Herbal medicine and epilepsy: Proconvulsive effects and interactions with antiepileptic drugs

Epilepsia

Volumn 49, Issue 3, 2008, Pages 373-380

  Samuels, Noah ^a,b   Finkelstein, Yoram ^b   Singer, Shepherd Roee ^a   Oberbaum, Menachem ^a  

^a Center for Integrative Complementary Medicine   (Israel)

^b SHAARE ZEDEK MEDICAL CENTER   (Israel)

Author keywords

Anti epileptics; Drug disposition; Epilepsy; Herbs; Interaction; Neurotoxic

Indexed keywords

ANTICONVULSIVE AGENT; ARTEMISIA ABSINTHIUM EXTRACT; AVERRHOA CARAMBOLA EXTRACT; AYURVEDIC DRUG; CARBAMAZEPINE; CYTOCHROME P450; DIAZEPAM; EPHEDRA SINICA EXTRACT; GINKGO BILOBA EXTRACT; GLYCOPROTEIN P; HEAVY METAL; HERBACEOUS AGENT; HYPERICUM PERFORATUM EXTRACT; ILLICIUM ANISATUM EXTRACT; ILLICIUM VERUM EXTRACT; PENNYROYAL EXTRACT; PHENYTOIN; PRIMROSE OIL; SHO SEIRYU TO; STARFLOWER EXTRACT; TACRINE; UNCLASSIFIED DRUG; VALPROIC ACID; XIAO CHAI HU TANG;

ALTERNATIVE MEDICINE; ANTICONVULSANT ACTIVITY; CEREBROVASCULAR ACCIDENT; CONVULSION; DRUG DISPOSITION; DRUG MECHANISM; DRUG SAFETY; EPILEPSY; GRAPEFRUIT JUICE; HEALTH CARE PERSONNEL; HERB DRUG INTERACTION; HERBAL MEDICINE; HUMAN; NEUROTOXICITY; NONHUMAN; PATIENT INFORMATION; PRIORITY JOURNAL; REVIEW; SEIZURE; SEIZURE SUSCEPTIBILITY; TREATMENT INDICATION;

ANTICONVULSANTS; CYTOCHROME P-450 ENZYME SYSTEM; EPILEPSY; HERB-DRUG INTERACTIONS; HUMANS; NEUROTOXINS; P-GLYCOPROTEINS; PHYTOTHERAPY; PLANT PREPARATIONS; PLANTS, MEDICINAL; SEIZURES;

EID: 39749187373     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2007.01379.x     Document Type: Review

References (100)

1. Al Khayat A, Menon NS, Alidina MR 1997) Acute lead encephalopathy in early infancy - clinical presentation and outcome. Ann Trop Paediatr 17 : 39 44.
2. Anderson IB, Mullen WH, Meeker JE, Khojasteh-Bakht SC, Oishi S, Nelson SD, Blanc PD 1996) Pennyroyal toxicity: measurement of toxic metabolite levels in two cases and review of the literature. Ann Intern Med 124 : 726 734.
3. Ang CY, Hu L, Heinze TM, Cui Y, Freeman JP, Kozak K, Luo W, Liu FF, Mattia A, DiNovi M 2004) Instability of St. John's wort (Hypericum perforatum) and degradation of hyperforin in aqueous solutions and functional beverage. J Agric Food Chem 52 : 6156 6164.
4. Arenz A, Klein M, Fiehe K, Gross J, Drewke C, Hemscheidt T, Leistner E 1996) Occurrence of neurotoxic 4′-O-methylpyridoxine in Ginkgo biloba leaves, Ginkgo medications and Japaese Ginkgo food. Planta Med 62 : 548 551.
5. Arnold WN 1998) Vincent van Gogh and the thujone connection. JAMA 260 : 3042 3044.
6. Ayrton AD, Ioannides C, Walker R 1988) Induction of rat hepatic cytochrome P-450 I proteins by the antimutagen anthraflavic acid. Food Chem Toxicol 26 : 909 915.
7. Bakerink JA, Gospe SM Jr., Dimand RJ, Eldridge MW 1996) Multiple organ failure after ingestion of pennyroyal oil from herbal tea in two infants. Pediatrics 98 : 944 947.
8. Bayly GR, Braithwaite RA, Sheehan TM, Dyer NH, Grimley C, Ferner RE 1995) Lead poisoning from Asian traditional remedies in the West Midlands: report of a series of five cases. Hum Exp Toxicol 14 : 24 28.
9. Bruno A, Nolte KB, Chapin J 1993) Stroke associated with ephedrine use. Neurology 43 : 1313 1316.
10. Burkhard PR, Burkhardt K, Haenggeli CA, Landis T 1999) Plant-induced seizures: reappearance of an old problem. J Neurol 246 : 667 670.
11. Burstein AH, Horton RL, Dunn T, Alfaro RM, Piscitelli SC, Theodore W 2000) Lack of effect of St. John's wort on carbamazepine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 68 : 605 612.
12. Canter PH, Ernst E 2002) Ginkgo biloba: a smart drug? A systemic review of controlled trials of the cognitive effects of ginkgo biloba extracts in healthy people. Psychopharmacol Bull 36 : 108 123.
13. Canter PH, Ernst E 2004) Herbal supplementation use by persons aged over 50 years in Britain: frequently used herbs, concomitant use of herbs, nutritional supplements and prescription drugs, rate of informing doctors and potential for negative interactions. Drugs Aging 21 : 597 605.
14. Chan H, Billmeier GJ Jr., Evans WE, Chan H 1977) Lead poisoning from ingestion of Chinese herbal medicine. Clin Toxicol 10 : 273 281.
15. Chen LC, Chen YF, Chou MH, Lin MF, Yang LL, Yen KY 2002) Pharmacokinetic interactions between carbamazepine and the traditional Chinese medicine Paeoniae Radix. Biol Pharm Bull 25 : 532 535.
16. Chang HS, Yeh JH 2004) Non-convulsive status epilepticus and consciousness disturbance after star fruit (Averrhoa carambola) ingestion in a dialysis patient. Nephrology 9 : 362 365.
17. Crowe A, Teoh YK 2006) Limited P-glycoprotein mediated efflux for anti-epileptic drugs. J Drug Target 14 : 291 300.
18. Cui J, Garle M, Eneroth P, Bjorkhem I 1994) What do commercial ginseng preparations contain? Lancet 344 : 134.
19. Dandekar UP, Chandra RS, Dalvi SS, Joshi MV, Gokhale PC, Sharma AV, Shah PU, Kshirsagar NA 1992) Analysis of a clinically important interaction between phenytoin and Shankhapushpi, an Ayurvedic preparation. J Ethnopharmacol 35 : 285 288.
20. Danesi MA, Adetunji JB 1994) Use of alternative medicine by patients with epilepsy: a survey of 265 epileptic patients in a developing country. Epilepsia 35 : 344 31.
21. Deckers CL, Genton P, Sills GJ, Schmidt D 2003) Current limitations of antiepileptic drug therapy: a conference review. Epilepsy Res 53 : 1 17.
22. De Smet PAGM 2002) Herbal remedies. N Engl J Med 347 : 2046 2056.
23. Draves AH, Walker SE 2003) Analysis of the hypericin and pseudohypericin content of commercially available St. John's wort preparations. Can J Clin Pharmacol 10 : 114 118.
24. Dunbabin DW, Tallis GA, Popplewell PY, Lee RA 1992) Lead poisoning from Indian herbal medicine (Ayurveda). Med J Austr 157 : 835 836.
25. Eisenberg DM 1997) Advising patients who seek alternative therapies. Ann Intern Med 127 : 61 69.
26. Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, van Rompay M, Kessler RC 1998) Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA 280 : 1569 1575.
27. Ernst E 1998) Harmless herbs? A review of the recent literature. Am J Med 104 : 170 178.
28. Ernst E 2000) Prevalence of use of complementary/alternative medicine: a systematic review. Bull World Health Organ 78 : 252 257.
29. Fang HC, Chen CL, Lee PT, Hsu CY, Tseng CJ, Lu PJ, Lai SL, Chung HM, Chou KJ 2007) The role of oxalate in star fruit neurotoxicity of five-sixths nephrectomized rats. Food Chem Toxicol [Epub ahead of print].
30. Fiehe K, Arenz A, Drewke C, Hemscheidt T, Williamson RT, Leistner E 2000) Biosynthesis of 4′-O-methylpyridoxine (Gingkotoxin) from primary precursors. J Nat Prod 63 : 185 189.
31. Gammon GD, Gumnit R 1957-1958) Observations on the mechanism of seizures induced by a pyridoxine antagonist, methoxypyridoxine. Trans Am Neurol Assoc 82nd Meeting : 57 59.
32. Garg SK, Kumar N, Bhargava VK, Prabhakar SK 1998) Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy. Clin Pharacol Ther 64 : 286 288.
33. Gil Campos M, Perez Navero JL, Ibarra De La Rosa I 2002) Convulsive status secondary to star anise poisoning in a neonate. [Article in Spanish]. An Esp Pediatr 57 : 366 368.
34. Giveon SM, Liberman N, Klang S, Kahan E 2004) Are people who use "natural drugs" aware of their potentially harmful side effects and reporting to family physician? Pat Educ Counsel 53 : 5 11.
35. Gordon WP, Forte AJ, McMurtry RJ, Gal J, Nelson SD 1982) Hepatotoxicity and pulmonary toxicity of pennyroyal oil and its constituent terpenes in the mouse. Toxicol Appl Pharmacol 65 : 413 424.
36. Granger AS 2001) Ginkgo biloba precipitating epileptic seizures. Age Ageing 30 : 523 525.
37. Gregory PJ 2001) Seizure associated with Ginkgo biloba? Ann Intern Med 134 : 344.
38. Gulla J, Singer AJ 2000) Use of alternative therapies among emergency department patients. Ann Emerg Med 35 : 226 228.
39. Haller CA, Meier KH, Olson KR 2005) Seizures reported in association with use of dietary supplements. Clin Toxicol (Phila) 43 : 23 30.
40. He K, Iyer KR, Hayes RN, Sinz MW, Woolf TF, Hollenberg PF 1998) Inactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juice. Chem Res Toxicol 11 : 252 259.
41. Hoffman D 1987) The Herb users guide: the basic skills of medical herbalism. Thorsons, Wellingborough, England.
42. Holland GW 1902) A case of poisoning from pennyroyal. Virginia Medical Semi-Monthly 7 : 319.
43. Ioannides C 2002) Pharmacokinetic interactions between herbal remedies and medicinal drugs. Xenobiotica 32 : 451 478.
44. Itil TM, Eralp E, Tsambis E, Itil KZ, Stein U 1996) Central nervous system effects of Ginkgo biloba, a plant extract. Am J Ther 3 : 63 73.
45. Ize-Ludlow D, Ragone S, Bruck IS, Bernstein JN, Duchowny M, Garcia Pena BM 2004) Neurotoxicities in infants seen with the consumption of Star Anise tea. Pediatrics 114 : 653 656.
46. Johanns ES, van de Kolk LE, van Gemert HM, Sijben AE, Peters PW, de Vries I 2002) An epidemic of epiloeptic seizures after consumption of herbal tea. [Article in Dutch]. Ned Tijdschr Geneeskd 146 : 813 816.
47. Kajiyama Y, Fujii K, Takeuchi H, Manabe Y 2002) Ginkgo seed poisoning. Pediatrics 109 : 325 327.
48. Kaufman DW, Kelly JP, Rosenberg L, Anderson TE, Mitchell AA 2002) Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey. JAMA 287 : 337 344.
49. Keen RW, Deacon AC, Delves HT, Moreton JA, Frost PG 1994) Indian herbal remedies for diabetes as a cause of lead poisoning. Postgrad Med J 70 : 113 114.
50. Kerr BM, Thummel KE, Wurden CJ, Klein SM, Droetz DL, Gonzalez FJ, Levy RJ 1994) Human liver carbamazepine metabolism: role of CYP3A4 and CYP2C8 in 10,11-epoxide formation. Biochem Pharmacol 47 : 1969 1979.
51. Kew J, Morris C, Ashie A, Fysh R, Nones S, Brooks D 1993) Lesson of the week: arsenic and mercury intoxication due to Indian ethnic remedies. Br Med J 306 : 506 507.
52. Kimball HW 1898) A case of poisoning by oil of pennyroyal. Atlant Medl Week 307 308.
53. Kshirsagar NA 1993) Misleading herbal Ayurvedic brand name. Lancet 341 : 1595.
54. Kudo Y, Oka JI, Yamada K 1981) Anisatin, a potent GABA-antagonist, isolated from Illicium Anisatum. Neurosci Lett 25 : 83 88.
55. Kudolo GB, Dorsey S, Blodgett J 2003) Effect of the ingestion of ginkgo biloba extract on platelet aggregation and urinary prostanoid excretion in healthy and Type 2 diabetic subjects. Thromb Res 108 : 151 160.
56. Kupiec T, Raj V 2005) Fatal seizures due to potential herb-drug interactions with Gingko biloba. J Analyt Toxicol 29 : 755 758.
57. Lau KK, Lai CK, Chan AYW 2000) Phenytoin poisoning after using Chinese proprietary medicines. Hum Exp Tox 19 : 385 386.
58. Lawson LD, Ransom DK, Hughes BG 1992) Inhibition of whole blood platelet-aggregation by compounds in garlic clove extracts and commercial garlic products. Thromb Res 65 : 141 156.
59. Le Bars PL, Katz MM, Berman N, Itil TM, Freedman AM, Schatzberg AF 1997) A placebo-controlled, double-blind randomized trial of an extract of Ginkgo biloba for dementia. JAMA 278 : 1327 1332.
60. Lebert F, Hasenboekx C, Pasquier F, Petit H 1996) Convulsive effects of tacrine. Lancet 347 : 1339 1340.
61. Löscher W, Potschka H 2005) Drug resistance in brain diseases and the role of drug efflux transporters. Nat Rev Neurosci 6 : 591 602.
62. Löscher W 2007) Drug transporters in the epileptic brain. Epilepsia 48 (Suppl 8 13.
63. Macedo AF, Marques FB, Ribeiro CF, Teixeira F 2003) Causality assessment of adverse drug reactions: comparison of the results obtained from published decisional algorithms and from the evaluations of an expert panel, according to different levels of imputability. J Clin Pharm Ther 28 : 137 143.
64. Manocha A, Pillai KK, Husain SZ 1996) Influence of ginkgo biloba on the effect of anti-convulsants. Indian J Pharmacol 28 : 84 87.
65. Manocha A, Pillai KK, Husain SZ 1997) Effect of ginkgo biloba on chemoshock in mice. Indian J Pharmacol 29 : 198 200.
66. Markowitz JS, De Vane CL, Boulton DW, Carson SW, Nahas Z, Risch SC 2000) Effect of St. John's wort (Hypericum perforatum) on cytochrome P-450 2D6 and 3A4 activity in healthy volunteers. Life Sci 66 : PL133 PL139.
67. Mashour NH, Lin GI, Frishman WH 1998) Herbal medicine for the treatment of cardiovascular disease. Arch Intern Med 158 : 2225 2234.
68. Matsuda H, Shimoda H, Morikawa T, Yoshidawa M 2001) Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity. Bioorg Med Chem Lett 11 : 1839 1842.
69. Miller LG 1998) Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med 158 : 2200 2211.
70. Miwa H, Iijima M, Tanaka S, Mizuno Y 2001) Generalized convulsions after consuming a large amount of ginkgo nuts. Epilepsia 42 : 280 281.
71. Nakamura T, Okuyama E, Yamazaki M 1996) Neurotropic components from star anise (illicium verum Hook.fil.). Chem Pharm Bull (Tokyo) 44 : 1908 1914.
72. NCCAM : Get the facts: herbal supplements: consider safety, too. nccam.nih.gov/health.
73. Neto MM, da Costa JA, Garcia-Cairasco N, Netto JC, Nakagawa B, Dantas M 2003) Intoxication by star fruit (Averrhoa carambola) in 32 uraemic patients: treatment and outcome. Nephrol Dial Transplant 18 : 120 125.
74. Newall CA, Anderson LA, Phillipson JD 1997) Evening primrose monograph. In JD Newall CA, Anderson LA, Phillipson JD Eds Herbal medicines: a guide for health-care professionals. Pharmaceutical Press, London, England, 49, 110 113, 114.
75. Obach RS 2000) Inhibition of cytochrome P50 by constituents of St. John's wort, and herbal preparation used in the treatment of depression. J Pharmacol Exp Ther 294 : 88 95.
76. Ohnishi N, Yonekawa Y, Nakasako S, Nagasawa K, Yokoyama T, Yoshioka M, Kuroda K 1999) Studies on interactions between traditional herbal and Western medicines. I. Effects of Sho-seiryu-to on the pharmacokinetics of carbamazepine in rats. Biol Pharm Bull 22 : 527 531.
77. Ohnishi N, Okada K, Yoshioka M, Kuroda K, Nagasawa K, Takara K, Yokoyama T 2002) Studies on interactions between traditional herbal and Western medicines. V. Effects of Sho-saiko-to (Xiao-Cai-hu-Tang) on the pharmacokinetics of carbamazepine in rats. Biol Pharm Bull 25 : 1461 1465.
78. Okuyama E, Nakamura T, Yamazaki M 1993) Convulsants from star anise (Illicium verum Hook.F.) Chem Pharm Bull (Tokyo) 41 : 1670 1671.
79. Ozdemir M, Aktan Y, Boydag BS, Cingi MI, Musmul A 1998) Interaction between grapefruit juice and diazepam in humans. Eur J Drug Metab Pharmacokinet 23 : 55 59.
80. Pattanaik S, Hota D, Prabhakar S, Kharbanda P, Pandhi P 2006) Effect of piperine on the steady-state pharmacokinetics of phenytoin in patients with epilepsy. Phytother Res 20 : 683 686.
81. Peebles CT, McAuley JW, Roach J, Moore JL, Reeves AL 2000) Alternative medicine use by patients with epilepsy. Epilepsy Behav 1 : 74 77.
82. Perharic L, Shaw D, Colbridge M, House I, Leon C, Murray V 1994) Toxicological problems resulting from exposure to traditional remedies and food supplements. Drug Saf 11 : 284 294.
83. Pittler MH, Ernst E 2000) Gingko biloba extract for the treatment of intermittent claudication: a meta-analysis of randomized trials. Am J Med 108 : 276 281.
84. Potschka H, Loscher W 2001) Multidrug resistance-associated protein is involved in the regulation of extracellular levels of phenytoin in the brain. Neuroreport 12 : 2387 2389.
85. Pye KG, Kelsey SM, House IM, Newland AC 1992) Severe dyserythropoeiesis and autoimmune thrombocytopenia associated with ingestion of kelp supplement. Lancet 339 : 1540.
86. Saper RB, Kales SN, Paquin J, Burns MJ, Eisenberg DM, Davis RB, Phillips RS 2004) Heavy metal content of Ayurvedic herbal medicine products. JAMA 292 : 2868 2873.
87. Shannon M, McElroy EA, Liebelt EL 2003) Toxic seizures in children: case scenarios and treatment strategies. Pedatr Emerg Care 19 : 206 210.
88. Southwell IA, Bourke CA 2001) Seasonal variation in hypericin content of Hypericum perforaum L. (St. John's wort). Phytochem 56 : 437 441.
89. Spinella M 2001) Herbal medicines and epilepsy: the potential for benefit and adverse effects. Epilepsy Behav 2 : 524 532.
90. Swinyard EA, Woodhead JH 1982) Experimental detection quantification and evaluation of anticonvulsants. In Woodbury DM, Penry JK Pippenger CE Eds Antiepileptic drugs. Raven Press, New York, NY, 111 126.
91. Thatte UM, Rege NN, Phatak SC, Dahanukar SA 1993) The flip side of Ayurveda. J Postgrad Med 39 : 179 182.
92. Treleaven J, Meller S, Farmer P, Birchall D, Goldman J, Piller G 1993) Arsenic and Ayurveda. Leuk Lymphoma 10 : 343 345.
93. Vaddadi KS 1981) The use of gamma-linoleic acid and linoleic acid to differentiate between temporal lobe epilepsy and schizophrenia. Prostaglandins Med 6 : 375 379.
94. Vandenberghe N, Pittion-Vouyouvitch S, Flesch F, Wagner M, Godet E 2003) An inaugural generalized tonic-clonic seizure crisis following ingestion of Japanese star anise. [Article in French]. Presse Med 32 : 27 28.
95. Voskuyl RA, Vreugdenhil M, Kang JX, Leaf A 1998) Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. Eur J Pharmacol 341 : 145 152.
96. Wilkinson GR 2004) Drug metabolism and variability among patients in drug response. New Engl J Med 352 : 2211 2221.
97. Yagi M, Wada K, Sakata M, Kokubo M, Haga M 1993) Studies on the constituents of edible and medicinal plants. IV. Determination of 4-O-methypyroxidine in serum of the patient with gi-nan poisoning. [Article in Japanese]. Yakugaku Zasshi 113 : 596 599.
98. Yehuda S, Carasso RL, Mostofsky DI (1994) Essential fatty acid preparation (SR-3) raises the seizure threshold in rats. Eur J Pharmacol 254 : 193 198.
99. Yin OQP, Tomlinson B, Waye MMY, Chow AHL, Chow MSS 2004) Pharmacogenetics and herb-drug interactions: experience with ginkgo biloba and omeprazole. Pharmacogen 14 : 841 850.
100. Zhou S, Lim LY, Chowbay B 2004) Herbal modulation of P-glycoprotein. Drug Metab Rev 36 : 57 104.