Dual stem cell therapy after myocardial infarction acts specifically by enhanced homing via the SDF-1/CXCR4 axis

Stem Cell Research

Volumn 7, Issue 3, 2011, Pages 244-255

  Theiss, Hans D ^a   Vallaster, Markus ^a   Rischpler, Christoph ^a   Krieg, Lisa ^a   Zaruba, Marc Michael ^a   Brunner, Stefan ^a   Vanchev, Yordan ^a   Fischer, Rebekka ^a   Gröbner, Michael ^a   Huber, Bruno ^a   Wollenweber, Timm ^a   Assmann, Gerald ^b   Mueller Hoecker, Josef ^b   Hacker, Markus ^a   Franz, Wolfgang M ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; DIPEPTIDYL PEPTIDASE IV; DIPROTIN A; PLERIXAFOR; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; STROMAL CELL DERIVED FACTOR 1;

ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE BLOOD FLOW; HEMATOPOIETIC STEM CELL; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; STEM CELL MOBILIZATION; STEM CELL TRANSPLANTATION;

ANIMALS; ANTIGENS, CD34; ANTIGENS, CD45; CHEMOKINE CXCL12; DIPEPTIDYL PEPTIDASE 4; DOSE-RESPONSE RELATIONSHIP, DRUG; GRANULOCYTE COLONY-STIMULATING FACTOR; HEART FUNCTION TESTS; HEMATOPOIETIC STEM CELL MOBILIZATION; HETEROCYCLIC COMPOUNDS; MICE; MODELS, BIOLOGICAL; MYOCARDIAL INFARCTION; NEOVASCULARIZATION, PHYSIOLOGIC; OLIGOPEPTIDES; PERFUSION; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTORS, CXCR4; STEM CELL TRANSPLANTATION; SURVIVAL ANALYSIS;

ANIMALIA; MUS;

EID: 80052661942     PISSN: 18735061     EISSN: 18767753     Source Type: Journal    
DOI: 10.1016/j.scr.2011.05.003     Document Type: Article

References (35)

1. Abbott J.D., Huang Y., Liu D., Hickey R., Krause D.S., Giordano F.J. Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury. Circulation 2004, 110(21):3300-3305.
2. Aiuti A., Webb I.J., Bleul C., Springer T., Gutierrez-Ramos J.C. The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J. Exp. Med. 1997, 185(1):111-120.
3. Askari A.T., Unzek S., Popovic Z.B., Goldman C.K., Forudi F., Kiedrowski M., et al. Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy. Lancet 2003, 362(9385):697-703.
4. Balsam L.B., Wagers A.J., Christensen J.L., Kofidis T., Weissman I.L., Robbins R.C. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature 2004, 428(6983):668-673.
5. Beltrami A.P., Barlucchi L., Torella D., Baker M., Limana F., Chimenti S., et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003, 114(6):763-776.
6. Broxmeyer H.E., Orschell C.M., Clapp D.W., Hangoc G., Cooper S., Plett P.A., et al. Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. J. Exp. Med. 2005, 201(8):1307-1318.
7. Ceradini D.J., Kulkarni A.R., Callaghan M.J., Tepper O.M., Bastidas N., Kleinman M.E., et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat. Med. 2004, 10(8):858-864.
8. Christopherson K.W., Hangoc G., Mantel C.R., Broxmeyer H.E. Modulation of hematopoietic stem cell homing and engraftment by CD26. Science 2004, 305(5686):1000-1003.
9. Crump M.P., Gong J.H., Loetscher P., Rajarathnam K., Amara A., Arenzana-Seisdedos F., et al. Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1. EMBO J. 1997, 16(23):6996-7007.
10. Deindl E., Zaruba M.M., Brunner S., Huber B., Mehl U., Assmann G., et al. G-CSF administration after myocardial infarction in mice attenuates late ischemic cardiomyopathy by enhanced arteriogenesis. FASEB J. 2006, 20(7):956-958.
11. Dickstein K., Cohen-Solal A., Filippatos G., McMurray J.J., Ponikowski P., Poole-Wilson P.A., et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008 The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur. J. Heart Fail. 2008, 10(10):933-989.
12. Engelmann M.G., Theiss H.D., Hennig-Theiss C., Huber A., Wintersperger B.J., Werle-Ruedinger A.E., et al. Autologous bone marrow stem cell mobilization induced by granulocyte colony-stimulating factor after subacute ST-segment elevation myocardial infarction undergoing late revascularization: final results from the G-CSF-STEMI (Granulocyte Colony-Stimulating Factor ST-Segment Elevation Myocardial Infarction) trial. J. Am. Coll. Cardiol. 2006, 48(8):1712-1721.
13. Engelmann M.G., Theiss H.D., Theiss C., Henschel V., Huber A., Wintersperger B.J., et al. G-CSF in patients suffering from late revascularised ST elevation myocardial infarction: final 1-year-results of the G-CSF-STEMI Trial. Int. J. Cardiol. 2010, 144(3):399-404.
14. Fazel S., Cimini M., Chen L., Li S., Angoulvant D., Fedak P., et al. Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J. Clin. Invest. 2006, 116(7):1865-1877.
15. Franz W.M., Zaruba M., Theiss H., David R. Stem-cell homing and tissue regeneration in ischaemic cardiomyopathy. Lancet 2003, 362(9385):675-676.
16. Harada M., Qin Y., Takano H., Minamino T., Zou Y., Toko H., et al. G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat. Med. 2005, 11(3):305-311.
17. Huhn J., Ehrlich S., Fleischer B., von Bonin A. Molecular analysis of CD26-mediated signal transduction in T cells. Immunol. Lett. 2000, 72(2):127-132.
18. Ince H., Petzsch M., Kleine H.D., Eckard H., Rehders T., Burska D., et al. Prevention of left ventricular remodeling with granulocyte colony-stimulating factor after acute myocardial infarction: final 1-year results of the Front-Integrated Revascularization and Stem Cell Liberation in Evolving Acute Myocardial Infarction by Granulocyte Colony-Stimulating Factor (FIRSTLINE-AMI) Trial. Circulation 2005, 112(9 Suppl):I73-I80.
19. Ince H., Petzsch M., Kleine H.D., Schmidt H., Rehders T., Korber T., et al. Preservation from left ventricular remodeling by front-integrated revascularization and stem cell liberation in evolving acute myocardial infarction by use of granulocyte-colony-stimulating factor (FIRSTLINE-AMI). Circulation 2005, 112(20):3097-3106.
20. Kahne T., Lendeckel U., Wrenger S., Neubert K., Ansorge S., Reinhold D. Dipeptidyl peptidase IV: a cell surface peptidase involved in regulating T cell growth (review). Int. J. Mol. Med. 1999, 4(1):3-15.
21. Messina E., De Angelis L., Frati G., Morrone S., Chimenti S., Fiordaliso F., et al. Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ. Res. 2004, 95(9):911-921.
22. Murry C.E., Soonpaa M.H., Reinecke H., Nakajima H., Nakajima H.O., Rubart M., et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 2004, 428(6983):664-668.
23. Nekolla S.G., Miethaner C., Nguyen N., Ziegler S.I., Schwaiger M. Reproducibility of polar map generation and assessment of defect severity and extent assessment in myocardial perfusion imaging using positron emission tomography. Eur. J. Nucl. Med. 1998, 25(9):1313-1321.
24. Orlic D., Kajstura J., Chimenti S., Limana F., Jakoniuk I., Quaini F., et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc. Natl. Acad. Sci. U.S.A. 2001, 98(18):10344-10349.
25. Ruiz P., Zacharievich N., Viciana A.L., Shenkin M. Peripheral CD34+ progenitor cells express CD26 and contain increased dipeptidyl peptidase IV activity. Acta Haematol. 1998, 100(2):110-112.
26. Saxena A., Fish J.E., White M.D., Yu S., Smyth J.W., Shaw R.M., et al. Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction. Circulation 2008, 117(17):2224-2231.
27. Segers V.F., Tokunou T., Higgins L.J., MacGillivray C., Gannon J., Lee R.T. Local delivery of protease-resistant stromal cell derived factor-1 for stem cell recruitment after myocardial infarction. Circulation 2007, 116(15):1683-1692.
28. Tang Y.L., Zhu W., Cheng M., Chen L., Zhang J., Sun T., et al. Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression. Circ. Res. 2009, 104(10):1209-1216.
29. Theiss H.D., Brenner C., Engelmann M.G., Zaruba M.M., Huber B., Henschel V., et al. Safety and efficacy of SITAgliptin plus GRanulocyte-colony-stimulating factor in patients suffering from Acute Myocardial Infarction (SITAGRAMI-Trial) - rationale, design and first interim analysis. Int. J. Cardiol. 2010, 145(2):282-284.
30. Vanham G., Kestens L., De Meester I., Vingerhoets J., Penne G., Vanhoof G., et al. Decreased expression of the memory marker CD26 on both CD4+ and CD8+ T lymphocytes of HIV-infected subjects. J. Acquir. Immune Defic. Syndr. 1993, 6(7):749-757.
31. Wollenweber T., Zach C., Rischpler C., Fischer R., Nowak S., Nekolla S.G., et al. Myocardial perfusion imaging is feasible for infarct size quantification in mice using a clinical single-photon emission computed tomography system equipped with pinhole collimators. Mol. Imaging Biol. 2010, 12(4):427-434.
32. Zaruba M.M., Huber B.C., Brunner S., Deindl E., David R., Fischer R., et al. Parathyroid hormone treatment after myocardial infarction promotes cardiac repair by enhanced neovascularization and cell survival. Cardiovasc. Res. 2008, 77(4):722-731.
33. Zaruba M.M., Theiss H.D., Vallaster M., Mehl U., Brunner S., David R., et al. Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction. Cell Stem Cell 2009, 4(4):313-323.
34. Zhou Y.Y., Wang S.Q., Zhu W.Z., Chruscinski A., Kobilka B.K., Ziman B., et al. Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology. Am. J. Physiol. Heart Circ. Physiol. 2000, 279(1):H429-H436.
35. Zohlnhofer D., Dibra A., Koppara T., de Waha A., Ripa R.S., Kastrup J., et al. Stem cell mobilization by granulocyte colony-stimulating factor for myocardial recovery after acute myocardial infarction: a meta-analysis. J. Am. Coll. Cardiol. 2008, 51(15):1429-1437.