Decrease in antibody somatic hypermutation frequency under extreme, extended spaceflight conditions

FASEB Journal

Volumn 25, Issue 9, 2011, Pages 2947-2955

  Bascove, Matthieu ^a   Guéguinou, Nathan ^a   Schaerlinger, Bérénice ^a   Gauquelin Koch, Guillemette ^b   Frippiat, Jean Pol ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

^b French Medicines Agency   (France)

Author keywords

Affinity maturation; B lymphocytes; Immune response; Immunoglobulin; Microgravity

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; AMINO ACID; B LYMPHOCYTE ANTIGEN; B LYMPHOCYTE RECEPTOR; CELL ADHESION MOLECULE; I KAPPA B; IMMUNOGLOBULIN MU CHAIN; MESSENGER RNA; NUCLEAR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; FOOD INTAKE; GENE EXPRESSION; GENE REARRANGEMENT; GENE SEQUENCE; GERMINAL CENTER; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGLOBULIN HEAVY CHAIN GENE; IMMUNOGLOBULIN PRODUCTION; MUTATION RATE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; RECEPTOR BINDING; SALAMANDER; SOMATIC HYPERMUTATION; SPACE FLIGHT; STOP CODON; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; VHII GENE;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BINDING SITES, ANTIBODY; GENE EXPRESSION REGULATION; IMMUNOGLOBULIN M; PLEURODELES; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; SPACE FLIGHT; TIME FACTORS; WEIGHTLESSNESS;

AMPHIBIA; ANIMALIA; PLEURODELES WALTL;

EID: 80052680216     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-185215     Document Type: Article

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