Cranberries: Ripe for more cancer research?

Journal of the Science of Food and Agriculture

Volumn 91, Issue 13, 2011, Pages 2303-2307

  Neto, Catherine C ^a  

^a UNIVERSITY OF MASSACHUSETTS DARTMOUTH   (United States)

Author keywords

Apoptosis; Cancer; Cranberry; Polyphenol; Proanthocyanidin; Prostate; Tumor; Ursolic acid

Indexed keywords

ANTINEOPLASTIC AGENT; PLANT EXTRACT;

ANIMAL; ARTICLE; CHEMISTRY; CRANBERRY; FRUIT; FUNCTIONAL FOOD; HUMAN; NEOPLASM;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; FRUIT; FUNCTIONAL FOOD; HUMANS; NEOPLASMS; PLANT EXTRACTS; VACCINIUM MACROCARPON;

ANIMALIA; VACCINIUM MACROCARPON;

EID: 80052633083     PISSN: 00225142     EISSN: 10970010     Source Type: Journal    
DOI: 10.1002/jsfa.4621     Document Type: Article

References (40)

1. Seeram NP, Berries, in Nutritional Oncology (2nd edn), ed. by Heber D. Academic Press/Elsevier, New York, pp. 615-628 (2006).
2. Stoner GD and Seeram NP (eds), Berries and Cancer Prevention. Springer, New York (2011).
3. Cranberry Institute. [Online]. Available: [12 August 2011].
4. Howell A, Cranberry proanthocyanidins and the maintenance of urinary tract health. Crit Rev Food Sci Nutr 42S: 273-278 (2002).
5. Jepson RG and Craig JC, A systematic review of the evidence for cranberries and blueberries in UTI prevention. Mol Nutr Food Res 51: 738-745 (2007).
6. Bodet C, Grenier D, Chandad F, Ofek I, Steinberg D and Weiss EI, Potential oral health benefits of cranberry. Crit Rev Food Sci Nutr 48: 672-680 (2008).
7. Burger O, Ofek I, Tabak M, Weiss EI, Sharon N and Neeman I, A high molecular mass constituent of cranberry juice inhibits Helicobacter pylori adhesion to human gastric mucus. FEMS Immunol Med Microbiol 29: 295-301 (2000).
8. Vinson JA, Su X, Zubik L and Bose P, Phenol antioxidant quantity and quality in foods: fruits. J Agric Food Chem 49: 5315-5321 (2001).
9. Neto CC, Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases. Mol Nutr Food Res 51: 652-664 (2007).
10. Pappas E and Schaich KM, Phytochemicals of cranberries and cranberry products: characterization, potential health effects, and processing stability. Crit Rev Food Sci Nutr 49: 741-781 (2009).
11. USDA Database for the Proanthocyanidin Content of Selected Foods (August 2004). [Online]. Available: [12 August 2011].
12. Neto CC, Krueger CG, Lamoureaux TL, Kondo M, Vaisberg AJ, Hurta RAR, et al, MALDI-TOF MS characterization of proanthocyanidins from cranberry fruit (Vaccinium macrocarpon) that inhibit tumor cell growth and matrix metalloproteinase expression in vitro. J Sci Food Agric 86: 18-25 (2006).
13. Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE and Prior RL, Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption. J Agric Food Chem 54: 4069-4075 (2006).
14. Neto CC, Cranberry and its phytochemicals: a review of in vitro anticancer studies. J Nutr 137: 186S-193S (2007).
15. Murphy BT, MacKinnon SL, Yan X, Hammond GB, Vaisberg AJ and Neto CC, Identification of triterpene hydroxycinnamates with in vitro antitumor activity from whole cranberry fruit (Vaccinium macrocarpon). J Agric Food Chem 51: 3541-3545 (2003).
16. Kondo M, MacKinnon SL, Craft CC, Matchett MD, Hurta RAR and Neto CC, Ursolic acid and its esters: occurrence in cranberries and other Vaccinium fruit and effects on matrix metalloproteinase activity in DU145 prostate tumor cells. J Sci Food Agric 91: 789-796 (2011).
17. Neto CC, Amoroso JW and Liberty AM, Anticancer activities of cranberry phytochemicals: an update. Mol Nutr Food Res 52: 18-27 (2008).
18. Bomser J, Madhavi DL, Singletary K and Smith MAL, In vitro anticancer activity of fruit extracts from Vaccinium species. Planta Med 62: 212-216 (1996).
19. Kandil FE, Smith MAL, Rogers RB, Pépin MF, Song LL, Pezzuto JM, et al, Composition of a chemopreventive proanthocyanidin-rich fraction from cranberry fruits responsible for the inhibition of TPA-induced ODC activity. J Agric Food Chem 50: 1063-1069 (2002).
20. Matchett MD, Compton KA, Kondo M, Neto CC and Hurta RAR, Lipopolysaccharide, cranberry flavonoids and regulation of ornithine decarboxylase (ODC) and spermidine/spermine N1-acetyltransferase (SSAT) expression in H-ras transformed cells. FASEB J, 19: A825 (2005).
21. Roy S, Khanna S, Alessio HM, Vider J, Bagchi D, Bagchi M, et al, Antiangiogenic property of edible berries. Free Radic Res 36: 1023-1031 (2002).
22. Liberty AM, Amoroso JW, Hart PE and Neto CC, Cranberry PACs and triterpenoids: anti-cancer activities in colon tumor cell lines. Acta Hortic 841: 61-66 (2009).
23. Ferguson P, Kurowska E, Freeman DJ, Chambers AF and Koropatnick DJ, A flavonoid fraction from cranberry extract inhibits proliferation of human tumor cell lines. J Nutr 134: 1529-1535 (2004).
24. Sun J and Liu RH, Cranberry phytochemical extracts induce cell cycle arrest and apoptosis in human MCF-7 breast cancer cells. Cancer Lett 241: 124-134 (2006).
25. Ferguson PJ, Kurowska EM, Freeman DJ, Chambers AF and Koropatnick DJ, In vivo inhibition of growth of human tumor lines by flavonoid fractions from cranberry extract. Nutr Cancer 56: 86-94 (2006).
26. Chatelain K, Phippen S, McCabe J, Teeters CA, O'Malley S and Kingsley K, Cranberry and grape seed extracts inhibit the proliferative phenotype of oral squamous cell carcinomas. Evid Based Complement Alternat Med (2011). ID 467691 (2011).
27. Singh A, Singh R, Kim K, Satyan K, Nussbaum R, Brard L, et al, Cranberry proanthocyanidins are cytotoxic to human cancer cells and sensitize platinum-resistant ovarian cancer cells to paraplatin. Phytother Res 23: 1066-1074 (2009).
28. Kresty LA, Howell AB and Baird M, Cranberry proanthocyanidins induce apoptosis and inhibit acid-induced proliferation of human esophageal adenocarcinoma cells. J Agric Food Chem 56: 676-680 (2008).
29. Seeram NP, Adams LS, Hardy ML and Heber D, Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell lines. J Agric Food Chem 52: 2512-2517 (2004).
30. MacLean MA, Scott BE, Deziel BA, Liberty AM, Nunnelley M, Gottschall-Pass KT, et al, North American cranberry (Vaccinium macrocarpon) stimulates apoptotic pathways in DU145 human prostate cancer cells in vitro. Nutr Cancer 63: 109-120 (2011).
31. Kresty L, Howell A and Baird M, Cranberry proanthocyanidins mediate growth arrest of lung cancer cells through modulation of gene expression and rapid induction of apoptosis. Molecules 16: 2375-2390 (2011).
32. Yousif R, Herzog M, Che M, Upadhyay J, Shekarriz B, Bhagut S, et al, Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis. J Natl Cancer Inst 94: 17-25 (2002).
33. Déziel B, Patel K, Neto C, Gottschall-Pass K and Hurta R, Proantho-cyanidins from the American cranberry (Vaccinium macrocarpon) inhibit matrix metalloproteinase-2 and matrix metalloproteinase-9 activity in human prostate cancer cells via alterations in multiple cellular signalling pathways. J Cell Biochem 111: 742-754 (2010).
34. Prasain JK, Jones K, Moore R, Barnes S, Leahy M, Roderick R, et al, Effect of cranberry juice concentrate on chemically-induced urinary bladder cancers. Oncol Rep 19: 1565-1570 (2008).
35. Koli R, Erlund I, Jula A, Marniemi J, Mattila P and Alfthan G, Bioavailability of various polyphenols from a diet containing moderate amounts of berries. J Agric Food Chem 58: 3927-3932 (2010).
36. Ohnishi R, Ito H, Kasajima N, Kaneda M, Kariyama R, Kumon H, et al, Urinary excretion of anthocyanins in humans after cranberry juice ingestion. Biosci Biotechnol Biochem 70: 1681-1687 (2006).
37. Prior RL, Rogers TR, Khanal RC, Wilkes SE, Wu X and Howard LR, Urinary excretion of phenolic acids in rats fed cranberry. J Agric Food Chem 58: 3940-3949 (2010).
38. Del Rio D, Borges G and Crozier A, Berry flavonoids and phenolics: bioavailability and evidence of protective effects. Br J Nutr 104: S67-90 (2010).
39. DeAngel RE, Smith SM, Glickman RD, Perkins SN and Hursting SD, Antitumor effects of ursolic acid in a mouse model of postmenopausal breast cancer. Nutr Cancer 62: 1074-1086 (2010).
40. Hochman N, Houri-Haddad Y, Koblinski J, Wahl L, Roniger M, Bar-Sinai A, et al, Cranberry juice constituents impair lymphoma growth and augment the generation of antilymphoma antibodies in syngeneic mice. Nutr Cancer 60: 511-517 (2008).