G., Winkler M.E., Schirch V. Expression, purification, and characterization of recombinant Escherichia coli pyridoxine 5'-phosphate oxidase. Protein Expression and Purification 1998, 13:349-356.
20. Dong Y.X., Sueda S., Nikawa J., Kondo H. Characterization of the products of the genes SNO1 and SNZ1 involved in pyridoxine synthesis in Saccharomyces cerevisiae. European Journal of Biochemistry 2004, 271:745-752.
21. Drewke C., Leistner E. Biosynthesis of vitamin B6 and structurally related derivatives. Vitamins and Hormones 2001, Vol. 63:121-155. Academic Press, San Diego. G. Litwack (Ed.).
22. Dunathan H.C. Conformation and reaction specificity in pyridoxal phosphate enzymes. Proceedings of the National Academy of Sciences of the United States of America 1966, 55:712-716.
23. Ehrenshaft M., Daub M.E. Isolation of PDX2, a second novel gene in the pyridoxine biosynthesis pathway of eukaryotes, archaebacteria, and a subset of eubacteria. Journal of Bacteriology 2001, 183:3383-3390.
24. Ehrenshaft M., Jenns A.E., Chung K.R., Daub M.E. SOR1, a gene required for photosensitizer and singlet oxygen resistance in Cercospora fungi is highly conserved in divergent organisms. Molecular Cell 1998, 1:603-609.
25. Ehrenshaft M., Bilski P., Li M.Y., Chignell C.F., Daub M.E. A highly conserved sequence is a novel gene involved in de novo vitamin B6 biosynthesis. Proceedings of the National Academy of Sciences of the United States of America 1999, 96:9374-9378.
26. Eliot A.C., Kirsch J. Pyridoxal phosphate enzymes: Mechanistic, structural and evolutionary considerations. Annual Review of Biochemistry 2004, 73:383-415.
27. Fitzpatrick T.B., Amrhein N., Kappes B., Macheroux P., Tews I., Raschle T. Two independent routes of de novo vitamin B6 biosynthesis: Not that different after all. The Biochemical Journal 2007, 407:1-13.
28. Fitzpatrick T.B., Moccand C., Roux C. Vitamin B6 biosynthesis: Charting the mechanistic landscape. ChemBioChem 2010, 11:1185-1193.
29. Gengenbacher M., Fitzpatrick T.B., Raschle T., Flicker K., Sinning I., Müller S., Macheroux P., Tews I., Kappes B. Vitamin B6 biosynthesis by the malaria parasite Plasmodium falciparum: Biochemical and structural insights. Journal of Biological Chemistry 2006, 281:3633-3641.
30. González E., Danehower D., Daub M.E. Vitamer levels, stress response, enzyme activity, and gene regulation of Arabidopsis lines mutant in the pyridoxine/pyridoxamine 5'-phosphate oxidase (PDX3) and the pyridoxal kinase (SOS4) genes involved in the vitamin B6 salvage pathway. Plant Physiology 2007, 145:985-996.
31. Graham C.M., Ehrenshaft M., Hausner G., Reid D.M. A highly conserved gene for vitamin B6 biosynthesis may have consequences for stress and hormone responses in plants. Physiologia Plantarum 2004, 121:8-14.
32. Gregory J.F. Nutritional properties and significance of vitamin glycosides. Annual Review of Nutrition 1998, 18:277-296.
33. Gregory J.F., Ink S.L. Identification and quantification of pyridoxine-β-glucoside as a major form of vitamin B6 in plant derived foods. Journal of Agricultural and Food Chemistry 1987, 35:76-82.
34. Gunsalus I.C., Bellamy W.D. Function of pyridoxine and pyridoxine derivatives in the decarboxylation of tyrosine. Journal of Biological Chemistry 1944, 155:557-563.
35. György P. Vitamin BZ and the pellagra-like dermatitis in rats. Nature 1934, 133:498-499.
36. Hanes J.W., Keresztes I., Begley T.P. 13C NMR snapshots of the complex reaction coordinate of pyridoxal phosphate synthase. Nature Chemical Biology 2009, 4:425-430.
37. Harris S.A., Folkers K. Synthetic vitamin B6. Science 1939, 89:347.
38. Havaux M., Ksas B., Szewczyk A., Rumeau D., Franck F., Caffarri S., Triantaphylidès C. Vitamin B6 deficient plants display increased sensitivity to high light and photo-oxidative stress. BMC Plant Biology 2009, 9:130.
39. Herrero S., Daub M.E. Genetic manipulation of vitamin B6 biosynthesis in tobacco and fungi uncovers limitations to upregulation of the pathway. Plant Science 2007, 172:609-620.
40. Hill R.E., Spenser I.D. Biosynthesis of vitamin B6. Coenzyme and Cofactors 1986, 1:417-476.
41. Hill R.E., Himmeldirk K., Kennedy I.A., Paulowski R.M., Sayer B.G., Wolf E., Spenser I.D. The biogenetic anatomy of vitamin B6. A 13C NMR investigation of the biosynthesis of pyridoxol in Escherichia coli. Journal of Biological Chemistry 1996, 271:30426-30435.
42. Jain S.K., Lim G. Pyridoxine and pyridoxamine inhibits superoxide radicals and prevents lipid peroxidation, protein glycosylation and (Na+ + K+)-ATPase activity reduction in high glucose treated human erythrocytes. Free Radical Biology & Medicine 2001, 30:232-237.
43. Jakoby M., Weisshaar B., Dröge-Laser W., Vicente-Carbajosa J., Tiedemann J., Kroj T., Parcy F. bZIP transcription factors in Arabidopsis. Trends in Plant Sciences 2002, 7:106-111.
44. Jenns A.E., Scott D.L., Bowden E.F., Daub M.E. Isolation of mutants of the fungus Cercospora nicotianae altered in their response to singlet oxygen generating photosensitizers. Photochemistry and Photobiology 1995, 61:488-493.
45. John R.A. Pyridoxal phosphate dependent enzymes. Biochimica et Biophysica Acta 1995, 1248:81-96.
46. Jong Y.J., Nelson M.J., Snell E.E. Enzymes of vitamin B6 degradation. Purification and properties of pyridoxine 5'-dehydrogenase (oxidase). Journal of Biological Chemistry 1986, 261:15102-15105.
47. Kabir H., Leklem J., Miller L.T. Measurement of glycosylated vitamin-B6 in foods. Journal of Food Science 1983, 48:1422-1425.
48. Kabir H., Leklem J.E., Miller L.T. Relationship of the glycosylated vitamin B6 content of foods to vitamin-B6 bioavailability in humans. Nutrition Reports International 1983, 28:709-716.
49. Kannan K., Jain S.K. Effect of vitamin B6 on oxygen radicals, mitochondrial membrane potential, and lipid peroxidation in H2O2-treated U937 monocytes. Free Radical Biology & Medicine 2004, 36:423-428.
50. Kästner U., Hallmen C., Wiese M., Leistner E., Drewke C. The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba. FEBS Journal 2007, 274:1036-1045.
51. Kaye A.D., Kaye A.M., Hegazi A., Sabar R., Deaton B., Powell J., Hofbauer R. Nutraceuticals: Potential roles and potential risks for pain management. Pain Practice 2002, 2:122-128.
52. Kern A.D., Oliveira M.A., Coffino P., Hackert M.L. Structure of mammalian ornithine decarboxylase at 1.6Å resolution: Stereochemical implications of PLP-dependent amino acid decarboxylases. Structure 1999, 7:567-581.
53. Laber B., Maurer W., Scharf S., Stepusin K., Schmidt F.S. Vitamin B6 biosynthesis: Formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein. FEBS Letters 1999, 449:45-48.
54. Lam H.-M., Winkler M.E. Metabolic relationships between pyridoxine (vitamin B6) and serine biosynthesis in Escherichia coli K-12. Journal of Bacteriology 1990, 172:6518-6528.
55. Lam H.-M., Winkler M.E. Characterization of the complex pdxH-tyrS operon of Escherichia coli K-12 and pleiotropic phenotypes caused by pdxH insertion mutations. Journal of Bacteriology 1992, 174:1554-1567.
56. Lee Y.C., Nelson M.J., Snell E.E. Enzymes of vitamin B6 degradation. Purification and properties of isopyridoxal dehydrogenase and 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid dehydrogenase. Journal of Biological Chemistry 1986, 261:15106-15111.
57. Lepkovsky S. Crystalline factor 1. Science 1938, 87:169-170.
58. Lieberman S., Brunig N. The Real Vitamin and Mineral Book 2003, Avery, New York.
59. Linkswiler H. Biochemical and physiological changes in vitamin B6 deficiency. The American Journal of Clinical Nutrition 1967, 20:547-557.
60. Manzano C., Abraham Z., Lopez-Torrejon G., Del Pozo J.-C. Identification of ubiquitinated proteins in Arabidopsis. Plant Molecular Biology 2008, 68:145-158.
61. Marceau M., Lewis S.D., Kojiro C.L., Mountjoy K., Shafer J.A. Disruption of active site interactions with pyridoxal 5'-phosphate and substrates by conservative replacements in the glycine-rich loop of Escherichia coli D-serine dehydratase. Journal of Biological Chemistry 1990, 263:20421-20429.
62. Matxain J.M., Ristilä M., Strid Å., Eriksson L.A. Theoretical study of the antioxidant properties of pyridoxine. The Journal of Physical Chemistry 2006, 110:13068-13072.
63. Matxain J.M., Ristilä M., Strid Å., Eriksson L.A. Theoretical study of the reaction of vitamin B6 with 1O2. Chemistry: A European Journal 2007, 13:4636-4642.
64. McDonnell L., Plett J.M., Andersson-Gunnerås S., Kozela C., Dugardeyn J., Van Der Straeten D., Glick B.R., Sundberg B., Regan S. Ethylene levels are regulated by a plant encoded 1-aminocyclopropane-1-carboxylic acid deaminase. Physiologia Plantarum 2009, 136:94-109.
65. Meinnel T., Peynot P., Giglione C. Processed N-termini of mature proteins in higher eukaryotes and their major contribution to dynamic proteomics. Biochemie 2005, 87:701-712.
66. Merrill A.H., Henderson J.M. Diseases associated with defects in vitamin B6 metabolism or utilization. Annual Review of Nutrition 1987, 7:137-156.
67. Mikkelsen M.D., Naur P., Halkier B.A. Arabidopsis mutants in the C-S lyase of glucosinolate biosynthesis establish a critical role for indole-3-acetaldoxime in auxin homeostasis. The Plant Journal 2004, 37:770-777.
68. Mittenhuber G. Phylogenetic analyses and comparative genomics of vitamin B6 (pyridoxine) and pyridoxal phosphate biosynthesis pathways. Journal of Molecular Microbiology and Biotechnology 2001, 3:1-20.
69. Mooney S., Hellmann H. Vitamin B6: Killing two birds with one stone. Phytochemistry 2010, 71:495-501.
70. Mukhopadhyay D., Riezman H. Proteasome-independent functions of ubiquitin in endocytosis and signaling. Science 2007, 315:201-205.
71. Nakano M., Morita T., Yamamoto T., Sano H., Ashiuchi M., Masui R., Kuramitsu S., Yagi T. Purification, molecular cloning, and catalytic activity of Schizosaccharomyces pombe pyridoxal reductase. A possible additional family in the aldo-keto reductase superfamily. Journal of Biological Chemistry 1999, 274:23185-23190.
72. Nelson M.J., Snell E.E. Enzymes of vitamin B6 degradation. Purification and properties of 5-pyridoxic-acid oxygenase from Arthrobacter sp. Journal of Biological Chemistry 1986, 261:15115-15120.
73. Neuwirth M., Strohmeier M., Windeisen V., Wallner S., Deller S., Rippe K., Sinning I., Macheroux P., Tews I. X-ray crystal structure of Saccharomyces cerevisiae Pdx1 provides insights into the oligomeric nature of PLP synthases. FEBS Letters 2009, 583:2179-2186.
74. Nushimura S., Nagano S., Crai C.A., Yokochi N., Yoshikane Y., Ge F., Yagi T. Determination of individual vitamin B6 compounds based on enzymatic conversion to 4-pyridoxolactone. Journal of Nutritional Science and Vitaminology 2008, 54:18-24.
75. Oka T. Modulation of gene expression by vitamin B6. Nutrition Research Reviews 2001, 14:257-265.
76. Osmani A.H., May G.S., Osmani S.A. The extremely conserved pyroA gene of Aspergillus nidulans is required for pyridoxine synthesis and is required indirectly for resistance to photosensitizers. Journal of Biological Chemistry 1999, 274:23565-23569.
77. Palm D., Klein H.W., Schinzel R., Buehner M., Helmreich E.J.M. The role of pyridoxal 5'-phosphate in glycogen phosphorylase catalysis. Biochemistry 1990, 29:1099-1107.
78. Percudani R., Peracchi A. A genomic overview of pyridoxal-phosphate dependent enzymes. EMBO Reports 2003, 4:850-854.
79. Raschke M., Boycheva S., Crèvecoeur M., Nunes-Nesi A., Witt S., Fernie A.R., Amrhein N., Fitzpatrick T.B. Enhanced levels of vitamin B6 increase aerial organ size and positively affect stress tolerance in Arabidopsis. The Plant Journal 2011, 66, 414-432.
80. Raschle T., Amrhein N., Fitzpatrick T.B. On the two components of pyridoxal 5'-phosphate synthase from Bacillus subtilis. Journal of Biological Chemistry 2005, 280:32291-32300.
81. Raschle T., Arigoni D., Brunisholz R., Amrhein N., Fitzpatrick T.B. Reaction mechanism of pyridoxal 5'-phosphate synthase: Detection of an enzyme bound chromophoric intermediate. Journal of Biological Chemistry 2007, 282:6098-6105.
82. Raschle T., Speziga D., Kress W., Moccand C., Gehrig P., Amrhein N., Weber-Ban E., Fitzpatrick T.B. Intersubunit cross-talk in pyridoxal 5'-phosphate synthase, coordinated by the C terminus of the synthase subunit. Journal of Biological Chemistry 2009, 284:7706-7718.
83. Rodionov D.A., Hebbeln P., Eudes A., Ter Beek J., Rodionova I.A., Erkens G.B., Slotbottom D.J., Gelfand M.S., Osterman A., Hanson A.D., Eitinger T. A novel class of modular transporters for vitamins in prokaryotes. Journal of Bacteriology 2009, 1:42-51.
84. Rubenstein P.A., Strominger J.L. Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. Journal of Biological Chemistry 1974, 249:3776-3781.
85. Said H.M., Mohammed Z.M. Intestinal absorption of water-soluble vitamins: An update. Current Opinion in Gastroenterology 2006, 22:140-146.
86. Sakai A., Kita M., Katsuragi T., Ogasawara N., Tani Y. yaaD and yaaE are involved in vitamin B6 biosynthesis in Bacillus subtilis. Journal of Bioscience and Bioengineering 2002, 93:309-312.
87. Samuels N., Finkelstein Y., Singer S.R., Oberbaum M. Herbal medicine and epilepsy: Proconvulsive effects and interactions with antiepileptic drugs. Epilepsia 2008, 49:373-380.
88. Sang Y., Barbosa J.M., Wu H.C., Locy R.D., Singh N.K. Identification of a pyridoxine (pyridoxamine) 5'-phosphate oxidase from Arabidopsis thaliana. FEBS Letters 2007, 581:344-348.
89. Sang Y., Locy R.D., Goertzen L.R., Rashotte A.M., Si Y., Knag K., Singh N.K. Expression, in vivo localization and phylogenetic analysis of a pyridoxine 5'-phosphate oxidase in Arabidopsis. Plant Physiology and Biochemistry 2011, 49:88-95.
90. Scountzou J., Malissiovas A., Antoniadis A., Traktellis A.C. Inhibitory effect of deoxypyridoxine on the action of certain mitogenic factors. Immunopharmacology and Immunotoxicology 1989, 11:657-666.
91. Shi H., Zhu J.-K. SOS4, a pyridoxal kinase gene, is required for root hair development in Arabidopsis. Plant Physiology 2002, 129:585-593.
92. Shi H., Xiong L., Stevenson B., Lu T., Zhu J.-K. The Arabidopsis salt overly sensitive 4 mutants uncover a critical role for vitamin B6 in plant salt tolerance. The Plant Cell 2002, 14:575-588.
93. Sivasubramaniam S., Vanniasingham V.M., Tan C.T., Chua N.H. Characterisation of HEVER, a novel stress-induced gene from Hevea brasiliensis. Plant Molecular Biology 1995, 29:173-178.
94. Snell E.E. The vitamin activities of " pyridoxal" and " pyridoxamine" Journal of Biological Chemistry 1944, 154:313-314.
95. Sprenger G.A., Schorken U., Wiegert T., Grolle S., de Graaf A.A., Taylor S.V., Begley T.P., Bringer-Meyer S., Sahm H. Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol. Proceedings of the National Academy of Sciences of the United States of America 1997, 94:12857-12862.
96. Stanulović M., Jeremic V., Leskovac V., Chaykin S. New pathway of conversion of pyridoxal to 4-pyridoxic acid. Enzyme 1976, 21:357-369.
97. Stepanova A.N., Robertson-Hoyt J., Yun J., Benavente L.M., Xie D.Y., Dolezal K., Schlereth A., Jürgens G., Alonso J.M. TAA1-mediated auxin biosynthesis is essential for hormone crosstalk and plant development. Cell 2008, 133:177-191.
98. Stolz J., Vielreicher M. Tpn1p, the plasma membrane vitamin B6 transporter of Saccharomyces cerevisiae. Journal of Biological Chemistry 2003, 278:18990-18996.
99. Strohmeier M., Raschle T., Mazurkiewicz J., Rippe K., Sinning I., Fitzpatrick T.B., Tews I. Structure of a bacterial pyridoxal 5'-phosphate synthase complex. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:19284-19289.
100. Tambasco-Studart M., Titiz O., Raschle T., Forster G., Amrhein N., Fitzpatrick T.B. Vitamin B6 biosynthesis in higher plants. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:13687-13692.
101. Tambasco-Studart M., Tews I., Amrhein N., Fitzpatrick T.B. Functional analysis of PDX2 from Arabidopsis thaliana, a glutaminase involved in vitamin B6 biosynthesis. Plant Physiology 2007, 144:915-925.
102. Titiz O., Tambasco-Studart M., Warzych E., Apel K., Amrhein N., Laloi C., Fitzpatrick T.B. PDX1 is essential for vitamin B6 biosynthesis, development and stress tolerance in Arabidopsis. The Plant Journal 2006, 48:933-946.
103. Toney M.D. Reaction specificity in pyridoxal phosphate enzymes. Archives of Biochemistry and Biophysics 2005, 433:279-287.
104. Tully D.B., Allgood V.E., Cidlowski J.A. Modulation of steroid receptor-mediated gene expression by vitamin B6. FASEB Journal 1994, 8:343-349.
105. Wagner S., Bernhardt A., Leuendorf J.E., Drewke C., Lytovchenko A., Mujahed N., Gurgui C., Frommer W.B., Leistner E., Fernie A.R., Hellmann H. Analysis of the Arabidopsis rsr4-1/pdx1-3 mutant reveals the critical function of the PDX1 protein family in metabolism, development, and vitamin B6 biosynthesis. The Plant Cell 2006, 18:1722-1735.
106. Yang Y., Zhao G., Man T.K., Winkler M.E. Involvement of the gapA- and epd (gapB)-encoded dehydrogenases in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12. Journal of Bacteriology 1998, 180:4294-4299.
107. Yasumoto K., Tsuji H., Iwami K., Mitsuda H. Isolation from rice bran of a bound form of vitamin-B6 and its identification as 5'-O-(beta-D-glucopyranosyl) pyridoxine. Agricultural and Biological Chemistry 1977, 41:1061-1067.
108. Zalkin H., Smith J.L. Enzymes utilizing glutamine as an amide donor. Advances in Enzymology and Related Areas of Molecular Biology 1998, 72:87-144.
109. Zeeman S.C., Thorneycroft D., Schupp N., Chapple A., Weck M., Dunstan H., Haldimann P., Bechtold N., Smith A.M., Smith S.M. Plastidial alpha-glucan phosphorylase is not required for starch degradation in Arabidopsis leaves but has a role in the tolerance of abiotic stress. Plant Physiology 2004, 135:849-858.
110. Zein F., Zhang Y., Kang Y.-N., Burns K., Begley T.P., Ealick S.E. Structural insights into the mechanism of the PLP synthase holoenzyme from Thermotoga maritima. Biochemistry 2006, 45:14609-14620.
111. Zhao G., Winkler M.E. An Escherichia coli K-12 tktA tktB mutant deficient in transketolase activity requires pyridoxine (vitamin B6) as well as the aromatic amino acids and vitamins for growth. Journal of Bacteriology 1994, 176:6134-6138.
112. Zhao G., Winkler M.E. Kinetic limitation and cellular amount of pyridoxine (pyridoxamine) 5'-phosphate oxidase of Escherichia coli K-12. Journal of Bacteriology 1995, 177:883-891.
113. Zhao G., Winkler M.E. 4-Phospho-hydroxy-L-threonine is an obligatory intermediate in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12. FEMS Microbiology Letters 1996, 135:275-280.
114. Zhao G., Pease A.J., Bharani N., Winkler M.E. Biochemical characterization of gapB-encoded erythrose 4-phosphate dehydrogenase of Escherichia coli K-12 and its possible role in pyridoxal 5'-phosphate biosynthesis. Journal of Bacteriology 1995, 177:2804-2812.
115. Zhu J., Burgner J.W., Harms E., Belitsky B.R., Smith J.L. A new arrangement of (β/α)8 barrels in the synthase subunit of PLP synthase. Journal of Biological Chemistry 2005, 280:27914-27923.