G-CSF in patients suffering from late revascularised ST elevation myocardial infarction: Final 1-year-results of the G-CSF-STEMI Trial

International Journal of Cardiology

Volumn 144, Issue 3, 2010, Pages 399-404

  Engelmann, Markus G ^a,c   Theiss, Hans D ^a   Theiss, Christine ^a   Henschel, Volkmar ^a   Huber, Armin ^a   Wintersperger, Bernd J ^a   Schoenberg, Stefan O ^a,b   Steinbeck, Gerhard ^a   Franz, Wolfgang M ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c Kardiologische Praxis im Würmtal ^*  (Germany)

Author keywords

1 year results; Acute myocardial infarction stem mobilization; G CSF

Indexed keywords

ACETYLSALICYLIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CLOPIDOGREL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PLACEBO; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ACUTE CORONARY SYNDROME; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART MUSCLE PERFUSION; HUMAN; LABORATORY TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PERCUTANEOUS CORONARY INTERVENTION; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVASCULARIZATION; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; SURVIVAL RATE;

AGED; ANGIOPLASTY, BALLOON, CORONARY; DOUBLE-BLIND METHOD; FEMALE; FILGRASTIM; FOLLOW-UP STUDIES; GRANULOCYTE COLONY-STIMULATING FACTOR; HEART CONDUCTION SYSTEM; HUMANS; INJECTIONS, SUBCUTANEOUS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; STROKE VOLUME; TREATMENT OUTCOME; VENTRICULAR FUNCTION, LEFT;

EID: 77957881723     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2009.04.047     Document Type: Article

References (36)

1. E. Deindl, M.M. Zaruba, S. Brunner, B. Huber, U. Mehl, and G. Assmann G-CSF administration after myocardial infarction in mice attenuates late ischemic cardiomyopathy by enhanced arteriogenesis Faseb J 20 7 2006 956 958
2. D. Orlic, J. Kajstura, S. Chimenti, D.M. Bodine, A. Leri, and P. Anversa Transplanted adult bone marrow cells repair myocardial infarcts in mice Ann N Y Acad Sci 938 2001 221 229 discussion 229-30
3. S. Fazel, M. Cimini, L. Chen, S. Li, D. Angoulvant, and P. Fedak Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines J Clin Invest 116 7 2006 1865 1877
4. M. Harada, Y. Qin, H. Takano, T. Minamino, Y. Zou, and H. Toko G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes Nat Med 11 3 2005 305 311
5. S. Brunner, B.C. Huber, R. Fischer, M. Groebner, M. Hacker, and R. David G-CSF treatment after myocardial infarction: impact on bone marrow-derived vs cardiac progenitor cells Exp Hematol 36 6 2008 695 702 (Electronic publication ahead of print, Mar 17)
6. H. Ince, M. Petzsch, H.D. Kleine, H. Schmidt, T. Rehders, and T. Korber Preservation from left ventricular remodeling by front-integrated revascularization and stem cell liberation in evolving acute myocardial infarction by use of granulocyte-colony-stimulating factor (FIRSTLINE-AMI) Circulation 112 20 2005 3097 3106
7. H. Ince, M. Petzsch, H.D. Kleine, H. Eckard, T. Rehders, and D. Burska Prevention of left ventricular remodeling with granulocyte colony-stimulating factor after acute myocardial infarction: final 1-year results of the Front-Integrated Revascularization and Stem Cell Liberation in Evolving Acute Myocardial Infarction by Granulocyte Colony-Stimulating Factor (FIRSTLINE-AMI) Trial Circulation 112 9 Suppl 2005 I73 80
8. M. Valgimigli, G.M. Rigolin, C. Cittanti, P. Malagutti, S. Curello, and G. Percoco Use of granulocyte-colony stimulating factor during acute myocardial infarction to enhance bone marrow stem cell mobilization in humans: clinical and angiographic safety profile Eur Heart J 26 18 2005 1838 1845
9. M.G. Engelmann, H.D. Theiss, C. Hennig-Theiss, A. Huber, B.J. Wintersperger, and A.E. Werle-Ruedinger Autologous bone marrow stem cell mobilization induced by granulocyte colony-stimulating factor after subacute ST-segment elevation myocardial infarction undergoing late revascularization: final results from the G-CSF-STEMI (Granulocyte Colony-Stimulating Factor ST-Segment Elevation Myocardial Infarction) trial J Am Coll Cardiol 48 8 2006 1712 1721
10. D. Zohlnhofer, I. Ott, J. Mehilli, K. Schomig, F. Michalk, and T. Ibrahim Stem cell mobilization by granulocyte colony-stimulating factor in patients with acute myocardial infarction: a randomized controlled trial Jama 295 9 2006 1003 1010
11. R.S. Ripa, E. Jorgensen, Y. Wang, J.J. Thune, J.C. Nilsson, and L. Sondergaard Stem cell mobilization induced by subcutaneous granulocyte-colony stimulating factor to improve cardiac regeneration after acute ST-elevation myocardial infarction: result of the double-blind, randomized, placebo-controlled stem cells in myocardial infarction (STEMMI) trial Circulation 113 16 2006 1983 1992
12. M.G. Engelmann, H.D. Theiss, C. Theiss, A. Huber, B.J. Wintersperger, A.E. Werle-Ruedinger, et al., G-CSF in patients suffering from late revascularized ST elevation myocardial infarction: Analysis on the timing of G-CSF administration. Exp Hematol 2008;36(6):703-9 (Electronic publication ahead of print).
13. A. Huber, K. Bauner, B.J. Wintersperger, S.B. Reeder, F. Stadie, and E. Mueller Value of phase-sensitive inversion recovery (PSIR) for detection of myocardial infarction Radiology 237 3 2005 854 860
14. M.G. Engelmann, and W.M. Franz Stem cell therapy after myocardial infarction: ready for clinical application? Curr Opin Mol Ther 8 5 2006 396 414
15. H. Takano, H. Hasegawa, Y. Kuwabara, T. Nakayama, K. Matsuno, and Y. Miyazaki Feasibility and safety of granulocyte colony-stimulating factor treatment in patients with acute myocardial infarction Int J Cardiol 122 1 2007 41 47
16. A. Abdel-Latif, R. Bolli, E.K. Zuba-Surma, I.M. Tleyjeh, C.A. Hornung, and B. Dawn Granulocyte colony-stimulating factor therapy for cardiac repair after acute myocardial infarction: a systematic review and meta-analysis of randomized controlled trials Am Heart J 156 2 2008 216 226 e9
17. E. Jorgensen, F. Baldazzi, R.S. Ripa, T. Friis, Y. Wang, and S. Helqvist Instent neointimal hyperplasia after percutaneous intervention for ST-elevation myocardial infarction and treatment with granulocyte-colony stimulating factor. Results from the stem cells in myocardial infarction (STEMMI) trial Int J Cardiol 139 2010 269 275
18. D. Zohlnhofer, A. Dibra, T. Koppara, A. de Waha, R.S. Ripa, and J. Kastrup Stem cell mobilization by granulocyte colony-stimulating factor for myocardial recovery after acute myocardial infarction: a meta-analysis J Am Coll Cardiol 51 15 2008 1429 1437
19. V. Schachinger, S. Erbs, A. Elsasser, W. Haberbosch, R. Hambrecht, and H. Holschermann Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction N Engl J Med 355 12 2006 1210 1221 (Pubitemid 44427445)
20. K. Lunde, S. Solheim, S. Aakhus, H. Arnesen, M. Abdelnoor, and T. Egeland Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction N Engl J Med 355 12 2006 1199 1209
21. R.S. Ripa, M. Haack-Sorensen, Y. Wang, E. Jorgensen, S. Mortensen, and L. Bindslev Bone marrow derived mesenchymal cell mobilization by granulocyte-colony stimulating factor after acute myocardial infarction: results from the Stem Cells in Myocardial Infarction (STEMMI) trial Circulation 116 11 Suppl 2007 I24 I30
22. S.C. Pitchford, R.C. Furze, C.P. Jones, A.M. Wengner, and S.M. Rankin Differential mobilization of subsets of progenitor cells from the bone marrow Cell Stem Cell 4 1 2009 62 72
23. J. Honold, R. Lehmann, C. Heeschen, D.H. Walter, B. Assmus, and K. Sasaki Effects of granulocyte colony simulating factor on functional activities of endothelial progenitor cells in patients with chronic ischemic heart disease Arterioscler Thromb Vasc Biol 26 10 2006 2238 2243
24. A.T. Askari, S. Unzek, Z.B. Popovic, C.K. Goldman, F. Forudi, and M. Kiedrowski Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy Lancet 362 9385 2003 697 703
25. S. Shintani, T. Murohara, H. Ikeda, T. Ueno, T. Honma, and A. Katoh Mobilization of endothelial progenitor cells in patients with acute myocardial infarction Circulation 103 23 2001 2776 2779
26. W.M. Franz, M. Zaruba, H. Theiss, and R. David Stem-cell homing and tissue regeneration in ischaemic cardiomyopathy Lancet 362 9385 2003 675 676
27. K. Iwanaga, H. Takano, M. Ohtsuka, H. Hasegawa, Y. Zou, and Y. Qin Effects of G-CSF on cardiac remodeling after acute myocardial infarction in swine Biochem Biophys Res Commun 325 4 2004 1353 1359
28. F. Norol, P. Merlet, R. Isnard, P. Sebillon, N. Bonnet, and C. Cailliot Influence of mobilized stem cells on myocardial infarct repair in a nonhuman primate model Blood 102 13 2003 4361 4368
29. M.T. Kuhlmann, P. Kirchhof, R. Klocke, L. Hasib, J. Stypmann, and L. Fabritz G-CSF/SCF reduces inducible arrhythmias in the infarcted heart potentially via increased connexin43 expression and arteriogenesis J Exp Med 203 1 2006 87 97
30. S. Brunner, H.D. Theiss, A. Murr, T. Negele, and W.M. Franz Primary hyperparathyroidism is associated with increased circulating bone marrow-derived progenitor cells Am J Physiol Endocrinol Metab 293 6 2007 E1670 E1675 (Electronic publication ahead of print, 2007 Oct 2)
31. M.M. Zaruba, B.C. Huber, S. Brunner, E. Deindl, R. David, and R. Fischer Parathyroid hormone treatment after myocardial infarction promotes cardiac repair by enhanced neovascularization and cell survival Cardiovasc Res 77 4 2008 722 731
32. S. Brunner, M.M. Zaruba, B. Huber, R. David, M. Vallaster, and G. Assmann Parathyroid hormone effectively induces mobilization of progenitor cells without depletion of bone marrow Exp Hematol 36 9 2008 1157 1166
33. S. Brunner, J. Winogradow, B.C. Huber, M.M. Zaruba, R. Fischer, and R. David Erythropoietin administration after myocardial infarction in mice attenuates ischemic cardiomyopathy associated with enhanced homing of bone marrow-derived progenitor cells via the CXCR-4/SDF-1 axis Faseb J 23 2 2009 351 361
34. V.F. Segers, T. Tokunou, L.J. Higgins, C. MacGillivray, J. Gannon, and R.T. Lee Local delivery of protease-resistant stromal cell derived factor-1 for stem cell recruitment after myocardial infarction Circulation 116 15 2007 1683 1692
35. J.D. Abbott, Y. Huang, D. Liu, R. Hickey, D.S. Krause, and F.J. Giordano Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury Circulation 110 21 2004 3300 3305
36. A.J. Coats Ethical authorship and publishing Int J Cardiol 131 2009 149 150